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Gene: Mc2r (melanocortin 2 receptor) Rattus norvegicus

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Symbol:

Mc2r

Name:

melanocortin 2 receptor

RGD ID:

628649

Description:

Predicted to enable G protein-coupled receptor activity. Involved in placenta development. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Biomarker of toxic shock syndrome. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; INTERACTS WITH ammonium chloride; bis(2-butoxyethyl)phthalate; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adrenocorticotropic hormone receptor; melanocortin 2 receptor (adrenocorticotropic hormone)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MC2R (melanocortin 2 receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mc2r (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mc2r (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MC2R (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MC2R (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mc2r (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MC2R (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MC2R (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mc2r (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mc2r (melanocortin 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	BLK (BLK proto-oncogene, Src family tyrosine kinase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MC2R (melanocortin 2 receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mc2r (melanocortin 2 receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mc2r (melanocortin 2 receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mc2r (melanocortin 2 receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mc2r	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	64,279,878 - 64,291,775 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	64,277,360 - 64,291,881 (-)	Ensembl				GRCr8
mRatBN7.2	18	62,001,980 - 62,015,567 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	62,004,948 - 62,015,488 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	64,080,111 - 64,090,647 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	64,772,227 - 64,782,780 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	62,617,456 - 62,627,960 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	64,166,959 - 64,178,729 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	64,167,191 - 64,177,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	63,380,608 - 63,392,678 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	64,591,344 - 64,601,883 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	60,097,107 - 60,107,646 (-)	NCBI		Celera
RGSC_v3.1	18	64,674,282 - 64,675,002 (+)	NCBI
Cytogenetic Map	18	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute-Phase Reaction (IEP)

Disorders of Environmental Origin (IEP)

genetic disease (ISO)

glucocorticoid deficiency 1 (ISO)

Hyperoxia (ISO)

hypertension (ISO)

Metabolic Brain Diseases, Inborn (ISO)

Prostatic Neoplasms (ISO)

toxic shock syndrome (IEP)

West syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

20-hydroxycholesterol (ISO)

3',5'-cyclic AMP (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,5,6-trichloro-2-pyridinol (ISO)

3,5,6-trichloropyridine-2-one (ISO)

3-phenoxybenzoic acid (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alternariol (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

asbestos (ISO)

benzo[a]pyrene (ISO)

bis(2-butoxyethyl)phthalate (EXP)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

colforsin daropate hydrochloride (ISO)

corticosterone (EXP)

DDE (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

diethyl phthalate (ISO)

Diisodecyl phthalate (ISO)

dipentyl phthalate (EXP)

enniatin (ISO)

ethanol (ISO)

lamotrigine (ISO)

methylmercury chloride (ISO)

mycotoxin (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

potassium dichromate (ISO)

progesterone (EXP)

resveratrol (ISO)

silicon dioxide (EXP)

tamoxifen (ISO)

telbivudine (EXP)

triadimefon (EXP)

tributylstannane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

G protein-coupled receptor signaling pathway (IEA)

neuropeptide signaling pathway (IEA)

placenta development (IEP)

positive regulation of glucocorticoid biosynthetic process (ISO)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA,ISO)

Molecular Function

corticotropin receptor activity (IEA,ISO)

G protein-coupled receptor activity (IEA)

melanocortin receptor activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

G protein mediated signaling pathway via Galphas family (ISO)

