Acox3 (acyl-CoA oxidase 3, pristanoyl) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Acox3 (acyl-CoA oxidase 3, pristanoyl) Rattus norvegicus
Analyze
Symbol: Acox3
Name: acyl-CoA oxidase 3, pristanoyl
RGD ID: 69245
Description: Enables acyl-CoA oxidase activity and anion binding activity. Involved in fatty acid beta-oxidation using acyl-CoA oxidase. Located in peroxisome. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl); PARTICIPATES IN alpha-linolenic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acyl-Coenzyme A oxidase 3; acyl-Coenzyme A oxidase 3, pristanoyl; branched-chain acyl-CoA oxidase; BRCACox; peroxisomal acyl-coenzyme A oxidase 3; pristanoyl-CoA oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,358,604 - 79,405,160 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,302,042 - 79,400,881 (-)EnsemblGRCr8
mRatBN7.21475,133,986 - 75,176,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,094,676 - 75,176,205 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,575,514 - 79,629,707 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,816,379 - 80,870,575 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,261,371 - 77,315,558 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,313,202 - 80,358,115 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,314,431 - 80,355,420 (-)Ensemblrn6Rnor6.0
Rnor_5.01479,942,668 - 79,982,780 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,769,000 - 80,809,809 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,065,866 - 74,104,532 (-)NCBICelera
RGSC_v3.11480,771,390 - 80,812,200 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dimethyl sulfoxide  (ISO)
entacapone  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
indometacin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
obeticholic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Propiverine  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tolcapone  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
peroxisome  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Large-scale purification and further characterization of rat pristanoyl-CoA oxidase. Van Veldhoven PP, etal., Eur J Biochem. 1994 Jun 15;222(3):795-801.
11. Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase. Van Veldhoven PP, etal., FEBS Lett. 1996 Jun 10;388(1):80-4.
12. Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase. Van Veldhoven PP, etal., J Biol Chem. 1992 Oct 5;267(28):20065-74.
13. Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor. Vanhooren JC, etal., Eur J Biochem 1996 Jul 15;239(2):302-9.
Additional References at PubMed
PMID:8993592   PMID:18614015   PMID:19946888   PMID:20178365  


Genomics

Comparative Map Data
Acox3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,358,604 - 79,405,160 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,302,042 - 79,400,881 (-)EnsemblGRCr8
mRatBN7.21475,133,986 - 75,176,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,094,676 - 75,176,205 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,575,514 - 79,629,707 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,816,379 - 80,870,575 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,261,371 - 77,315,558 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,313,202 - 80,358,115 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,314,431 - 80,355,420 (-)Ensemblrn6Rnor6.0
Rnor_5.01479,942,668 - 79,982,780 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,769,000 - 80,809,809 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,065,866 - 74,104,532 (-)NCBICelera
RGSC_v3.11480,771,390 - 80,812,200 (-)NCBI
Cytogenetic Map14q21NCBI
ACOX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3848,355,305 - 8,440,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl48,365,885 - 8,440,750 (-)Ensemblhg38GRCh38
GRCh3748,368,009 - 8,442,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3648,418,909 - 8,493,352 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3448,486,518 - 8,560,499NCBI
Celera48,261,321 - 8,335,759 (-)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef48,287,364 - 8,362,315 (-)NCBIHuRef
CHM1_148,366,366 - 8,440,788 (-)NCBICHM1_1
T2T-CHM13v2.048,337,453 - 8,420,469 (-)NCBIT2T-CHM13v2.0
Acox3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,740,293 - 35,772,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,740,384 - 35,772,696 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38535,582,981 - 35,614,208 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,583,040 - 35,615,352 (+)Ensemblmm10GRCm38
MGSCv37535,925,709 - 35,956,450 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36535,899,921 - 35,930,662 (+)NCBIMGSCv36mm8
Celera533,056,108 - 33,087,085 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map518.32NCBI
Acox3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,656,144 - 2,685,896 (+)Ensembl
ChiLan1.0NW_0049555142,653,502 - 2,690,452 (+)NCBIChiLan1.0ChiLan1.0
ACOX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v238,642,020 - 8,727,303 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan148,569,231 - 8,654,531 (-)NCBINHGRI_mPanPan1
PanPan1.148,432,788 - 8,506,499 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl48,432,788 - 8,494,157 (-)EnsemblpanPan2panpan1.1
ACOX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,154,012 - 60,205,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,153,775 - 60,203,554 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha362,804,141 - 62,856,135 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0360,631,684 - 60,683,139 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl360,628,819 - 60,680,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,123,908 - 60,162,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0360,327,224 - 60,379,691 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0360,685,106 - 60,736,638 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acox3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,992,882 - 66,029,673 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647719,694,555 - 19,731,386 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647719,696,274 - 19,731,338 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,716,918 - 2,770,801 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.182,716,913 - 2,756,221 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.284,391,443 - 4,418,723 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACOX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12744,313,297 - 44,366,702 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666051635,738 - 689,992 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acox3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,995,089 - 24,024,083 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475523,995,256 - 24,026,581 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Acox3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11169,463,291 - 69,491,170 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acox3
102 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000049798
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH142447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,162,876 - 75,163,041 (+)MAPPERmRatBN7.2
Rnor_6.01480,342,167 - 80,342,331NCBIRnor6.0
Rnor_5.01479,969,361 - 79,969,525UniSTSRnor5.0
RGSC_v3.41480,796,837 - 80,797,001UniSTSRGSC3.4
Celera1474,091,190 - 74,091,354UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC108312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB873101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB882963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB894292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC930510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC940372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC951701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000049798   ⟹   ENSRNOP00000042002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,302,042 - 79,400,881 (-)Ensembl
mRatBN7.2 Ensembl1475,135,215 - 75,165,068 (-)Ensembl
Rnor_6.0 Ensembl1480,314,431 - 80,355,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101859   ⟹   ENSRNOP00000081580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,345,469 - 79,400,881 (-)Ensembl
mRatBN7.2 Ensembl1475,094,676 - 75,176,205 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110399   ⟹   ENSRNOP00000092103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,358,604 - 79,400,881 (-)Ensembl
mRatBN7.2 Ensembl1475,133,996 - 75,176,205 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132862   ⟹   ENSRNOP00000108430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,358,604 - 79,389,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166916   ⟹   ENSRNOP00000109149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,312,038 - 79,400,881 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167490   ⟹   ENSRNOP00000100606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,317,581 - 79,400,881 (-)Ensembl
RefSeq Acc Id: NM_053339   ⟹   NP_445791
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,358,604 - 79,400,881 (-)NCBI
mRatBN7.21475,133,986 - 75,176,269 (-)NCBI
Rnor_6.01480,314,431 - 80,355,420 (-)NCBI
Rnor_5.01479,942,668 - 79,982,780 (-)NCBI
RGSC_v3.41480,769,000 - 80,809,809 (-)RGD
Celera1474,065,866 - 74,104,532 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599392   ⟹   XP_017454881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,358,604 - 79,400,894 (-)NCBI
mRatBN7.21475,133,986 - 75,176,762 (-)NCBI
Rnor_6.01480,313,202 - 80,358,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092496   ⟹   XP_038948424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,358,604 - 79,400,024 (-)NCBI
mRatBN7.21475,133,986 - 75,175,407 (-)NCBI
RefSeq Acc Id: XM_063273675   ⟹   XP_063129745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,358,604 - 79,405,160 (-)NCBI
RefSeq Acc Id: XM_063273676   ⟹   XP_063129746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,358,604 - 79,387,204 (-)NCBI
RefSeq Acc Id: XM_063273677   ⟹   XP_063129747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,366,972 - 79,405,160 (-)NCBI
RefSeq Acc Id: XM_063273678   ⟹   XP_063129748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,367,563 - 79,405,160 (-)NCBI
RefSeq Acc Id: NP_445791   ⟸   NM_053339
- UniProtKB: A6IJZ3 (UniProtKB/TrEMBL),   F1M9A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454881   ⟸   XM_017599392
- Peptide Label: isoform X2
- UniProtKB: A6IJZ3 (UniProtKB/TrEMBL),   F1M9A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042002   ⟸   ENSRNOT00000049798
RefSeq Acc Id: XP_038948424   ⟸   XM_039092496
- Peptide Label: isoform X2
- UniProtKB: A6IJZ3 (UniProtKB/TrEMBL),   F1M9A7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092103   ⟸   ENSRNOT00000110399
Ensembl Acc Id: ENSRNOP00000081580   ⟸   ENSRNOT00000101859
RefSeq Acc Id: XP_063129745   ⟸   XM_063273675
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G857 (UniProtKB/TrEMBL),   A0A8I6AGJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129746   ⟸   XM_063273676
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063129747   ⟸   XM_063273677
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063129748   ⟸   XM_063273678
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000100606   ⟸   ENSRNOT00000167490
Ensembl Acc Id: ENSRNOP00000109149   ⟸   ENSRNOT00000166916
Ensembl Acc Id: ENSRNOP00000108430   ⟸   ENSRNOT00000132862
Protein Domains
Acyl-CoA oxidase C-alpha1   Acyl-CoA oxidase C-terminal   Acyl-CoA oxidase/dehydrogenase middle

