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Gene: Pcdh8 (protocadherin 8) Rattus norvegicus

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Symbol:

Pcdh8

Name:

protocadherin 8

RGD ID:

69350

Description:

Predicted to enable cell adhesion molecule binding activity. Involved in chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of synaptic membrane adhesion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic membrane. Orthologous to human PCDH8 (protocadherin 8); INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

activity-regulated cadherin-like protein; Arcadlin; protocadherin-8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PCDH8 (protocadherin 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pcdh8 (protocadherin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pcdh8 (protocadherin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100983617 (protocadherin-8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PCDH8 (protocadherin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101972150 (protocadherin-8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100155738 (protocadherin-8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103214488 (protocadherin-8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pcdh8 (protocadherin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pcdh8 (protocadherin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PCDH8 (protocadherin 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pcdh8 (protocadherin 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-199f5.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pcdh8l	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	pcdh8l	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pcdh8.2	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pcdh8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	61,607,521 - 61,612,090 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	61,607,521 - 61,612,097 (-)	Ensembl				GRCr8
mRatBN7.2	15	55,198,470 - 55,203,039 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	55,198,459 - 55,205,872 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	59,313,542 - 59,317,323 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	60,431,918 - 60,435,699 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	57,256,791 - 57,260,575 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	62,196,469 - 62,201,498 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	62,197,060 - 62,200,837 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	65,856,803 - 65,861,374 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	61,056,994 - 61,060,741 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	54,773,168 - 54,776,945 (-)	NCBI		Celera
RGSC_v3.1	15	61,072,773 - 61,076,521 (-)	NCBI
Cytogenetic Map	15	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,3-dinitrobenzene (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetaldehyde (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

amosite asbestos (ISO)

antimycin A (ISO)

arsenite(3-) (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

cocaine (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

flusilazole (ISO)

fulvestrant (ISO)

genistein (ISO)

GW 4064 (ISO)

mercury dibromide (ISO)

methylmercury chloride (EXP,ISO)

Moniliformin (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

N(4)-hydroxycytidine (ISO)

nickel atom (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

tebufenpyrad (ISO)

thifluzamide (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

cell-cell adhesion (IBA)

chemical synaptic transmission (IDA)

homophilic cell-cell adhesion (IEA)

long-term memory (TAS)

modulation of chemical synaptic transmission (EXP,IDA)

morphogenesis of embryonic epithelium (ISO)

regulation of synaptic membrane adhesion (IDA,IMP)

somitogenesis (ISO)

Cellular Component

dendrite (IEA)

glutamatergic synapse (IDA,IMP)

membrane (IEA)

plasma membrane (IBA,IEA)

postsynaptic membrane (IDA,IEA)

presynaptic membrane (IEA)

Schaffer collateral - CA1 synapse (EXP,IDA)

synapse (IBA,IDA)

Molecular Function

calcium ion binding (IEA)

cell adhesion molecule binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9.	Arcadlin is a neural activity-regulated cadherin involved in long term potentiation.	Yamagata K, etal., J Biol Chem 1999 Jul 2;274(27):19473-1979.
10.	Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases.	Yasuda S, etal., Neuron. 2007 Nov 8;56(3):456-71. doi: 10.1016/j.neuron.2007.08.020.

Additional References at PubMed

PMID:12477932	PMID:12591245	PMID:31981722

Genomics

Comparative Map Data

Pcdh8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	61,607,521 - 61,612,090 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	61,607,521 - 61,612,097 (-)	Ensembl				GRCr8
mRatBN7.2	15	55,198,470 - 55,203,039 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	55,198,459 - 55,205,872 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	59,313,542 - 59,317,323 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	60,431,918 - 60,435,699 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	57,256,791 - 57,260,575 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	62,196,469 - 62,201,498 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	62,197,060 - 62,200,837 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	65,856,803 - 65,861,374 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	61,056,994 - 61,060,741 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	54,773,168 - 54,776,945 (-)	NCBI		Celera
RGSC_v3.1	15	61,072,773 - 61,076,521 (-)	NCBI
Cytogenetic Map	15	q12	NCBI

