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Gene: Cubn (cubilin) Rattus norvegicus

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Symbol:

Cubn

Name:

cubilin

RGD ID:

68355

Description:

Enables cargo receptor activity; hemoglobin binding activity; and identical protein binding activity. Involved in several processes, including cobalamin catabolic process; cobalamin transport; and endocytic hemoglobin import into cell. Located in several cellular components, including brush border membrane; cytoplasmic vesicle; and lysosomal lumen. Part of receptor complex. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

460 kDa receptor; cubilin (intrinsic factor-cobalamin receptor); glycoprotein 280; GP280; IFCR; intrinsic factor-cobalamin receptor; intrinsic factor-vitamin B12 receptor; MGA1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CUBN (cubilin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cubn (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cubn (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CUBN (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CUBN (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cubn (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CUBN (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CUBN (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cubn (cubilin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CUBN (cubilin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cubn (cubilin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cubn (cubilin (intrinsic factor-cobalamin receptor))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG42255	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Cubn	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC116.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cubn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Cubn^em1Mcwi

Genetic Models:

SS-Cubn^em1Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	81,293,619 - 81,501,694 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	81,293,619 - 81,501,694 (-)	Ensembl				GRCr8
mRatBN7.2	17	76,385,046 - 76,593,133 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	76,385,060 - 76,593,231 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	79,857,681 - 80,065,673 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	83,693,064 - 83,901,073 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	77,740,972 - 77,948,974 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	80,584,921 - 80,807,181 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	80,584,878 - 80,807,243 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	82,205,509 - 82,425,565 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	87,545,893 - 87,772,079 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	75,753,959 - 75,962,017 (-)	NCBI		Celera
RGSC_v3.1	17	87,556,725 - 87,782,912 (-)	NCBI
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amphetamine abuse (ISO)

autism spectrum disorder (ISO)

Chronic Benign Proteinuria (ISO)

chronic kidney disease (ISO)

coronary artery disease (ISO)

Diabetic Nephropathies (IEP)

focal segmental glomerulosclerosis (ISO)

focal segmental glomerulosclerosis 1 (ISO)

genetic disease (ISO)

Imerslund-Grasbeck Syndrome (ISO)

Imerslund-Grasbeck Syndrome 1 (ISO)

megaloblastic anemia (ISO)

melanoma (ISO)

pre-eclampsia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (EXP,ISO)

bicalutamide (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (ISO)

Cuprizon (EXP)

dextran sulfate (ISO)

entinostat (ISO)

ethanol (EXP)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

GW 4064 (ISO)

losartan (EXP)

mercaptopurine (EXP)

methamphetamine (ISO)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

N-Nitrosopyrrolidine (ISO)

ochratoxin A (ISO)

paracetamol (EXP)

perfluorooctanoic acid (EXP)

permethrin (EXP)

pirinixic acid (ISO)

purine-6-thiol (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

streptozocin (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol metabolic process (IEA)

cobalamin catabolic process (IMP)

cobalamin metabolic process (IEA,ISO)

cobalamin transport (IEA,IMP,ISO)

endocytic hemoglobin import into cell (IMP)

in utero embryonic development (IDA)

lipid metabolic process (IEA)

lipoprotein transport (ISO)

protein transport (IEA)

receptor-mediated endocytosis (IDA,IEA,IMP,ISO)

response to bacterium (ISO)

response to nutrient (IMP)

steroid metabolic process (IEA)

Cellular Component

apical part of cell (IEA,ISO)

apical plasma membrane (IDA,IEA,ISO)

brush border (IEA,ISO)

brush border membrane (IDA)

cell projection membrane (IEA)

clathrin-coated pit (IDA,IEA,ISO)

coated vesicle (IDA)

cytoplasm (IEA,ISO)

endocytic vesicle (IEA,ISO)

endocytic vesicle membrane (IDA)

endoplasmic reticulum (IEA,ISO)

endosome (IEA,ISO)

endosome membrane (IEA)

extracellular exosome (IEA,ISO)

Golgi apparatus (IEA,ISO)

Golgi-associated vesicle (IDA)

lysosomal lumen (IDA)

lysosomal membrane (IEA)

membrane (IEA,ISO)

microvillus membrane (IEA,ISO)

plasma membrane (IBA,IEA)

protein-containing complex (IDA)

receptor complex (IDA)

Molecular Function

calcium ion binding (IEA)

cargo receptor activity (IEA,IMP,ISO)

cobalamin binding (IEA)

hemoglobin binding (IDA)

identical protein binding (IPI)

metal ion binding (IEA)

protein binding (IPI,ISO)

protein homodimerization activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability.	Ahuja R, etal., Biochem J. 2008 Mar 1;410(2):301-8.
2.	Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.	Aminoff M, etal., Nat Genet 1999 Mar;21(3):309-13.
3.	Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.	Andersen CB, etal., Nature. 2010 Mar 18;464(7287):445-8. doi: 10.1038/nature08874.
4.	Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo.	Assemat E, etal., Biol Reprod. 2005 May;72(5):1079-86. Epub 2004 Dec 22.
5.	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition	Feng M, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Sep;37(5):738-41.
6.	The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.	Fyfe JC, etal., Blood. 2004 Mar 1;103(5):1573-9. Epub 2003 Oct 23.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.	Gburek J, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F451-8. Epub 2003 Apr 29.
9.	Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin.	Gburek J, etal., J Am Soc Nephrol. 2002 Feb;13(2):423-30.
10.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
11.	Immunocytochemical analysis of cubilin-mediated endocytosis of high density lipoproteins (HDL) in epithelial cells of the rat visceral yolk sac.	Ishida T, etal., Cell Tissue Res. 2004 Dec;318(3):533-43. Epub 2004 Oct 2.
12.	Vitamin-D dysregulation in early- and late-onset preeclampsia: A gestational-age matched study.	Martin CB, etal., J Steroid Biochem Mol Biol. 2020 Oct;203:105729. doi: 10.1016/j.jsbmb.2020.105729. Epub 2020 Jul 15.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.	Moestrup SK, etal., J Biol Chem 1998 Feb 27;273(9):5235-42.
15.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
16.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
17.	A study of associations between CUBN, HNF1A, and LIPC gene polymorphisms and coronary artery disease.	Park HS, etal., Sci Rep. 2020 Oct 1;10(1):16294. doi: 10.1038/s41598-020-73048-6.
18.	GOA pipeline	RGD automated data pipeline
19.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
21.	Cubilin and megalin co-localize in the neonatal inner ear.	Tauris J, etal., Audiol Neurootol. 2009;14(4):267-78. doi: 10.1159/000199446. Epub 2009 Feb 6.
22.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23.	Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy.	Yammani RR, etal., Am J Physiol Endocrinol Metab 2001 Nov;281(5):E900-7.
24.	Identification and characterization of two distinct ligand binding regions of cubilin.	Yammani RR, etal., J Biol Chem 2001 Nov 30;276(48):44777-84.

