Cdk5r1 (cyclin-dependent kinase 5 regulatory subunit 1) - Rat Genome Database

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Gene: Cdk5r1 (cyclin-dependent kinase 5 regulatory subunit 1) Rattus norvegicus
Analyze
Symbol: Cdk5r1
Name: cyclin-dependent kinase 5 regulatory subunit 1
RGD ID: 629472
Description: Enables several functions, including cadherin binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and ephrin receptor binding activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; ionotropic glutamate receptor signaling pathway; and regulation of synaptic vesicle cycle. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Part of protein kinase 5 complex. Is active in presynapse. Biomarker of hypothyroidism and trigeminal neuralgia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1); PARTICIPATES IN Reelin signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (S)-amphetamine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDK5 activator 1; Cdk5r; cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5, regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); p23; p35; tau protein kinase II 23 kDa subunit; TPKII regulatory subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau9
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,981,692 - 65,985,831 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1065,978,911 - 65,989,272 (+)EnsemblGRCr8
mRatBN7.21065,484,266 - 65,485,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1065,483,941 - 65,488,456 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1070,112,198 - 70,113,399 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01069,617,518 - 69,618,719 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01065,079,197 - 65,080,398 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01067,862,054 - 67,863,255 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,862,054 - 67,863,255 (+)Ensemblrn6Rnor6.0
Rnor_5.01067,515,764 - 67,516,965 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41068,715,844 - 68,717,045 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1064,442,587 - 64,443,788 (+)NCBICelera
RGSC_v3.11068,729,476 - 68,730,668 (+)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calpeptin  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
cytarabine  (ISO)
deguelin  (ISO)
dexmedetomidine  (EXP)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenpyroximate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
galactose  (ISO)
gamma-tocopherol  (ISO)
gentamycin  (EXP)
Gentiopicrin  (ISO)
hydroxyurea  (ISO)
ionomycin  (EXP)
lead diacetate  (ISO)
Licochalcone B  (ISO)
maneb  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylphenidate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propofol  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease. Chang WS, etal., Med Sci Monit. 2017 Jun 4;23:2721-2731.
2. Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. Cheng K, etal., J Biol Chem 2002 Aug 30;277(35):31988-93.
3. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. Cheung ZH, etal., PLoS Biol. 2007 Apr;5(4):e63.
4. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. Dhavan R, etal., J Neurosci. 2002 Sep 15;22(18):7879-91.
5. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Fu AK, etal., Nat Neurosci. 2001 Apr;4(4):374-81.
6. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Fu WY, etal., Nat Neurosci. 2007 Jan;10(1):67-76. Epub 2006 Dec 3.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Axonal cap-dependent translation regulates presynaptic p35. Hsiao K, etal., Dev Neurobiol. 2014 Mar;74(3):351-64. doi: 10.1002/dneu.22154. Epub 2013 Dec 14.
10. Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase. Kesavapany S, etal., J Neurosci. 2003 Jun 15;23(12):4975-83.
11. Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. Kwon YT, etal., Curr Biol. 2000 Apr 6;10(7):363-72.
12. [Expression and activity of Cdk5/p35 in a rat model of trigeminal neuropathic pain]. Li W, etal., Shanghai Kou Qiang Yi Xue. 2010 Oct;19(5):545-8.
13. Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Luo W, etal., Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. doi: 10.1073/pnas.0701055104. Epub 2007 May 21.
14. Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity. Maestre C, etal., EMBO J. 2008 Oct 22;27(20):2736-45. doi: 10.1038/emboj.2008.195. Epub 2008 Sep 25.
15. Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk. Mateo I, etal., Acta Neurol Scand. 2009 Aug;120(2):130-3. doi: 10.1111/j.1600-0404.2008.01128.x. Epub 2008 Dec 22.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Nikolic M, etal., Genes Dev. 1996 Apr 1;10(7):816-25.
18. Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. O'Hare MJ, etal., J Neurosci. 2005 Sep 28;25(39):8954-66.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. Sahlgren CM, etal., EMBO J. 2006 Oct 18;25(20):4808-19. Epub 2006 Oct 12.
25. Cdk5 regulates the organization of Nestin and its association with p35. Sahlgren CM, etal., Mol Cell Biol 2003 Jul;23(14):5090-106.
26. Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation. Saito T, etal., J Neurosci 2003 Feb 15;23(4):1189-97.
27. Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. Sakaue F, etal., J Biol Chem. 2005 Sep 9;280(36):31522-9. Epub 2005 Jul 1.
28. Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35. Sato K, etal., J Neurosci Res. 2007 Nov 1;85(14):3071-8. doi: 10.1002/jnr.21438.
29. Activity-dependent p25 generation regulates synaptic plasticity and Aß-induced cognitive impairment. Seo J, etal., Cell. 2014 Apr 10;157(2):486-498. doi: 10.1016/j.cell.2014.01.065.
30. Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35. Sun D, etal., J Biol Chem 1996 Jun 14;271(24):14245-51.
