Kcnq3 (potassium voltage-gated channel subfamily Q member 3) - Rat Genome Database

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Gene: Kcnq3 (potassium voltage-gated channel subfamily Q member 3) Rattus norvegicus
Analyze
Symbol: Kcnq3
Name: potassium voltage-gated channel subfamily Q member 3
RGD ID: 69222
Description: Enables several functions, including calmodulin binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to ammonium ion; nervous system development; and potassium ion transmembrane transport. Located in several cellular components, including axon initial segment; cell surface; and neuronal cell body. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KQT-like 3; potassium channel subunit alpha KvLQT3; potassium channel, voltage-gated KQT-like subfamily Q, member 3; potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; voltage-gated potassium channel subunit Kv7.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,614,089 - 99,914,736 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl799,619,544 - 99,914,610 (-)EnsemblGRCr8
mRatBN7.2797,730,219 - 98,025,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,730,465 - 98,025,653 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx799,483,729 - 99,777,542 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,685,392 - 101,979,218 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,604,737 - 101,898,571 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,714,479 - 107,009,639 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,717,229 - 107,009,330 (-)Ensemblrn6Rnor6.0
Rnor_5.07106,662,621 - 106,956,409 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47103,325,185 - 103,627,045 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera794,285,105 - 94,579,630 (-)NCBICelera
RGSC_v3.17103,359,425 - 103,661,275 (-)NCBI
Cytogenetic Map7q33NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Charlier C, etal., Nat Genet. 1998 Jan;18(1):53-5.
2. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. Ekberg J, etal., J Biol Chem. 2007 Apr 20;282(16):12135-42. Epub 2007 Feb 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders. Gilling M, etal., Front Genet. 2013 Apr 16;4:54. doi: 10.3389/fgene.2013.00054. eCollection 2013.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. Hadley JK, etal., J Neurosci. 2003 Jun 15;23(12):5012-9.
7. A novel mutation of KCNQ3 (c.925T-->C) in a Japanese family with benign familial neonatal convulsions. Hirose S, etal., Ann Neurol. 2000 Jun;47(6):822-6.
8. Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. Li Y, etal., J Biol Chem. 2004 Oct 29;279(44):45399-407. Epub 2004 Aug 10.
9. Calmodulin orchestrates the heteromeric assembly and the trafficking of KCNQ2/3 (Kv7.2/3) channels in neurons. Liu W and Devaux JJ, Mol Cell Neurosci. 2014 Jan;58:40-52. doi: 10.1016/j.mcn.2013.12.005. Epub 2013 Dec 11.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
12. Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. Oldfield S, etal., Mol Pharmacol. 2009 Dec;76(6):1279-89. doi: 10.1124/mol.109.058008. Epub 2009 Sep 2.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Molecular correlates of the M-current in cultured rat hippocampal neurons. Shah MM, etal., J Physiol 2002 Oct 1;544(Pt 1):29-37.
17. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Wang HS, etal., Science 1998 Dec 4;282(5395):1890-3.
18. K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells. Wang W, etal., PLoS One. 2011;6(7):e21792. doi: 10.1371/journal.pone.0021792. Epub 2011 Jul 5.
19. The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. Yus-Najera E, etal., J Biol Chem 2002 Aug 9;277(32):28545-53.
20. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Zheng Q, etal., Pain. 2013 Mar;154(3):434-48. doi: 10.1016/j.pain.2012.12.005. Epub 2012 Dec 20.