Additional References at PubMed

PMID:6321516	PMID:9153271	PMID:9691015	PMID:10400683	PMID:10552972	PMID:10766831	PMID:10811843	PMID:11856751	PMID:12815097	PMID:15286052	PMID:15342463	PMID:15976000
PMID:16027047	PMID:17442257	PMID:17453355	PMID:19056867	PMID:21082674	PMID:22337902	PMID:23012479	PMID:23376485	PMID:23533145	PMID:24122887	PMID:26025362	PMID:26173747
PMID:33510115

Genomics

Comparative Map Data

Cubn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	81,293,619 - 81,501,694 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	81,293,619 - 81,501,694 (-)	Ensembl				GRCr8
mRatBN7.2	17	76,385,046 - 76,593,133 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	76,385,060 - 76,593,231 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	79,857,681 - 80,065,673 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	83,693,064 - 83,901,073 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	77,740,972 - 77,948,974 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	80,584,921 - 80,807,181 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	80,584,878 - 80,807,243 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	82,205,509 - 82,425,565 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	87,545,893 - 87,772,079 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	75,753,959 - 75,962,017 (-)	NCBI		Celera
RGSC_v3.1	17	87,556,725 - 87,782,912 (-)	NCBI
Cytogenetic Map	17	q12.3	NCBI

CUBN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	16,823,966 - 17,129,811 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	16,823,966 - 17,129,811 (-)	Ensembl			hg38	GRCh38
GRCh37	10	16,865,965 - 17,171,810 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	16,905,971 - 17,211,822 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	16,906,543 - 17,211,796	NCBI
Celera	10	16,799,178 - 17,105,066 (-)	NCBI		Celera
Cytogenetic Map	10	p13	NCBI
HuRef	10	16,779,758 - 17,084,998 (-)	NCBI		HuRef
CHM1_1	10	16,866,152 - 17,171,970 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	16,842,423 - 17,148,343 (-)	NCBI		T2T-CHM13v2.0

Cubn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	13,281,149 - 13,496,687 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	13,281,149 - 13,496,624 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	13,276,338 - 13,491,876 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	13,276,338 - 13,491,813 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	13,197,965 - 13,413,503 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	13,194,189 - 13,409,729 (-)	NCBI		MGSCv36	mm8
Celera	2	13,186,219 - 13,402,130 (-)	NCBI		Celera
Cytogenetic Map	2	A1	NCBI
cM Map	2	9.86	NCBI

Cubn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	10,788,959 - 11,038,845 (+)	Ensembl
ChiLan1.0	NW_004955429	10,789,674 - 11,038,297 (+)	NCBI	ChiLan1.0	ChiLan1.0

CUBN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	29,666,975 - 29,981,918 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	29,672,298 - 29,977,993 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	17,141,464 - 17,446,867 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	17,415,551 - 17,719,126 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	17,415,551 - 17,719,129 (-)	Ensembl			panPan2	panpan1.1

CUBN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	19,784,125 - 20,041,840 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	19,784,198 - 20,041,839 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	16,887,230 - 17,151,382 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	20,075,720 - 20,333,544 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	20,075,720 - 20,333,543 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	17,278,052 - 17,541,754 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	18,116,485 - 18,374,283 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	18,734,135 - 18,999,935 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cubn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	17,550,256 - 17,808,034 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936520	10,140,784 - 10,409,851 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936520	10,140,784 - 10,410,082 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CUBN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	43,102,946 - 43,414,758 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	43,102,931 - 43,414,692 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	47,746,354 - 48,023,009 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CUBN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	16,774,644 - 17,079,776 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	16,774,757 - 17,079,681 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666051	22,409,233 - 22,718,741 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cubn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624796	10,728,983 - 10,988,361 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624796	10,728,853 - 10,987,292 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Cubn
1091 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	826
Count of miRNA genes:	293
Interacting mature miRNAs:	376
Transcripts:	ENSRNOT00000040052
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	70613502	86062352	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63697147	82818564	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	64569820	86954580	Rat

Markers in Region

RH128210

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	76,385,189 - 76,385,376 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	80,585,051 - 80,585,237	NCBI	Rnor6.0
Rnor_5.0	17	82,205,639 - 82,205,825	UniSTS	Rnor5.0
RGSC_v3.4	17	87,546,023 - 87,546,209	UniSTS	RGSC3.4
Celera	17	75,754,089 - 75,754,275	UniSTS
RH 3.4 Map	17	774.0	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

BM387042

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	17	81,491,580 - 81,492,390 (+)	Marker Load Pipeline
mRatBN7.2	17	76,583,018 - 76,583,828 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	80,797,136 - 80,797,945	NCBI	Rnor6.0
Rnor_5.0	17	82,415,520 - 82,416,329	UniSTS	Rnor5.0
RGSC_v3.4	17	87,762,034 - 87,762,843	UniSTS	RGSC3.4
Celera	17	75,951,986 - 75,952,795	UniSTS
RH 3.4 Map	17	807.2	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

RH124704

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	76,385,143 - 76,385,523 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	80,585,005 - 80,585,384	NCBI	Rnor6.0
Rnor_5.0	17	82,205,593 - 82,205,972	UniSTS	Rnor5.0
RGSC_v3.4	17	87,545,977 - 87,546,356	UniSTS	RGSC3.4
Celera	17	75,754,043 - 75,754,422	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Genetic Models

This gene Cubn is modified in the following models/strains:

SS-Cubn^em1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	11	66	151	78	77	46	50	46	6	290	148	10	130	81	92	31	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF022247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040052 ⟹ ENSRNOP00000048477

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	81,293,619 - 81,501,694 (-)	Ensembl
mRatBN7.2 Ensembl	17	76,385,060 - 76,593,231 (-)	Ensembl
Rnor_6.0 Ensembl	17	80,585,303 - 80,807,181 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090064 ⟹ ENSRNOP00000075097

