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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69237 Species: Rattus norvegicus RGD Object: Gene Symbol: Celsr2 Name: cadherin, EGF LAG seven-pass G-type receptor 2

Acc ID: CHEBI:17243 Term: mono(2-ethylhexyl) phthalate Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid. CasRN: 4376-20-9 Chemical ID: MESH:C016599

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:733345	6480464	CTD	[IC 261 results in decreased activity of CSNK1A1 protein] inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein]	PMID:16484285
affects transport	ISO	RGD:736028	6480464	CTD	mono-(2-ethylhexyl)phthalate affects the transport of CELSR2 protein	PMID:16484285
increases phosphorylation	ISO	RGD:736028	6480464	CTD	mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein	PMID:16484285