melanocortin system pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Metallothionein and zinc metabolism in endotoxin shock rats.	Abe S, etal., Experientia Suppl. 1987;52:587-94.
2.	The melanocortin system in control of inflammation.	Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
3.	Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor.	Clark AJ, etal., Lancet. 1993 Feb 20;341(8843):461-2.
4.	Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay.	Fluck CE, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4318-23.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Immunohistochemical localization of the ACTH (MC-2) receptor in the rat placenta and adrenal gland.	Izumi S, etal., Arch Histol Cytol. 2004 Dec;67(5):443-53.
8.	Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways.	Liu M, etal., Environ Toxicol. 2022 Oct;37(10):2419-2433. doi: 10.1002/tox.23607. Epub 2022 Jun 28.
9.	Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasms.	Liu ZL, etal., Chin Med J (Engl). 2008 Sep 5;121(17):1627-32.
10.	Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response.	Malik IA, etal., Histochem Cell Biol. 2012 Mar;137(3):279-91. Epub 2011 Dec 20.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Adrenocorticotropic hormone (MC-2) receptor mRNA is expressed in rat sympathetic ganglia and up-regulated by stress.	Nankova BB, etal., Neurosci Lett 2003 Jul 3;344(3):149-52.
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure.	Piedboeuf B, etal., Am J Respir Cell Mol Biol. 1994 Feb;10(2):123-32.
15.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
16.	GOA pipeline	RGD automated data pipeline
17.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:17947354	PMID:19329486	PMID:19808775	PMID:20042918	PMID:26868281	PMID:29140411	PMID:29943847

Genomics

Comparative Map Data

Mc2r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	64,279,878 - 64,291,775 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	64,277,360 - 64,291,881 (-)	Ensembl				GRCr8
mRatBN7.2	18	62,001,980 - 62,015,567 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	62,004,948 - 62,015,488 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	64,080,111 - 64,090,647 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	64,772,227 - 64,782,780 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	62,617,456 - 62,627,960 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	64,166,959 - 64,178,729 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	64,167,191 - 64,177,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	63,380,608 - 63,392,678 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	64,591,344 - 64,601,883 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	60,097,107 - 60,107,646 (-)	NCBI		Celera
RGSC_v3.1	18	64,674,282 - 64,675,002 (+)	NCBI
Cytogenetic Map	18	q12.1	NCBI

MC2R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	13,882,044 - 13,915,707 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	13,882,043 - 13,915,707 (-)	Ensembl			hg38	GRCh38
GRCh37	18	13,882,043 - 13,915,706 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	13,872,043 - 13,905,535 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	13,874,623 - 13,875,517	NCBI
Celera	18	13,762,993 - 13,796,477 (-)	NCBI		Celera
Cytogenetic Map	18	p11.21	NCBI
HuRef	18	13,835,653 - 13,869,147 (-)	NCBI		HuRef
CHM1_1	18	13,881,179 - 13,914,672 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	14,044,399 - 14,078,045 (-)	NCBI		T2T-CHM13v2.0

Mc2r
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	68,539,970 - 68,562,391 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	68,539,978 - 68,562,391 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	68,406,899 - 68,429,320 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	68,406,907 - 68,429,320 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	68,566,561 - 68,588,913 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	68,532,276 - 68,554,628 (-)	NCBI		MGSCv36	mm8
Celera	18	69,709,404 - 69,724,852 (-)	NCBI		Celera
Cytogenetic Map	18	E2	NCBI
cM Map	18	41.89	NCBI

Mc2r
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	190,513 - 225,627 (+)	Ensembl
ChiLan1.0	NW_004955402	190,513 - 225,627 (+)	NCBI	ChiLan1.0	ChiLan1.0

MC2R
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	24,129,931 - 24,163,435 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	9,822,527 - 9,856,031 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	409,141 - 442,578 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	2,578,783 - 2,612,149 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	2,608,691 - 2,609,584 (+)	Ensembl			panPan2	panpan1.1