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	81,293,619 - 81,501,694 (-)	Ensembl
mRatBN7.2 Ensembl	17	76,385,060 - 76,593,231 (-)	Ensembl
Rnor_6.0 Ensembl	17	80,584,878 - 80,807,243 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000149856 ⟹ ENSRNOP00000106447

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	81,293,619 - 81,501,694 (-)	Ensembl

RefSeq Acc Id:

NM_053332 ⟹ NP_445784

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	81,293,619 - 81,501,694 (-)	NCBI
mRatBN7.2	17	76,385,046 - 76,593,133 (-)	NCBI
Rnor_6.0	17	80,584,921 - 80,807,181 (-)	NCBI
Rnor_5.0	17	82,205,509 - 82,425,565 (-)	NCBI
RGSC_v3.4	17	87,545,893 - 87,772,079 (-)	RGD
Celera	17	75,753,959 - 75,962,017 (-)	RGD

Sequence:

show sequence

ATGTCCTCGCAGTTTCTCTGGGGTTTTGTTACTTTGTTGATGATAGCTGAATTAGATGGCAAAA
CTGGAAAGCCGGAGCAGAGGGGACAGAAAAGGATCGCTGACCTGCACCAGCCTCGGATGACTAC
GGAGGAGGGAAACTTAGTATTTCTTACAAGCTCTACCCAAAACATTGAATTTAGAACTGGATCC
CTGGGGAAAATCAAATTAAATGATGAAGACCTTGGCGAATGTTTACACCAGATCCAGAGAAACA
AAGATGATATTATAGATTTAAGAAAGAATACAACTGGCCTCCCTCAAAATATACTTAGTCAAGT
CCACCAACTTAACTCGAAGCTCGTGGATCTGGAGAGAGATTTTCAAAACTTACAGCAGAATGTG
GAGAGAAAAGTTTGCAGTAGCAATCCCTGCCTTAATGGTGGCACCTGCGTCAACCTGCACGACT
CCTTTGTGTGTATCTGCCCTTCTCAGTGGAAGGGTCTCTTCTGCTCAGAGGATGTCAACGAGTG
TGTAGTTTACTCAGGAACACCCTTTGGCTGCCAGAGTGGATCCACCTGTGTGAACACAGTGGGG
AGTTTCAGATGTGACTGCACGCCGGATACGTACGGACCTCAGTGTGCATCCAAATATAATGACT
GTGAACAGGGCTCTAAACAGCTCTGCAAGCACGGCATCTGTGAGGATTTACAGCGAGTTCACCA
TGGACAGCCGAATTTTCACTGCATCTGTGATGCTGGGTGGACAACACCGCCAAATGGAATCTCC
TGCACAGAGGACAAAGACGAATGCAGCCTCCAGCCTTCACCTTGTTCGGAGCATGCGCAGTGTT
TCAATACACAAGGCTCCTTCTACTGTGGGGCCTGCCCCAAAGGTTGGCAGGGAAATGGTTATGA
ATGCCAGGATATCAATGAATGCGAGATCAACAATGGAGGCTGTTCCCAGGCGCCACTGGTCCCA
TGCCTGAACACACCTGGATCATTCTCCTGTGGGAACTGTCCAGCAGGTTTCAGTGGTGACGGGA
GAGTGTGCACTCCCGTGGACATCTGTTCGATCCACAATGGAGGCTGCCATCCAGAGGCAACCTG
CTCCTCATCTCCTGTTCTAGGGTCCTTCTTGCCTGTCTGCACCTGTCCTCCGGGATATACAGGA
AATGGTTACGGGTCTAATGGATGTGTACGCCTCAGTAATATTTGCTCAAGGCACCCGTGTGTAA
ATGGACAGTGCATAGAAACAGTATCAAGTTATTTCTGTAAGTGTGACTCAGGCTGGTCTGGACA
GAACTGTACAGAAAACATTAATGACTGTTCGAGCAACCCCTGTTTGAATGGGGGCACCTGTATT
GATGGCATCAATGGCTTCACCTGCGACTGCACAAGCTCTTGGACTGGCTATTACTGTCAGACTC
CCCAGGCAGCTTGCGGAGGGATCCTCTCAGGGACACAAGGAACCTTTGCCTACCACAGCCCAAA
TGATACCTATATTCACAATGTGAACTGTTTCTGGATTGTCAGAACTGATGAGGAAAAGGTTCTG
CATGTCACCTTCACGTTTTTTGATTTAGAATCAGCAAGCAATTGTCCCCGGGAGTACCTTCAGA
TTCATGATGGAGACTCCTCAGCGGATTTCCCACTTGGTAGATACTGTGGCTCCAGGCCCCCCCA
GGGGATCCACAGCAGTGCCAATGCTCTCTATTTCCATCTCTACTCCGAGTACATAAGGAGTGGG
AGAGGCTTTACAGCAAGGTGGGAGGCGAAGCTGCCAGAGTGTGGCGGCATCCTGACTGATAATT
ACGGTTCTATTACGTCTCCGGGGTACCCTGGAAACTACCCCCCAGGAAGAGATTGTGTCTGGCA
GGTTTTAGTCAATCCTAACTCCTTGATAACATTTACCTTTGGAACCTTGAGCCTGGAGAGCCAC
AATGACTGCAGCAAAGACTATTTGGAGATTCGAGACGGTCCTTTCCACCAAGACCCTGTTCTTG
GGAAATTCTGCACTTCCTTGTCTACCCCACCCCTCAAGACTACCGGTCCTGCAGCAAGAATTCA
TTTCCATTCTGACTCTGAGACCAGTGACAAAGGCTTCCACATCACCTATCTAACCACACAGTCG
GATCTGGACTGTGGTGGGAACTACACAGACACGGATGGCGAGCTCCTCCTTCCTCCTTTGTCTG
GTCCTTTCAGTCACAGCAGACAGTGTGTCTATCTCATCACCCAAGCCCAGGGAGAACAAATAGT
TATCAACTTCACCCATGTGGAGCTGGAGAGCCAGATGGGCTGTTCTCACACTTACATCGAGGTT
GGAGACCATGACAGCTTACTTCGAAAGATCTGTGGCAATGAAACCTTGTTCCCCATTAGATCAG
TTTCTAATAAAGTCTGGATCAGATTGAGAATAGACGCTTTAGTCCAGAAGGCTAGTTTCAGAGC
TGACTACCAAGTTGCTTGTGGGGGTATGTTAAGAGGAGAAGGATTCTTTCGCTCACCTTTCTAT