31. The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats. Tan X, etal., Neuroscience. 2015 Apr 2;290:552-60. doi: 10.1016/j.neuroscience.2015.01.054. Epub 2015 Feb 7.
32. The neuroprotective mechanism of puerarin in the treatment of acute spinal ischemia-reperfusion injury is linked to cyclin-dependent kinase 5. Tian F, etal., Neurosci Lett. 2015 Jan 1;584:50-5. doi: 10.1016/j.neulet.2014.09.049. Epub 2014 Oct 7.
33. Developmental iodine deficiency delays the maturation of newborn granule neurons associated with downregulation of p35 in postnatal rat hippocampus. Yu F, etal., Environ Toxicol. 2014 Aug;29(8):847-55. doi: 10.1002/tox.21811. Epub 2012 Sep 15.
34. Increased Cdk5/p35 activity in the dentate gyrus mediates depressive-like behaviour in rats. Zhu WL, etal., Int J Neuropsychopharmacol. 2012 Jul;15(6):795-809. doi: 10.1017/S1461145711000915. Epub 2011 Jun 20.
Additional References at PubMed
PMID:9010203   PMID:10545161   PMID:10903889   PMID:11113134   PMID:11226314   PMID:11517264   PMID:12393264   PMID:14521924   PMID:14976144   PMID:15051507   PMID:15096606   PMID:15123626  
PMID:15592431   PMID:17121855   PMID:17334225   PMID:17498664   PMID:17591690   PMID:17728463   PMID:18054859   PMID:18247371   PMID:18289510   PMID:18385322   PMID:18771616   PMID:18991853  
PMID:19118186   PMID:19141975   PMID:19304511   PMID:19638632   PMID:19965374   PMID:20033852   PMID:20357208   PMID:20624590   PMID:21554958   PMID:21566658   PMID:22106156   PMID:22573681  
PMID:22801079   PMID:22870316   PMID:25864429   PMID:26788519   PMID:28559121   PMID:29020624   PMID:29388152   PMID:31314915   PMID:33456665   PMID:36847717   PMID:37848102  


Genomics

Comparative Map Data
Cdk5r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,981,692 - 65,985,831 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1065,978,911 - 65,989,272 (+)EnsemblGRCr8
mRatBN7.21065,484,266 - 65,485,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1065,483,941 - 65,488,456 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1070,112,198 - 70,113,399 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01069,617,518 - 69,618,719 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01065,079,197 - 65,080,398 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01067,862,054 - 67,863,255 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,862,054 - 67,863,255 (+)Ensemblrn6Rnor6.0
Rnor_5.01067,515,764 - 67,516,965 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41068,715,844 - 68,717,045 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1064,442,587 - 64,443,788 (+)NCBICelera
RGSC_v3.11068,729,476 - 68,730,668 (+)NCBI
Cytogenetic Map10q26NCBI
CDK5R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381732,486,993 - 32,491,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1732,486,156 - 32,491,253 (+)Ensemblhg38GRCh38
GRCh371730,814,011 - 30,818,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361727,838,218 - 27,842,384 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341727,838,217 - 27,842,383NCBI
Celera1727,724,307 - 27,728,473 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1727,000,601 - 27,004,486 (+)NCBIHuRef
CHM1_11730,876,567 - 30,880,733 (+)NCBICHM1_1
T2T-CHM13v2.01733,432,760 - 33,437,020 (+)NCBIT2T-CHM13v2.0
Cdk5r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,367,849 - 80,372,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,367,849 - 80,372,010 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381180,477,023 - 80,481,184 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,477,023 - 80,481,184 (+)Ensemblmm10GRCm38
MGSCv371180,290,548 - 80,294,681 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361180,293,241 - 80,297,376 (+)NCBIMGSCv36mm8
Celera1190,115,053 - 90,119,186 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.94NCBI
Cdk5r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554817,408,205 - 7,409,128 (+)Ensembl
ChiLan1.0NW_0049554817,408,089 - 7,411,813 (+)NCBIChiLan1.0ChiLan1.0
CDK5R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21931,965,865 - 31,970,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11733,846,919 - 33,851,142 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01724,285,069 - 24,289,311 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11724,575,561 - 24,579,226 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1724,577,537 - 24,579,232 (-)EnsemblpanPan2panpan1.1
CDK5R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1940,481,111 - 40,502,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl940,501,646 - 40,502,569 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha939,645,753 - 39,661,533 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0941,302,927 - 41,318,699 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl941,314,917 - 41,318,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1940,089,089 - 40,104,860 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0940,383,316 - 40,399,074 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0940,458,001 - 40,473,768 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdk5r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560239,533,255 - 39,537,114 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365382,413,967 - 2,414,890 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365382,411,194 - 2,415,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK5R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,493,392 - 42,494,413 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11242,456,063 - 42,494,494 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,209,897 - 44,253,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK5R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11626,044,751 - 26,048,920 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1626,045,061 - 26,049,101 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660753,994,491 - 4,000,484 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk5r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624875538,790 - 543,044 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624875538,752 - 542,874 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdk5r1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1989,933,526 - 89,937,616 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdk5r1
