Bcat2 (branched chain amino acid transaminase 2)

Gene: Bcat2 (branched chain amino acid transaminase 2) Rattus norvegicus

Analyze

Symbol:

Bcat2

Name:

branched chain amino acid transaminase 2

RGD ID:

68948

Description:

Enables branched-chain-amino-acid transaminase activity. Involved in isoleucine catabolic process; lactation; and leucine biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human BCAT2 (branched chain amino acid transaminase 2); PARTICIPATES IN valine, leucine and isoleucine biosynthetic pathway; valine, leucine and isoleucine degradation pathway; pantothenic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BCAT(m); Bcatm; BCT2; branched chain amino acid transaminase 2, mitochondrial; branched chain aminotransferase 2, mitochondrial; branched-chain-amino-acid aminotransferase, mitochondrial; heart branched chain aminotransferase precursor encoding mitochondrial protein; mBcat

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BCAT2 (branched chain amino acid transaminase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Bcat2 (branched chain aminotransferase 2, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bcat2 (branched chain amino acid transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BCAT2 (branched chain amino acid transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BCAT2 (branched chain amino acid transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bcat2 (branched chain amino acid transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BCAT2 (branched chain amino acid transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BCAT2 (branched chain amino acid transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bcat2 (branched chain amino acid transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ALOX12B (arachidonate 12-lipoxygenase, 12R type)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	BCAT2 (branched chain amino acid transaminase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Bcat2 (branched chain aminotransferase 2, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bcat2 (branched chain amino-acid transaminase 2, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	BAT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BAT2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1673	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y44A6D.5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	bcat-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bcat2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	105,175,157 - 105,196,474 (+)	NCBI		GRCr8
mRatBN7.2	1	96,040,407 - 96,060,008 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	96,042,625 - 96,060,007 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	101,428,109 - 101,445,450 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	109,900,801 - 109,918,146 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	103,191,189 - 103,208,524 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	101,553,900 - 101,572,103 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	101,554,642 - 101,572,080 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	102,633,422 - 102,650,883 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	96,038,287 - 96,055,622 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	96,116,397 - 96,133,732 (+)	NCBI
Celera	1	90,298,174 - 90,315,510 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

HYPERVALINEMIA AND HYPERLEUCINE-ISOLEUCINEMIA (ISO)

maple syrup urine disease (ISO,ISS)

pre-malignant neoplasm (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clodronic acid (ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

cyclosporin A (EXP,ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

doxorubicin (EXP,ISO)

fenofibrate (ISO)

folic acid (ISO)

gentamycin (EXP)

haloperidol (ISO)

ibuprofen (ISO)

indometacin (EXP)

isotretinoin (ISO)

ivermectin (ISO)

metformin (EXP)

mifepristone (ISO)

N-ethyl-N-nitrosourea (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosodiethylamine (EXP)

naphthalenes (EXP)

Nivalenol (ISO)

okadaic acid (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phorone (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

Soman (EXP)

temozolomide (ISO)

testosterone (EXP,ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

troglitazone (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid biosynthetic process (IEA)

branched-chain amino acid biosynthetic process (IEA)

branched-chain amino acid catabolic process (IDA,ISO)

branched-chain amino acid metabolic process (ISO,TAS)

cellular response to leukemia inhibitory factor (IEA,ISO)

isoleucine catabolic process (IDA,IEA,ISO)

isoleucine metabolic process (ISO)

L-leucine biosynthetic process (IBA,IDA,IEA)

L-leucine metabolic process (IEA,ISO)

lactation (IEP)

lipid metabolic process (IEA)

regulation of hormone levels (IEA,ISO)

valine biosynthetic process (IBA,IEA)

valine metabolic process (IEA,ISO)

Cellular Component

mitochondrion (IBA,IEA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

branched-chain-amino-acid transaminase activity (IBA,IDA,ISO)

L-isoleucine transaminase activity (IEA,ISO)

L-leucine transaminase activity (IEA,ISO)

L-leucine:2-oxoglutarate aminotransferase activity (IEA)