CCTAACGCATATCCTGGACGAAGAACCTGTAGGTGGACCATCTCCCAACCCCAAAGACAAGTTG
TCCTTCTTAACTTCACTGACTTTCAGATCGGAAGTTCTGCCTCCTGTGATACAGATTATATTGA
GATTGGTCCCAGCTCTGTCTTGGGATCTCCTGGAAATGAGAAGTTTTGTAGCTCAAACATACCG
TCATTTATAACATCTGTATACAATATTCTTTATGTTACATTTGTGAAAAGTTCTTCCATGGAAA
ATCGTGGCTTCACGGCTAAGTTCAGCAGTGACAAACTAGAGTGTGGAGAAGTTCTCACGGCATC
TACAGGAATTATCGAAAGTCCAGGTCATCCAAACGTCTACCCAAGAGGTGTAAATTGTACTTGG
CATGTAGTAGTCCAACGCGGCCAACTGATCCGTTTGGAGTTCAGTTCCTTTTACCTGGAGTTTC
ATTACAACTGCACAAACGACTACCTGGAAATTTATGACACTGCCGCTCAGACTTTTCTTGGGAG
ATACTGTGGAAAATCCATCCCGCCTTCTCTTACCAGCAACTCTAATTCAATAAAGCTGATATTT
GTGTCTGACTCCGCCCTTGCCCACGAAGGCTTTTCCATAAATTATGAGGCAATCGATGCATCAT
CAGTATGTTTATATGACTATACAGATAATTTTGGGATGCTCTCCTCCCCGAACTTCCCCAATAA
TTACCCCAGTAACTGGGAGTGCATCTACAGAATCACTGTGGGACTCAACCAACAGATTGCATTG
CATTTCACAGACTTCACCTTGGAGGACTATTTTGGGTCACAGTGTGTAGATTTTGTAGAAATCA
GAGACGGAGGCTACGAAACGTCGCCGCTTGTTGGGATTTACTGTGGCTCAGTTTTGCCTCCTAC
AATCATCTCCCACAGTAACAAGCTCTGGCTAAAGTTTAAGAGTGACGCCGCACTCACGGCAAAG
GGGTTCTCAGCGTACTGGGACGGATCATCAACAGGCTGTGGAGGTAATCTCACCACCCCCACAG
GGGTGCTCACATCGCCCAACTACCCGATGCCCTACTACCACAGCTCCGAATGCTACTGGCGGCT
GGAAGCCAGTCATGGCAGCCCTTTCGAGCTGGAATTCCAAGACTTCCACCTGGAACACCACCCC
AGCTGCTCTCTGGATTACTTGGCCGTGTTTGATGGCCCGACTACCAACTCCCGACTGATAGATA
AACTGTGTGGGGATACGACACCTGCTCCCATCCGTTCCAATAAAGACGTCGTATTGTTAAAACT
GAGGACTGATGCAGGTCAGCAAGGCCGTGGCTTTGAGATCAACTTCCGGCAGAGATGTGACAAT
GTGGTGATAGTGAACAAAACCTCTGGCATCCTGGAGAGCATAAATTATCCAAATCCCTATGATA
AGAACCAACGTTGTAACTGGACCATCCAAGCAACCACCGGCAACACCGTGAACTACACGTTTCT
GGGATTTGATGTGGAAAGTTACATGAACTGCTCCACAGATTATGTAGAGCTCTATGATGGACCA
CAATGGATGGGACGCTACTGTGGAAATAACATGCCCCCACCAGGGGCTACAACAGGCTCCCAAC
TCCACGTACTGTTCCATACAGATGGGATCAATTCTGGGGAAAAAGGATTTAAGATGCAGTGGTT
CACTCATGGCTGTGGTGGAGAGATGTCTGGAACCGCAGGCTCCTTCAGCAGCCCTGGGTACCCC
AACAGCTATCCTCACAACAAAGAGTGTATCTGGAACATTCGCGTGGCCCCAGGGAGTAGCATTC
AGCTCACCATCCATGACTTTGATGTGGAATATCATACAAGCTGCAACTATGACTCCCTGGAGAT
CTATGCAGGTCTTGATTTTAACTCTCCAAGAATAGCCCAACTGTGTTCCCAATCACCGTCAGCG
AACCCCATGCAGGTCTCCAGCACTGGCAATGAACTAGCAATCCGATTTAAGACGGATAGCACTT
TAAATGGAAGAGGTTTCAATGCCTCGTGGCGAGCAGTCCCTGGAGGTTGTGGTGGAATTATCCA
GCTTTCCAGAGGAGAGATTCATTCTCCAAATTACCCCAACAACTACAGAGCTAACACAGAGTGC
TCCTGGATCATTCAAGTTGAGCGACATCACCGTGTTCTCTTGAATATCACTGACTTTGACCTTG
AAGCTCCAGATTCTTGCTTACGACTTATGGATGGCTCAAGTTCCACAAACGCCCGTGTCGCCAG
TGTGTGTGGAAGACAGCAGCCCCCTAACTCTATCATCGCTTCAGGAAACAGCCTCTTTGTGAGA
TTCCGGTCTGGATCTTCCAGCCAGAACAGGGGCTTCCGGGCTGAATTCAGGGAAGAGTGCGGAG
GCCGCATCATGACCGACTCTTCCGATACTATCTTCTCTCCACTGTACCCTCACAACTATCTACA
CAACCAGAACTGTTCCTGGATAATTGAAGCTCAGCCTCCATTCAATCACATTACTCTCTCCTTT
ACTCACTTTCAACTTCAAAACAGCACAGACTGTACACGGGACTTTGTAGAAATTTTGGATGGCA
ACGACTATGACGCACCTGTCCAAGGCCGTTACTGTGGTTTCTCCCTGCCCCACCCCATCATATC
ATTTGGCAATGCCCTAACCGTGAGGTTTGTCACTGATTCCACACGCAGTTTTGAGGGTTTCCGT
GCCATCTATTCTGCATCGACATCATCTTGTGGTGGAAGCTTCTACACACTTGATGGCATCTTCA
ATAGCCCCGACTACCCAGCAGACTACCATCCAAATGCAGAATGTGTCTGGAACATTGCCAGCTC
CCCTGGCAACCGCCTGCAACTGTCCTTCCTATCCTTCAATTTGGAGAATTCTCTAAACTGTAAC
AAGGATTTTGTGGAAATCCGAGAAGGAAATGCCACGGGCCACTTGATTGGACGATACTGTGGAA
ACTCCCTCCCTGGGAATTATTCGTCAGCTGAGGGACATAGTCTATGGGTCCGATTTGTCTCTGA
TGGCTCAGGCACTGGCATGGGCTTCCAGGCCAGGTTCAAAAATATATTTGGCAATAATAATATT
GTGGGAACTCATGGGAAAATCGCATCTCCCTTCTGGCCTGGAAAATACCCCTACAACTCCAATT
ACAAATGGGTGGTAAATGTGGACGCATATCATATTATCCACGGTAGAATCTTAGAGATGGACAT
