Pdk2 (pyruvate dehydrogenase kinase 2) - Rat Genome Database

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Gene: Pdk2 (pyruvate dehydrogenase kinase 2) Rattus norvegicus
Analyze
Symbol: Pdk2
Name: pyruvate dehydrogenase kinase 2
RGD ID: 69428
Description: Enables ATP binding activity; identical protein binding activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in peptidyl-serine phosphorylation. Part of pyruvate dehydrogenase complex. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; PDH kinase 2; PDK P45; pyruvate dehydrogenase 2; pyruvate dehydrogenase kinase 2 subunit p45 (PDK2); pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isozyme 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,469,388 - 80,483,988 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1080,469,389 - 80,484,355 (-)EnsemblGRCr8
mRatBN7.21079,972,550 - 79,987,074 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,972,556 - 79,987,085 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1084,921,543 - 84,936,179 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,419,615 - 84,434,251 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,812,846 - 79,827,353 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,838,270 - 82,852,758 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,839,153 - 82,852,660 (-)Ensemblrn6Rnor6.0
Rnor_5.01082,649,285 - 82,663,773 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41083,710,448 - 83,724,973 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,746,233 - 78,760,783 (-)NCBICelera
RGSC_v3.11083,724,817 - 83,739,343 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
dibutyl phthalate  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
ketamine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
methoxyacetic acid  (EXP)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
Triptolide  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus. Bajotto G, etal., Life Sci. 2004 Sep 10;75(17):2117-30.
2. Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase. Boulatnikov I and Popov KM, Biochim Biophys Acta. 2003 Feb 21;1645(2):183-92.
3. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Bowker-Kinley MM, etal., Biochem J 1998 Jan 1;329 ( Pt 1):191-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone. Holness MJ, etal., Biochem J 2003 Feb 1;369(Pt 3):687-95.
7. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. Korotchkina LG and Patel MS, J Biol Chem. 2001 Oct 5;276(40):37223-9. Epub 2001 Aug 2.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
10. Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase. Popov KM, etal., J Biol Chem 1994 Nov 25;269(47):29720-4.
11. Medical College of Ohio's SSLP Data file transfer Rapp J, Dene H,Direct Electronic Data transfer Feb.(5)2001 . Medical College of Ohio Department of Physiology and Molecular Medicine.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Sugden MC, etal., Biochem J. 2000 Mar 15;346 Pt 3:651-7.
Additional References at PubMed
PMID:11485553   PMID:14651853   PMID:14966024   PMID:15489334   PMID:16216081   PMID:16401071   PMID:16483874   PMID:17544412   PMID:18614015   PMID:18627174   PMID:19833728   PMID:21190881  
PMID:21283817   PMID:22123926   PMID:22360721   PMID:22910903   PMID:23357539   PMID:25436986   PMID:26769971   PMID:30053369  


Genomics

Comparative Map Data
Pdk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,469,388 - 80,483,988 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1080,469,389 - 80,484,355 (-)EnsemblGRCr8
mRatBN7.21079,972,550 - 79,987,074 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,972,556 - 79,987,085 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1084,921,543 - 84,936,179 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,419,615 - 84,434,251 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,812,846 - 79,827,353 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,838,270 - 82,852,758 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,839,153 - 82,852,660 (-)Ensemblrn6Rnor6.0
Rnor_5.01082,649,285 - 82,663,773 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41083,710,448 - 83,724,973 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,746,233 - 78,760,783 (-)NCBICelera
RGSC_v3.11083,724,817 - 83,739,343 (-)NCBI
Cytogenetic Map10q26NCBI
