Cyp4a3 (cytochrome P450, family 4, subfamily a, polypeptide 3) - Rat Genome Database

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Gene: Cyp4a3 (cytochrome P450, family 4, subfamily a, polypeptide 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp4a3
Name: cytochrome P450, family 4, subfamily a, polypeptide 3
RGD ID: 631356
Description: Enables alkane 1-monooxygenase activity and arachidonate monooxygenase activity. Involved in several processes, including fatty acid metabolic process; icosanoid biosynthetic process; and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; linoleic acid metabolic pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp4a14; CYPIVA14; CYPIVA3; cytochrome P450 4A14; cytochrome P450 4A3; cytochrome P450, family 4, subfamily a, polypeptide 14; cytochrome P450-LA-omega 3; long-chain fatty acid omega-monooxygenase; P450-LA-omega 3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: Cyp4a3em3Mcwi
Genetic Models: SS-Chr 5BN-Cyp4a3em3Mcwi
Candidate Gene For: Rf54
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,334,396 - 134,352,268 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5134,334,701 - 134,352,236 (-)EnsemblGRCr8
mRatBN7.25129,097,571 - 129,115,488 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,097,926 - 129,115,463 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5131,708,433 - 131,725,952 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,463,313 - 133,480,832 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,485,473 - 133,502,990 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,468,666 - 134,484,851 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,469,270 - 134,484,839 (-)Ensemblrn6Rnor6.0
Rnor_5.05138,258,628 - 138,274,813 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45135,876,140 - 135,893,753 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5127,635,617 - 127,653,155 (-)NCBICelera
RGSC_v3.15135,881,365 - 135,898,979 (-)NCBI
Cytogenetic Map5q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
ammonium chloride  (EXP)
barium sulfate  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bromobenzene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
curcumin  (EXP)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
dexamethasone  (EXP)
dichlorine  (EXP)
dodecanoic acid  (EXP)
doxorubicin  (EXP)
endosulfan  (EXP)
eugenol  (EXP)
farnesol  (EXP)
fenofibrate  (EXP)
fipronil  (EXP)
flutamide  (EXP)
gemfibrozil  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
mercaptopurine  (EXP)
methapyrilene  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (EXP)
nimesulide  (EXP)
oxybenzone  (EXP)
ozone  (EXP)
p-toluidine  (EXP)
paraquat  (EXP)
perfluorodecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
purine-6-thiol  (EXP)
ritonavir  (EXP)
sodium arsenite  (EXP)
Sudan III  (EXP)
sunitinib  (EXP)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
triadimefon  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
tungsten  (EXP)
valdecoxib  (EXP)
zaragozic acid A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat. Hercule HC, etal., J Physiol. 2003 Sep 15;551(Pt 3):971-9. Epub 2003 Jul 11.
4. The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes. Kimura S, etal., DNA 1989 Sep;8(7):517-25.
5. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Kroetz DL, etal., Mol Pharmacol. 1997 Sep;52(3):362-72.
6. Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway. Maayah ZH, etal., Arch Toxicol. 2014 Mar;88(3):725-38. doi: 10.1007/s00204-013-1159-5. Epub 2013 Nov 19.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Nguyen X, etal., Am J Physiol. 1999 Jun;276(6 Pt 2):R1691-700.
9. Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. Park F, etal., Am J Physiol Renal Physiol. 2009 Jan 7.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. Wang MH, etal., Am J Physiol Renal Physiol 2003 Aug;285(2):F295-302. Epub 2003 Apr 8.
Additional References at PubMed
PMID:1739747   PMID:2306108   PMID:2766932   PMID:3365247   PMID:11139583   PMID:11821421   PMID:12477932   PMID:15280100   PMID:15489334   PMID:16396499   PMID:28270609  