L-valine transaminase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

pantothenic acid metabolic pathway (IEA)

valine, leucine and isoleucine biosynthetic pathway (IDA,IEA)

valine, leucine and isoleucine degradation pathway (IDA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm).	Bledsoe RK, etal., Biochim Biophys Acta 1997 Apr 25;1339(1):9-13.
2.	Induction of expression of branched-chain aminotransferase and alpha-keto acid dehydrogenase in rat tissues during lactation.	DeSantiago S, etal., Adv Exp Med Biol. 2001;501:93-9.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14.	Ontogeny and subcellular localization of rat liver mitochondrial branched chain amino-acid aminotransferase.	Torres N, etal., Eur J Biochem. 2001 Dec;268(23):6132-9.
15.	Localization and expression of BCAT during pregnancy and lactation in the rat mammary gland.	Tovar AR, etal., Am J Physiol Endocrinol Metab 2001 Mar;280(3):E480-8.
16.	ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.	Wu JY, etal., J Clin Invest 2004 Feb;113(3):434-40.

Additional References at PubMed

PMID:8428987	PMID:11264579	PMID:12269802	PMID:14651853	PMID:17767905	PMID:18614015	PMID:19858196	PMID:20237068	PMID:20439489	PMID:27488662	PMID:31833233

Genomics

Comparative Map Data

Bcat2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	105,175,157 - 105,196,474 (+)	NCBI		GRCr8
mRatBN7.2	1	96,040,407 - 96,060,008 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	96,042,625 - 96,060,007 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	101,428,109 - 101,445,450 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	109,900,801 - 109,918,146 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	103,191,189 - 103,208,524 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	101,553,900 - 101,572,103 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	101,554,642 - 101,572,080 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	102,633,422 - 102,650,883 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	96,038,287 - 96,055,622 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	96,116,397 - 96,133,732 (+)	NCBI
Celera	1	90,298,174 - 90,315,510 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

BCAT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	48,795,064 - 48,811,029 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	48,795,062 - 48,811,029 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	49,298,321 - 49,314,286 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	53,990,131 - 54,006,113 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	53,990,131 - 54,006,113	NCBI
Celera	19	46,166,129 - 46,182,134 (-)	NCBI		Celera
Cytogenetic Map	19	q13.33	NCBI
HuRef	19	45,677,853 - 45,693,853 (-)	NCBI		HuRef
CHM1_1	19	49,300,194 - 49,316,125 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	51,790,087 - 51,806,051 (-)	NCBI		T2T-CHM13v2.0

Bcat2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	45,219,773 - 45,239,134 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	45,219,577 - 45,239,135 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	45,568,967 - 45,589,710 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	45,570,153 - 45,589,711 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	52,825,733 - 52,845,078 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	45,438,405 - 45,457,750 (+)	NCBI		MGSCv36	mm8
Celera	7	41,023,580 - 41,045,483 (+)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	29.36	NCBI

Bcat2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955559	1,785,253 - 1,797,899 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955559	1,785,253 - 1,796,838 (+)	NCBI	ChiLan1.0	ChiLan1.0

BCAT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	54,897,417 - 54,914,501 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	56,823,445 - 56,840,050 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	45,793,433 - 45,809,546 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	54,945,156 - 54,962,887 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	54,945,157 - 54,962,887 (+)	Ensembl	panpan1.1		panPan2

BCAT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	107,539,125 - 107,549,286 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	107,538,465 - 107,549,234 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	107,061,565 - 107,071,746 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	108,063,749 - 108,073,941 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	108,063,615 - 108,073,930 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	107,730,663 - 107,740,841 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	107,377,548 - 107,387,729 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	108,213,156 - 108,223,338 (+)	NCBI		UU_Cfam_GSD_1.0