PCDH8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	52,842,889 - 52,848,640 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	52,842,889 - 52,848,641 (-)	Ensembl			hg38	GRCh38
GRCh37	13	53,417,024 - 53,422,775 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	52,316,110 - 52,320,775 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	13	52,316,111 - 52,320,775	NCBI
Celera	13	34,403,981 - 34,408,646 (-)	NCBI		Celera
Cytogenetic Map	13	q14.3	NCBI
HuRef	13	34,132,296 - 34,136,846 (-)	NCBI		HuRef
CHM1_1	13	53,386,066 - 53,390,732 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	52,058,334 - 52,064,085 (-)	NCBI		T2T-CHM13v2.0

Pcdh8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	80,004,224 - 80,008,752 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	80,004,215 - 80,008,752 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	79,766,772 - 79,771,312 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	79,766,775 - 79,771,312 (-)	Ensembl			mm10	GRCm38
MGSCv37	14	80,166,582 - 80,171,119 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	78,500,948 - 78,505,388 (-)	NCBI		MGSCv36	mm8
Celera	14	77,267,150 - 77,271,687 (-)	NCBI		Celera
Cytogenetic Map	14	D3	NCBI
cM Map	14	42.76	NCBI

Pcdh8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955404	50,403,752 - 50,413,264 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100983617
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	54,183,685 - 54,188,750 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	52,827,777 - 52,833,666 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	33,880,543 - 33,886,243 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	52,687,943 - 52,692,601 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	52,688,522 - 52,692,399 (-)	Ensembl			panPan2	panpan1.1

PCDH8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	9,860,590 - 9,865,298 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	9,860,827 - 9,865,412 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	9,857,555 - 9,862,239 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	10,085,702 - 10,090,390 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	10,085,937 - 10,090,183 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	9,782,421 - 9,787,104 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	9,832,472 - 9,837,157 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	9,847,219 - 9,851,906 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101972150
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	151,178,242 - 151,182,890 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936667	716,625 - 721,503 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936667	716,802 - 721,441 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100155738
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	26,127,401 - 26,132,123 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	11	26,127,398 - 26,133,481 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	26,882,342 - 26,887,069 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103214488
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	30,602,449 - 30,610,656 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	30,602,321 - 30,606,926 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666057	13,206,860 - 13,211,564 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pcdh8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624748	14,285,475 - 14,290,166 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624748	14,285,553 - 14,290,236 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pcdh8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	12	44,560,856 - 44,565,389 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pcdh8
21 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	33
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000017599
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	44806773	104695021	Rat
1576315	Schws6	Schwannoma susceptibility QTL 6		0.0069	nervous system integrity trait (VT:0010566)	post-insult time of death (CMO:0002005)	15	60213984	105213984	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	31855803	92671517	Rat
724545	Niddm54	Non-insulin dependent diabetes mellitus QTL 54		0.02	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	57203895	80107161	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	28527732	73527732	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	43677244	88677244	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	43677244	88677244	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	25285835	104695021	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	25285835	104695021	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	19155762	87086765	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	40463152	85463152	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	14926594	71614418	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	22336351	67336351	Rat
2317050	Aia24	Adjuvant induced arthritis QTL 24	2.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	59257087	104257087	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	43677244	88677244	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	25285835	104695021	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	43677244	88677244	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	43677244	88677244	Rat

Markers in Region

42.MMHAP38FLF6.seq

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	55,199,005 - 55,199,187 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	62,197,005 - 62,197,186	NCBI	Rnor6.0
Rnor_5.0	15	65,857,339 - 65,857,520	UniSTS	Rnor5.0
RGSC_v3.4	15	61,056,939 - 61,057,120	UniSTS	RGSC3.4
Celera	15	54,773,113 - 54,773,294	UniSTS
Cytogenetic Map	15	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	4	28	150	42	25	22	16	22	2	174	69	11	132	67	74	3	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001411975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB026154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC128737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017599 ⟹ ENSRNOP00000017599

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	61,607,521 - 61,612,090 (-)	Ensembl
mRatBN7.2 Ensembl	15	55,198,459 - 55,205,872 (-)	Ensembl
Rnor_6.0 Ensembl	15	62,197,060 - 62,200,837 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000154254 ⟹ ENSRNOP00000105986