Genomics

Variants

.
Variants in Cyp4a3
50 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Mcw1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,098,900 - 129,099,033 (+)MAPPERmRatBN7.2
mRatBN7.25128,924,597 - 128,924,722 (+)MAPPERmRatBN7.2
Rnor_6.05134,469,641 - 134,469,771NCBIRnor6.0
Rnor_6.05134,197,895 - 134,198,019NCBIRnor6.0
Rnor_5.05138,259,603 - 138,259,733UniSTSRnor5.0
Rnor_5.05137,990,312 - 137,990,436UniSTSRnor5.0
RGSC_v3.45135,877,115 - 135,877,245UniSTSRGSC3.4
Celera5127,636,592 - 127,636,722UniSTS
Cytogenetic Map5q36UniSTS
D5Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25128,924,607 - 128,924,723 (+)MAPPERmRatBN7.2
mRatBN7.25129,098,910 - 129,099,034 (+)MAPPERmRatBN7.2
Rnor_6.05134,197,905 - 134,198,020NCBIRnor6.0
Rnor_6.05134,469,651 - 134,469,772NCBIRnor6.0
Rnor_5.05138,259,613 - 138,259,734UniSTSRnor5.0
Rnor_5.05137,990,322 - 137,990,437UniSTSRnor5.0
RGSC_v3.45135,877,125 - 135,877,246UniSTSRGSC3.4
RGSC_v3.45135,877,124 - 135,877,246RGDRGSC3.4
Celera5127,636,602 - 127,636,723UniSTS
RGSC_v3.15135,882,350 - 135,882,472RGD
RH 3.4 Map5837.7UniSTS
RH 3.4 Map5837.7RGD
Cytogenetic Map5q36UniSTS
RH131600  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,098,021 - 129,098,201 (+)MAPPERmRatBN7.2
mRatBN7.25128,923,713 - 128,923,893 (+)MAPPERmRatBN7.2
mRatBN7.25129,010,601 - 129,010,781 (+)MAPPERmRatBN7.2
Rnor_6.05134,468,762 - 134,468,941NCBIRnor6.0
Rnor_6.05134,197,011 - 134,197,190NCBIRnor6.0
Rnor_5.05138,258,724 - 138,258,903UniSTSRnor5.0
Rnor_5.05137,989,428 - 137,989,607UniSTSRnor5.0
RGSC_v3.45135,876,236 - 135,876,415UniSTSRGSC3.4
Celera5127,635,713 - 127,635,892UniSTS
RH 3.4 Map5836.4UniSTS
Cytogenetic Map5q36UniSTS


Genetic Models
This gene Cyp4a3 is modified in the following models/strains:
SS-Chr 5BN-Cyp4a3em3Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
11 9 28 54 91 89 59 22 59 6 225 73 3 32 74 48 30