AGAACCCACAACGAACTGCTTTTATGACAGTTTAAAGATTTATGATGGATTTGACACTCATTCC
CGTCTCATTGGCACTTACTGTGGTACCCAGACAGAATCCTTTAGCTCCAGTAGAAACTCTCTGA
CATTCCAGTTTTCTTCCGACTCTTCTGTGTCAGGAAGGGGATTCCTTCTGGAGTGGTTTGCAGT
AGATGTTTCTGATAGCACCCCTCCCACCATCGCTCCAGGAGCTTGTGGAGGGTTTATGGTGACG
GGAGACACTCCTGTCCATATTTTCTCCCCGGGTTGGCCTAGAGAGTATGCTAATGGTGCTGACT
GTATCTGGATCATCTATGCTCCTGACTCTACTGTGGAACTCAACATTCTCTCCTTGGACATCGA
ACCGCAGCAGTCATGCAATTATGACAAGCTGATCGTAAAAGACGGAGACAGTGACTTATCCCCA
GAGCTGGCTGTTCTGTGTGGCGTAAGCCCTCCTGGGCCCATCCGGTCAACTGGAGAATACATGT
ACATCCGCTTCACTTCAGACACCAGCGTCGCGGGGACAGGCTTCAACGCCTCCTTTCACAAGAG
CTGTGGTGGATATTTGCATGCAGATCGAGGAGTTATCACATCCCCCAAGTATCCAGACACCTAC
CTTCCCAACCTCAACTGCTCCTGGCATGTTCTGGTCCAGACTGGTCTGACCATCGCCGTCCATT
TTGAGCAGCCTTTCCAGATTCAAAACAGAGACTCTTTTTGCAGTCAGGGGGATTACTTGGTGCT
AAGAAACGGACCAGATAACCATTCTCCACCACTGGGACCTTCTGGAAGAAATGGTCGTTTCTGC
GGAATGTACGCACCGTCCACTCTGTTCACCTCAGGCAATGAAATGTTTGTTCAGTTCATCTCGG
ACAGTAGTAATGGTGGACAAGGGTTTAAGATCAGATATGAGGCAAAGAGTTTAGCCTGCGGGGG
CACTGTCTACATCCATGATGCTGACTCTGACGGATACCTGACCTCCCCCAACTACCCTGCTAAT
TATCCCCAACATGCCGAATGCATTTGGATCTTAGAGGCGCCTCCAGGGAGAAGCATACAGCTCC
AATTTGAAGATCAATTCAATATTGAAGACACACCCAACTGTTCTGTGAGCTATCTTGAATTGCG
TGACGGAGCCAACTCGAATGCACGTCTGGTTTCCAAGTTGTGTGGCCACACTCTGCCTCATAGC
TGGGTATCCTCGAGAGAACGAATATACTTGAAGTTTCACACTGACGGTGGTTCCAGCTACATGG
GATTCAAGGCCAAGTACTCTATAGCTTCCTGTGGAGGAACAGTCTCAGGGGACAGTGGAGTCAT
CGAGAGCATTGGCTACCCGACCCTTCCGTATGCAAACAATGTGTTTTGTCAGTGGTTTATCCGA
GGCCTCCCAGGACACTACCTCACTCTCAGTTTTGAAGATTTTAACCTTCAGAGCTCTCCTGGTT
GTACAAAAGACTTTGTGGAGATCTGGGAAAACCATACCTCTGGAAGAGTTCTGGGGAGATATTG
TGGAAACTCCACTCCTAGCAGTGTTGACACTTCCAGCAATGTTGCTTCCGTCAAGTTTGTCACA
GATGGCTCTGTCACTGCCTCAGGATTTAGGCTGCAGTTTAAGTCCAGCAGACAAGTGTGTGGTG
GGGATTTACATGGCCCTACTGGCACATTTACTTCTCCCAACTACCCAAACCCAAATCCTCATGC
CCGGATCTGTGAGTGGACGATCACTGTACAAGAAGGAAGGCGGATCGTCCTGACGTTTACCAAC
TTGAGGCTGAGTACCCAGCCATCTTGTAACAGTGAGCACCTCATCGTATTCAATGGCATTAGAA
GCAACTCGCCCCTACTACAGAAACTGTGCAGCCGTGTGAATGTGACCAATGAATTCAAATCTTC
AGGAAACACCATGAAAGTGGTATTTTTCACTGATGGCTCCCGGCCGTATGGAGGCTTCACTGCT
TCCTACACCTCTACTGAAGATGCAGTGTGTGGTGGATTTCTTCCAAGTGTCTCCGGTGGAAACT
TTTCTTCTCCTGGCTATAATGGAATCCGTGATTATGCCAGAAACCTAGACTGTGAATGGACTCT
CAGTAATCCAAATCGGGAAAATTCATCCATAAGTATCTATTTTCTAGAACTTTCCATTGAAAGT
CATCAAGACTGTACATTTGATGTCCTTGAGTTTCGAGTAGGGGATGCTGATGGGCCCCTGATAG
AGAAGTTCTGTAGCCTGTCAGCACCAACAGCGCCCTTGGTCATCCCCTACCCTCAGGTGTGGAT
ACACTTCGTCAGCAATGAGCGTGTAGAATATACTGGATTCTATATAGAGTACTCCTTTACAGAT
TGTGGTGGAATACGGACAGGTGACAATGGAGTGATCTCAAGTCCTAACTATCCAAACTTGTACA
GTGCATGGACCCACTGTTCATGGCTGCTGAAAGCCCCAGAAGGGCACACCATCACTCTCACATT
CAGTGACTTTCTTCTCGAGGCTCATCCAACTTGCACTTCAGACTCCGTCACTGTCAGGAATGGT
GACTCCCCAGGATCGCCCGTCATAGGACGATACTGTGGACAGTCAGTCCCAAGGCCGATACAGT
CTGGTTCCAACCAACTTATAGTGACTTTTAACACAAACAATCAAGGGCAAACTCGTGGATTTTA
TGCAACATGGACCACAAACGCTTTAGGTTGTGGGGGAACATTCCACTCAGCTAATGGTACAATC
AAATCTCCTCACTGGCCTCAGACATTCCCAGAAAACAGCAGATGCTCCTGGACAGTGATCACTC
ACGAAAGTAAACACTGGGAGATTAGCTTTGACAGCAATTTCCGAATCCCCAGCAGTGACAGCCA
GTGTCAGAACAGCTTCGTGAAGGTTTGGGAAGGAAGGTTGATGATCAATAAGACCCTGTTAGCC
ACGAGCTGTGGAGATGTGGCTCCAAGTCCCATTGTCACATCAGGGAACATTTTCACTGCTGTCT
TCCAATCTGAGGAGATGGCAGCCCAGGGCTTCTCTGCATCCTTCATTAGCCGGTGCGGACGCAC
ATTCAATACCTCCCCTGGTGACATCATCTCTCCAAACTTCCCGAAGCAATACGACAACAACATG
AACTGCACCTACCTCATAGACGCTGACCCTCAGTCTCTGGTCATCCTGACTTTTGTGTCCTTTC
ATTTGGAAGATCGCTCAGCTATCACCGGAACCTGTGATCATGATGGCTTGCACATCATCAAAGG
