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Gene: Akr1c14 (aldo-keto reductase family 1, member C14) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Akr1c14

Name:

aldo-keto reductase family 1, member C14

RGD ID:

708361

Description:

Enables steroid dehydrogenase activity. Involved in androgen catabolic process; hippocampus development; and response to resveratrol. Located in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3); INTERACTS WITH 1,4-benzoquinone; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

3-alpha-HSD; 3-alpha-hydroxysteroid dehydrogenase; Akr1c9; hydroxyprostaglandin dehydrogenase; LOC191574; steroid 3-alpha-dehydrogenase; steroid3-alpha-dehydrogenase

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	AKR1C4 (aldo-keto reductase family 1 member C4)	HGNC	OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):	AKR1C3 (aldo-keto reductase family 1 member C3)	HGNC	OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):	AKR1C1 (aldo-keto reductase family 1 member C1)	HGNC	OrthoDB, Panther, PhylomeDB
Homo sapiens (human):	AKR1C2 (aldo-keto reductase family 1 member C2)	HGNC	OrthoDB, Panther, PhylomeDB
Alliance orthologs ³
Mus musculus (house mouse):	Akr1c14 (aldo-keto reductase family 1, member C14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1C1 (aldo-keto reductase family 1 member C1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Homo sapiens (human):	AKR1C1 (aldo-keto reductase family 1 member C1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1C4 (aldo-keto reductase family 1 member C4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Homo sapiens (human):	AKR1C4 (aldo-keto reductase family 1 member C4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1C3 (aldo-keto reductase family 1 member C3)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Homo sapiens (human):	AKR1C3 (aldo-keto reductase family 1 member C3)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1C2 (aldo-keto reductase family 1 member C2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Homo sapiens (human):	AKR1C2 (aldo-keto reductase family 1 member C2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:56622	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12766	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG9436	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	GCY1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	GRE3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder)
Caenorhabditis elegans (roundworm):	T08H10.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	T08H10.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YPR1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	ARY	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10638	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10638	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ARA1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG10863	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector)
Caenorhabditis elegans (roundworm):	C07D8.6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	C56G3.2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	C56G3.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	akr1c2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	akr1c2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	akr1c8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	akr1c1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	akr1c3	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	XB5895996 [provisional:cbr1]	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	akr1c4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	LOC116406435	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	LOC734139	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	71,066,197 - 71,083,184 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	71,066,200 - 71,083,157 (-)	Ensembl				GRCr8
mRatBN7.2	17	66,156,286 - 66,173,277 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	66,156,288 - 66,173,277 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	69,641,423 - 69,658,409 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,470,268 - 73,487,254 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	67,513,246 - 67,530,234 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	69,806,095 - 69,827,125 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	69,806,065 - 69,827,112 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	71,510,873 - 71,530,255 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	77,316,456 - 77,332,903 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	65,671,422 - 65,688,400 (-)	NCBI		Celera
RGSC_v3.1	17	77,327,313 - 77,343,731 (-)	NCBI
Cytogenetic Map	17	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,4-benzoquinone (EXP)

17alpha-ethynylestradiol (EXP)

17beta-hydroxy-5alpha-androstan-3-one (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-methoxyethanol (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (EXP)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (EXP)

9,10-phenanthroquinone (EXP)

acetamide (EXP)

acrylamide (EXP)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

androstane-3,17-diol (EXP)

androsterone (EXP)

benzo[a]pyrene (EXP)

benzo[a]pyrene-7,8-dione (EXP)

bisphenol A (EXP)

Bisphenol B (EXP)

bromobenzene (EXP)

buspirone (EXP)

cholic acid (EXP)

cisplatin (EXP)

clofibrate (EXP)

cobalt dichloride (EXP)

cyclophosphamide (EXP)

decabromodiphenyl ether (EXP)

dehydroepiandrosterone (EXP)

dibutyl phthalate (EXP)

diethyl maleate (EXP)

dioxygen (EXP)

diuron (EXP)

endosulfan (EXP)

flurbiprofen (EXP)

furan (EXP)

gentamycin (EXP)

glafenine (EXP)

indometacin (EXP)

methamphetamine (EXP)

methapyrilene (EXP)

mifepristone (EXP)

N-nitrosomorpholine (EXP)

NADP zwitterion (EXP)

NADP(+) (EXP)

naphthalenes (EXP)

nefazodone (EXP)

nitrofen (EXP)

Nonylphenol (EXP)

oxaliplatin (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

pirinixic acid (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

quercetin (EXP)