Additional References at PubMed
PMID:10788442   PMID:11159685   PMID:12223552   PMID:14638935   PMID:16525039   PMID:16527853   PMID:17311847   PMID:17442834   PMID:17724161   PMID:18048450   PMID:18089837   PMID:18448631  
PMID:18786918   PMID:18827480   PMID:19060215   PMID:20885443   PMID:21787867   PMID:22871113   PMID:23623937   PMID:24599470   PMID:25796298   PMID:27445338   PMID:27450567   PMID:27564677  
PMID:31373759   PMID:33512443   PMID:34318654   PMID:38219422   PMID:39192337  


Genomics

Comparative Map Data
Kcnq3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,614,089 - 99,914,736 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl799,619,544 - 99,914,610 (-)EnsemblGRCr8
mRatBN7.2797,730,219 - 98,025,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,730,465 - 98,025,653 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx799,483,729 - 99,777,542 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,685,392 - 101,979,218 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,604,737 - 101,898,571 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,714,479 - 107,009,639 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,717,229 - 107,009,330 (-)Ensemblrn6Rnor6.0
Rnor_5.07106,662,621 - 106,956,409 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47103,325,185 - 103,627,045 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera794,285,105 - 94,579,630 (-)NCBICelera
RGSC_v3.17103,359,425 - 103,661,275 (-)NCBI
Cytogenetic Map7q33NCBI
KCNQ3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388132,120,861 - 132,481,095 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8132,120,861 - 132,481,095 (-)Ensemblhg38GRCh38
GRCh378133,133,108 - 133,493,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368133,210,438 - 133,562,186 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348133,210,437 - 133,562,186NCBI
Celera8129,316,946 - 129,668,720 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8128,450,644 - 128,810,822 (-)NCBIHuRef
CHM1_18133,173,913 - 133,533,807 (-)NCBICHM1_1
T2T-CHM13v2.08133,243,767 - 133,604,173 (-)NCBIT2T-CHM13v2.0
Kcnq3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391565,858,223 - 66,158,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1565,858,236 - 66,158,491 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381565,986,374 - 66,286,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1565,986,387 - 66,286,642 (-)Ensemblmm10GRCm38
MGSCv371565,826,477 - 66,117,786 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361565,824,844 - 66,115,893 (-)NCBIMGSCv36mm8
Celera1567,502,496 - 67,809,639 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.16NCBI
Kcnq3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554616,797,018 - 7,119,569 (-)Ensembl
ChiLan1.0NW_0049554616,793,877 - 7,119,859 (-)NCBIChiLan1.0ChiLan1.0
KCNQ3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27149,504,271 - 149,869,035 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18125,018,869 - 125,383,609 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08128,769,930 - 129,134,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18131,747,069 - 132,110,448 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8131,755,454 - 131,815,237 (-)EnsemblpanPan2panpan1.1
KCNQ3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11328,765,472 - 29,062,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1328,773,738 - 29,062,370 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1328,738,298 - 29,035,933 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01329,120,132 - 29,417,368 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1329,126,114 - 29,417,147 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11328,847,191 - 29,144,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01328,946,895 - 29,244,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01329,258,881 - 29,556,646 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnq3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053039,286,465 - 9,587,259 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647016,712,703 - 17,009,397 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647016,712,508 - 17,009,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,669,121 - 8,970,342 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.148,669,969 - 8,978,656 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.248,707,508 - 9,006,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNQ3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18126,566,288 - 126,921,354 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8126,566,545 - 126,622,712 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603913,185,447 - 13,545,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473523,441,042 - 23,751,247 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473523,441,042 - 23,752,197 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnq3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11240,136,667 - 240,429,889 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnq3
2263 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:39
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000006930, ENSRNOT00000074573
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Rat18  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8799,900,464 - 99,900,612 (+)Marker Load Pipeline
mRatBN7.2798,011,396 - 98,011,544 (+)MAPPERmRatBN7.2
Rnor_6.07106,995,385 - 106,995,532NCBIRnor6.0
Rnor_5.07106,942,155 - 106,942,302UniSTSRnor5.0
RGSC_v3.47103,612,739 - 103,612,887RGDRGSC3.4
RGSC_v3.47103,612,740 - 103,612,887UniSTSRGSC3.4
Celera794,565,424 - 94,565,579UniSTS
RGSC_v3.17103,646,970 - 103,647,117RGD
RH 3.4 Map7678.2UniSTS
RH 3.4 Map7678.2RGD
RH 2.0 Map7531.1RGD
FHH x ACI Map746.7299RGD
Cytogenetic Map7q33UniSTS
D7Got81  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,960,870 - 97,961,107 (+)MAPPERmRatBN7.2
Rnor_6.07106,944,740 - 106,944,974NCBIRnor6.0
Rnor_5.07106,892,767 - 106,893,001UniSTSRnor5.0
RGSC_v3.47103,561,784 - 103,562,018UniSTSRGSC3.4
RGSC_v3.47103,561,783 - 103,562,018RGDRGSC3.4
RGSC_v3.17103,596,014 - 103,596,248RGD
RH 3.4 Map7677.1RGD
RH 3.4 Map7677.1UniSTS
RH 2.0 Map7529.9RGD
Cytogenetic Map7q33UniSTS
BF400035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,963,860 - 97,963,995 (+)MAPPERmRatBN7.2
Rnor_6.07106,947,728 - 106,947,862NCBIRnor6.0
Rnor_5.07106,895,755 - 106,895,889UniSTSRnor5.0
RGSC_v3.47103,564,772 - 103,564,906UniSTSRGSC3.4
Celera794,518,301 - 94,518,435UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS
RH144157  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,730,712 - 97,730,880 (+)MAPPERmRatBN7.2
Rnor_6.07106,714,973 - 106,715,140NCBIRnor6.0
Rnor_5.07106,663,115 - 106,663,282UniSTSRnor5.0
RGSC_v3.47103,325,444 - 103,325,611UniSTSRGSC3.4
Celera794,285,599 - 94,285,766UniSTS
RH 3.4 Map7672.8UniSTS
Cytogenetic Map7q33UniSTS
BE102380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,730,599 - 97,730,775 (+)MAPPERmRatBN7.2
Rnor_6.07106,714,860 - 106,715,035NCBIRnor6.0
Rnor_5.07106,663,002 - 106,663,177UniSTSRnor5.0
RGSC_v3.47103,325,331 - 103,325,506UniSTSRGSC3.4
Celera794,285,486 - 94,285,661UniSTS
RH 3.4 Map7671.9UniSTS
Cytogenetic Map7q33UniSTS
AU046741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,736,536 - 97,736,823 (+)MAPPERmRatBN7.2
mRatBN7.2797,736,649 - 97,736,823 (+)MAPPERmRatBN7.2
Rnor_6.07106,720,910 - 106,721,251NCBIRnor6.0
Rnor_6.07106,721,078 - 106,721,251NCBIRnor6.0
Rnor_5.07106,669,220 - 106,669,393UniSTSRnor5.0
Rnor_5.07106,669,052 - 106,669,393UniSTSRnor5.0
RGSC_v3.47103,331,381 - 103,331,554UniSTSRGSC3.4
Celera794,291,536 - 94,291,709UniSTS
Cytogenetic Map7q33UniSTS
BF416665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,002,380 - 98,002,579 (+)MAPPERmRatBN7.2
Rnor_6.07106,986,265 - 106,986,463NCBIRnor6.0
Rnor_5.07106,933,035 - 106,933,233UniSTSRnor5.0
RGSC_v3.47103,603,721 - 103,603,919UniSTSRGSC3.4
Celera794,556,405 - 94,556,603UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS
BF390526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,877,581 - 97,877,781 (+)MAPPERmRatBN7.2
Rnor_6.07106,861,674 - 106,861,873NCBIRnor6.0
Rnor_5.07106,810,377 - 106,810,576UniSTSRnor5.0
RGSC_v3.47103,472,015 - 103,472,214UniSTSRGSC3.4
Celera794,432,370 - 94,432,569UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 6 53 146 60 59 28 66 28 6 251 146 8 124 61 63 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000006930   ⟹   ENSRNOP00000006930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl799,619,544 - 99,914,610 (-)Ensembl