Bcat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	21,247,666 - 21,259,021 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	2,864,231 - 2,890,018 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	2,865,804 - 2,890,038 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BCAT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	54,107,684 - 54,142,790 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	54,107,682 - 54,123,595 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	49,855,038 - 49,870,815 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BCAT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	42,031,003 - 42,051,770 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	42,030,984 - 42,049,050 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	21,910,508 - 21,927,833 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bcat2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	5,134,590 - 5,147,290 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	5,132,667 - 5,147,099 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bcat2
43 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	59
Count of miRNA genes:	45
Interacting mature miRNAs:	55
Transcripts:	ENSRNOT00000028474
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	77494165	122494165	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	77857876	122857876	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	77876254	106047988	Rat
61344	Bp29	Blood pressure QTL 29	7.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	78350581	123350581	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	78430536	123430536	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	78479925	123479925	Rat
4889494	Scort2	Serum corticosterone level QTL 2	4.2		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	80592172	125592172	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	82174743	118944897	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)	1	83547917	128547917	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	85424647	100358001	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	87580395	150700247	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	90532338	123479925	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	90664883	143200202	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	92184926	137184926	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	92948896	144267916	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	94494440	117601394	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat

Markers in Region

RH127555

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	96,059,638 - 96,059,820 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	101,571,734 - 101,571,915	NCBI	Rnor6.0
Rnor_5.0	1	102,650,514 - 102,650,695	UniSTS	Rnor5.0
RGSC_v3.4	1	96,055,253 - 96,055,434	UniSTS	RGSC3.4
Celera	1	90,315,141 - 90,315,322	UniSTS
RH 3.4 Map	1	907.6	UniSTS
Cytogenetic Map	1	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	38	22	19	22	8	11	66	35	41	11	8
Low			19	19		19			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229149	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC061790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U68417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000028474 ⟹ ENSRNOP00000028474

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	96,042,625 - 96,060,007 (+)	Ensembl
Rnor_6.0 Ensembl	1	101,554,642 - 101,572,080 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095787 ⟹ ENSRNOP00000095006

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	96,042,625 - 96,060,001 (+)	Ensembl

RefSeq Acc Id:

NM_022400 ⟹ NP_071795

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	105,179,139 - 105,196,474 (+)	NCBI
mRatBN7.2	1	96,042,671 - 96,060,008 (+)	NCBI
Rnor_6.0	1	101,554,642 - 101,572,103 (+)	NCBI
Rnor_5.0	1	102,633,422 - 102,650,883 (+)	NCBI
RGSC_v3.4	1	96,038,287 - 96,055,622 (+)	RGD
Celera	1	90,298,174 - 90,315,510 (+)	RGD

Sequence:

show sequence

CGGGATCATGTCTGCAGCTATACTAGGACAGGTCTGGACCCGGAAGCTTCTGCCTATTCCCTGG
CGTCTATGTGTGCCCGGAAGATGTGTGTCCTCCAACTTCAAGGCGGCAGACCTCCAGGTTCAGG
TGACCAGAGAGCCACAGAAGAAGCCAGCCCCTAGCCAGCCTCTGCTGTTTGGGAAGACATTCAC
GGACCACATGCTGATGGTGGAGTGGAACAGCAAGACAGGCTGGGGCCCTCCAAGGATCCAGCCC
TTCCAGAACCTCACACTGCACCCAGCCTGCTCCGGCCTGCACTACTCATTGCAGCTCTTTGAAG
GCTTGAAAGCTTATAAAGGCAGAGACAAGCAGGTACGCCTCTTCCGGCCCTGGCTCAACATGGA
CAGGATGCTACGTTCTGCAAGGCGCCTCTGCCTGCCAGACTTTGACAAGCAGGAACTGCTGGAG
TGCATCCGCCAGCTCATTGAAGTAGACAAAGACTGGGTTCCCGATGGCAATGGAACAAGCCTCT
ATGTGCGGCCGGTGCTTATTGGAAATGAGCCCTCCCTGGGTGTTGGAATGGTCACACAAGCCCT
CCTGTTCGTCATTCTGTGCCCTGTGGGCTCCTACTTCCCCGGAGACTCCATGACACCTGTCTCC
CTCCTGGCGGACCCCTCATTCGTCAGAGCCTGGATTGGTGGGGTCGGTGACTGCAAGTTGGGGG
GGAATTACGGCCCCACTGTGGCTGTGCAACAAGAAGCCCAGAAGAAAGGCTGCGAGCAGGTCCT
CTGGCTGTACGGGCCGGACCACCAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGG
ACTCATGAAGACGGAGAACTGGAGCTGGCAACCCCCCCACTGGATGGCATCATCCTCCCCGGAG
TGGTTCGACAAAGCCTGCTGGATCTGGCCAGGACTTGGGGTGAGTTCCGGGTGGCAGAACGCAA
GGTCACTATGAAGGAATTGAAGCGGGCACTGGAGGAGGGCCGGGTGCGAGAAGTCTTCGGCTCA
GGCACTGCTTGTCAGGTCTGCCCAGTGCACCAAATCCTATATGAAGGCAAGCAACTCCACATTC
CTACCATGGAAAATGGGCCGGAACTCATCCTGCGCTTCCAGAAGGAGTTGAAGGCTATTCAGTA
CGGAACCAGTGCCCACGATTGGATGCTTCGTGTGTGACGTTAGGGAGGTTGTGCCCTACCTGGT
TGGATCCGCTGACGTGCAGCATCCAGTTCAGCGTCCTCGCCTCCCAGAGACTCAAGAGAAGTGC
AATAGGGAAGGTCGTTCCAGACTGCTGGCTCTCTGGCACCCTCACGTGGAAGTTACACTCCAAA
GCCTTAAGGGCGGACCCATGTAATTTGGACCCCACCTCAGTTCAGCTCGTCCGCGTCCTGGTGT
TCAAGAGAGAACCTTGGCTTCTTCTCGATCTCCGTTCTCAGGCGGATCCCCGGTGCTCTTCATG
TCTTTTTTTTTTTTTTTTTCCGTCTCTCTCTCCTTGCTGCAATTTTGAAATAAAAATGCCAAAG
AACAAGAAAAAA