Rebamipide (EXP)

sevoflurane (EXP)

silicon dioxide (EXP)

sodium arsenite (EXP)

tauroursodeoxycholic acid (EXP)

tetraphene (EXP)

thioacetamide (EXP)

topotecan (EXP)

valdecoxib (EXP)

valproic acid (EXP)

vitamin K (EXP)

zinc atom (EXP)

zinc(0) (EXP)

ziram (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen catabolic process (IDA)

daunorubicin metabolic process (IBA)

doxorubicin metabolic process (IBA)

hippocampus development (IEP)

progesterone metabolic process (IBA)

prostaglandin metabolic process (IBA)

response to resveratrol (IEP)

steroid metabolic process (TAS)

Cellular Component

cytoplasm (IEA)

cytosol (IBA,IDA)

Molecular Function

3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity (IEA)

aldose reductase (NADPH) activity (IBA)

androsterone dehydrogenase [NAD(P)+] activity (IBA,IEA)

bile acid binding (IBA)

ketosteroid monooxygenase activity (IBA)

oxidoreductase activity (IEA)

steroid dehydrogenase activity (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning and expression of rat liver 3 alpha-hydroxysteroid dehydrogenase.	Cheng KC, etal., Mol Endocrinol 1991 Jun;5(6):823-8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Butylated hydroxyanisole alters rat 5α-reductase and 3α-hydroxysteroid dehydrogenase: Implications for influences of neurosteroidogenesis.	Guo J, etal., Neurosci Lett. 2017 Jul 13;653:132-138. doi: 10.1016/j.neulet.2017.05.034. Epub 2017 May 24.
4.	Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus.	Kimoto T, etal., Endocrinology. 2010 Nov 3.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.	Pawlowski JE, etal., J Biol Chem 1991 May 15;266(14):8820-5.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Molecular structure of rat hepatic 3 alpha-hydroxysteroid dehydrogenase. A member of the oxidoreductase gene family.	Stolz A, etal., J Biol Chem 1991 Aug 15;266(23):15253-7.
10.	Rat hepatic 3 alpha-hydroxysteroid dehydrogenase: expression of cDNA and physiological function in bile acid biosynthetic pathway.	Usui E, etal., J Biochem (Tokyo) 1994 Feb;115(2):230-7.
11.	Effects of resveratrol on rat neurosteroid synthetic enzymes.	Wang Y, etal., Fitoterapia. 2017 Oct;122:61-66. doi: 10.1016/j.fitote.2017.08.005. Epub 2017 Aug 18.

Additional References at PubMed

PMID:1793046	PMID:2026597	PMID:7626489	PMID:7998972	PMID:8146147	PMID:8718859	PMID:10619355	PMID:12477932	PMID:15134457	PMID:15305365	PMID:15379543	PMID:17848571
PMID:22217852	PMID:28707553

Genomics

Variants

Variants in Akr1c14
126 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	140
Count of miRNA genes:	117
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000023835
Prediction methods:	Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	30066472	75066472	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	70613502	86062352	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	33104645	78104645	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	26522051	71522051	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	35446949	75762341	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	33104645	78104645	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27233445	72233445	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63697147	82818564	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	64569820	86954580	Rat

Markers in Region

RH143757

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	66,157,024 - 66,157,181 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	69,806,834 - 69,806,990	NCBI	Rnor6.0
Rnor_5.0	17	71,511,612 - 71,511,768	UniSTS	Rnor5.0
RGSC_v3.4	17	77,317,195 - 77,317,351	UniSTS	RGSC3.4
Celera	17	65,672,161 - 65,672,317	UniSTS
RH 3.4 Map	17	636.0	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	65	144	91	90	59	33	59	6	289	131	11	120	75	92	31	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH009074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JC188766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JC236380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JC240263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M64393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S57790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023835 ⟹ ENSRNOP00000023835

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	71,066,200 - 71,083,157 (-)	Ensembl
mRatBN7.2 Ensembl	17	66,156,289 - 66,173,277 (-)	Ensembl
Rnor_6.0 Ensembl	17	69,806,065 - 69,827,112 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102344 ⟹ ENSRNOP00000089621

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	66,156,288 - 66,173,277 (-)	Ensembl

RefSeq Acc Id:

NM_138547 ⟹ NP_612556

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	71,066,197 - 71,083,184 (-)	NCBI
mRatBN7.2	17	66,156,286 - 66,173,277 (-)	NCBI
Rnor_6.0	17	69,806,095 - 69,827,125 (-)	NCBI
Rnor_5.0	17	71,510,873 - 71,530,255 (-)	NCBI
RGSC_v3.4	17	77,316,456 - 77,332,903 (-)	RGD
Celera	17	65,671,422 - 65,688,400 (-)	NCBI