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	61,607,521 - 61,612,097 (-)	Ensembl

RefSeq Acc Id:

NM_001411975 ⟹ NP_001398904

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	61,607,521 - 61,612,090 (-)	NCBI
mRatBN7.2	15	55,198,470 - 55,203,039 (-)	NCBI

RefSeq Acc Id:

NM_022868 ⟹ NP_074059

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	61,607,521 - 61,612,090 (-)	NCBI
mRatBN7.2	15	55,198,470 - 55,203,039 (-)	NCBI
Rnor_6.0	15	62,197,060 - 62,200,837 (-)	NCBI
Rnor_5.0	15	65,856,803 - 65,861,374 (-)	NCBI
RGSC_v3.4	15	61,056,994 - 61,060,741 (-)	RGD
Celera	15	54,773,168 - 54,776,945 (-)	RGD

Sequence:

show sequence

ATGAGTCCAGTGAAGCGCTGGGGCAGCCCCTGCCTTTTCCCCTTGCAGCTATTTAGTCTCTGCT
GGGTGCTCTCAGTGGCCCAGAGCAAGACAGTCCGATACAGCACCTTCGAAGAGGATGCCCCTGG
CACAGTCATCGGGACCCTTGCAGAGGATCTGCATATGAAAGTGTCTGGAGACACAAGCTTCCGC
CTGATGAAGCAATTCAACAGCTCTCTGCTCCGGGTACGCGAGGGGGACGGGCAGCTGACCGTCG
GGGATGCAGGCCTGGACCGGGAGCGCCTGTGTGGCCAGTCCCCACAGTGTGTGCTGGCCTTCGA
TGTTGTCAGCTTCTCGCAGGAACAGTTCCGGCTTGTGCACGTGGAGGTGGAGGTGAGGGATGTA
AACGACCACGCGCCCCGCTTTCCCCGAGCCCAGATCCCGGTGGAGGTCTCAGAGAGTGCTCCGG
TAGGCACGCGCATCCCCCTGGAGGTGCCTGTAGACGAGGACGTGGGTGCCAATGGGCTGCAGAG
TGTACGCCTGGCCGAGCCTCACAGCCCCTTCCGAGTGGAGCTGCAGACGCGCGCGGACGGTGCC
CAGTGTGCGGACCTGGTGCTGCTACAGGAGCTGGACCGCGAGAGCCAGGCCTCCTACAGCCTGG
AGCTGGTGGCTCAGGACGGCGGGCGACCGCCGCGTTCCGCCACAGCAGCCCTCAGCGTGCGTGT
GCTAGATGCCAATGACCATAGCCCGGCCTTCCCGCAGGGTGCCGTGGCGGAGGTGGAATTGGCC
GAGGACGCACCTGTGGGATCGCTGCTGCTGGACCTGGACGCTGCCGATCCCGACGAAGGTCCCA
ACGGCGACGTTGTGTTCACCTTTGGCGCCCGCACCCCTCCCGAAGCCCGCCACCTTTTCCGGCT
CGACCCACGCTCTGGCCGCCTCACCTTGGCTGGGCAGGTGGACTACGAGCGCCAAGATACCTAT
GAGCTGGACGTGCGGGCTCAAGACCGAGGCCCAGGACCCCGGACAGCCACCTGCAAGGTCATCG
TGCGCATCCGAGACGTCAACGACAACCCTCCTGATATTTCTATCACCCCTCTGGCCGCCCCCGG
GGCTCCAGCCACCTCGCCCTTCGCAGCCGCTGCCGCTGCCGCCGCACTTGGAGGAGCGGACGCA
GCCTCGTCGGCAGGGTCTGGAACACAGGAAACCGGCGTCACCTCGTTGGTGCCAGAGGGGGCGG
CGCGGGAGAGCCTAGTGGCGCTGGTCAGCACCTCGGACAGGGACTCTGGCGCCAACGGGCAGGT
GCGCTGCGCCCTCTACGGGCACGAGCACTTTAGGCTACAGCCGGCCTATGCTGGCAGCTACCTG