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000031746
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106174653268282731Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106184363367241334Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
PMC30213P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21065,484,808 - 65,485,468 (+)MAPPERmRatBN7.2
Rnor_6.01067,862,597 - 67,863,256NCBIRnor6.0
Rnor_5.01067,516,307 - 67,516,966UniSTSRnor5.0
RGSC_v3.41068,716,387 - 68,717,046UniSTSRGSC3.4
Celera1064,443,130 - 64,443,789UniSTS
Cytogenetic Map10q26UniSTS
CDK5R1_1797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21065,484,627 - 65,485,459 (+)MAPPERmRatBN7.2
Rnor_6.01067,862,416 - 67,863,247NCBIRnor6.0
Rnor_5.01067,516,126 - 67,516,957UniSTSRnor5.0
RGSC_v3.41068,716,206 - 68,717,037UniSTSRGSC3.4
Celera1064,442,949 - 64,443,780UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 63 159 91 90 59 89 59 6 330 181 7 137 67 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031746   ⟹   ENSRNOP00000062473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1067,862,054 - 67,863,255 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119428   ⟹   ENSRNOP00000079807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1065,980,781 - 65,985,924 (+)Ensembl
mRatBN7.2 Ensembl1065,483,941 - 65,488,456 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124829   ⟹   ENSRNOP00000100126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1065,981,695 - 65,984,122 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147921   ⟹   ENSRNOP00000098931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1065,978,911 - 65,985,924 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160992   ⟹   ENSRNOP00000111001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1065,981,156 - 65,989,272 (+)Ensembl
RefSeq Acc Id: NM_053891   ⟹   NP_446343
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81065,982,015 - 65,983,216 (+)NCBI
mRatBN7.21065,484,266 - 65,485,467 (+)NCBI
Rnor_6.01067,862,054 - 67,863,255 (+)NCBI
Rnor_5.01067,515,764 - 67,516,965 (+)NCBI
RGSC_v3.41068,715,844 - 68,717,045 (+)RGD
Celera1064,442,587 - 64,443,788 (+)RGD
Sequence:
RefSeq Acc Id: XM_063268305   ⟹   XP_063124375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81065,981,692 - 65,985,831 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001426406 (Get FASTA)   NCBI Sequence Viewer  
  NP_446343 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124375 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52611 (Get FASTA)   NCBI Sequence Viewer  
  EDM05425 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079807.1
  ENSRNOP00000111001
GenBank Protein P61810 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446343   ⟸   NM_053891
- UniProtKB: P61810 (UniProtKB/Swiss-Prot),   A6HHC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062473   ⟸   ENSRNOT00000031746
Ensembl Acc Id: ENSRNOP00000079807   ⟸   ENSRNOT00000119428
RefSeq Acc Id: XP_063124375   ⟸   XM_063268305
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000098931   ⟸   ENSRNOT00000147921
Ensembl Acc Id: ENSRNOP00000111001   ⟸   ENSRNOT00000160992
Ensembl Acc Id: ENSRNOP00000100126   ⟸   ENSRNOT00000124829

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61810-F1-model_v2 AlphaFold P61810 1-307 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:629472 AgrOrtholog
BioCyc Gene G2FUF-23965 BioCyc
Ensembl Genes ENSRNOG00000021685 Ensembl
  ENSRNOG00000068243 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000119428.1 UniProtKB/Swiss-Prot
  ENSRNOT00000160992 ENTREZGENE
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot
InterPro CDK5_activator UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:116671 UniProtKB/Swiss-Prot
NCBI Gene 116671 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 UniProtKB/Swiss-Prot
  PTHR23401 UniProtKB/Swiss-Prot
Pfam CDK5_activator UniProtKB/Swiss-Prot
PhenoGen Cdk5r1 PhenoGen
PIRSF Cdk5_activator UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021685 RatGTEx
  ENSRNOG00000068243 RatGTEx
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt A0ABK0LGV9_RAT UniProtKB/TrEMBL
  A6HHC0 ENTREZGENE, UniProtKB/TrEMBL
  CD5R1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q62938 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Cdk5r1  cyclin-dependent kinase 5 regulatory subunit 1  Cdk5r1  cyclin-dependent kinase 5, regulatory subunit 1 (p35)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-29 Cdk5r1  cyclin-dependent kinase 5, regulatory subunit 1 (p35)  Cdk5r1  cyclin-dependent kinase 5, regulatory subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 Cdk5r1  cyclin-dependent kinase 5, regulatory subunit 1  Cdk5r1  cyclin-dependent kinase 5, regulatory subunit 1 (p35)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Cdk5r1  cyclin-dependent kinase 5, regulatory subunit 1 (p35)  Cdk5r    Symbol updated 1299863 APPROVED
2005-01-20 Cdk5r  cyclin-dependent kinase 5, regulatory subunit 1 (p35)      Symbol and Name status set to approved 1299863 APPROVED
2003-04-06 Cdk5r  cyclin-dependent kinase 5, regulatory subunit 1 (p35)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activity depends on its regulatory partners, p35 or p39 632377