Sequence


Ensembl Acc Id: ENSRNOT00000012681   ⟹   ENSRNOP00000012681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5134,469,270 - 134,484,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000045571   ⟹   ENSRNOP00000045567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5134,469,270 - 134,484,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051385   ⟹   ENSRNOP00000041025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,334,701 - 134,352,236 (-)Ensembl
mRatBN7.2 Ensembl5129,097,926 - 129,115,463 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000057095   ⟹   ENSRNOP00000053925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,334,701 - 134,352,224 (-)Ensembl
mRatBN7.2 Ensembl5129,097,926 - 129,115,451 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116290   ⟹   ENSRNOP00000096771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,334,701 - 134,352,224 (-)Ensembl
mRatBN7.2 Ensembl5129,097,926 - 129,115,451 (-)Ensembl
RefSeq Acc Id: NM_175760   ⟹   NP_786936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,334,701 - 134,352,236 (-)NCBI
mRatBN7.25129,097,926 - 129,115,463 (-)NCBI
Rnor_6.05134,468,666 - 134,484,851 (-)NCBI
Rnor_5.05138,258,628 - 138,274,813 (-)NCBI
RGSC_v3.45135,876,140 - 135,893,753 (-)RGD
Celera5127,635,617 - 127,653,155 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109588   ⟹   XP_038965516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,334,696 - 134,352,266 (-)NCBI
mRatBN7.25129,097,921 - 129,115,488 (-)NCBI
RefSeq Acc Id: XM_039109589   ⟹   XP_038965517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,334,696 - 134,352,266 (-)NCBI
mRatBN7.25129,097,921 - 129,115,488 (-)NCBI
RefSeq Acc Id: XM_039109590   ⟹   XP_038965518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,334,446 - 134,352,266 (-)NCBI
mRatBN7.25129,097,571 - 129,115,488 (-)NCBI
RefSeq Acc Id: XM_063287400   ⟹   XP_063143470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,334,396 - 134,352,268 (-)NCBI
RefSeq Acc Id: NP_786936   ⟸   NM_175760
- UniProtKB: P20817 (UniProtKB/Swiss-Prot),   F1M7X1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045567   ⟸   ENSRNOT00000045571
Ensembl Acc Id: ENSRNOP00000012681   ⟸   ENSRNOT00000012681
RefSeq Acc Id: XP_038965518   ⟸   XM_039109590
- Peptide Label: isoform X1
- UniProtKB: F1M7X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965517   ⟸   XM_039109589
- Peptide Label: isoform X1
- UniProtKB: F1M7X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965516   ⟸   XM_039109588
- Peptide Label: isoform X1
- UniProtKB: F1M7X1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000053925   ⟸   ENSRNOT00000057095
Ensembl Acc Id: ENSRNOP00000096771   ⟸   ENSRNOT00000116290
Ensembl Acc Id: ENSRNOP00000041025   ⟸   ENSRNOT00000051385
RefSeq Acc Id: XP_063143470   ⟸   XM_063287400
- Peptide Label: isoform X2
- UniProtKB: F1M7X1 (UniProtKB/TrEMBL),   A6JZ41 (UniProtKB/TrEMBL),   D3ZHZ6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20817-F1-model_v2 AlphaFold P20817 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693925
Promoter ID:EPDNEW_R4445
Type:multiple initiation site
Name:Cyp4a3_1
Description:cytochrome P450, family 4, subfamily a, polypeptide 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05134,484,867 - 134,484,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631356 AgrOrtholog
BioCyc Gene G2FUF-40283 BioCyc
Ensembl Genes ENSRNOG00000009741 Ensembl
  ENSRNOG00000066878 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051385 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106510 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_Monoox UniProtKB/Swiss-Prot
KEGG Report rno:298423 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112691 IMAGE-MGC_LOAD
NCBI Gene 298423 ENTREZGENE
PANTHER CYTOCHROME P450 4A14-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp4a3 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009741 RatGTEx
  ENSRNOG00000066878 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I6GLR5_RAT UniProtKB/TrEMBL
  A6JZ41 ENTREZGENE, UniProtKB/TrEMBL
  CP4AE_RAT UniProtKB/Swiss-Prot
  D3ZHZ6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJX6_RAT UniProtKB/TrEMBL
  F1M7X1 ENTREZGENE, UniProtKB/TrEMBL
  P20817 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp4a3  cytochrome P450, family 4, subfamily a, polypeptide 3  Cyp4a14  cytochrome P450, family 4, subfamily a, polypeptide 14  Name updated 1299863 APPROVED
2004-09-10 Cyp4a14  cytochrome P450, family 4, subfamily a, polypeptide 14  Cyp4a3  cytochrome P450, family 4, subfamily a, polypeptide 3  Symbol and Name updated 1299863 APPROVED
2004-02-11 Vnr7  cytochrome P450, family 4, subfamily a, polypeptide 3  Cyp4a3  cytochrome P450 4A3  Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression low levels of expression in liver 1299360
gene_function interacts with nitric oxide 1299169
gene_regulation expression induced by clofibrate in both kidney and liver 1299360