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63448-F1-model_v2 AlphaFold Q63448 1-700 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699389
Promoter ID:EPDNEW_R9914
Type:initiation region
Name:Acox3_1
Description:acyl-CoA oxidase 3, pristanoyl
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01480,355,468 - 80,355,528EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69245 AgrOrtholog
BioCyc Gene G2FUF-15326 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000008474 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000110399 ENTREZGENE
Gene3D-CATH 2.40.110.10 UniProtKB/Swiss-Prot
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot
InterPro ACO UniProtKB/Swiss-Prot
  ACOX_C_alpha1 UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot
  Acyl-CoA_oxidase UniProtKB/Swiss-Prot
  Acyl-CoA_oxidase_C UniProtKB/Swiss-Prot
  AcylCo_DH-like_C UniProtKB/Swiss-Prot
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot
KEGG Report rno:83522 UniProtKB/Swiss-Prot
NCBI Gene 83522 ENTREZGENE
PANTHER PEROXISOMAL ACYL-COENZYME A OXIDASE 3 UniProtKB/Swiss-Prot
  PTHR10909 UniProtKB/Swiss-Prot
Pfam ACOX UniProtKB/Swiss-Prot
  ACOX_C_alpha1 UniProtKB/Swiss-Prot
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot
PhenoGen Acox3 PhenoGen
PIRSF Acyl-CoA_oxidase UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008474 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot
  SSF56645 UniProtKB/Swiss-Prot
UniProt A0A8I6AGJ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G857 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LI58_RAT UniProtKB/TrEMBL
  A0ABK0M2J7_RAT UniProtKB/TrEMBL
  A0ABK0M3X4_RAT UniProtKB/TrEMBL
  A6IJZ3 ENTREZGENE, UniProtKB/TrEMBL
  ACOX3_RAT UniProtKB/Swiss-Prot
  F1M9A7 ENTREZGENE, UniProtKB/TrEMBL
  Q63448 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acox3  acyl-CoA oxidase 3, pristanoyl  Acox3  acyl-Coenzyme A oxidase 3, pristanoyl  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Acox3  acyl-Coenzyme A oxidase 3, pristanoyl       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function oxidizes the CoA-esters of 2-methyl-branched fatty acids 724707