TCGTAACCTCTCTTCCACTCCTCTCGTGACCATATGTGGTTCTGAAACTTTGCGTCCCCTCACT
GTGGACGGCCCAGTGTTGCTCAACTTCTATTCTGATGCATACACCACAGACTTTGGCTTCAAGA
TTTCCTACAGAGCCATCACCTGTGGTGGGATCTACAATGAATCCTCTGGAATCCTTAGGAGCCC
TTCCTACTCATACAGCAACTACCCCAACAACCTCTACTGTGTCTACAGCCTCCATGTTAGAAGC
AGCAGAGTGATAATAATTAGGTTCAATGATTTCGATGTGGCTCCTTCCAACCTTTGTGCACATG
ACTTCCTGGAGGTGTTTGATGGTCCCAGCATTGGAAATCGATCTCTTGGAAAGTTCTGTGGTTC
CACGCGTCCACAAACTGTTAAGAGCACCAATAGCAGCCTGACCCTGCTGTTCAAGACAGATTCT
TCTCAAACAGCAAGAGGTTGGAAAATATTTTTCCGGGAGACAATAGGGCCACAGCAGGGATGTG
GTGGATACCTGACCGAGGACAACCAGAGCTTTGTGTCTCCTGATTCTGATTCGAATGGACGCTA
TGACAAGGGTCTCAGCTGCATATGGTACATAGTTGCACCTGAAAACAAACTGGTTAAGCTCACC
TTCAATGTGTTCACTCTGGAGGGACCATCGTCAGCTGGGAGCTGCGTCTATGATTATGTGCAGA
TAGCAGATGGCGCAAGCATAAACTCATATTTAGGTGGAAAATTCTGTGGCTCCCGTATGCCTGC
CCCATTTATCTCTTCCGGCAACTTCCTTACGTTTCAGTTTGTCTCTGACGTAACTGTTGAAATG
AGGGGATTTAATGCAACATATACCTTTGTGGACATGCCTTGCGGGGGAACATATAACGCAACCT
CGACACCTCAAAATGCGTCATCACCTCATTTATCCAACATCGGACGGCCATACTCCACCTGTAC
TTGGGTCATCGCAGCTCCCCCACAGCAGCAGGTTCAGATAACTGTGTGGGACTTACAGCTGCCC
TCACAAGACTGCTCACAAAGCTACTTAGAACTTCAGGATTCAGTACAGACTGGTGGAAACCGGG
TGACTCAGTTCTGCGGTGCGAACTATACAACCTTGCCAGTGTTCTACTCCTCAATGAGCACTGC
GGTTGTCGTTTTCAAGTCTGGAGTTTTAAACAGAAACTCGCAAGTGCAATTCTCCTATCAGATT
GCAGATTGCAACAGAGAATACAACCAAACGTTTGGCAATCTGAAGAGTCCTGGGTGGCCTCAGA
ACTATGACAATAACCTGGACTGCACCATCATTCTCAGAGCCCCGCAGAACCACAGCATTTCCCT
CTTTTTCTATTGGTTTCAGCTGGAAGATTCAAGACAATGCATGAATGATTTCTTGGAGGTAAGA
AACGGCGGCAGCAGCACCTCACCACTGCTTGACAAGTACTGTAGCAACCTGCTGCCCAACCCGG
TCTTCTCTCAGAGCAACGAACTGTATCTGCACTTTCACAGCGACCACTCAGTCACCAACAATGG
CTATGAAATTATTTGGACCTCCTCTGCTGCTGGCTGTGGAGGGACTCTTTTGGGCGACGAAGGG
ATATTCACCAACCCTGGCTTTCCTGACAGTTACCCGAACAACACTCATTGTGAATGGACCATTG
TTGCTCCTTCTGGAAGGCCTGTCTCTGTCGGGTTTCCCTTTCTCAGTATCGACTCTTCTGGTGG
CTGTGACCAGAACTACCTCATAGTCTTTAATGGTCCAGACGCCAACTCCCCACCCTTTGGACCG
TTGTGTGGCATCAACACTGGGATAGCGCCCTTCTATGCTTCATCAAATCGGGTCTTTATAAGGT
TTCATGCTGAGTATACGACACGTCTTTCAGGGTTTGAAATAATGTGGAGCAGCTGAATCAGGAG
AGCTGTGTATAACCCCAGGACTCTGGTTCTGCCCAGTGCTGTCAGATGCAACCCTGCCCAGTAC
TCATTCTGCTGTTCTCATCCCCGTCTCTGCCTGCGTCATCAAACATGGACTGAGCTTCTACAGC
CTTGACCAGAGAAAGTGCACGACTGACTTCATACATTAGGCGTTCTGAAGGCTTTGATCTACTC
AGCTGTGCACACCATCTTTACTGGATGCCCTGTTTAGCCGACATCTTCTAAAATGTTCTTTAAA
GGGTGGAAGTTATCCTGGCACATTGATGTACGGTTTTAAAACTTGGTGATACAAATGGATGTAT
TGTTCCACTACAAAAGTCAAAGTGCAGGTAATAAACATTCTTCACATGTAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445784	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC71661	(Get FASTA)	NCBI Sequence Viewer
	EDL78717	(Get FASTA)	NCBI Sequence Viewer
	EDL78718	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075097
GenBank Protein	O70244	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_445784 ⟸ NM_053332
- Peptide Label:	precursor
- UniProtKB:	A0A0G2K9R4 (UniProtKB/TrEMBL), A6JM40 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSQFLWGFVTLLMIAELDGKTGKPEQRGQKRIADLHQPRMTTEEGNLVFLTSSTQNIEFRTGS LGKIKLNDEDLGECLHQIQRNKDDIIDLRKNTTGLPQNILSQVHQLNSKLVDLERDFQNLQQNV ERKVCSSNPCLNGGTCVNLHDSFVCICPSQWKGLFCSEDVNECVVYSGTPFGCQSGSTCVNTVG SFRCDCTPDTYGPQCASKYNDCEQGSKQLCKHGICEDLQRVHHGQPNFHCICDAGWTTPPNGIS CTEDKDECSLQPSPCSEHAQCFNTQGSFYCGACPKGWQGNGYECQDINECEINNGGCSQAPLVP CLNTPGSFSCGNCPAGFSGDGRVCTPVDICSIHNGGCHPEATCSSSPVLGSFLPVCTCPPGYTG NGYGSNGCVRLSNICSRHPCVNGQCIETVSSYFCKCDSGWSGQNCTENINDCSSNPCLNGGTCI