Gene: PCDH8 (protocadherin 8)
Homo sapiens
Symbol:
PCDH8
Name:
protocadherin 8
Description:
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
ARCADLIN; OTTHUMP00000018464; OTTHUMP00000018465; PAPC; protocadherin-8
Orthologs:
Mus musculus : Pcdh8
(protocadherin 8)
MGI
Pcdh8
(protocadherin 8)
Related Pseudogenes:
PCDH8P1
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 13 34,355,547 - 34,360,213 - NCBI Human Genome Assembly HuRef 13 34,132,296 - 34,136,846 - NCBI Human Genome Assembly GRCh37 13 53,418,109 - 53,422,775 - NCBI Human Celera Assembly 13 34,403,981 - 34,408,646 - NCBI Human Genome Assembly Build 36 13 52,316,110 - 52,320,775 - NCBI Human Cytogenetic Map 13 q21.1 NCBI Human Genome Assembly 13 52,316,111 - 52,320,775 NCBI
Model
Gene-Chemical Interaction Annotations
17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PCDH8 mRNA CTD PMID:19619570 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of PCDH8 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PCDH8 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735354 6480464 Tetrachlorodibenzodioxin affects the expression of PCDH8 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735354 6480464 Tetrachlorodibenzodioxin results in increased expression of PCDH8 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PCDH8 mRNA CTD PMID:19901195 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PCDH8 mRNA CTD PMID:19619570 acetaldehyde affects expression ISO RGD:735354 6480464 Acetaldehyde affects the expression of PCDH8 mRNA CTD PMID:22634333 afimoxifene increases expression EXP 6480464 4-hydroxytamoxifen results in increased expression of PCDH8 mRNA CTD PMID:19901195 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of PCDH8 mRNA CTD PMID:21934132 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of PCDH8 mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:69350 6480464 Ammonium Chloride affects the expression of PCDH8 mRNA CTD PMID:16483693 cocaine increases expression EXP 6480464 Cocaine results in increased expression of PCDH8 mRNA; more ... CTD PMID:18000554 methylmercury chloride affects expression ISO RGD:69350 6480464 methylmercuric chloride affects the expression of PCDH8 mRNA CTD PMID:20864626 valproic acid affects expression ISO RGD:735354 6480464 Valproic Acid affects the expression of PCDH8 mRNA CTD PMID:17292431
Gene Ontology Annotations
Biological Process cell-cell signaling TAS 2290271 PMID:9787079 PINC PMID:9787079 homophilic cell adhesion IEA InterPro:IPR002126 2290271 GO_REF:0000002 InterPro GO_REF:0000002 morphogenesis of embryonic epithelium IEA Ensembl:ENSMUSP00000045333 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 somitogenesis IEA Ensembl:ENSMUSP00000045333 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 synaptic transmission IEA Ensembl:ENSRNOP00000017599 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019
2316894 INSUL45_H Insulin level QTL 45 (human) 1.52 Insulin level fasting 13 29081051 55081051 Human 1298460 OSTEAR7_H Osteoarthritis QTL 7 (human) 1.61 Joint/bone inflammation hand osteoarthritis 13 30173455 56173455 Human 1643074 BW161_H Body weight QTL 161 (human) .0245 Body fat amount percent body fat 13 34811520 60811520 Human 1357313 AASTH36_H Allergic/atopic asthma related QTL 36 (human) 4.32 Atopy reversible airflow obstruction 13 35890890 61890890 Human 1357316 AASTH33_H Allergic/atopic asthma related QTL 33 (human) 3.12 RASTI reversible airflow obstruction 13 35890890 61890890 Human 2314549 GLUCO54_H Glucose level QTL 54 (human) 1 Glucose level 13 38892760 64892760 Human 1358855 MULTSCL32_H Multiple sclerosis susceptibility QTL 32 (human) 1.1 Multiple sclerosis susceptibility 13 39032331 112795540 Human 2292823 PRSTS88_H Prostate tumor susceptibility QTL 88 (human) Prostate tumor susceptibility 13 42106193 68106193 Human 1357325 AASTH15_H Allergic/atopic asthma related QTL 15 (human) 2 Reversible airflow obstruction 13 48890773 74657774 Human 2289473 SLEP17_H Serum leptin level QTL 17 (human) 1.77 Hormone level leptin 13 48890773 74657774 Human
Gene Ontology Annotations
