Celsr2 (cadherin, EGF LAG seven-pass G-type receptor 2) - Rat Genome Database

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Pathways
Gene: Celsr2 (cadherin, EGF LAG seven-pass G-type receptor 2) Rattus norvegicus
Analyze
Symbol: Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
RGD ID: 69237
Description: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in dendrite morphogenesis; regulation of cell-cell adhesion; and spermatogenesis. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cadherin EGF LAG seven-pas G-type receptor 2; cadherin EGF LAG seven-pass G-type receptor 2; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); flamingo-like protein celsr2; Flamingo1; Megf3; multiple EGF-like domains protein 3; multiple epidermal growth factor-like domains 3; multiple epidermal growth factor-like domains protein 3; seven-pass transmembrane cadherin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,717,333 - 198,741,689 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2198,717,896 - 198,741,581 (-)EnsemblGRCr8
mRatBN7.22196,029,206 - 196,053,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2196,029,434 - 196,053,845 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2203,673,871 - 203,696,491 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,555,989 - 201,578,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02196,372,945 - 196,395,565 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02211,183,410 - 211,207,458 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2211,183,311 - 211,207,465 (-)Ensemblrn6Rnor6.0
Rnor_5.02230,653,341 - 230,677,459 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42203,960,513 - 203,983,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2188,676,929 - 188,699,559 (-)NCBICelera
RGSC_v3.12203,923,277 - 203,943,562 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Bisphenol Z  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isoflavones  (EXP)
L-methionine  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
picene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. Beall SA, etal., J Androl. 2005 Jul-Aug;26(4):529-38.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, etal., Endocrinology 2000 Feb;141(2):675-83.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Nakayama M, etal., Genomics 1998 Jul 1;51(1):27-34.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Shima Y, etal., Dev Cell. 2004 Aug;7(2):205-16.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10907856   PMID:12755329   PMID:15744052   PMID:16484285   PMID:17618280   PMID:20473291   PMID:20631168   PMID:21746835   PMID:32988580  


