RGD Reference Report - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Authors: Feng, M  Zhang, Z  Fu, P  Huang, SM  Yang, YB  Su, KL  Chen, ZJ  Tang, WX 
Citation: Feng M, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Sep;37(5):738-41.
RGD ID: 1599655
Pubmed: PMID:17037740   (View Abstract at PubMed)

OBJECTIVE: To observe the expression level of Cubilin in the renal tubules of rats with STZ-induced diabetic nephropathy, to assess its correlation with 24 hours' albuminuria, and to investigate the mechanisms of tubular dysfunction at the early stage of diabetic nephropathy. METHODS: Diabetic nephropathy was induced in Sprague-Dalwley rats by intraperitoneal injection of STZ, while the rats of normal group were injected with normal saline. Biochemical indices of blood and urine specimens were observed in both groups at weeks 2, 4 and 6 respectively. The renal expression levels of Cubilin in the two groups were determined by immunohistochemistry and RT-PCR. RESULTS: The expression level of Cubilin in the diabetic nephropathy group was significantly decreased at week 2 after operation (P < 0.05), and it continued to decrease from week 2 to week 6. Also there was significant difference between each two time-points (P < 0.05), and the Cubilin expression level was negatively correlated with albuminuria (P < 0.01). CONCLUSION: The decreased expression level of Cubilin in early-stage diabetic nephropathy rats may partly contribute to the development of microalbuminuria. Cubilin can be regarded as one of the early markers when tubular dysfunction develops in the case of diabetic nephropathy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies  ISOCubn (Rattus norvegicus)1599655; 1599655 RGD 
Diabetic Nephropathies  IEP 1599655 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cubn  (cubilin)

Genes (Mus musculus)
Cubn  (cubilin)

Genes (Homo sapiens)
CUBN  (cubilin)


Additional Information