DGINGFTCDCTSSWTGYYCQTPQAACGGILSGTQGTFAYHSPNDTYIHNVNCFWIVRTDEEKVL HVTFTFFDLESASNCPREYLQIHDGDSSADFPLGRYCGSRPPQGIHSSANALYFHLYSEYIRSG RGFTARWEAKLPECGGILTDNYGSITSPGYPGNYPPGRDCVWQVLVNPNSLITFTFGTLSLESH NDCSKDYLEIRDGPFHQDPVLGKFCTSLSTPPLKTTGPAARIHFHSDSETSDKGFHITYLTTQS DLDCGGNYTDTDGELLLPPLSGPFSHSRQCVYLITQAQGEQIVINFTHVELESQMGCSHTYIEV GDHDSLLRKICGNETLFPIRSVSNKVWIRLRIDALVQKASFRADYQVACGGMLRGEGFFRSPFY PNAYPGRRTCRWTISQPQRQVVLLNFTDFQIGSSASCDTDYIEIGPSSVLGSPGNEKFCSSNIP SFITSVYNILYVTFVKSSSMENRGFTAKFSSDKLECGEVLTASTGIIESPGHPNVYPRGVNCTW HVVVQRGQLIRLEFSSFYLEFHYNCTNDYLEIYDTAAQTFLGRYCGKSIPPSLTSNSNSIKLIF VSDSALAHEGFSINYEAIDASSVCLYDYTDNFGMLSSPNFPNNYPSNWECIYRITVGLNQQIAL HFTDFTLEDYFGSQCVDFVEIRDGGYETSPLVGIYCGSVLPPTIISHSNKLWLKFKSDAALTAK GFSAYWDGSSTGCGGNLTTPTGVLTSPNYPMPYYHSSECYWRLEASHGSPFELEFQDFHLEHHP SCSLDYLAVFDGPTTNSRLIDKLCGDTTPAPIRSNKDVVLLKLRTDAGQQGRGFEINFRQRCDN VVIVNKTSGILESINYPNPYDKNQRCNWTIQATTGNTVNYTFLGFDVESYMNCSTDYVELYDGP QWMGRYCGNNMPPPGATTGSQLHVLFHTDGINSGEKGFKMQWFTHGCGGEMSGTAGSFSSPGYP NSYPHNKECIWNIRVAPGSSIQLTIHDFDVEYHTSCNYDSLEIYAGLDFNSPRIAQLCSQSPSA NPMQVSSTGNELAIRFKTDSTLNGRGFNASWRAVPGGCGGIIQLSRGEIHSPNYPNNYRANTEC SWIIQVERHHRVLLNITDFDLEAPDSCLRLMDGSSSTNARVASVCGRQQPPNSIIASGNSLFVR FRSGSSSQNRGFRAEFREECGGRIMTDSSDTIFSPLYPHNYLHNQNCSWIIEAQPPFNHITLSF THFQLQNSTDCTRDFVEILDGNDYDAPVQGRYCGFSLPHPIISFGNALTVRFVTDSTRSFEGFR AIYSASTSSCGGSFYTLDGIFNSPDYPADYHPNAECVWNIASSPGNRLQLSFLSFNLENSLNCN KDFVEIREGNATGHLIGRYCGNSLPGNYSSAEGHSLWVRFVSDGSGTGMGFQARFKNIFGNNNI VGTHGKIASPFWPGKYPYNSNYKWVVNVDAYHIIHGRILEMDIEPTTNCFYDSLKIYDGFDTHS RLIGTYCGTQTESFSSSRNSLTFQFSSDSSVSGRGFLLEWFAVDVSDSTPPTIAPGACGGFMVT GDTPVHIFSPGWPREYANGADCIWIIYAPDSTVELNILSLDIEPQQSCNYDKLIVKDGDSDLSP ELAVLCGVSPPGPIRSTGEYMYIRFTSDTSVAGTGFNASFHKSCGGYLHADRGVITSPKYPDTY LPNLNCSWHVLVQTGLTIAVHFEQPFQIQNRDSFCSQGDYLVLRNGPDNHSPPLGPSGRNGRFC GMYAPSTLFTSGNEMFVQFISDSSNGGQGFKIRYEAKSLACGGTVYIHDADSDGYLTSPNYPAN YPQHAECIWILEAPPGRSIQLQFEDQFNIEDTPNCSVSYLELRDGANSNARLVSKLCGHTLPHS WVSSRERIYLKFHTDGGSSYMGFKAKYSIASCGGTVSGDSGVIESIGYPTLPYANNVFCQWFIR GLPGHYLTLSFEDFNLQSSPGCTKDFVEIWENHTSGRVLGRYCGNSTPSSVDTSSNVASVKFVT DGSVTASGFRLQFKSSRQVCGGDLHGPTGTFTSPNYPNPNPHARICEWTITVQEGRRIVLTFTN LRLSTQPSCNSEHLIVFNGIRSNSPLLQKLCSRVNVTNEFKSSGNTMKVVFFTDGSRPYGGFTA SYTSTEDAVCGGFLPSVSGGNFSSPGYNGIRDYARNLDCEWTLSNPNRENSSISIYFLELSIES HQDCTFDVLEFRVGDADGPLIEKFCSLSAPTAPLVIPYPQVWIHFVSNERVEYTGFYIEYSFTD CGGIRTGDNGVISSPNYPNLYSAWTHCSWLLKAPEGHTITLTFSDFLLEAHPTCTSDSVTVRNG DSPGSPVIGRYCGQSVPRPIQSGSNQLIVTFNTNNQGQTRGFYATWTTNALGCGGTFHSANGTI KSPHWPQTFPENSRCSWTVITHESKHWEISFDSNFRIPSSDSQCQNSFVKVWEGRLMINKTLLA TSCGDVAPSPIVTSGNIFTAVFQSEEMAAQGFSASFISRCGRTFNTSPGDIISPNFPKQYDNNM NCTYLIDADPQSLVILTFVSFHLEDRSAITGTCDHDGLHIIKGRNLSSTPLVTICGSETLRPLT VDGPVLLNFYSDAYTTDFGFKISYRAITCGGIYNESSGILRSPSYSYSNYPNNLYCVYSLHVRS SRVIIIRFNDFDVAPSNLCAHDFLEVFDGPSIGNRSLGKFCGSTRPQTVKSTNSSLTLLFKTDS SQTARGWKIFFRETIGPQQGCGGYLTEDNQSFVSPDSDSNGRYDKGLSCIWYIVAPENKLVKLT FNVFTLEGPSSAGSCVYDYVQIADGASINSYLGGKFCGSRMPAPFISSGNFLTFQFVSDVTVEM RGFNATYTFVDMPCGGTYNATSTPQNASSPHLSNIGRPYSTCTWVIAAPPQQQVQITVWDLQLP SQDCSQSYLELQDSVQTGGNRVTQFCGANYTTLPVFYSSMSTAVVVFKSGVLNRNSQVQFSYQI ADCNREYNQTFGNLKSPGWPQNYDNNLDCTIILRAPQNHSISLFFYWFQLEDSRQCMNDFLEVR NGGSSTSPLLDKYCSNLLPNPVFSQSNELYLHFHSDHSVTNNGYEIIWTSSAAGCGGTLLGDEG IFTNPGFPDSYPNNTHCEWTIVAPSGRPVSVGFPFLSIDSSGGCDQNYLIVFNGPDANSPPFGP LCGINTGIAPFYASSNRVFIRFHAEYTTRLSGFEIMWSS hide sequence