Sequence:

show sequence

TTTTATCCTGTGCAAAAAGAAGACCCAAGACCTGCTTGGTTGCATGAGTAACAAGCGATGGATT
CCATATCTCTGCGTGTAGCACTAAATGATGGTAACTTCATTCCTGTACTGGGGTTTGGAACCAC
TGTGCCTGAGAAGGTTGCTAAGGATGAAGTTATCAAGGCTACTAAAATAGCTATAGATAATGGA
TTCCGCCATTTTGACTCTGCTTATTTGTACGAAGTAGAAGAGGAAGTGGGCCAAGCCATTAGAA
GCAAGATTGAAGACGGCACTGTGAAGAGAGAAGATATATTCTATACTTCAAAGCTTTGGAGCAC
TTTCCATAGACCAGAGCTGGTCCGAACTTGCTTGGAAAAGACACTGAAAAGCACTCAACTGGAC
TATGTGGATCTTTATATTATTCATTTCCCAATGGCTTTGCAGCCTGGAGATATATTTTTCCCAC
GAGATGAGCATGGAAAACTATTGTTTGAAACAGTGGATATCTGTGACACATGGGAGGCCATGGA
GAAGTGTAAGGATGCAGGATTGGCCAAGTCTATTGGGGTGTCCAACTTTAACTGCAGGCAGCTG
GAGAGGATTCTGAATAAGCCAGGGCTCAAATACAAGCCTGTGTGCAACCAGGTGGAATGTCACC
TTTATCTCAACCAGAGCAAAATGCTGGACTATTGTAAGTCAAAAGACATCATTCTGGTTTCCTA
CTGCACGCTGGGAAGTTCACGAGACAAAACATGGGTGGATCAGAAAAGTCCAGTTCTCCTAGAT
GATCCAGTTCTTTGTGCCATAGCAAAGAAGTACAAGCAAACCCCAGCCCTAGTTGCCCTTCGCT
ACCAGCTGCAGCGTGGGGTTGTGCCCCTGATCAGGAGTTTCAACGCGAAGCGGATCAAAGAGCT
AACACAGGTTTTTGAATTCCAGTTGGCTTCAGAGGACATGAAAGCCCTGGATGGCTTGAACAGA
AATTTCAGATACAACAATGCAAAATATTTTGATGACCATCCCAATCATCCATTTACTGATGAAT
AGTAACATGGTGGACTTTGTCAGCATTTCTATCGGAAGATCTGTTTATGCATTGTGATTTGAAA
GATATCTTGGATACTGGTGACTGAACGCATCAGACCACTGTTTCTGTTAATTCACAGTCAGCTG
GAGCAATGTCCACAGTGCTATGAGGGAAGCCATGTTTTTGTCACACTCTGAAATGGAACATCAC
GTTGCTTTTCCTTGTGTTTTTAAATATTCATTTATTTTGCTTTCCATATATGAATATTTTCCCT
ACATGTATGTGTATCTCATGAATGTCTATGTCCATGCAGGGTTGAAGAGTGTTGCAGGTCACTT
GGAACCGGAGTTACATTGATTATGGAGTTACCATGTGGGTGCTGGGAGCCAAACCTAGGTCTTC
TGTGAGACTAGCAAGTGCCTTTGAATGCTGAGCCATCTCATTAGGTCCAACCCTAAAGATCCTT
GCCTGCCACTATTTCTGTGATCTCAATGTTTTGTTTTCTCCTGACTTCTGACACCAAGCTGATT
TGCTAGAAGTCTTGGGCATGAAGTGGGTGTTGAGGACAGTTATTGCAAAGGGATTTCTGGGTGG
GAGTTGAAAGAACGTTCAACATTCAGGGAATTAATTGTTCGAGGTTATTGATTAGTCAATATTC
CCCATATTCTTTGAGGAAGAAGAAAGTACTCCATAGATTTTCCCTTTTTCTTAGTTTTGAGGTA
GGGCACCTGTGGCAGGAGTGACCAAGAGACCCAGGGTTCTCTCCAACAGCCCAAGAACCAGAGC
TCCAAGAACCTGGAGAGCAAGTTCTTGTGGGAAGGTTGGAATGTTGGTAAGAAGAGAACCAATC
TAAAAGCATCATCATGATTCAGATGTGGGGAGTTTGAGAGGAAATTTGAATGTGTCTCTCTTTT
TGGGAAATATATCATCTTTTTTCTTTTTGTAATTACATGTTGGGAGCAATGCCCTTGAAACCCT
CCATTATTGATGTTATGGTTAGAATTAAGTATGACTGGGTTCATGGAAAATCCCCAGCCAGCTG
CAGAAGACTAATACAAATCTGGTGGTCAGGATGAATAATGATATGATAAAGTTCTGACCTTGCT
GAGAAATACATCTGACATCAAGATACCCAATGTGATGACCTGTAAGCTTTCTGAAAAACCAACA
TCCTGTTGACATCAGCTGACTACATGTATACTGTGCCCTTGGCCTGTGTAAATGTTTCACACTT
CCCCCCTCCCTCTGTTACCCATGTTATGGTATAAATTCAGCCTTGGTAAAAAATAAAATTGTCG
CCTTGATCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_612556	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40605	(Get FASTA)	NCBI Sequence Viewer
	AAB19918	(Get FASTA)	NCBI Sequence Viewer
	AAF25813	(Get FASTA)	NCBI Sequence Viewer
	AAH91123	(Get FASTA)	NCBI Sequence Viewer
	CDM21972	(Get FASTA)	NCBI Sequence Viewer
	CDM43050	(Get FASTA)	NCBI Sequence Viewer
	CDM55235	(Get FASTA)	NCBI Sequence Viewer
	EDL78575	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023835
	ENSRNOP00000023835.4
GenBank Protein	P23457	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_612556 ⟸ NM_138547