PDK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,094,737 - 50,112,152 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,094,737 - 50,112,152 (+)Ensemblhg38GRCh38
GRCh371748,172,101 - 48,189,516 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,527,695 - 45,543,422 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341745,527,694 - 45,543,421NCBI
Celera1744,632,807 - 44,648,538 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,539,977 - 43,556,609 (+)NCBIHuRef
CHM1_11748,236,413 - 48,253,044 (+)NCBICHM1_1
T2T-CHM13v2.01750,961,834 - 50,979,254 (+)NCBIT2T-CHM13v2.0
Pdk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,917,084 - 94,932,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,917,084 - 94,932,180 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381195,026,258 - 95,041,371 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,026,258 - 95,041,354 (-)Ensemblmm10GRCm38
MGSCv371194,887,572 - 94,902,685 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361194,842,348 - 94,862,996 (-)NCBIMGSCv36mm8
Celera11104,636,649 - 104,651,762 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Pdk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,547,660 - 11,559,403 (-)Ensembl
ChiLan1.0NW_00495545111,547,660 - 11,559,266 (-)NCBIChiLan1.0ChiLan1.0
PDK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,283,348 - 66,299,812 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,089,859 - 71,106,300 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,185,463 - 44,202,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,060,030 - 49,076,115 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,060,030 - 49,076,115 (+)EnsemblpanPan2panpan1.1
PDK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,099,457 - 26,116,094 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,100,343 - 26,115,423 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha925,492,516 - 25,509,234 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0926,893,879 - 26,910,588 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,894,791 - 26,910,584 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,661,663 - 25,678,380 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,920,287 - 25,937,009 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,050,254 - 26,066,966 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,526,072 - 25,540,727 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,534,243 - 11,549,642 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,534,412 - 11,549,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,274,606 - 26,301,878 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11226,274,562 - 26,295,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,313,934 - 26,335,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,227,843 - 43,243,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,229,093 - 43,243,627 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607713,943,908 - 13,959,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,095,948 - 6,107,271 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247956,096,164 - 6,107,271 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1959,342,026 - 59,356,903 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pdk2
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000005641
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
Pdk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,972,807 - 79,973,068 (+)MAPPERmRatBN7.2
Rnor_6.01082,838,525 - 82,838,785NCBIRnor6.0
Rnor_5.01082,649,540 - 82,649,800UniSTSRnor5.0
RGSC_v3.41083,710,703 - 83,710,963UniSTSRGSC3.4
Celera1078,746,488 - 78,746,748UniSTS
Cytogenetic Map10q31UniSTS
RH141314  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81080,469,576 - 80,470,150 (+)Marker Load Pipeline
mRatBN7.21079,972,738 - 79,973,312 (+)MAPPERmRatBN7.2
Rnor_6.01082,838,456 - 82,839,029NCBIRnor6.0
Rnor_6.01082,835,813 - 82,836,373NCBIRnor6.0
Rnor_5.01082,649,471 - 82,650,044UniSTSRnor5.0
RGSC_v3.41083,710,634 - 83,711,207UniSTSRGSC3.4
Celera1078,746,419 - 78,746,992UniSTS
RH 3.4 Map10721.1UniSTS
Cytogenetic Map10q31UniSTS
MARC_7915-7916:996688163:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81080,470,338 - 80,471,025 (+)Marker Load Pipeline
mRatBN7.21079,973,500 - 79,974,187 (+)MAPPERmRatBN7.2
Rnor_6.01082,839,218 - 82,839,904NCBIRnor6.0
Rnor_5.01082,650,233 - 82,650,919UniSTSRnor5.0
RGSC_v3.41083,711,396 - 83,712,082UniSTSRGSC3.4
