Pcdh8 (protocadherin 8) - Rat Genome Database

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Keyword

Gene: Pcdh8 (protocadherin 8) Mus musculus

Symbol:

Pcdh8

Name:

protocadherin 8

Description:

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

1700080P15Rik; arcadlin; Papc; paraxial protocadherin; protocadherin 8; protocadherin-8

Orthologs:

Homo sapiens : PCDH8 (protocadherin 8) HGNC
Rattus norvegicus : Pcdh8 (protocadherin 8)

Related Pseudogenes:

Gm17923

Latest Assembly:

Mouse Genome Assembly Build 37

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	14	79,766,772 - 79,771,312	-	NCBI
Mouse cM Map	14	42.76		NCBI
Mouse Celera Assembly	14	77,267,147 - 77,271,687	-	NCBI
Mouse Genome Assembly Build 37	14	80,166,582 - 80,171,119	-	NCBI
Mouse Genome Assembly Build 36.1	14	80,166,591 - 80,171,107	-	NCBI
Mouse Cytogenetic Map	14	D3		NCBI