Cyp4a1 (cytochrome P450, family 4, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp4a1 (cytochrome P450, family 4, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
RGD ID: 68945
Description: Enables alkane 1-monooxygenase activity and arachidonate monooxygenase activity. Involved in several processes, including fatty acid metabolic process; icosanoid biosynthetic process; and placenta development. Predicted to be located in extracellular space. Biomarker of autosomal recessive polycystic kidney disease and hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4A22 (cytochrome P450 family 4 subfamily A member 22); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; linoleic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp4a10; Cyp4a22; CYPIVA10; cytochrome P450 4A10; Cytochrome P450 IVA1; cytochrome P450, 4A1; cytochrome P450, 4a10; cytochrome P450, family 4, subfamily a, polypeptide 10; cytochrome P450, family 4, subfamily A, polypeptide 22; Cytochrome P450, IVA1; cytochrome P450-LA-omega 1; cytochrome P452; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase; MGC108515; P450-LA-omega 1; P452
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Candidate Gene For: Rf54 Bp359
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,360,096 - 134,374,233 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5134,360,111 - 134,374,231 (+)EnsemblGRCr8
mRatBN7.25129,123,323 - 129,137,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,123,336 - 129,137,464 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5131,733,814 - 131,747,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,488,694 - 133,502,837 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,510,852 - 133,524,991 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,492,734 - 134,507,158 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,492,756 - 134,507,154 (+)Ensemblrn6Rnor6.0
Rnor_5.05138,283,577 - 138,297,981 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45135,901,653 - 135,915,754 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5127,661,027 - 127,675,153 (+)NCBICelera
RGSC_v3.15135,906,849 - 135,920,979 (+)NCBI
Cytogenetic Map5q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
20-HETE  (EXP)
3-phenoxybenzoic acid  (EXP)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
azoxystrobin  (EXP)
barium sulfate  (EXP)
benoxaprofen  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
carbamazepine  (EXP)
chlorpyrifos  (EXP)
ciprofibrate  (EXP)
climbazole  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (EXP)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
deoxycholic acid  (EXP)
Diallyl sulfide  (EXP)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diquat  (EXP)
dodecanoic acid  (EXP)
doxorubicin  (EXP)
ethanol  (EXP)
farnesol  (EXP)
felbamate  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
fipronil  (EXP,ISO)
flutamide  (EXP)
fomepizole  (EXP)
fructose  (EXP)
furan  (EXP)
gabapentin  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemfibrozil  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
GW 6471  (EXP)
GW 7647  (EXP)
Heliotrine  (ISO)
hexadecanoic acid  (EXP,ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
kojic acid  (EXP)
lansoprazole  (EXP)
lead nitrate  (EXP)
leflunomide  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nafenopin  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (EXP,ISO)
oleic acid  (EXP)
orotic acid  (EXP)
orphenadrine  (EXP)
oxycodone  (EXP)
p-tert-Amylphenol  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP)
pent-4-enoic acid  (EXP)
perfluorobutyric acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorohexanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenytoin  (EXP)
pirinixic acid  (EXP)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
propyzamide  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
Senkirkine  (ISO)
simazine  (EXP)
soybean oil  (EXP)
streptozocin  (EXP)
sucrose  (EXP)
Sudan III  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
Tautomycin  (EXP)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP)
VX nerve agent  (ISO)
zaragozic acid A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. Dunn KM, etal., Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2455-65. Epub 2008 Oct 24.
2. Parenchymal tissue cytochrome P450 4A enzymes contribute to oxygen-induced alterations in skeletal muscle arteriolar tone. Frisbee JC and Lombard JH, Microvasc Res 2002 May;63(3):340-3.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Renal cytochrome p450 oxygenases and preglomerular vascular response to arachidonic acid and endothelin-1 following ischemia/reperfusion. Hercule H and Oyekan A, J Pharmacol Exp Ther 2002 Aug;302(2):717-24.
5. Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat. Hercule HC, etal., J Physiol. 2003 Sep 15;551(Pt 3):971-9. Epub 2003 Jul 11.
6. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Kroetz DL, etal., Mol Pharmacol. 1997 Sep;52(3):362-72.
7. Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries. Marji JS, etal., Am J Physiol Renal Physiol 2002 Jul;283(1):F60-7.
8. Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy. Mayer B, etal., Hypertension. 2005 Oct;46(4):766-71. Epub 2005 Sep 6.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Nguyen X, etal., Am J Physiol. 1999 Jun;276(6 Pt 2):R1691-700.
11. Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Pan J, etal., Xenobiotica 2002 Sep;32(9):739-47.
12. Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. Park F, etal., Am J Physiol Renal Physiol. 2009 Jan 7.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. Wang MH, etal., Am J Physiol Renal Physiol 2003 Aug;285(2):F295-302. Epub 2003 Apr 8.
20. Expression of CYP4A isoforms in developing rat placental tissue and rat trophoblastic cell models. Xu Y, etal., Placenta. 2005 Feb-Mar;26(2-3):218-25.
21. Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. Zhou Y, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):11-8. Epub 2005 Dec 8.
Additional References at PubMed
PMID:1567203   PMID:1980193   PMID:2766932   PMID:3027069   PMID:3410047   PMID:10860550   PMID:11139583   PMID:11821421   PMID:12477932   PMID:14670847   PMID:15280100   PMID:15489334  
PMID:15632090   PMID:15849199   PMID:16806293   PMID:17112342   PMID:18842817   PMID:18971561   PMID:19225982   PMID:21894443   PMID:22938512   PMID:25540098   PMID:25636742   PMID:27537772  
PMID:30227249  


Genomics

Comparative Map Data
Cyp4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,360,096 - 134,374,233 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5134,360,111 - 134,374,231 (+)EnsemblGRCr8
mRatBN7.25129,123,323 - 129,137,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,123,336 - 129,137,464 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5131,733,814 - 131,747,957 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,488,694 - 133,502,837 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,510,852 - 133,524,991 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,492,734 - 134,507,158 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,492,756 - 134,507,154 (+)Ensemblrn6Rnor6.0
Rnor_5.05138,283,577 - 138,297,981 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45135,901,653 - 135,915,754 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5127,661,027 - 127,675,153 (+)NCBICelera
RGSC_v3.15135,906,849 - 135,920,979 (+)NCBI
Cytogenetic Map5q35NCBI
CYP4A22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38147,137,441 - 47,149,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl147,137,419 - 47,149,742 (+)Ensemblhg38GRCh38
GRCh37147,603,113 - 47,615,399 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,375,694 - 47,387,113 (+)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map1p33NCBI
HuRef145,718,762 - 45,730,181 (+)NCBIHuRef
CHM1_1147,719,841 - 47,731,260 (+)NCBICHM1_1
T2T-CHM13v2.0147,014,885 - 47,027,171 (+)NCBIT2T-CHM13v2.0
Cyp4a12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,268,821 - 115,296,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,268,821 - 115,296,231 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384115,411,624 - 115,439,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,411,624 - 115,439,034 (+)Ensemblmm10GRCm38
MGSCv374115,084,229 - 115,111,639 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364114,909,556 - 114,936,966 (+)NCBIMGSCv36mm8
Celera4114,149,964 - 114,177,583 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map452.99NCBI
CYP4A22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,656,319 - 179,668,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,798,121 - 178,810,407 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,442,854 - 46,455,153 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,958,331 - 47,970,288 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,958,368 - 47,970,230 (+)EnsemblpanPan2panpan1.1
CYP4A37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,604,130 - 13,623,797 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01513,754,121 - 13,773,797 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,754,121 - 13,807,927 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,555,766 - 13,575,343 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,623,843 - 13,643,440 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,693,343 - 13,712,941 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CYP4A90
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16128,704,964 - 128,722,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26119,141,289 - 119,159,198 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Cyp4a1
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:240
Count of miRNA genes:108
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000012888, ENSRNOT00000051385, ENSRNOT00000057095
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Mgh27  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85134,369,218 - 134,369,446 (+)Marker Load Pipeline
mRatBN7.25129,132,447 - 129,132,675 (+)MAPPERmRatBN7.2
Rnor_6.05134,502,140 - 134,502,367NCBIRnor6.0
Rnor_5.05138,292,963 - 138,293,190UniSTSRnor5.0
RGSC_v3.45135,910,739 - 135,910,966UniSTSRGSC3.4
RGSC_v3.45135,910,738 - 135,910,966RGDRGSC3.4
Celera5127,670,139 - 127,670,366UniSTS
