Irs3 (insulin receptor substrate 3) - Rat Genome Database

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Gene: Irs3 (insulin receptor substrate 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Irs3
Name: insulin receptor substrate 3
RGD ID: 69317
Description: Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane; PARTICIPATES IN insulin signaling pathway; aldosterone signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,689,930 - 24,692,068 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1224,689,909 - 24,692,068 (+)EnsemblGRCr8
mRatBN7.21219,053,148 - 19,055,286 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,053,148 - 19,055,286 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1220,208,348 - 20,210,486 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,821,232 - 20,823,370 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,885,559 - 19,887,697 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,120,305 - 22,125,103 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,122,953 - 22,125,091 (+)Ensemblrn6Rnor6.0
Rnor_5.01224,137,698 - 24,142,470 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41219,709,141 - 19,711,279 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1220,858,542 - 20,860,680 (+)NCBICelera
RGSC_v3.11219,698,702 - 19,700,841 (-)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
plasma membrane  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Insulin receptor substrate-3 functions as transcriptional activator in the nucleus. Kabuta T, etal., J Biol Chem 2002 Mar 1;277(9):6846-51.
3. MicroRNAs: a new ray of hope for diabetes mellitus. Kumar M, etal., Protein Cell. 2012 Oct;3(10):726-38. doi: 10.1007/s13238-012-2055-0. Epub 2012 Oct 11.
4. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. Lavan BE, etal., J Biol Chem 1997 Apr 25;272(17):11439-43.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes. Villar M, etal., Biochim Biophys Acta. 2006 Feb;1763(2):197-206. Epub 2006 Jan 4.
Additional References at PubMed
PMID:10860857   PMID:12477932   PMID:12850284   PMID:15331570   PMID:16055922   PMID:17965023  


Genomics

Variants

.
Variants in Irs3
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:65
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000001874
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH131481  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,055,065 - 19,055,268 (+)MAPPERmRatBN7.2
Rnor_6.01222,124,871 - 22,125,073NCBIRnor6.0
Rnor_5.01224,142,247 - 24,142,449UniSTSRnor5.0
Celera1220,860,460 - 20,860,662UniSTS
Cytogenetic Map12q12UniSTS
RH94802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,055,085 - 19,055,244 (+)MAPPERmRatBN7.2
Rnor_6.01222,124,891 - 22,125,049NCBIRnor6.0
Rnor_5.01224,142,267 - 24,142,425UniSTSRnor5.0
Celera1220,860,480 - 20,860,638UniSTS
Cytogenetic Map12q12UniSTS
PMC86565P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,053,353 - 19,053,954 (+)MAPPERmRatBN7.2
Rnor_6.01222,123,159 - 22,123,759NCBIRnor6.0
Rnor_5.01224,140,535 - 24,141,135UniSTSRnor5.0
RGSC_v3.41219,710,473 - 19,711,073UniSTSRGSC3.4
Celera1220,858,748 - 20,859,348UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 159 91 90 59 83 59 6 345 183 11 138 80 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000001874   ⟹   ENSRNOP00000001874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1224,689,909 - 24,692,068 (+)Ensembl
mRatBN7.2 Ensembl1219,053,148 - 19,055,286 (+)Ensembl
Rnor_6.0 Ensembl1222,122,953 - 22,125,091 (+)Ensembl
RefSeq Acc Id: NM_032074   ⟹   NP_114463
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,689,930 - 24,692,068 (+)NCBI
mRatBN7.21219,053,148 - 19,055,286 (+)NCBI
Rnor_6.01222,122,953 - 22,125,091 (+)NCBI
Rnor_5.01224,137,698 - 24,142,470 (+)NCBI
RGSC_v3.41219,709,141 - 19,711,279 (-)RGD
Celera1220,858,542 - 20,860,680 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53161 (Get FASTA)   NCBI Sequence Viewer  
  AAI61840 (Get FASTA)   NCBI Sequence Viewer  
  EDM13246 (Get FASTA)   NCBI Sequence Viewer  
  EDM13247 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001874
  ENSRNOP00000001874.1
RefSeq Acc Id: NP_114463   ⟸   NM_032074
- UniProtKB: O08724 (UniProtKB/TrEMBL),   B1WBQ1 (UniProtKB/TrEMBL),   F7F0S6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001874   ⟸   ENSRNOT00000001874
Protein Domains
IRS-type PTB   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WBQ1-F1-model_v2 AlphaFold B1WBQ1 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698511
Promoter ID:EPDNEW_R9036
Type:multiple initiation site
Name:Irs3_1
Description:insulin receptor substrate 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,122,930 - 22,122,990EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69317 AgrOrtholog
BioCyc Gene G2FUF-19715 BioCyc
Ensembl Genes ENSRNOG00000001389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001874 ENTREZGENE
  ENSRNOT00000001874.4 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9027966 IMAGE-MGC_LOAD
InterPro Insln_rcpt_S1 UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:84021 UniProtKB/TrEMBL
MGC_CLONE MGC:187353 IMAGE-MGC_LOAD
NCBI Gene 84021 ENTREZGENE
PANTHER INSULIN RECEPTOR SUBSTRATE 3 UniProtKB/TrEMBL
  PTHR10614 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
PhenoGen Irs3 PhenoGen
PRINTS INSULINRSI UniProtKB/TrEMBL
PROSITE IRS_PTB UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001389 RatGTEx
SMART IRS UniProtKB/TrEMBL
  PTBI UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
TIGR TC211151
UniProt A6J007_RAT UniProtKB/TrEMBL
  B1WBQ1 ENTREZGENE, UniProtKB/TrEMBL
  F7F0S6 ENTREZGENE, UniProtKB/TrEMBL
  O08724 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Irs3  insulin receptor substrate 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes near the plasma membrane 633068
gene_domains contains a phosphotyrosine binding domain that functions in nuclear localization 633068
gene_expression expressed in COS-7 cells 633068
gene_function a transcription regulator during signal transduction 633068
gene_product member of the insulin receptor substrates family 633068