Genomics

Comparative Map Data
Celsr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,717,333 - 198,741,689 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2198,717,896 - 198,741,581 (-)EnsemblGRCr8
mRatBN7.22196,029,206 - 196,053,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2196,029,434 - 196,053,845 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2203,673,871 - 203,696,491 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,555,989 - 201,578,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02196,372,945 - 196,395,565 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02211,183,410 - 211,207,458 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2211,183,311 - 211,207,465 (-)Ensemblrn6Rnor6.0
Rnor_5.02230,653,341 - 230,677,459 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42203,960,513 - 203,983,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2188,676,929 - 188,699,559 (-)NCBICelera
RGSC_v3.12203,923,277 - 203,943,562 (-)NCBI
Cytogenetic Map2q34NCBI
CELSR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,249,539 - 109,275,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,249,539 - 109,275,751 (+)Ensemblhg38GRCh38
GRCh371109,792,161 - 109,818,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,594,164 - 109,619,901 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341109,504,682 - 109,530,414NCBI
Celera1108,062,003 - 108,087,743 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1107,685,865 - 107,711,622 (+)NCBIHuRef
CHM1_11109,907,493 - 109,933,231 (+)NCBICHM1_1
T2T-CHM13v2.01109,282,346 - 109,308,548 (+)NCBIT2T-CHM13v2.0
Celsr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393108,298,164 - 108,323,416 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3108,298,167 - 108,323,383 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383108,390,848 - 108,416,069 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,390,851 - 108,415,552 (-)Ensemblmm10GRCm38
MGSCv373108,193,766 - 108,218,412 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363108,520,500 - 108,543,550 (-)NCBIMGSCv36mm8
Celera3110,725,058 - 110,749,705 (-)NCBICelera
Cytogenetic Map3F3NCBI
cM Map347.02NCBI
Celsr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543512,671,759 - 12,695,564 (+)Ensembl
ChiLan1.0NW_00495543512,671,759 - 12,695,070 (+)NCBIChiLan1.0ChiLan1.0
CELSR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,028,278 - 118,054,493 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,188,189 - 117,214,398 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01111,627,551 - 111,653,775 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,791,720 - 110,817,125 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,791,682 - 110,815,421 (+)EnsemblpanPan2panpan1.1
CELSR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,547,638 - 42,573,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,548,983 - 42,573,962 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha645,322,198 - 45,348,111 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0642,878,783 - 42,904,743 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,879,935 - 42,904,724 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,610,137 - 42,636,081 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,568,221 - 42,594,142 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0643,003,504 - 43,029,464 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Celsr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505819,310,286 - 19,334,616 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936704778,480 - 803,886 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936704779,528 - 803,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CELSR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,819,428 - 110,845,132 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14110,819,422 - 110,845,354 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24121,290,848 - 121,295,430 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CELSR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12024,270,963 - 24,296,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2024,270,952 - 24,296,647 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603834,162,262 - 34,190,697 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Celsr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247724,990,178 - 5,014,119 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247724,990,185 - 5,014,008 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Celsr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1349,842,272 - 49,866,622 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Celsr2
157 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:67
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000027263
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH135417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,031,286 - 196,031,476 (+)MAPPERmRatBN7.2
Rnor_6.02211,185,491 - 211,185,680NCBIRnor6.0
Rnor_5.02230,655,422 - 230,655,611UniSTSRnor5.0
RGSC_v3.42203,961,164 - 203,961,353UniSTSRGSC3.4
Celera2188,677,580 - 188,677,769UniSTS
RH 3.4 Map21397.7UniSTS
Cytogenetic Map2q34UniSTS
Celsr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,031,934 - 196,032,556 (+)MAPPERmRatBN7.2
Rnor_6.02211,186,139 - 211,186,760NCBIRnor6.0
Rnor_5.02230,656,070 - 230,656,691UniSTSRnor5.0
RGSC_v3.42203,961,812 - 203,962,433UniSTSRGSC3.4
Celera2188,678,228 - 188,678,849UniSTS
Cytogenetic Map2q34UniSTS
G16013  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,053,050 - 196,053,269 (+)MAPPERmRatBN7.2
Rnor_6.02211,207,254 - 211,207,472NCBIRnor6.0
Rnor_5.02230,677,187 - 230,677,405UniSTSRnor5.0
RGSC_v3.42203,982,929 - 203,983,147UniSTSRGSC3.4
Celera2188,699,355 - 188,699,573UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:495983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22196,052,960 - 196,053,041 (+)MAPPERmRatBN7.2
Rnor_6.02211,207,164 - 211,207,244NCBIRnor6.0
Rnor_5.02230,677,097 - 230,677,177UniSTSRnor5.0
RGSC_v3.42203,982,839 - 203,982,919UniSTSRGSC3.4
Celera2188,699,265 - 188,699,345UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 87 59 6 351 187 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027263   ⟹   ENSRNOP00000027263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2198,717,896 - 198,741,581 (-)Ensembl
mRatBN7.2 Ensembl2196,029,434 - 196,053,845 (-)Ensembl
Rnor_6.0 Ensembl2211,183,311 - 211,207,465 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132314   ⟹   ENSRNOP00000106325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2198,718,774 - 198,741,581 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168722   ⟹   ENSRNOP00000101341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2198,718,774 - 198,741,581 (-)Ensembl
RefSeq Acc Id: NM_001191110   ⟹   NP_001178039
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,718,763 - 198,741,382 (-)NCBI
mRatBN7.22196,030,636 - 196,053,255 (-)NCBI
Rnor_6.02211,184,840 - 211,207,458 (-)NCBI
Rnor_5.02230,653,341 - 230,677,459 (-)NCBI
Celera2188,676,929 - 188,699,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233192   ⟹   XP_006233254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,717,333 - 198,741,689 (-)NCBI
mRatBN7.22196,029,206 - 196,053,845 (-)NCBI
Rnor_6.02211,183,410 - 211,207,458 (-)NCBI
Rnor_5.02230,653,341 - 230,677,459 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591134   ⟹   XP_017446623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,717,333 - 198,741,689 (-)NCBI
mRatBN7.22196,029,206 - 196,053,846 (-)NCBI
Rnor_6.02211,183,410 - 211,207,458 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103241   ⟹   XP_038959169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,717,333 - 198,741,689 (-)NCBI
mRatBN7.22196,029,206 - 196,053,848 (-)NCBI
RefSeq Acc Id: NP_001178039   ⟸   NM_001191110
- Peptide Label: precursor
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL),   A6HV01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233254   ⟸   XM_006233192
- Peptide Label: isoform X1
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446623   ⟸   XM_017591134
- Peptide Label: isoform X2
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027263   ⟸   ENSRNOT00000027263
RefSeq Acc Id: XP_038959169   ⟸   XM_039103241
- Peptide Label: isoform X3
- UniProtKB: G3V8P3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101341   ⟸   ENSRNOT00000168722
Ensembl Acc Id: ENSRNOP00000106325   ⟸   ENSRNOT00000132314
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYP2-F1-model_v2 AlphaFold Q9QYP2 1-2144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69237 AgrOrtholog
BioCyc Gene G2FUF-51619 BioCyc
Ensembl Genes ENSRNOG00000020058 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027263 ENTREZGENE
  ENSRNOT00000132314 ENTREZGENE
  ENSRNOT00000168722 ENTREZGENE
Gene3D-CATH 1.25.40.610 UniProtKB/Swiss-Prot
  2.60.120.200 UniProtKB/Swiss-Prot
  2.60.220.50 UniProtKB/Swiss-Prot
  4.10.1240.10 UniProtKB/Swiss-Prot
  Cadherins UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CELSR1-3_9th UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  GAIN_B UniProtKB/Swiss-Prot
  GAIN_dom_N UniProtKB/Swiss-Prot
  GAIN_dom_sf UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot
  GPCR_2_secretin-like UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
  Laminin_EGF UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
NCBI Gene 83465 ENTREZGENE
PANTHER CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2 UniProtKB/Swiss-Prot
  FAT ATYPICAL CADHERIN-RELATED UniProtKB/Swiss-Prot
Pfam 7tm_2 UniProtKB/Swiss-Prot
  Cadherin UniProtKB/Swiss-Prot
  Cadherin_CELSR2_9th UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  GAIN UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
  Laminin_EGF UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
PhenoGen Celsr2 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
  GPCRSECRETIN UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_LAM_1 UniProtKB/Swiss-Prot
  EGF_LAM_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020058 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  EGF_Lam UniProtKB/Swiss-Prot
  GPS UniProtKB/Swiss-Prot
  HormR UniProtKB/Swiss-Prot
  LamG UniProtKB/Swiss-Prot
  SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF49313 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
TIGR TC232810
UniProt A0ABK0L7Y5_RAT UniProtKB/TrEMBL
  A0ABK0LIM0_RAT UniProtKB/TrEMBL
  A6HV01 ENTREZGENE, UniProtKB/TrEMBL
  CELR2_RAT UniProtKB/Swiss-Prot
  G3V8P3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYP2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Celsr2  cadherin, EGF LAG seven-pass G-type receptor 2  Celsr2  cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Celsr2  cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)  Celsr2  cadherin EGF LAG seven-pass G-type receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Celsr2  cadherin EGF LAG seven-pass G-type receptor 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains seven transmembrane-spanning segments 68759
gene_process promotes homophilic cell aggregation 68759