RGSC_v3.15135,915,964 - 135,916,192RGD
RH 3.4 Map5839.41RGD
RH 3.4 Map5839.41UniSTS
RH 2.0 Map5820.9RGD
Cytogenetic Map5q36UniSTS
D5Rjr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85134,369,199 - 134,369,373 (+)Marker Load Pipeline
mRatBN7.25129,132,428 - 129,132,602 (+)MAPPERmRatBN7.2
Rnor_6.05134,502,121 - 134,502,294NCBIRnor6.0
Rnor_5.05138,292,944 - 138,293,117UniSTSRnor5.0
RGSC_v3.45135,910,720 - 135,910,893UniSTSRGSC3.4
RGSC_v3.45135,900,621 - 135,916,908RGDRGSC3.4
Celera5127,670,120 - 127,670,293UniSTS
RGSC_v3.15135,915,945 - 135,916,119RGD
RH 3.4 Map5837.2RGD
RH 3.4 Map5837.2UniSTS
Cytogenetic Map5q36UniSTS
RH129146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,137,262 - 129,137,462 (+)MAPPERmRatBN7.2
Rnor_6.05134,506,953 - 134,507,152NCBIRnor6.0
Rnor_5.05138,297,776 - 138,297,975UniSTSRnor5.0
RGSC_v3.45135,915,552 - 135,915,751UniSTSRGSC3.4
Celera5127,674,952 - 127,675,151UniSTS
RH 3.4 Map5836.0UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 8 21 40 74 74 48 20 48 6 205 66 4 16 74 34 26 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000012888   ⟹   ENSRNOP00000012888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,360,111 - 134,374,231 (+)Ensembl
mRatBN7.2 Ensembl5129,123,336 - 129,137,464 (+)Ensembl
Rnor_6.0 Ensembl5134,492,756 - 134,507,154 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051385   ⟹   ENSRNOP00000041025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5134,492,858 - 134,506,234 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057095   ⟹   ENSRNOP00000053925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5134,492,795 - 134,503,169 (+)Ensembl
RefSeq Acc Id: NM_175837   ⟹   NP_787031
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,360,107 - 134,374,233 (+)NCBI
mRatBN7.25129,123,336 - 129,137,464 (+)NCBI
Rnor_6.05134,492,756 - 134,507,154 (+)NCBI
Rnor_5.05138,283,577 - 138,297,981 (+)NCBI
RGSC_v3.45135,901,624 - 135,915,753 (+)RGD
Celera5127,661,027 - 127,675,153 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238712   ⟹   XP_006238774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,360,096 - 134,373,962 (+)NCBI
mRatBN7.25129,123,323 - 129,137,463 (+)NCBI
Rnor_6.05134,492,740 - 134,507,158 (+)NCBI
Rnor_5.05138,283,577 - 138,297,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063288320   ⟹   XP_063144390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,360,096 - 134,370,248 (+)NCBI
RefSeq Acc Id: NP_787031   ⟸   NM_175837
- UniProtKB: Q5EBD8 (UniProtKB/Swiss-Prot),   P08516 (UniProtKB/Swiss-Prot),   A6JZ42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238774   ⟸   XM_006238712
- Peptide Label: isoform X1
- UniProtKB: Q5EBD8 (UniProtKB/Swiss-Prot),   P08516 (UniProtKB/Swiss-Prot),   A6JZ42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053925   ⟸   ENSRNOT00000057095
Ensembl Acc Id: ENSRNOP00000041025   ⟸   ENSRNOT00000051385
Ensembl Acc Id: ENSRNOP00000012888   ⟸   ENSRNOT00000012888
RefSeq Acc Id: XP_063144390   ⟸   XM_063288320
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08516-F1-model_v2 AlphaFold P08516 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693921
Promoter ID:EPDNEW_R4446
Type:multiple initiation site
Name:Cyp4a1_1
Description:cytochrome P450, family 4, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05134,492,760 - 134,492,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68945 AgrOrtholog
BioCyc Gene G2FUF-40282 BioCyc
Ensembl Genes ENSRNOG00000009597 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012888 ENTREZGENE
  ENSRNOT00000012888.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7324500 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_Monoox UniProtKB/Swiss-Prot
KEGG Report rno:50549 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108515 IMAGE-MGC_LOAD
NCBI Gene Cyp4a1 ENTREZGENE
PANTHER CYTOCHROME P450 4A10-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp4a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009597 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A6JZ42 ENTREZGENE, UniProtKB/TrEMBL
  CP4AA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBD8 ENTREZGENE
UniProt Secondary Q5EBD8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp4a1  cytochrome P450, family 4, subfamily a, polypeptide 1  Cyp4a22  cytochrome P450, family 4, subfamily A, polypeptide 22  Name updated 1299863 APPROVED
2004-09-10 Cyp4a22  cytochrome P450, family 4, subfamily A, polypeptide 22  Cyp4a1  cytochrome P450, IVA1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cyp4a1  cytochrome P450,4A1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function has the highest catalytic efficiency (Vmax/Km) among the cytochrome P-450 (CYP) 4A isoforms 628319
gene_function catalyzes the hydroxylation of omega-terminal -carbon of the arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) 628319