GTGGTGACCGCCGCATCTCTGGACCGGGAGCGCATCGCGGAGTACAACCTGACGCTGGTGGCCG
AAGACCGTGGCGCGCCCCCTCTGCGCACTGTCAGGCCCTACACCGTGCGCGTGGGTGACGAGAA
TGACAACGCTCCACTCTTCACCAAGCCAGTCTACGAGGTGTCAGTCCGCGAAAACAACCCTCCG
GGCGCCTACCTGGCCACAGTGGCCGCCCGCGACCCTGACCTGGGCCGCAACGGTCAGGTCACCT
ACCGGCTGGTAGAGGCCGAAGTGGGGCGCTCCGGGGAAGCCGTGTCCACTTACGTCTCAGTAGA
CCCGGCTACCGGGGCCATCTACGCTCTGCGTAGCTTTGACTATGAGACTCTGCGCCAGCTTGAC
GTGCGTGTCCAGGCCAGCGACGGCGGTTCCCCTCAGCTTTCCAGCAATGCTCTGGTGCAAGTGC
GAGTGCTGGACCAGAACGATCACTCTCCGGTCCTCGTGCATCCGGCGCCGGCCAATGGCTCCCT
AGAAGTAGCAGTCCCTGGACGTTCCACCAAGGACACAGCTGTGGCACGCATCCAGGCCCGGGAT
GCAGACGAAGGAGCCAACGGGGAACTGGCCTTCGATCTCCTGCAGCAGGAGCCACGCGAGGCCT
TCTCCATAGGCCGCCACACGGGGGAGATCGTGCTCACCGGAGACCTCTCGCAGGAGCCTCCTGG
CCGCGTGTTCAAGGCCCTACTGGTCATATCCGACGGCGGCCGCCCCCCTCTCACCACCACAGCA
ACCGTCAGTTTCGTGGTAACAGCCGGTGGTGGGTCAGCTGTGCCTGCCAGCGCCGGGAGCCCGG
AGCACTTCCGGCCACCCGGCTCTCGCCTCGCGCCGTCGGGGCCTTCGCTGCAGTGGGACACGCC
GCTGATCGTCATCATCGTGTTAGCCGGGAGCTGCACCCTGCTGCTTGCAGCCATCATCGCCATC
GCCACCACCTGCAACCGCCGCAAGAAGGAGCCCTACAGTGCCTCTCCGGGCTTTGGGAAGGAGC
CTGCGCCCCCTGTTGCAGTCTGGAAGGGCCATTCATTCAACACCATCTCAGGCCGAGAAGCTGA
GAAGTTCAGTGGGAAAGACAGCGGGAAAGGAGACAGTGATTTCAATGACAGTGACTCGGACATC
AGCGGGGACGCCTTGAAAAAAGACCTCATCAACCACATGCAGAGTGGACTGTGGGCATGCACGG
CTGAGTGCAAGATCCTAGGCCATTCTGATCGCTGCTGGAGCCCATCCTGTGCCGGACCCAACAC
ACACCCGCCTCCTCACCCACCAGCCCAGATGTCAACCTTCTGTAAGAGCACGTCCCTGCCTCGG
GATCCTCTGCGCAGGGACAATTACTACCAGGCCCAGCTCCCCAAGACAGTGGGGCTGCAGAGCG
TCTATGAGAAAGTGCTGCATAGAGACTATGACAGGACAGTCACTTTGCTCTCCCCTCCCCGTCC
AGGAAGGCTCCCAGACCTGCAGGAGATTGGAGTACCCCTCTATGAGTCCCCTCCTGGTGGCAGA
TATGTGTCCCCGAAGAAGGGAACCAATGAAAATGTGTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001398904	(Get FASTA)	NCBI Sequence Viewer
	NP_074059	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI28738	(Get FASTA)	NCBI Sequence Viewer
	BAA82442	(Get FASTA)	NCBI Sequence Viewer
	D3ZE55	(Get FASTA)	NCBI Sequence Viewer
	EDM02373	(Get FASTA)	NCBI Sequence Viewer
	EDM02374	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017599
	ENSRNOP00000017599.3