Celera1078,747,181 - 78,747,867UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005641   ⟹   ENSRNOP00000005641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,469,389 - 80,484,355 (-)Ensembl
mRatBN7.2 Ensembl1079,972,556 - 79,987,085 (-)Ensembl
Rnor_6.0 Ensembl1082,839,153 - 82,852,660 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102681   ⟹   ENSRNOP00000093282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,469,389 - 80,483,682 (-)Ensembl
mRatBN7.2 Ensembl1079,972,556 - 79,987,085 (-)Ensembl
RefSeq Acc Id: NM_030872   ⟹   NP_110499
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,469,391 - 80,483,912 (-)NCBI
mRatBN7.21079,972,553 - 79,987,074 (-)NCBI
Rnor_6.01082,838,270 - 82,852,758 (-)NCBI
Rnor_5.01082,649,285 - 82,663,773 (-)NCBI
RGSC_v3.41083,710,448 - 83,724,973 (-)RGD
Celera1078,746,233 - 78,760,783 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086929   ⟹   XP_038942857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,469,388 - 80,483,687 (-)NCBI
mRatBN7.21079,972,550 - 79,986,716 (-)NCBI
RefSeq Acc Id: XM_063269941   ⟹   XP_063126011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,469,388 - 80,483,955 (-)NCBI
RefSeq Acc Id: XM_063269942   ⟹   XP_063126012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,470,329 - 80,483,988 (-)NCBI
RefSeq Acc Id: NP_110499   ⟸   NM_030872
- UniProtKB: Q64536 (UniProtKB/Swiss-Prot),   A6HI79 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005641   ⟸   ENSRNOT00000005641
RefSeq Acc Id: XP_038942857   ⟸   XM_039086929
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AJH2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093282   ⟸   ENSRNOT00000102681
RefSeq Acc Id: XP_063126011   ⟸   XM_063269941
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AJH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126012   ⟸   XM_063269942
- Peptide Label: isoform X3
- UniProtKB: F1LMM8 (UniProtKB/TrEMBL),   Q9JID3 (UniProtKB/TrEMBL)
Protein Domains
Branched-chain alpha-ketoacid dehydrogenase   Histidine kinase   Histidine kinase/HSP90-like ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64536-F1-model_v2 AlphaFold Q64536 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697615
Promoter ID:EPDNEW_R8140
Type:initiation region
Name:Pdk2_1
Description:pyruvate dehydrogenase kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,852,759 - 82,852,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69428 AgrOrtholog
BioCyc Gene G2FUF-23570 BioCyc
Ensembl Genes ENSRNOG00000004172 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000102681 ENTREZGENE
Gene3D-CATH 1.20.140.20 UniProtKB/Swiss-Prot
  3.30.565.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599188 IMAGE-MGC_LOAD
InterPro AK/P_DHK_N_sf UniProtKB/Swiss-Prot
  BCDHK/PDK_N UniProtKB/Swiss-Prot
  BCKD/PDK UniProtKB/Swiss-Prot
  HATPase_C_sf UniProtKB/Swiss-Prot
  His_kinase_dom UniProtKB/Swiss-Prot
KEGG Report rno:81530 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72420 IMAGE-MGC_LOAD
NCBI Gene 81530 ENTREZGENE
PANTHER [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11947 UniProtKB/Swiss-Prot
Pfam BCDHK_Adom3 UniProtKB/Swiss-Prot
  HATPase_c UniProtKB/Swiss-Prot
PhenoGen Pdk2 PhenoGen
PROSITE HIS_KIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004172 RatGTEx
SMART HATPase_c UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55874 UniProtKB/Swiss-Prot
  SSF69012 UniProtKB/Swiss-Prot
UniProt A0A8I6AJH2 ENTREZGENE, UniProtKB/TrEMBL
  A6HI79 ENTREZGENE, UniProtKB/TrEMBL
  A6HI80_RAT UniProtKB/TrEMBL
  A6HI81_RAT UniProtKB/TrEMBL
  A6HI82_RAT UniProtKB/TrEMBL
  F1LMM8 ENTREZGENE, UniProtKB/TrEMBL
  PDK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JID3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Pdk2  pyruvate dehydrogenase kinase 2  Pdk2  pyruvate dehydrogenase kinase, isozyme 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Pdk2  pyruvate dehydrogenase kinase, isozyme 2  Pdk2  pyruvate dehydrogenase kinase, isoenzyme 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pdk2  pyruvate dehydrogenase kinase, isoenzyme 2    pyruvate dehydrogenase kinase 2  Name updated 1299863 APPROVED
2002-06-10 Pdk2  pyruvate dehydrogenase kinase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation protein levels in liver increase in response to high fat feeding and to hyperthyroidism 729541