- UniProtKB:

Q6LDE6 (UniProtKB/Swiss-Prot), Q5BKC8 (UniProtKB/Swiss-Prot), Q6LDE7 (UniProtKB/Swiss-Prot), P23457 (UniProtKB/Swiss-Prot), A6JLP8 (UniProtKB/TrEMBL), A0A8I6AD00 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDSISLRVALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQA
IRSKIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGDIF
FPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKPVCNQVE
CHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPVLCAIAKKYKQTPALVA
LRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFRYNNAKYFDDHPNHPFT
DE

hide sequence

Ensembl Acc Id:

ENSRNOP00000023835 ⟸ ENSRNOT00000023835

Ensembl Acc Id:

ENSRNOP00000089621 ⟸ ENSRNOT00000102344

Protein Domains

NADP-dependent oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P23457-F1-model_v2	AlphaFold	P23457	1-322	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700548

Promoter ID:

EPDNEW_R11071

Type:

multiple initiation site

Name:

Akr1c14_1

Description:

aldo-keto reductase family 1, member C14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	69,827,121 - 69,827,181	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708361	AgrOrtholog
BioCyc Gene	G2FUF-8831	BioCyc
BioCyc Pathway	PWY-6061 [bile acid biosynthesis, neutral pathway]	BioCyc
	PWY-7455 [allopregnanolone biosynthesis]	BioCyc
	PWY-8200 [backdoor pathway of androgen biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6061	BioCyc
	PWY-7455	BioCyc
	PWY-8200	BioCyc
Ensembl Genes	ENSRNOG00000017672	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023835	ENTREZGENE
	ENSRNOT00000023835.7	UniProtKB/Swiss-Prot
Gene3D-CATH	3.20.20.100	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7372929	IMAGE-MGC_LOAD
InterPro	AKR1C	UniProtKB/Swiss-Prot
	Aldo/ket_reductase_CS	UniProtKB/Swiss-Prot
	Aldo/keto_reductase	UniProtKB/Swiss-Prot
	NADP_OxRdtase_dom	UniProtKB/Swiss-Prot
	NADP_OxRdtase_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:191574	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108595	IMAGE-MGC_LOAD
NCBI Gene	191574	ENTREZGENE
PANTHER	ALDO/KETO REDUCTASE	UniProtKB/Swiss-Prot
Pfam	Aldo_ket_red	UniProtKB/Swiss-Prot
PhenoGen	Akr1c14	PhenoGen
PIRSF	AKR	UniProtKB/Swiss-Prot
PRINTS	ALDKETRDTASE	UniProtKB/Swiss-Prot
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/Swiss-Prot
	ALDOKETO_REDUCTASE_2	UniProtKB/Swiss-Prot
	ALDOKETO_REDUCTASE_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017672	RatGTEx
Superfamily-SCOP	SSF51430	UniProtKB/Swiss-Prot
UniProt	A0A8I6AD00	ENTREZGENE
	A6JLP8	ENTREZGENE, UniProtKB/TrEMBL
	DIDH_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5BKC8	ENTREZGENE
	Q6LDE6	ENTREZGENE
	Q6LDE7	ENTREZGENE
UniProt Secondary	Q5BKC8	UniProtKB/Swiss-Prot
	Q6LDE6	UniProtKB/Swiss-Prot
	Q6LDE7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Akr1c14	aldo-keto reductase family 1, member C14	LOC191574	3-alpha-hydroxysteroid dehydrogenase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	LOC191574				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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