hide sequence

RefSeq Acc Id:

XM_006229149 ⟹ XP_006229211

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	105,179,281 - 105,196,474 (+)	NCBI
mRatBN7.2	1	96,042,769 - 96,060,008 (+)	NCBI
Rnor_6.0	1	101,554,679 - 101,572,103 (+)	NCBI
Rnor_5.0	1	102,633,422 - 102,650,883 (+)	NCBI

Sequence:

show sequence

GCGTGGCCGATCGGTGCTGGGGGCTCTGGGGAACCTGATGGGGGGCGCACTTCCGGGTGGACCA
CTGGCGTGCAGCCTTTCCGGGTTGGCGTCATTCCTCTGTGCCCTGGGGTTCCGCTGCCCCACAC
AGAGGCGGATGGGCCCCTTGGAAAGGAGTACCGGGCTTTAACGAGCGGCAAAATGGGTAGACAC
GAGTCGGGTGCGAGAGGTCTGGGCCCGGAAGCTTCTGCCTATTCCCTGGCGTCTATGTGTGCCC
GGAAGATGTGTGTCCTCCAACTTCAAGGCGGCAGACCTCCAGGTTCAGGTGACCAGAGAGCCAC
AGAAGAAGCCAGCCCCTAGCCAGCCTCTGCTGTTTGGGAAGACATTCACGGACCACATGCTGAT
GGTGGAGTGGAACAGCAAGACAGGCTGGGGCCCTCCAAGGATCCAGCCCTTCCAGAACCTCACA
CTGCACCCAGCCTGCTCCGGCCTGCACTACTCATTGCAGCTCTTTGAAGGCTTGAAAGCTTATA
AAGGCAGAGACAAGCAGGTACGCCTCTTCCGGCCCTGGCTCAACATGGACAGGATGCTACGTTC
TGCAAGGCGCCTCTGCCTGCCAGACTTTGACAAGCAGGAACTGCTGGAGTGCATCCGCCAGCTC
ATTGAAGTAGACAAAGACTGGGTTCCCGATGGCAATGGAACAAGCCTCTATGTGCGGCCGGTGC
TTATTGGAAATGAGCCCTCCCTGGGTGTTGGAATGGTCACACAAGCCCTCCTGTTCGTCATTCT
GTGCCCTGTGGGCTCCTACTTCCCCGGAGACTCCATGACACCTGTCTCCCTCCTGGCGGACCCC
TCATTCGTCAGAGCCTGGATTGGTGGGGTCGGTGACTGCAAGTTGGGGGGGAATTACGGCCCCA
CTGTGGCTGTGCAACAAGAAGCCCAGAAGAAAGGCTGCGAGCAGGTCCTCTGGCTGTACGGGCC
GGACCACCAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGGACTCATGAAGACGGA
GAACTGGAGCTGGCAACCCCCCCACTGGATGGCATCATCCTCCCCGGAGTGGTTCGACAAAGCC
TGCTGGATCTGGCCAGGACTTGGGGTGAGTTCCGGGTGGCAGAACGCAAGGTCACTATGAAGGA
ATTGAAGCGGGCACTGGAGGAGGGCCGGGTGCGAGAAGTCTTCGGCTCAGGCACTGCTTGTCAG
GTCTGCCCAGTGCACCAAATCCTATATGAAGGCAAGCAACTCCACATTCCTACCATGGAAAATG
GGCCGGAACTCATCCTGCGCTTCCAGAAGGAGTTGAAGGCTATTCAGTACGGAACCAGTGCCCA
CGATTGGATGCTTCGTGTGTGACGTTAGGGAGGTTGTGCCCTACCTGGTTGGATCCGCTGACGT
GCAGCATCCAGTTCAGCGTCCTCGCCTCCCAGAGACTCAAGAGAAGTGCAATAGGGAAAGGTCG
TTCCAGACTGCTGGCTCTCTGGCACCCTCACGTGGAAGTTACACTCCAAAGCCTTAAGGGCGGG
ACCCATGTAATTTGGACCCCACCTCAGTTCAGCTGCTCCGCGTCCTGGTGTTCAAGAGAGAACC
TTGGCTTCTTCTCGATCTCCGTTCTCAGGCCGGATCCCCGGTGCTCTTCATGTCTTTTTTTTTT
TTTTTTCCGTCTCTCTCTCCTTGCTGCAATTTTGAAATAAAATGCCAAAGAACAAGA