mRatBN7.2 Ensembl797,730,465 - 98,025,343 (-)Ensembl
Rnor_6.0 Ensembl7106,717,229 - 106,753,592 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074573   ⟹   ENSRNOP00000065354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl799,619,544 - 99,914,411 (-)Ensembl
mRatBN7.2 Ensembl797,730,465 - 98,025,343 (-)Ensembl
Rnor_6.0 Ensembl7106,717,232 - 107,009,330 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109659   ⟹   ENSRNOP00000093985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl797,730,465 - 98,025,653 (-)Ensembl
RefSeq Acc Id: NM_031597   ⟹   NP_113785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,619,298 - 99,914,720 (-)NCBI
mRatBN7.2797,730,219 - 98,025,652 (-)NCBI
Rnor_6.07106,714,479 - 107,009,639 (-)NCBI
Rnor_5.07106,662,621 - 106,956,409 (-)NCBI
RGSC_v3.47103,325,185 - 103,627,045 (-)RGD
Celera794,285,105 - 94,579,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063263127   ⟹   XP_063119197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,614,089 - 99,650,879 (-)NCBI
RefSeq Acc Id: XM_063263128   ⟹   XP_063119198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,614,089 - 99,914,735 (-)NCBI
RefSeq Acc Id: XR_010052948
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,632,223 - 99,914,736 (-)NCBI
RefSeq Acc Id: NP_113785   ⟸   NM_031597
- UniProtKB: O88944 (UniProtKB/Swiss-Prot),   Q9Z240 (UniProtKB/Swiss-Prot),   F1LPA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006930   ⟸   ENSRNOT00000006930
Ensembl Acc Id: ENSRNOP00000065354   ⟸   ENSRNOT00000074573
Ensembl Acc Id: ENSRNOP00000093985   ⟸   ENSRNOT00000109659
RefSeq Acc Id: XP_063119198   ⟸   XM_063263128
- Peptide Label: isoform X2
- UniProtKB: F1LPA2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119197   ⟸   XM_063263127
- Peptide Label: isoform X1
- UniProtKB: A6HRQ8 (UniProtKB/TrEMBL)
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88944-F1-model_v2 AlphaFold O88944 1-873 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69222 AgrOrtholog
BioCyc Gene G2FUF-33128 BioCyc
Ensembl Genes ENSRNOG00000005206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006930 ENTREZGENE
  ENSRNOT00000109659.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  6.10.140.1910 UniProtKB/Swiss-Prot
InterPro Ankyrin-G_BS UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_KCNQ UniProtKB/Swiss-Prot
  K_chnl_volt-dep_KCNQ3 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_KCNQ_C UniProtKB/Swiss-Prot
KEGG Report rno:29682 UniProtKB/Swiss-Prot
NCBI Gene 29682 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3 UniProtKB/Swiss-Prot
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  KCNQ_channel UniProtKB/Swiss-Prot
  KCNQC3-Ank-G_bd UniProtKB/Swiss-Prot
PhenoGen Kcnq3 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KCNQ3CHANNEL UniProtKB/Swiss-Prot
  KCNQCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005206 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0H2UI30_RAT UniProtKB/TrEMBL
  A6HRQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6HRQ9_RAT UniProtKB/TrEMBL
  A6HRR0_RAT UniProtKB/TrEMBL
  F1LPA2 ENTREZGENE, UniProtKB/TrEMBL
  KCNQ3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z240 ENTREZGENE
UniProt Secondary Q9Z240 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnq3  potassium voltage-gated channel subfamily Q member 3  Kcnq3  potassium channel, voltage-gated KQT-like subfamily Q, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnq3  potassium channel, voltage-gated KQT-like subfamily Q, member 3  Kcnq3  potassium voltage-gated channel, KQT-like subfamily, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kcnq3  potassium voltage-gated channel, KQT-like subfamily, member 3  Kcnq3  potassium voltage-gated channel, subfamily Q, member 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnq3  potassium voltage-gated channel, subfamily Q, member 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in smooth muscle cells of the stomach 625508
gene_expression expressed at high levels in the brain but not in heart 625508
gene_physical_interaction interacts with calmodulin (CaM) 634683
gene_product 424 bp 625508