MC2R
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	24,351,219 - 24,390,071 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	24,388,280 - 24,389,170 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	25,333,175 - 25,372,054 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	24,250,353 - 24,289,508 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	24,287,716 - 24,288,606 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	24,304,147 - 24,343,019 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	24,190,528 - 24,229,405 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	24,463,475 - 24,502,476 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mc2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	4,024,784 - 4,025,686 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936626	3,253,112 - 3,253,999 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936626	3,253,100 - 3,254,002 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MC2R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	96,265,764 - 96,266,657 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	96,241,744 - 96,268,870 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	89,575,397 - 89,602,023 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MC2R
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	72,286,380 - 72,296,607 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	72,288,224 - 72,289,105 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	47,353,947 - 47,364,420 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mc2r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624770	20,431,571 - 20,476,405 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mc2r
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	62,859,297 - 62,869,995 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mc2r
141 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	114
Count of miRNA genes:	93
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000022347
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1331730	Scl27	Serum cholesterol level QTL 27	3.826		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	54490801	86134022	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
1300125	Rf26	Renal function QTL 26	3.2		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	18	53350521	68120379	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	38575919	83575919	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	45620306	86134022	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	48915737	86134022	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	48915737	86134022	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	45620306	86134022	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61982204	76619168	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	61446853	86134022	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40462383	85462383	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	54490801	76272247	Rat
2312600	Bp341	Blood pressure QTL 341		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61600384	72538878	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1331752	Bw27	Body weight QTL 27	2.963		body mass (VT:0001259)	body weight (CMO:0000012)	18	54490801	68120379	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	50795212	86134022	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	62892257	79484461	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	57825243	85493247	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	48915737	86134022	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
1598832	Glom11	Glomerulus QTL 11	2.9		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	53266671	86134022	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	50795212	86134022	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	62892257	79484461	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat
7411719	Strs5	Sensitivity to stroke QTL 5	9.4		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	18	52198059	68120379	Rat

Markers in Region

Mc2r

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	62,005,033 - 62,005,149 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	64,167,277 - 64,167,392	NCBI	Rnor6.0
Rnor_5.0	18	63,381,260 - 63,381,375	UniSTS	Rnor5.0
RGSC_v3.4	18	64,601,682 - 64,601,797	UniSTS	RGSC3.4
Celera	18	60,097,193 - 60,097,308	UniSTS
Cytogenetic Map	18	q12.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
9	12	25	58	34	36	6	20	6	6	154	78	11	29	53	84	30

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF547168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022347 ⟹ ENSRNOP00000022347

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	62,004,948 - 62,015,488 (-)	Ensembl
Rnor_6.0 Ensembl	18	64,167,191 - 64,177,729 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000126493 ⟹ ENSRNOP00000102791

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	64,277,360 - 64,291,881 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000134916 ⟹ ENSRNOP00000103024

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	64,277,360 - 64,291,881 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135912 ⟹ ENSRNOP00000103356

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	64,277,360 - 64,290,841 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148665 ⟹ ENSRNOP00000110155

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	64,277,709 - 64,290,829 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000164299 ⟹ ENSRNOP00000111537

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	64,277,360 - 64,291,881 (-)	Ensembl

RefSeq Acc Id:

NM_001100491 ⟹ NP_001093961

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,280,224 - 64,290,763 (-)	NCBI
mRatBN7.2	18	62,004,948 - 62,015,488 (-)	NCBI
Rnor_6.0	18	64,167,191 - 64,177,729 (-)	NCBI
Rnor_5.0	18	63,380,608 - 63,392,678 (-)	NCBI
RGSC_v3.4	18	64,591,344 - 64,601,883 (+)	RGD
Celera	18	60,097,107 - 60,107,646 (-)	RGD

Sequence:

show sequence

AAACGAAGCCTCACAGCGGCTCCTGCAAAGAACGAAGTCCGTGAGGTTGCACACAGAGCGACAA
ACCTTTTTTGGTGGGATCCCCTCGGGCCAGGGGCAGGACAAGGGGGGAGGCAGAAACTGGATCC
TTCCGCACAAAGAAAACATTCTGAAGAGCCGATCAGGATTTCTGTAGGTCAACAGCAAGCACCA
TCCCCTTCTTAACCGCAAGCAAGAAAAATGAAGCACATTATCAATTCGTATGAACACACCAACA
ACACAGCAAGAAATAACTCTGATTGTCCTGATGTAGTTGTGCCAGAAGAGATATTTTTCACAAT
CTCCATCATTGGAGTTTTGGAGAACCTGATCGTCCTCCTGGCCGTGATCAAAAATAAAAATCTC
CAGTCCCCCGTGTACTTTTTCATCTGCAGTTTGGCCATTTCCGACATGTTGGGCAGTCTGTATA
AGATCTTGGAAAATATCCTGATCATGTTCAGAAACATGGGCTATCTCAAGCCTCGTGGCAGTTT
GGAAAGTACAGCAGATGACATCATTGACTGCATGTTCGTCCTCTCTTTGCTGGGCTCGATCTTC
AGCCTGTCTGTGATTGCAGCTGACCGCTACATCACCATCTTCCATGCCCTGCAATACCACAGCA
TTGTGACCATGCGACGCACCGTCATCACCCTAACGGTTATCTGGATGTTCTGTACAGGGAGCGG
CATCACCATGGTGATCTTCTCCCACCATATCCCCACAGTGCTCACCTTCACCTCGCTATTCCCT
TTGATGCTGGTTTTTATCCTGTGTCTCTACATCCACATGTTCTTACTTGCCCGCTCCCATGCTC
GGAAGATCTCTACCCTTCCTAGAGCCAACATGAAGGGTGCCATGACATTGACCATCCTTCTTGG
AGTCTTCATCTTCTGTTGGGCTCCCTTTGTGCTCCATGTTCTCTTAATGACCTTCTGCCCAAAT
AACCCTTACTGTGTTTGCTACATGTCTCTCTTCCAGGTCAATGGCATGTTGATTATGTGCAACG
CAGTTATTGATCCCTTTATATATGCCTTTCGGAGCCCAGAGCTCAGAGAGGCATTCAAAAAGAT
GCTCTTCTGCAACAGATATTAGTAGAGCTTTTGATCCCTGCTTTGAGTGTTGTAAAGGAA

hide sequence

RefSeq Acc Id:

XM_008772094 ⟹ XP_008770316

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,290,842 (-)	NCBI
mRatBN7.2	18	62,001,980 - 62,015,567 (-)	NCBI
Rnor_6.0	18	64,166,959 - 64,178,729 (-)	NCBI

Sequence:

show sequence

AGTAGCTGTCTCCCAGTGATGTGTATGTTCCGGTCTTTCCTGCTGCCAGGATCTTCTGTTTGCT
CTTCCTCAAAAATTATTTTCTCCCCTCAGTCCTCTTGGCCAGAAAGATCCTACTTCAGAGCTGA
AGGTAAGCATGTTTTGTACAAATTTCTCGGCTTCTCAAGTGCTCTGGACCCTGAACAGAAAAGC
TAGAACTATACCTAAGAAAAAAATTACATCTCAGTGCTTCCAAATCTTAATTGTGGTTCGTCCT
TCTTAAGGAAGCATCTTATTTCTTAATTAAAGTATGACAATAAAAATCTGTTACTTCTTTGTCT
AACTGAAACTTTCTTCCCTACTAATGAATTTATTAATTTCTCTGCTCCTCTTTAGTATAGTCTA
TTAAATTATTATAAACTCGATTCAGGAATCACAGCAGGCTTTGCTAATGGAACTAGGGTTGAAA
TTAAGATCATTCCCTTTAAGCTCTTCCTGAATCATCCTTTTTTAGCTGCTTAACCTTTCTTTCT
GCCTTTTAAAGGGGGATCGTTTTCTGCTAAAAGACCAGGGGAGGTGCCACAGGATGGCTCCCTG
CTATTCTGAGCAGCTCTACCGCTAGCACACACATAAATGACTGCAGCAACTTGGGGTGCAGAAT
AACTAAGTTAAGGTATTCATGATTGCATGCTCCCGAAAGTGATCAACAGTTGGAACATGCATTC
AGTAAAGACCCAGTATACTTGTGACTTTGCTTGACTGGCTGTCATAGAATATACAGAGTCCAAA
GGGAGATGGGAATGGGAAGGGTACTCGGAGGGGCTGAGAGAAGGGCCTTGAGCAAGACCTGGAG
AGAAGAGGCCTCCTTCTCTGCACTCCCAGGAGGAGCCAAAGGCTCTTATTCACCCTTTTCATGC
ATTGAGCAACACTGTTTACTGGATTCCTATGCACTGGCCTAATTTCAAGTTGAAGTCGGAGTGG
GGCCCGGGGGAGCCCCCAGAACAAGAACATTATGTTGCTGAAACGAAGCCTCACAGCGGCTCCT
GCAAAGAACGAAGTCCGTGAGGTTGCACACAGAGCGACAAACCTTTTTTGGTGGGATCCCCTCG
GGCCAGGGGCAGGACAAGGGGGGAGGCAGAAACTGGTCATTCTCCAATATGCGTTCTTTTGTGT
TCTGTTAAACCTCAGATCCTTCCGCACAAAGAAAACATTCTGAAGAGCCGATCAGGATTTCTGT
AGGTCAACAGCAAGCACCATCCCCTTCTTAACCGCAAGCAAGAAAAATGAAGCACATTATCAAT
TCGTATGAACACACCAACAACACAGCAAGAAATAACTCTGATTGTCCTGATGTAGTTGTGCCAG
AAGAGATATTTTTCACAATCTCCATCATTGGAGTTTTGGAGAACCTGATCGTCCTCCTGGCCGT
GATCAAAAATAAAAATCTCCAGTCCCCCGTGTACTTTTTCATCTGCAGTTTGGCCATTTCCGAC
ATGTTGGGCAGTCTGTATAAGATCTTGGAAAATATCCTGATCATGTTCAGAAACATGGGCTATC
TCAAGCCTCGTGGCAGTTTGGAAAGTACAGCAGATGACATCATTGACTGCATGTTCGTCCTCTC
TTTGCTGGGCTCGATCTTCAGCCTGTCTGTGATTGCAGCTGACCGCTACATCACCATCTTCCAT
GCCCTGCAATACCACAGCATTGTGACCATGCGACGCACCGTCATCACCCTAACGGTTATCTGGA
TGTTCTGTACAGGGAGCGGCATCACCATGGTGATCTTCTCCCACCATATCCCCACAGTGCTCAC
CTTCACCTCGCTATTCCCTTTGATGCTGGTTTTTATCCTGTGTCTCTACATCCACATGTTCTTA
CTTGCCCGCTCCCATGCTCGGAAGATCTCTACCCTTCCTAGAGCCAACATGAAGGGTGCCATGA
CATTGACCATCCTTCTTGGAGTCTTCATCTTCTGTTGGGCTCCCTTTGTGCTCCATGTTCTCTT
AATGACCTTCTGCCCAAATAACCCTTACTGTGTTTGCTACATGTCTCTCTTCCAGGTCAATGGC
ATGTTGATTATGTGCAACGCAGTTATTGATCCCTTTATATATGCCTTTCGGAGCCCAGAGCTCA
GAGAGGCATTCAAAAAGATGCTCTTCTGCAACAGATATTAGTAGAGCTTTTGATCCCTGCTTTG
AGTGTTGTAAAGGAACCAAGTAACACAGCACTCAGACAAACACCAGTGATTCTTCTGACCAGCC
TTTCCTTCTTTAACAGATGTAGATGATCCCACTGACTAGTATTTCCCATAGCTGCCTTTCTCAT
TAACACAGTCTTACTGTACCTGCAAACTTTATATTATATATGGAGAGATGAAATGATCTGCTAA
AAAGGATGGTTTACAAAGTATACATAGCAATACAAATGTGAGGACTTTGGGCTAA

hide sequence

RefSeq Acc Id:

XM_008772095 ⟹ XP_008770317

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,290,834 (-)	NCBI
mRatBN7.2	18	62,001,980 - 62,015,567 (-)	NCBI
Rnor_6.0	18	64,166,959 - 64,178,729 (-)	NCBI

