Timp4 (TIMP metallopeptidase inhibitor 4) - Rat Genome Database

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Gene: Timp4 (TIMP metallopeptidase inhibitor 4) Rattus norvegicus
Analyze
Symbol: Timp4
Name: TIMP metallopeptidase inhibitor 4
RGD ID: 69077
Description: Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Involved in several processes, including ovulation cycle; response to lipopolysaccharide; and response to peptide hormone. Located in extracellular space and sarcomere. Biomarker of abdominal aortic aneurysm; congestive heart failure; and renal hypertension. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC680130; metalloproteinase inhibitor 4; similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4); TIMP-4; Timp4_mapped; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinase 4 (mapped); tissue inhibitor of metalloproteinases 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,978,667 - 149,985,350 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4149,978,685 - 149,985,452 (-)EnsemblGRCr8
mRatBN7.24148,306,021 - 148,312,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,304,490 - 148,312,558 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4154,531,322 - 154,537,832 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,314,411 - 150,320,921 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,938,223 - 148,944,733 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,156,948 - 147,163,467 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,156,948 - 147,163,467 (-)Ensemblrn6Rnor6.0
Rnor_5.04210,445,694 - 210,452,213 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44151,375,072 - 151,381,591 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4137,199,851 - 137,206,370 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
alpha-Zearalanol  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
monodansylcadaverine  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (EXP)
ramipril  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
2. Inhibition of adjuvant-induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery. Celiker MY, etal., Arthritis Rheum. 2002 Dec;46(12):3361-8.
3. Inhibition of Wilms' tumor growth by intramuscular administration of tissue inhibitor of metalloproteinases-4 plasmid DNA. Celiker MY, etal., Oncogene. 2001 Jul 19;20(32):4337-43.
4. Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats. Chan CY, etal., J Vasc Surg. 2007 Apr;45(4):804-11.
5. Erythropoietin protects post-ischemic hearts by preventing extracellular matrix degradation: role of Jak2-ERK pathway. Chan CY, etal., Life Sci. 2007 Aug 9;81(9):717-23. Epub 2007 Jul 26.
6. TIMP-4 is regulated by vascular injury in rats. Dollery CM, etal., Circ Res. 1999 Mar 19;84(5):498-504.
7. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase-1. Ghose Roy S, etal., Matrix Biol. 2007 May;26(4):269-79. Epub 2006 Dec 29.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas. Hagemann T, etal., Eur J Cancer. 2001 Oct;37(15):1839-46.
12. Zhonghua wai ke za zhi [Chinese journal of surgery] Jiang X, etal., Zhonghua Wai Ke Za Zhi. 2000 Apr;38(4):291-3, 19.
13. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
14. Matrix metalloproteinases contribute to endotoxin and interleukin-1beta induced vascular dysfunction. Lalu MM, etal., Br J Pharmacol. 2006 Sep;149(1):31-42. Epub 2006 Jul 31.
15. Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor. Lee S, etal., Cell Res. 2006 Sep;16(9):750-8.
16. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
17. Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells. Li YY, etal., Cardiovasc Res. 1999 Apr;42(1):162-72.
18. Tissue inhibitor of metalloproteinases-4 is expressed in cervical cancer patients. Lizarraga F, etal., Anticancer Res. 2005 Jan-Feb;25(1B):623-7.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure. Mujumdar VS and Tyagi SC, J Hypertens. 1999 Feb;17(2):261-70.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26. Pilka R, etal., Mol Hum Reprod. 2004 Sep;10(9):641-50. Epub 2004 Jul 23.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary and ovarian carcinoma. Ripley D, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1794-800.
27. Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial ischemia-reperfusion injury. Schulze CJ, etal., Circulation. 2003 May 20;107(19):2487-92. Epub 2003 Apr 21.
28. Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts. Seeland U, etal., J Mol Cell Cardiol. 2002 Feb;34(2):151-63.
29. Localization and expression of tissue inhibitor of metalloproteinase-4 in the immature gonadotropin-stimulated and adult rat ovary. Simpson KS, etal., Biol Reprod 2003 Jan;68(1):214-21.
30. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
31. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer. Tunuguntla R, etal., Gynecol Oncol. 2003 Jun;89(3):453-9.
32. Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. Wang M, etal., Oncogene. 1997 Jun 12;14(23):2767-74.
33. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Zhao YG, etal., Cancer Res. 2004 Jan 15;64(2):590-8.
Additional References at PubMed
PMID:9503367   PMID:15057822   PMID:23117660   PMID:23427085   PMID:24126801   PMID:25028660   PMID:38069250  


Genomics

Comparative Map Data
Timp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,978,667 - 149,985,350 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4149,978,685 - 149,985,452 (-)EnsemblGRCr8
mRatBN7.24148,306,021 - 148,312,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,304,490 - 148,312,558 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4154,531,322 - 154,537,832 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,314,411 - 150,320,921 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,938,223 - 148,944,733 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,156,948 - 147,163,467 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,156,948 - 147,163,467 (-)Ensemblrn6Rnor6.0
Rnor_5.04210,445,694 - 210,452,213 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44151,375,072 - 151,381,591 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4137,199,851 - 137,206,370 (-)NCBICelera
Cytogenetic Map4q42NCBI
TIMP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,153,068 - 12,158,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,153,068 - 12,158,912 (-)Ensemblhg38GRCh38
GRCh37312,194,568 - 12,200,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,169,568 - 12,175,647 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34312,169,569 - 12,175,647NCBI
Celera312,132,043 - 12,138,067 (-)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,128,374 - 12,134,601 (-)NCBIHuRef
CHM1_1312,144,898 - 12,151,125 (-)NCBICHM1_1
T2T-CHM13v2.0312,151,357 - 12,157,146 (-)NCBIT2T-CHM13v2.0
Timp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,221,405 - 115,229,166 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,218,853 - 115,229,166 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386115,244,444 - 115,252,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,241,892 - 115,252,205 (-)Ensemblmm10GRCm38
MGSCv376115,195,634 - 115,201,867 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366115,211,438 - 115,217,467 (-)NCBIMGSCv36mm8
Celera6117,084,697 - 117,090,930 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.29NCBI
Timp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,685,031 - 14,693,211 (-)Ensembl
ChiLan1.0NW_00495542914,689,016 - 14,693,211 (-)NCBIChiLan1.0ChiLan1.0
TIMP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,141,127 - 12,149,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,144,168 - 12,154,025 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0312,079,195 - 12,087,485 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,425,429 - 12,433,192 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,425,429 - 12,433,192 (-)EnsemblpanPan2panpan1.1
TIMP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,399,522 - 6,405,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,399,522 - 6,405,089 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha206,435,643 - 6,441,210 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0206,428,241 - 6,462,722 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,428,701 - 6,439,507 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,146,856 - 6,152,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,497,799 - 6,503,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,473,392 - 6,478,960 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Timp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,413,957 - 17,420,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,489,545 - 1,495,478 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,488,993 - 1,496,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,179,806 - 68,190,942 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11368,179,803 - 68,191,199 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,371,793 - 75,377,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,134,133 - 48,140,870 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,134,637 - 48,140,600 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041118,360,254 - 118,370,994 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624956330,327 - 337,299 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624956331,275 - 341,561 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Timp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1631,460,689 - 31,467,850 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Timp4
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:334
Count of miRNA genes:192
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000010748
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 153 89 88 57 35 57 6 297 135 11 130 81 91 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000010748   ⟹   ENSRNOP00000010748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,978,685 - 149,985,204 (-)Ensembl
mRatBN7.2 Ensembl4148,304,490 - 148,312,558 (-)Ensembl
Rnor_6.0 Ensembl4147,156,948 - 147,163,467 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158232   ⟹   ENSRNOP00000102775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4149,978,685 - 149,985,452 (-)Ensembl
RefSeq Acc Id: NM_001109393   ⟹   NP_001102863
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,978,685 - 149,985,204 (-)NCBI
mRatBN7.24148,306,039 - 148,312,558 (-)NCBI
Rnor_6.04147,156,948 - 147,163,467 (-)NCBI
Rnor_5.04210,445,694 - 210,452,213 (-)NCBI
RGSC_v3.44151,375,072 - 151,381,591 (-)RGD
Celera4137,199,851 - 137,206,370 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108336   ⟹   XP_038964264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,978,667 - 149,985,350 (-)NCBI
mRatBN7.24148,306,021 - 148,312,308 (-)NCBI
RefSeq Acc Id: XM_063286672   ⟹   XP_063142742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,978,667 - 149,983,524 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102863 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964264 (Get FASTA)   NCBI Sequence Viewer  
  XP_063142742 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02160 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010748
GenBank Protein P81556 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102863   ⟸   NM_001109393
- Peptide Label: precursor
- UniProtKB: P81556 (UniProtKB/Swiss-Prot),   A6IKY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010748   ⟸   ENSRNOT00000010748
RefSeq Acc Id: XP_038964264   ⟸   XM_039108336
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q5Q1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142742   ⟸   XM_063286672
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000102775   ⟸   ENSRNOT00000158232
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81556-F1-model_v2 AlphaFold P81556 1-224 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69077 AgrOrtholog
BioCyc Gene G2FUF-43325 BioCyc
Ensembl Genes ENSRNOG00000007955 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010748 ENTREZGENE
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  3.90.370.10 UniProtKB/Swiss-Prot
InterPro Netrin_domain UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
  TIMP_C UniProtKB/Swiss-Prot
  TIMP_CS UniProtKB/Swiss-Prot
KEGG Report rno:680130 UniProtKB/Swiss-Prot
NCBI Gene Timp4 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot
  PTHR11844:SF26 UniProtKB/Swiss-Prot
Pfam TIMP UniProtKB/Swiss-Prot
PhenoGen Timp4 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007955 RatGTEx
SMART NTR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
UniProt A0A8L2Q5Q1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LD99_RAT UniProtKB/TrEMBL
  A6IKY2 ENTREZGENE, UniProtKB/TrEMBL
  P81556 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-05 Timp4  TIMP metallopeptidase inhibitor 4  Timp4  tissue inhibitor of metalloproteinase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Timp4  tissue inhibitor of metalloproteinase 4  Timp4_mapped  tissue inhibitor of metalloproteinase 4 (mapped)  Symbol and Name updated 1299863 APPROVED
2008-04-25 Timp4_mapped  tissue inhibitor of metalloproteinase 4 (mapped)  LOC680130  similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)  Data merged from RGD:1595493 737654 APPROVED
2008-01-09 LOC680130  similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)  LOC678834  similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)  Data merged from RGD:1595583 1643240 APPROVED
2006-11-20 LOC680130  similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC678834  similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Timp4_mapped  tissue inhibitor of metalloproteinase 4 (mapped)  Timp4  tissue inhibitor of metalloproteinase 4  Symbol and Name updated 1556543 APPROVED
2004-09-10 Timp4  tissue inhibitor of metalloproteinase 4    tissue inhibitor of metalloproteinase 4   Name updated 1299863 APPROVED
2002-06-10 Timp4  tissue inhibitor of metalloproteinase 4       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may have a role in hypertensive remodeling of the cortex and medulla in the SHR rat 1302333