Ensembl Acc Id:

ENSRNOP00000075097 ⟸ ENSRNOT00000090064

Ensembl Acc Id:

ENSRNOP00000048477 ⟸ ENSRNOT00000040052

Ensembl Acc Id:

ENSRNOP00000106447 ⟸ ENSRNOT00000149856

Protein Domains

CUB EGF-like

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700594

Promoter ID:

EPDNEW_R11118

Type:

initiation region

Name:

Cubn_1

Description:

cubilin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	80,807,226 - 80,807,286	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68355	AgrOrtholog
BIND	133316
BioCyc Gene	G2FUF-8611	BioCyc
Ensembl Genes	ENSRNOG00000029047	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000090064	ENTREZGENE
Gene3D-CATH	2.60.120.290	UniProtKB/Swiss-Prot
	Laminin	UniProtKB/Swiss-Prot
InterPro	CUB_dom	UniProtKB/Swiss-Prot
	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot
	EGF-like_CS	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/Swiss-Prot
	EGF_Ca-bd_CS	UniProtKB/Swiss-Prot
	EGF_dom	UniProtKB/Swiss-Prot
	NOTCH1_EGF-like	UniProtKB/Swiss-Prot
	Sperma_CUB_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:80848	UniProtKB/Swiss-Prot
NCBI Gene	80848	ENTREZGENE
PANTHER	CUB DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	OVOCHYMASE-RELATED	UniProtKB/Swiss-Prot
Pfam	CUB	UniProtKB/Swiss-Prot
	EGF	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	hEGF	UniProtKB/Swiss-Prot
PhenoGen	Cubn	PhenoGen
PROSITE	ASX_HYDROXYL	UniProtKB/Swiss-Prot
	CUB	UniProtKB/Swiss-Prot
	EGF_1	UniProtKB/Swiss-Prot
	EGF_2	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000029047	RatGTEx
SMART	CUB	UniProtKB/Swiss-Prot
	EGF	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot
	SSF49854	UniProtKB/Swiss-Prot
TIGR	TC218981
UniProt	A0A0G2K9R4	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LWV7_RAT	UniProtKB/TrEMBL
	A6JM39_RAT	UniProtKB/TrEMBL
	A6JM40	ENTREZGENE, UniProtKB/TrEMBL
	CUBN_RAT	UniProtKB/Swiss-Prot
	F1LNU2_RAT	UniProtKB/TrEMBL
	O70244	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Cubn	cubilin			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutations in gene cause hereditary megaloblastic anaemia 1	61796
gene_domains	NH2 terminal fragment comprised of 110 amino-acid residues followed by 8 epidermal growth factor (EGF)-like repeats and 27 CUB domains	628443
gene_expression	expressed in the apical membranes of epithelial cells	61796
gene_expression	expressed in the apical membranes of epithelial cells	70244
gene_function	receptor for intrinsic factor-vitamin B12 complexes	61796
gene_physical_interaction	binds to intrinsic factor (IF)-cobalamin (cbl, vitamin B12) complex to promote the transportation of cobalamin	628443
gene_process	facilitates vitamin B12 uptake (cyanocobalamin)	61796
gene_process	undergoes degradation in the intestine losing the NH2 terminal which impaires its binding affinity to megalin, the 230 kDa form may be a major intermediate during the degradation of the 460 kDa form	628443
gene_process	involved in renal reabsorption of myoglobin	1299150
gene_regulation	poor expression due to thyroixine defficiency results in decreased uptake and transport of cobalamin	628443

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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