Sequence:

show sequence

AGTAGCTGTCTCCCAGTGATGTGTATGTTCCGGTCTTTCCTGCTGCCAGGATCTTCTGTTTGCT
CTTCCTCAAAAATTATTTTCTCCCCTCAGTCCTCTTGGCCAGAAAGATCCTACTTCAGAGCTGA
AGGTAAGCATGTTTTGTACAAATTTCTCGGCTTCTCAAGTGCTCTGGACCCTGAACAGAAAAGC
TAGAACTATACCTAAGAAAAAAATTACATCTCAGTGCTTCCAAATCTTAATTGTGGTTCGTCCT
TCTTAAGGAAGCATCTTATTTCTTAATTAAAGTATGACAATAAAAATCTGTTACTTCTTTGTCT
AACTGAAACTTTCTTCCCTACTAATGAATTTATTAATTTCTCTGCTCCTCTTTAGTATAGTCTA
TTAAATTATTATAAACTCGATTCAGGAATCACAGCAGGCTTTGCTAATGGAACTAGGGTTGAAA
TTAAGATCATTCCCTTTAAGCTCTTCCTGAATCATCCTTTTTTAGCTGCTTAACCTTTCTTTCT
GCCTTTTAAAGGGGGATCGTTTTCTGCTAAAAGACCAGGGGAGGTGCCACAGGATGGCTCCCTG
CTATTCTGAGCAGCTCTACCGCTAGCACACACATAAATGACTGCAGCAACTTGGGGTGCAGAAT
AACTAAGTTAAGGTATTCATGATTGCATGCTCCCGAAAGTGATCAACAGTTGGAACATGCATTC
AGTAAAGACCCAGTATACTTGTGACTTTGCTTGACTGGCTGTCATAGAATATACAGAGTCCAAA
GGGAGATGGGAATGGGAAGGGTACTCGGAGGGGCTGAGAGAAGGGCCTTGAGCAAGACCTGGAG
AGAAGAGGCCTCCTTCTCTGCACTCCCAGGAGGAGCCAAAGGCTCTTATTCACCCTTTTCATGC
ATTGAGCAACACTGTTTACTGGATTCCTATGCACTGGCCTAATTTCAAGTTGAAGTCGGAGTGG
GGCCCGGGGGAGCCCCCAGAACAAGAACATTATGTTGCTGAAACGAAGCCTCACAGCGGCTCCT
GCAAAGAACGAAGTCCGTGAGGTTGCACACAGAGCGACAAACCTTTTTTGGTGGGATCCCCTCG
GGCCAGGGGCAGGACAAGGGGGGAGGCAGAAACTGGATCATTCTAGAGTCCGTCAGGTTGACAA
CGTTGACTGTCACACTCAAATCCTTCCGCACAAAGAAAACATTCTGAAGAGCCGATCAGGATTT
CTGTAGGTCAACAGCAAGCACCATCCCCTTCTTAACCGCAAGCAAGAAAAATGAAGCACATTAT
CAATTCGTATGAACACACCAACAACACAGCAAGAAATAACTCTGATTGTCCTGATGTAGTTGTG
CCAGAAGAGATATTTTTCACAATCTCCATCATTGGAGTTTTGGAGAACCTGATCGTCCTCCTGG
CCGTGATCAAAAATAAAAATCTCCAGTCCCCCGTGTACTTTTTCATCTGCAGTTTGGCCATTTC
CGACATGTTGGGCAGTCTGTATAAGATCTTGGAAAATATCCTGATCATGTTCAGAAACATGGGC
TATCTCAAGCCTCGTGGCAGTTTGGAAAGTACAGCAGATGACATCATTGACTGCATGTTCGTCC
TCTCTTTGCTGGGCTCGATCTTCAGCCTGTCTGTGATTGCAGCTGACCGCTACATCACCATCTT
CCATGCCCTGCAATACCACAGCATTGTGACCATGCGACGCACCGTCATCACCCTAACGGTTATC
TGGATGTTCTGTACAGGGAGCGGCATCACCATGGTGATCTTCTCCCACCATATCCCCACAGTGC
TCACCTTCACCTCGCTATTCCCTTTGATGCTGGTTTTTATCCTGTGTCTCTACATCCACATGTT
CTTACTTGCCCGCTCCCATGCTCGGAAGATCTCTACCCTTCCTAGAGCCAACATGAAGGGTGCC
ATGACATTGACCATCCTTCTTGGAGTCTTCATCTTCTGTTGGGCTCCCTTTGTGCTCCATGTTC
TCTTAATGACCTTCTGCCCAAATAACCCTTACTGTGTTTGCTACATGTCTCTCTTCCAGGTCAA
TGGCATGTTGATTATGTGCAACGCAGTTATTGATCCCTTTATATATGCCTTTCGGAGCCCAGAG
CTCAGAGAGGCATTCAAAAAGATGCTCTTCTGCAACAGATATTAGTAGAGCTTTTGATCCCTGC
TTTGAGTGTTGTAAAGGAACCAAGTAACACAGCACTCAGACAAACACCAGTGATTCTTCTGACC
AGCCTTTCCTTCTTTAACAGATGTAGATGATCCCACTGACTAGTATTTCCCATAGCTGCCTTTC
TCATTAACACAGTCTTACTGTACCTGCAAACTTTATATTATATATGGAGAGATGAAATGATCTG
CTAAAAAGGATGGTTTACAAAGTATACATAGCAATACAAATGTGAGGACTTTGGGCTAA