RefSeq Acc Id:	NP_074059 ⟸ NM_022868
- Peptide Label:	isoform 2 precursor
- UniProtKB:	A6HU10 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPVKRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFR LMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQSPQCVLAFDVVSFSQEQFRLVHVEVEVRDV NDHAPRFPRAQIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGA QCADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELA EDAPVGSLLLDLDAADPDEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTY ELDVRAQDRGPGPRTATCKVIVRIRDVNDNPPDISITPLAAPGAPATSPFAAAAAAAALGGADA ASSAGSGTQETGVTSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYL VVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTKPVYEVSVRENNPP GAYLATVAARDPDLGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLD VRVQASDGGSPQLSSNALVQVRVLDQNDHSPVLVHPAPANGSLEVAVPGRSTKDTAVARIQARD ADEGANGELAFDLLQQEPREAFSIGRHTGEIVLTGDLSQEPPGRVFKALLVISDGGRPPLTTTA TVSFVVTAGGGSAVPASAGSPEHFRPPGSRLAPSGPSLQWDTPLIVIIVLAGSCTLLLAAIIAI ATTCNRRKKEPYSASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDI SGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGPNTHPPPHPPAQMSTFCKSTSLPR DPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYESPPGGR YVSPKKGTNENV hide sequence

Ensembl Acc Id:

ENSRNOP00000017599 ⟸ ENSRNOT00000017599

RefSeq Acc Id:	NP_001398904 ⟸ NM_001411975
- Peptide Label:	isoform 1 precursor
- UniProtKB:	D3ZE55 (UniProtKB/Swiss-Prot), A1A5N4 (UniProtKB/Swiss-Prot), Q9WVR2 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000105986 ⟸ ENSRNOT00000154254

Protein Domains

Cadherin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZE55-F1-model_v2	AlphaFold	D3ZE55	1-1069	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69350	AgrOrtholog
BioCyc Gene	G2FUF-12983	BioCyc
Ensembl Genes	ENSRNOG00000013101	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000017599	ENTREZGENE
	ENSRNOT00000017599.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Cadherins	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:8362872	IMAGE-MGC_LOAD
InterPro	Cadherin-like_dom	UniProtKB/Swiss-Prot
	Cadherin-like_sf	UniProtKB/Swiss-Prot
	Cadherin_CS	UniProtKB/Swiss-Prot
	Cadherin_N	UniProtKB/Swiss-Prot
	Protocadherin/Cadherin-CA	UniProtKB/Swiss-Prot
KEGG Report	rno:64865	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156642	IMAGE-MGC_LOAD
NCBI Gene	64865	ENTREZGENE
PANTHER	CADHERIN-87A	UniProtKB/Swiss-Prot
	PTHR24028:SF46	UniProtKB/Swiss-Prot
Pfam	Cadherin	UniProtKB/Swiss-Prot
	Cadherin_2	UniProtKB/Swiss-Prot
PhenoGen	Pcdh8	PhenoGen
PRINTS	CADHERIN	UniProtKB/Swiss-Prot
PROSITE	CADHERIN_1	UniProtKB/Swiss-Prot
	CADHERIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013101	RatGTEx
SMART	SM00112	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF49313	UniProtKB/Swiss-Prot
TIGR	TC232455
UniProt	A0ABK0LJT2_RAT	UniProtKB/TrEMBL
	A1A5N4	ENTREZGENE
	A6HU10	ENTREZGENE, UniProtKB/TrEMBL
	D3ZE55	ENTREZGENE, UniProtKB/Swiss-Prot
	Q9WVR2	ENTREZGENE
UniProt Secondary	A1A5N4	UniProtKB/Swiss-Prot
	Q9WVR2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Pcdh8	protocadherin 8			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains six cadherin repeats	68758
gene_expression	expressed in synapses	68758
gene_protein	972 amino acids; 103.7 kDa,	68758
gene_regulation	induced in hippocampal granule cells by seizures, and by N-methyl-D-aspartate-dependent synaptic activity in long term potentiation	68758

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD