Cacnb2 (calcium voltage-gated channel auxiliary subunit beta 2) - Rat Genome Database

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Gene: Cacnb2 (calcium voltage-gated channel auxiliary subunit beta 2) Rattus norvegicus
Analyze
Symbol: Cacnb2
Name: calcium voltage-gated channel auxiliary subunit beta 2
RGD ID: 67385
Description: Enables several functions, including actin filament binding activity; calcium channel regulator activity; and identical protein binding activity. Contributes to voltage-gated calcium channel activity. Involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of high voltage-gated calcium channel activity; and protein localization to plasma membrane. Part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAB2; Cacnlb2; calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; voltage-dependent L-type calcium channel subunit beta-2; voltage-gated calcium channel beta2i subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cacnb2_v1   Cacnb2_v2  
Is Marker For: QTLs:   Bp369  
Candidate Gene For: Cm57
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81782,473,097 - 82,818,564 (+)NCBIGRCr8
mRatBN7.21777,564,630 - 77,910,000 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1777,564,460 - 77,909,106 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1781,014,900 - 81,360,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01784,850,313 - 85,195,829 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01778,898,224 - 79,243,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01781,673,862 - 82,019,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,798,756 - 82,017,682 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01783,418,158 - 83,762,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41788,832,905 - 89,078,870 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11788,864,078 - 89,089,703 (+)NCBI
Celera1776,999,835 - 77,240,592 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
aconitine  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (EXP)
cantharidin  (ISO)
CGP 52608  (ISO)
choline  (ISO)
clorgyline  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diethyl malate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
genistein  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. Abiria SA and Colbran RJ, J Neurochem. 2010 Jan;112(1):150-61. doi: 10.1111/j.1471-4159.2009.06436.x. Epub 2009 Oct 15.
2. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. Beguin P, etal., J Cell Biol. 2014 Apr 28;205(2):233-49. doi: 10.1083/jcb.201304101. Epub 2014 Apr 21.
3. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
4. Two sets of amino acids of the domain I of Cav2.3 Ca(2+) channels contribute to their high sensitivity to extracellular protons. Cens T, etal., Pflugers Arch. 2011 Aug;462(2):303-14. doi: 10.1007/s00424-011-0974-x. Epub 2011 May 25.
5. Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. Colecraft HM, etal., J Physiol 2002 Jun 1;541(Pt 2):435-52.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating. Gonzalez-Gutierrez G, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14198-203. doi: 10.1073/pnas.0806558105. Epub 2008 Sep 5.
8. Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Grueter CE, etal., Biochemistry. 2008 Feb 12;47(6):1760-7. Epub 2008 Jan 19.
9. Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population. Hong GL, etal., Genet Mol Res. 2013 Dec 4;12(4):6220-7. doi: 10.4238/2013.December.4.9.
10. Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2. Lautermilch NJ, etal., J Neurosci. 2005 Jul 27;25(30):7062-70.
11. Up-regulation of Cavß3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. Li L, etal., J Biol Chem. 2012 Feb 17;287(8):6002-13. doi: 10.1074/jbc.M111.310110. Epub 2011 Dec 20.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. The voltage-dependent calcium channel beta subunit contains two stable interacting domains. Opatowsky Y, etal., J Biol Chem 2003 Dec 26;278(52):52323-32. Epub 2003 Oct 14.
16. Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. Perez-Reyes E, etal., J Biol Chem 1992 Jan 25;267(3):1792-7.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
21. Direct interaction of CaVbeta with actin up-regulates L-type calcium currents in HL-1 cardiomyocytes. Stolting G, etal., J Biol Chem. 2015 Feb 20;290(8):4561-72. doi: 10.1074/jbc.M114.573956. Epub 2014 Dec 22.
22. Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23. Taviaux S, etal., Hum Genet 1997 Aug;100(2):151-4.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Structure of the voltage-gated calcium channel Cav1.1 complex. Wu J, etal., Science. 2015 Dec 18;350(6267):aad2395. doi: 10.1126/science.aad2395.
25. Cloning of a functional splice variant of L-type calcium channel beta 2 subunit from rat heart. Yamada Y, etal., J Biol Chem 2001 Dec 14;276(50):47163-70.
26. Next-generation sequencing identifies pathogenic and modifier mutations in a consanguineous Chinese family with hypertrophic cardiomyopathy. Zhang X, etal., Medicine (Baltimore). 2017 Jun;96(24):e7010. doi: 10.1097/MD.0000000000007010.
Additional References at PubMed
PMID:1309651   PMID:10328888   PMID:11980879   PMID:15141227   PMID:15750602   PMID:17110381   PMID:17224476   PMID:17626895   PMID:17893194   PMID:18356540   PMID:20194790   PMID:20937253  
PMID:21753737   PMID:21792084   PMID:24519939   PMID:24755552   PMID:25712868   PMID:29208674   PMID:30992131   PMID:35969184  


Genomics

Comparative Map Data
Cacnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81782,473,097 - 82,818,564 (+)NCBIGRCr8
mRatBN7.21777,564,630 - 77,910,000 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1777,564,460 - 77,909,106 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1781,014,900 - 81,360,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01784,850,313 - 85,195,829 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01778,898,224 - 79,243,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01781,673,862 - 82,019,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1781,798,756 - 82,017,682 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01783,418,158 - 83,762,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41788,832,905 - 89,078,870 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11788,864,078 - 89,089,703 (+)NCBI
Celera1776,999,835 - 77,240,592 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
CACNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381018,140,424 - 18,543,557 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1018,140,424 - 18,543,557 (+)EnsemblGRCh38hg38GRCh38
GRCh371018,429,353 - 18,832,486 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361018,469,612 - 18,870,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 341018,729,966 - 18,870,044NCBI
Celera1018,116,041 - 18,517,577 (+)NCBICelera
Cytogenetic Map10p12.33-p12.31NCBI
HuRef1018,094,960 - 18,495,622 (+)NCBIHuRef
CHM1_11018,429,651 - 18,830,663 (+)NCBICHM1_1
T2T-CHM13v2.01018,159,755 - 18,562,802 (+)NCBIT2T-CHM13v2.0
Cacnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39214,608,672 - 14,993,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl214,607,899 - 14,992,719 (+)EnsemblGRCm39 Ensembl
GRCm38214,603,861 - 14,988,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl214,603,088 - 14,987,908 (+)EnsemblGRCm38mm10GRCm38
MGSCv37214,525,933 - 14,908,560 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36214,522,060 - 14,904,687 (+)NCBIMGSCv36mm8
Celera214,505,146 - 14,888,354 (+)NCBICelera
Cytogenetic Map2A2NCBI
cM Map210.7NCBI
Cacnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554299,644,053 - 9,966,175 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554299,642,725 - 9,966,175 (-)NCBIChiLan1.0ChiLan1.0
CACNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2830,985,340 - 31,385,844 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11030,990,661 - 31,391,941 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01018,459,528 - 18,862,495 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11018,915,315 - 19,195,226 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1018,795,832 - 19,195,226 (+)Ensemblpanpan1.1panPan2
CACNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1218,537,100 - 18,787,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl218,538,620 - 18,902,286 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha215,637,443 - 16,012,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0218,828,779 - 19,204,759 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl218,828,796 - 19,205,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,027,565 - 16,402,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,863,689 - 17,237,595 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0217,483,280 - 17,857,968 (-)NCBIUU_Cfam_GSD_1.0
Cacnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934418,664,779 - 19,007,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365208,955,164 - 9,295,331 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365208,951,994 - 9,164,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1044,421,485 - 44,886,425 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11044,321,954 - 44,887,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21049,465,655 - 49,626,095 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1918,075,436 - 18,470,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl918,332,165 - 18,469,617 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605123,719,856 - 24,128,137 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247969,503,452 - 9,859,019 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247969,502,132 - 9,858,836 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacnb2
2180 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:565
Count of miRNA genes:179
Interacting mature miRNAs:237
Transcripts:ENSRNOT00000031542, ENSRNOT00000066826
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
11528636Bss120Bone structure and strength QTL 1208.553e-09femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)177783006478603788Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172418489079524188Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)177100332581153923Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172393042179524188Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2393042179524188Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172393042179524188Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat

Markers in Region
D17Wox7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,848,911 - 77,849,094 (+)MAPPERmRatBN7.2
Rnor_6.01781,959,297 - 81,959,481NCBIRnor6.0
Rnor_5.01783,701,284 - 83,701,468UniSTSRnor5.0
RGSC_v3.41789,018,677 - 89,018,862RGDRGSC3.4
RGSC_v3.41789,018,678 - 89,018,862UniSTSRGSC3.4
RGSC_v3.11789,029,511 - 89,029,695RGD
Celera1777,180,440 - 77,180,626UniSTS
RH 3.4 Map17789.9RGD
RH 3.4 Map17789.9UniSTS
RH 2.0 Map17679.3RGD
Cytogenetic Map17q12.3UniSTS
D17Got99  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,778,668 - 77,778,842 (+)MAPPERmRatBN7.2
Rnor_6.01781,889,089 - 81,889,262NCBIRnor6.0
Rnor_5.01783,631,224 - 83,631,397UniSTSRnor5.0
RGSC_v3.41788,948,948 - 88,949,122RGDRGSC3.4
RGSC_v3.41788,948,949 - 88,949,122UniSTSRGSC3.4
RGSC_v3.11788,959,782 - 88,959,955RGD
Celera1777,110,390 - 77,110,563UniSTS
RH 3.4 Map17792.5RGD
RH 3.4 Map17792.5UniSTS
Cytogenetic Map17q12.3UniSTS
D17Arb12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,907,699 - 77,907,996 (+)MAPPERmRatBN7.2
Rnor_6.01782,017,813 - 82,018,109NCBIRnor6.0
Rnor_5.01783,759,800 - 83,760,096UniSTSRnor5.0
RGSC_v3.41789,077,463 - 89,077,760RGDRGSC3.4
RGSC_v3.41789,077,464 - 89,077,760UniSTSRGSC3.4
RGSC_v3.11789,088,296 - 89,088,593RGD
Celera1777,239,186 - 77,239,482UniSTS
Cytogenetic Map17q12.3UniSTS
AU048422  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01781,909,601 - 81,909,758NCBIRnor6.0
Rnor_5.01783,651,684 - 83,651,841UniSTSRnor5.0
RGSC_v3.41788,969,056 - 88,969,213UniSTSRGSC3.4
Celera1777,130,958 - 77,131,115UniSTS
Cytogenetic Map17q12.3UniSTS
RH129340  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,908,379 - 77,908,564 (+)MAPPERmRatBN7.2
Rnor_6.01782,018,493 - 82,018,677NCBIRnor6.0
Rnor_5.01783,760,480 - 83,760,664UniSTSRnor5.0
RGSC_v3.41789,078,144 - 89,078,328UniSTSRGSC3.4
Celera1777,239,866 - 77,240,050UniSTS
RH 3.4 Map17792.5UniSTS
Cytogenetic Map17q12.3UniSTS
RH133733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,673,275 - 77,673,474 (+)MAPPERmRatBN7.2
Rnor_6.01781,783,413 - 81,783,611NCBIRnor6.0
Rnor_5.01783,525,714 - 83,525,912UniSTSRnor5.0
RGSC_v3.41788,838,599 - 88,838,797UniSTSRGSC3.4
Celera1777,005,533 - 77,005,731UniSTS
RH 3.4 Map17809.2UniSTS
Cytogenetic Map17q12.3UniSTS
RH144615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,766,984 - 77,767,165 (+)MAPPERmRatBN7.2
Rnor_6.01781,877,407 - 81,877,587NCBIRnor6.0
Rnor_5.01783,619,542 - 83,619,722UniSTSRnor5.0
RGSC_v3.41788,937,105 - 88,937,285UniSTSRGSC3.4
Celera1777,098,708 - 77,098,888UniSTS
RH 3.4 Map17794.5UniSTS
Cytogenetic Map17q12.3UniSTS
BE097150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,708,702 - 77,708,868 (+)MAPPERmRatBN7.2
Rnor_6.01781,819,191 - 81,819,356NCBIRnor6.0
Rnor_5.01783,561,492 - 83,561,657UniSTSRnor5.0
RGSC_v3.41788,874,451 - 88,874,616UniSTSRGSC3.4
Celera1777,040,924 - 77,041,089UniSTS
RH 3.4 Map17794.3UniSTS
Cytogenetic Map17q12.3UniSTS
BE109990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,908,157 - 77,908,332 (+)MAPPERmRatBN7.2
Rnor_6.01782,018,271 - 82,018,445NCBIRnor6.0
Rnor_5.01783,760,258 - 83,760,432UniSTSRnor5.0
RGSC_v3.41789,077,922 - 89,078,096UniSTSRGSC3.4
Celera1777,239,644 - 77,239,818UniSTS
RH 3.4 Map17789.8UniSTS
Cytogenetic Map17q12.3UniSTS
RH138021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,907,433 - 77,907,636 (+)MAPPERmRatBN7.2
Rnor_6.01782,017,547 - 82,017,749NCBIRnor6.0
Rnor_5.01783,759,534 - 83,759,736UniSTSRnor5.0
RGSC_v3.41789,077,198 - 89,077,400UniSTSRGSC3.4
Celera1777,238,920 - 77,239,122UniSTS
RH 3.4 Map17792.5UniSTS
Cytogenetic Map17q12.3UniSTS
RH138575  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,846,400 - 77,846,553 (+)MAPPERmRatBN7.2
Rnor_6.01781,956,792 - 81,956,944NCBIRnor6.0
Rnor_5.01783,698,875 - 83,699,027UniSTSRnor5.0
RGSC_v3.41789,016,208 - 89,016,360UniSTSRGSC3.4
Celera1777,178,062 - 77,178,214UniSTS
RH 3.4 Map17793.0UniSTS
Cytogenetic Map17q12.3UniSTS
G15938  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,907,745 - 77,907,978 (+)MAPPERmRatBN7.2
Rnor_6.01782,017,859 - 82,018,091NCBIRnor6.0
Rnor_5.01783,759,846 - 83,760,078UniSTSRnor5.0
RGSC_v3.41789,077,510 - 89,077,742UniSTSRGSC3.4
Celera1777,239,232 - 77,239,464UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF394941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF423193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY190119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY190120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH423075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000031542   ⟹   ENSRNOP00000037354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,811,451 - 77,909,106 (+)Ensembl
Rnor_6.0 Ensembl1781,922,329 - 82,017,682 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066826   ⟹   ENSRNOP00000063474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,767,577 - 77,909,106 (+)Ensembl
Rnor_6.0 Ensembl1781,798,756 - 82,017,481 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098193   ⟹   ENSRNOP00000086829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,812,536 - 77,832,718 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101293   ⟹   ENSRNOP00000094678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,812,742 - 77,909,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101858   ⟹   ENSRNOP00000088262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,564,460 - 77,909,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103017   ⟹   ENSRNOP00000093724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,715,696 - 77,909,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105795   ⟹   ENSRNOP00000094672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,811,451 - 77,909,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108342   ⟹   ENSRNOP00000090821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,715,696 - 77,909,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113123   ⟹   ENSRNOP00000078040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,812,536 - 77,909,106 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118698   ⟹   ENSRNOP00000093071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,687,925 - 77,909,106 (+)Ensembl
RefSeq Acc Id: NM_001398773   ⟹   NP_001385702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,473,215 - 82,818,564 (+)NCBI
mRatBN7.21777,564,630 - 77,910,000 (+)NCBI
RefSeq Acc Id: NM_053851   ⟹   NP_446303
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,596,792 - 82,817,214 (+)NCBI
mRatBN7.21777,688,217 - 77,908,650 (+)NCBI
Rnor_6.01781,777,719 - 82,019,219 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
RGSC_v3.41788,832,905 - 89,078,870 (+)RGD
Celera1776,999,835 - 77,240,592 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254298   ⟹   XP_006254360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,473,506 - 82,818,564 (+)NCBI
mRatBN7.21777,564,947 - 77,910,000 (+)NCBI
Rnor_6.01781,673,864 - 82,018,763 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254301   ⟹   XP_006254363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,720,037 - 82,818,564 (+)NCBI
mRatBN7.21777,811,464 - 77,910,000 (+)NCBI
Rnor_6.01781,921,314 - 82,018,763 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254303   ⟹   XP_006254365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,669,378 - 82,818,564 (+)NCBI
mRatBN7.21777,763,556 - 77,910,000 (+)NCBI
Rnor_6.01781,877,652 - 82,018,763 (+)NCBI
Rnor_5.01783,418,158 - 83,762,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600435   ⟹   XP_017455924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,473,506 - 82,818,564 (+)NCBI
mRatBN7.21777,564,944 - 77,910,000 (+)NCBI
Rnor_6.01781,673,862 - 82,018,763 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600436   ⟹   XP_017455925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,720,038 - 82,818,564 (+)NCBI
mRatBN7.21777,811,461 - 77,910,000 (+)NCBI
Rnor_6.01781,921,314 - 82,018,763 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600438   ⟹   XP_017455927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,473,506 - 82,818,564 (+)NCBI
mRatBN7.21777,564,942 - 77,910,000 (+)NCBI
Rnor_6.01781,673,863 - 82,018,763 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095296   ⟹   XP_038951224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,473,097 - 82,818,564 (+)NCBI
mRatBN7.21777,564,713 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095297   ⟹   XP_038951225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,473,097 - 82,818,564 (+)NCBI
mRatBN7.21777,564,713 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095298   ⟹   XP_038951226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,473,097 - 82,818,564 (+)NCBI
mRatBN7.21777,564,713 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095299   ⟹   XP_038951227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,669,376 - 82,818,564 (+)NCBI
mRatBN7.21777,763,554 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095300   ⟹   XP_038951228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,596,752 - 82,818,564 (+)NCBI
mRatBN7.21777,688,236 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_039095301   ⟹   XP_038951229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,793,549 - 82,818,564 (+)NCBI
mRatBN7.21777,885,015 - 77,910,000 (+)NCBI
RefSeq Acc Id: XM_063276023   ⟹   XP_063132093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,720,038 - 82,818,564 (+)NCBI
RefSeq Acc Id: XM_063276024   ⟹   XP_063132094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,720,038 - 82,818,564 (+)NCBI
RefSeq Acc Id: XM_063276025   ⟹   XP_063132095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,596,752 - 82,818,564 (+)NCBI
RefSeq Acc Id: XM_063276026   ⟹   XP_063132096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81782,596,752 - 82,818,564 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385702 (Get FASTA)   NCBI Sequence Viewer  
  NP_446303 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254360 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254363 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254365 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455924 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455925 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455927 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951224 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951226 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951227 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951228 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951229 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132093 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132094 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132095 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132096 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK14821 (Get FASTA)   NCBI Sequence Viewer  
  AAL16952 (Get FASTA)   NCBI Sequence Viewer  
  AAL47074 (Get FASTA)   NCBI Sequence Viewer  
  AAO38996 (Get FASTA)   NCBI Sequence Viewer  
  AAO38997 (Get FASTA)   NCBI Sequence Viewer  
  AYP71839 (Get FASTA)   NCBI Sequence Viewer  
  EDL78736 (Get FASTA)   NCBI Sequence Viewer  
  EDL78737 (Get FASTA)   NCBI Sequence Viewer  
  EDL78738 (Get FASTA)   NCBI Sequence Viewer  
  EDL78739 (Get FASTA)   NCBI Sequence Viewer  
  EDL78740 (Get FASTA)   NCBI Sequence Viewer  
  EDL78741 (Get FASTA)   NCBI Sequence Viewer  
  EDL78742 (Get FASTA)   NCBI Sequence Viewer  
  EDL78743 (Get FASTA)   NCBI Sequence Viewer  
  EDL78744 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037354.4
  ENSRNOP00000063474
  ENSRNOP00000063474.2
  ENSRNOP00000078040.1
  ENSRNOP00000086829.1
  ENSRNOP00000088262.1
  ENSRNOP00000090821.1
  ENSRNOP00000093071.1
  ENSRNOP00000093724.1
  ENSRNOP00000094672.1
  ENSRNOP00000094678.1
GenBank Protein Q8VGC3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446303   ⟸   NM_053851
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JSZ0 (UniProtKB/TrEMBL),   A6JM63 (UniProtKB/TrEMBL),   A0A8I5XWR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254360   ⟸   XM_006254298
- Peptide Label: isoform X2
- UniProtKB: Q9QUU7 (UniProtKB/Swiss-Prot),   Q91ZJ8 (UniProtKB/Swiss-Prot),   Q811Q7 (UniProtKB/Swiss-Prot),   Q811Q6 (UniProtKB/Swiss-Prot),   Q8VGC3 (UniProtKB/Swiss-Prot),   A6JM60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254365   ⟸   XM_006254303
- Peptide Label: isoform X8
- UniProtKB: A6JM66 (UniProtKB/TrEMBL),   A0A8I6GKE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254363   ⟸   XM_006254301
- Peptide Label: isoform X6
- UniProtKB: D3ZWK0 (UniProtKB/TrEMBL),   A6JM67 (UniProtKB/TrEMBL),   A0A8I6AK39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455924   ⟸   XM_017600435
- Peptide Label: isoform X3
- UniProtKB: Q9QUU7 (UniProtKB/Swiss-Prot),   Q91ZJ8 (UniProtKB/Swiss-Prot),   Q8VGC3 (UniProtKB/Swiss-Prot),   Q811Q7 (UniProtKB/Swiss-Prot),   Q811Q6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455927   ⟸   XM_017600438
- Peptide Label: isoform X10
- UniProtKB: Q9QUU7 (UniProtKB/Swiss-Prot),   Q91ZJ8 (UniProtKB/Swiss-Prot),   Q8VGC3 (UniProtKB/Swiss-Prot),   Q811Q7 (UniProtKB/Swiss-Prot),   Q811Q6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455925   ⟸   XM_017600436
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AK39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037354   ⟸   ENSRNOT00000031542
Ensembl Acc Id: ENSRNOP00000063474   ⟸   ENSRNOT00000066826
RefSeq Acc Id: XP_038951224   ⟸   XM_039095296
- Peptide Label: isoform X1
- UniProtKB: Q9QUU7 (UniProtKB/Swiss-Prot),   Q91ZJ8 (UniProtKB/Swiss-Prot),   Q8VGC3 (UniProtKB/Swiss-Prot),   Q811Q7 (UniProtKB/Swiss-Prot),   Q811Q6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951225   ⟸   XM_039095297
- Peptide Label: isoform X4
- UniProtKB: Q9QUU7 (UniProtKB/Swiss-Prot),   Q91ZJ8 (UniProtKB/Swiss-Prot),   Q8VGC3 (UniProtKB/Swiss-Prot),   Q811Q7 (UniProtKB/Swiss-Prot),   Q811Q6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951226   ⟸   XM_039095298
- Peptide Label: isoform X5
- UniProtKB: Q9QUU7 (UniProtKB/Swiss-Prot),   Q91ZJ8 (UniProtKB/Swiss-Prot),   Q8VGC3 (UniProtKB/Swiss-Prot),   Q811Q7 (UniProtKB/Swiss-Prot),   Q811Q6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951228   ⟸   XM_039095300
- Peptide Label: isoform X9
- UniProtKB: A0A8I5XWR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951227   ⟸   XM_039095299
- Peptide Label: isoform X13
- UniProtKB: A0A678X7M6 (UniProtKB/TrEMBL),   A0A8I6AEJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951229   ⟸   XM_039095301
- Peptide Label: isoform X16
Ensembl Acc Id: ENSRNOP00000078040   ⟸   ENSRNOT00000113123
Ensembl Acc Id: ENSRNOP00000086829   ⟸   ENSRNOT00000098193
Ensembl Acc Id: ENSRNOP00000093724   ⟸   ENSRNOT00000103017
Ensembl Acc Id: ENSRNOP00000090821   ⟸   ENSRNOT00000108342
Ensembl Acc Id: ENSRNOP00000088262   ⟸   ENSRNOT00000101858
Ensembl Acc Id: ENSRNOP00000094672   ⟸   ENSRNOT00000105795
Ensembl Acc Id: ENSRNOP00000094678   ⟸   ENSRNOT00000101293
Ensembl Acc Id: ENSRNOP00000093071   ⟸   ENSRNOT00000118698
RefSeq Acc Id: NP_001385702   ⟸   NM_001398773
- Peptide Label: isoform 1
- UniProtKB: A0A8I6A7Q8 (UniProtKB/TrEMBL),   A6JM59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132095   ⟸   XM_063276025
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063132096   ⟸   XM_063276026
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063132093   ⟸   XM_063276023
- Peptide Label: isoform X11
- UniProtKB: A6JM68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132094   ⟸   XM_063276024
- Peptide Label: isoform X12
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VGC3-F1-model_v2 AlphaFold Q8VGC3 1-655 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67385 AgrOrtholog
BioCyc Gene G2FUF-8597 BioCyc
Ensembl Genes ENSRNOG00000018378 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031542.6 UniProtKB/TrEMBL
  ENSRNOT00000066826 UniProtKB/TrEMBL
  ENSRNOT00000066826.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098193.1 UniProtKB/TrEMBL
  ENSRNOT00000101293.1 UniProtKB/TrEMBL
  ENSRNOT00000101858.1 UniProtKB/TrEMBL
  ENSRNOT00000103017.1 UniProtKB/TrEMBL
  ENSRNOT00000105795.1 UniProtKB/TrEMBL
  ENSRNOT00000108342.1 UniProtKB/TrEMBL
  ENSRNOT00000113123.1 UniProtKB/TrEMBL
  ENSRNOT00000118698.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CAB1-4_N_A-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CACNB2_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_b2su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116600 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116600 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VGCC_beta4Aa_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacnb2 PhenoGen
PRINTS LCACHANNELB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LCACHANNELB2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018378 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205597
UniProt A0A0G2JSZ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A678X7M6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5XWR2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4H7_RAT UniProtKB/TrEMBL
  A0A8I6A7Q8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKE9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKV4_RAT UniProtKB/TrEMBL
  A6JM59 ENTREZGENE, UniProtKB/TrEMBL
  A6JM60 ENTREZGENE, UniProtKB/TrEMBL
  A6JM61_RAT UniProtKB/TrEMBL
  A6JM63 ENTREZGENE, UniProtKB/TrEMBL
  A6JM65_RAT UniProtKB/TrEMBL
  A6JM66 ENTREZGENE, UniProtKB/TrEMBL
  A6JM67 ENTREZGENE, UniProtKB/TrEMBL
  A6JM68 ENTREZGENE, UniProtKB/TrEMBL
  A6JM69_RAT UniProtKB/TrEMBL
  CACB2_RAT UniProtKB/Swiss-Prot
  D3ZWK0 ENTREZGENE, UniProtKB/TrEMBL
  Q811Q6 ENTREZGENE
  Q811Q7 ENTREZGENE
  Q8VGC3 ENTREZGENE
  Q91ZJ8 ENTREZGENE
  Q9QUU7 ENTREZGENE
UniProt Secondary Q811Q6 UniProtKB/Swiss-Prot
  Q811Q7 UniProtKB/Swiss-Prot
  Q91ZJ8 UniProtKB/Swiss-Prot
  Q9QUU7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacnb2  calcium voltage-gated channel auxiliary subunit beta 2  Cacnb2  calcium channel, voltage-dependent, beta 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cacnb2  calcium channel, voltage-dependent, beta 2 subunit       Name updated 70584 APPROVED
2001-10-22 Cacnb2  calcium channel, voltage-dependent, beta 2 subunit      Name, Genbank IDs added from locuslink record 68916 PENDING

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and heart 625474
gene_function L-type Ca2+ channel subunit 625474
gene_process plays a role in shaping the action potential of cardiac myocytes and is a major pathway for extracellular Ca2+ entry into cardiomyocytes 625474
gene_process promotes the transportation of Ca2+ channel to the membrane and affects the activation and inactivation kinetics 625474
gene_process acts to increase peak currents, accelerate activation kinetics, and shift the current-voltage relationship toward more hyperpolarized potentials 632405