hide sequence

RefSeq Acc Id:

XM_017589657 ⟹ XP_017445146

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	105,179,334 - 105,196,474 (+)	NCBI
mRatBN7.2	1	96,042,777 - 96,060,008 (+)	NCBI
Rnor_6.0	1	101,554,679 - 101,572,103 (+)	NCBI

Sequence:

show sequence

GCGTGGCCGATCGGTGCTGGGGGCTCTGGGGAACCTGATGGGGGGCGCACTTCCGGGTGGACCA
CTGGCGTGCAGCCTTTCCGGGTTGGCGTCATTCCTCTGTGCCCTGGGGTTCCGCTGCCCCACAC
AGAGGCGGATGGGCCCCTTGGAAAGGAGTACCGGGCTTTAACGAGCGGCAAAATGGGTAGACAC
GAGTCGGGTGCGAGAGGTATCTGAACCGCGAGCGAGGTCTGGGCCCGGAAGCTTCTGCCTATTC
CCTGGCGTCTATGTGTGCCCGGAAGATGTGTGTCCTCCAACTTCAAGGCGGCAGACCTCCAGGT
TCAGGTGACCAGAGAGCCACAGAAGAAGCCAGCCCCTAGCCAGCCTCTGCTGTTTGGGAAGACA
TTCACGGACCACATGCTGATGGTGGAGTGGAACAGCAAGACAGGCTGGGGCCCTCCAAGGATCC
AGCCCTTCCAGAACCTCACACTGCACCCAGCCTGCTCCGGCCTGCACTACTCATTGCAGCTCTT
TGAAGGCTTGAAAGCTTATAAAGGCAGAGACAAGCAGGTACGCCTCTTCCGGCCCTGGCTCAAC
ATGGACAGGATGCTACGTTCTGCAAGGCGCCTCTGCCTGCCAGACTTTGACAAGCAGGAACTGC
TGGAGTGCATCCGCCAGCTCATTGAAGTAGACAAAGACTGGGTTCCCGATGGCAATGGAACAAG
CCTCTATGTGCGGCCGGTGCTTATTGGAAATGAGCCCTCCCTGGGTGTTGGAATGGTCACACAA
GCCCTCCTGTTCGTCATTCTGTGCCCTGTGGGCTCCTACTTCCCCGGAGACTCCATGACACCTG
TCTCCCTCCTGGCGGACCCCTCATTCGTCAGAGCCTGGATTGGTGGGGTCGGTGACTGCAAGTT
GGGGGGGAATTACGGCCCCACTGTGGCTGTGCAACAAGAAGCCCAGAAGAAAGGCTGCGAGCAG
GTCCTCTGGCTGTACGGGCCGGACCACCAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCT
ACTGGACTCATGAAGACGGAGAACTGGAGCTGGCAACCCCCCCACTGGATGGCATCATCCTCCC
CGGAGTGGTTCGACAAAGCCTGCTGGATCTGGCCAGGACTTGGGGTGAGTTCCGGGTGGCAGAA
CGCAAGGTCACTATGAAGGAATTGAAGCGGGCACTGGAGGAGGGCCGGGTGCGAGAAGTCTTCG
GCTCAGGCACTGCTTGTCAGGTCTGCCCAGTGCACCAAATCCTATATGAAGGCAAGCAACTCCA
CATTCCTACCATGGAAAATGGGCCGGAACTCATCCTGCGCTTCCAGAAGGAGTTGAAGGCTATT
CAGTACGGAACCAGTGCCCACGATTGGATGCTTCGTGTGTGACGTTAGGGAGGTTGTGCCCTAC
CTGGTTGGATCCGCTGACGTGCAGCATCCAGTTCAGCGTCCTCGCCTCCCAGAGACTCAAGAGA
AGTGCAATAGGGAAAGGTCGTTCCAGACTGCTGGCTCTCTGGCACCCTCACGTGGAAGTTACAC
TCCAAAGCCTTAAGGGCGGGACCCATGTAATTTGGACCCCACCTCAGTTCAGCTGCTCCGCGTC
CTGGTGTTCAAGAGAGAACCTTGGCTTCTTCTCGATCTCCGTTCTCAGGCCGGATCCCCGGTGC
TCTTCATGTCTTTTTTTTTTTTTTTTCCGTCTCTCTCTCCTTGCTGCAATTTTGAAATAAAATG
CCAAAGAACAAGA

hide sequence

RefSeq Acc Id:

XM_039089504 ⟹ XP_038945432

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	105,175,157 - 105,196,474 (+)	NCBI
mRatBN7.2	1	96,040,407 - 96,060,008 (+)	NCBI

RefSeq Acc Id:

XM_063272743 ⟹ XP_063128813

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	105,183,602 - 105,196,474 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071795	(Get FASTA)	NCBI Sequence Viewer
	XP_006229211	(Get FASTA)	NCBI Sequence Viewer
	XP_017445146	(Get FASTA)	NCBI Sequence Viewer
	XP_038945432	(Get FASTA)	NCBI Sequence Viewer
	XP_063128813	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB67673	(Get FASTA)	NCBI Sequence Viewer
	AAH61790	(Get FASTA)	NCBI Sequence Viewer
	EDM07328	(Get FASTA)	NCBI Sequence Viewer
	EDM07329	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028474
	ENSRNOP00000028474.3
	ENSRNOP00000095006.1
GenBank Protein	O35854	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071795 ⟸ NM_022400
- Peptide Label:	precursor
- UniProtKB:	O35854 (UniProtKB/Swiss-Prot), G3V8U8 (UniProtKB/TrEMBL), A6JB55 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSAAILGQVWTRKLLPIPWRLCVPGRCVSSNFKAADLQVQVTREPQKKPAPSQPLLFGKTFTDH MLMVEWNSKTGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGRDKQVRLFRPWLNMDRM LRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLF VILCPVGSYFPGDSMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQQEAQKKGCEQVLWL YGPDHQLTEVGTMNIFVYWTHEDGELELATPPLDGIILPGVVRQSLLDLARTWGEFRVAERKVT MKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRFQKELKAIQYGT SAHDWMLRV hide sequence

RefSeq Acc Id:	XP_006229211 ⟸ XM_006229149
- Peptide Label:	isoform X2
- UniProtKB:	O35854 (UniProtKB/Swiss-Prot), A6JB56 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLMVEWNSKTGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGRDKQVRLFRPWLNMDRM LRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLF VILCPVGSYFPGDSMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQQEAQKKGCEQVLWL YGPDHQLTEVGTMNIFVYWTHEDGELELATPPLDGIILPGVVRQSLLDLARTWGEFRVAERKVT MKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRFQKELKAIQYGT SAHDWMLRV hide sequence

RefSeq Acc Id:	XP_017445146 ⟸ XM_017589657
- Peptide Label:	isoform X2
- UniProtKB:	O35854 (UniProtKB/Swiss-Prot), A6JB56 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLMVEWNSKTGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGRDKQVRLFRPWLNMDRM LRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLF VILCPVGSYFPGDSMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQQEAQKKGCEQVLWL YGPDHQLTEVGTMNIFVYWTHEDGELELATPPLDGIILPGVVRQSLLDLARTWGEFRVAERKVT MKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRFQKELKAIQYGT SAHDWMLRV hide sequence

RefSeq Acc Id:

ENSRNOP00000028474 ⟸ ENSRNOT00000028474

RefSeq Acc Id:	XP_038945432 ⟸ XM_039089504
- Peptide Label:	isoform X1
- UniProtKB:	O35854 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:

ENSRNOP00000095006 ⟸ ENSRNOT00000095787

RefSeq Acc Id:	XP_063128813 ⟸ XM_063272743
- Peptide Label:	isoform X3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35854-F1-model_v2	AlphaFold	O35854	1-393	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690046

Promoter ID:

EPDNEW_R571

Type:

multiple initiation site

Name:

Bcat2_1

Description:

branched chain amino acid transaminase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	101,554,626 - 101,554,686	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68948	AgrOrtholog
BioCyc Gene	G2FUF-59671	BioCyc
BioCyc Pathway	ILEUDEG-PWY [L-isoleucine degradation I]	BioCyc
	ILEUSYN-PWY [L-isoleucine biosynthesis I (from threonine)]	BioCyc
	LEU-DEG2-PWY [L-leucine degradation I]	BioCyc
	VALDEG-PWY [L-valine degradation I]	BioCyc
BioCyc Pathway Image	ILEUDEG-PWY	BioCyc
	ILEUSYN-PWY	BioCyc
	LEU-DEG2-PWY	BioCyc
	VALDEG-PWY	BioCyc
Ensembl Genes	ENSRNOG00000020956	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028474	ENTREZGENE
	ENSRNOT00000028474.6	UniProtKB/TrEMBL
	ENSRNOT00000095787.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.470.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5623666	IMAGE-MGC_LOAD
InterPro	Aminotrans_IV	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aminotrans_IV_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aminotransferase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	B_amino_transII	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BCAT-like_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BCAT-like_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BCAT_family	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64203	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72449	IMAGE-MGC_LOAD
NCBI Gene	64203	ENTREZGENE
PANTHER	BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11825	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aminotran_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Bcat2	PhenoGen
PIRSF	BCAT1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	AA_TRANSFER_CLASS_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020956	RatGTEx
Superfamily-SCOP	SSF56752	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC205167
UniProt	A0A8I6AKN8_RAT	UniProtKB/TrEMBL
	A6JB55	ENTREZGENE, UniProtKB/TrEMBL
	A6JB56	ENTREZGENE, UniProtKB/TrEMBL
	BCAT2_RAT	UniProtKB/Swiss-Prot
	G3V8U8	ENTREZGENE, UniProtKB/TrEMBL
	O35854	ENTREZGENE
	Q6P784_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-15	Bcat2	branched chain amino acid transaminase 2	Bcat2	branched chain amino acid transaminase 2, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-28	Bcat2	branched chain amino acid transaminase 2, mitochondrial	Bcat2	branched chain aminotransferase 2, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Bcat2	branched chain aminotransferase 2, mitochondrial			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression follows stages I and II of lactogenesis and is specific to milk-producing epithelial acinar cells	62398
gene_expression	expression follows stages I and II of lactogenesis and is specific to milk-producing epithelial acinar cells	67954
gene_function	catalyzes the conversion of L-leucine and 2-oxoglutarate to 4-methyl-2-oxopentanoate and L-glutamate	67954
gene_protein	protein products of 41.2 and 41.3 kDa	67954

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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