hide sequence

RefSeq Acc Id:

XM_063277135 ⟹ XP_063133205

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,291,775 (-)	NCBI

RefSeq Acc Id:

XM_063277136 ⟹ XP_063133206

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,291,775 (-)	NCBI

RefSeq Acc Id:

XM_063277137 ⟹ XP_063133207

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,291,730 (-)	NCBI

RefSeq Acc Id:

XM_063277138 ⟹ XP_063133208

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,291,708 (-)	NCBI

RefSeq Acc Id:

XM_063277139 ⟹ XP_063133209

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,291,707 (-)	NCBI

RefSeq Acc Id:

XM_063277140 ⟹ XP_063133210

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,291,734 (-)	NCBI

RefSeq Acc Id:

XM_063277141 ⟹ XP_063133211

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,290,834 (-)	NCBI

RefSeq Acc Id:

XM_063277142 ⟹ XP_063133212

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,290,834 (-)	NCBI

RefSeq Acc Id:

XM_063277143 ⟹ XP_063133213

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,290,834 (-)	NCBI

RefSeq Acc Id:

XM_063277144 ⟹ XP_063133214

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,290,834 (-)	NCBI

RefSeq Acc Id:

XM_063277145 ⟹ XP_063133215

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	64,279,878 - 64,290,632 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001093961	(Get FASTA)	NCBI Sequence Viewer
	XP_008770316	(Get FASTA)	NCBI Sequence Viewer
	XP_008770317	(Get FASTA)	NCBI Sequence Viewer
	XP_063133205	(Get FASTA)	NCBI Sequence Viewer
	XP_063133206	(Get FASTA)	NCBI Sequence Viewer
	XP_063133207	(Get FASTA)	NCBI Sequence Viewer
	XP_063133208	(Get FASTA)	NCBI Sequence Viewer
	XP_063133209	(Get FASTA)	NCBI Sequence Viewer
	XP_063133210	(Get FASTA)	NCBI Sequence Viewer
	XP_063133211	(Get FASTA)	NCBI Sequence Viewer
	XP_063133212	(Get FASTA)	NCBI Sequence Viewer
	XP_063133213	(Get FASTA)	NCBI Sequence Viewer
	XP_063133214	(Get FASTA)	NCBI Sequence Viewer
	XP_063133215	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN64994	(Get FASTA)	NCBI Sequence Viewer
	EDM14760	(Get FASTA)	NCBI Sequence Viewer
	EDM14761	(Get FASTA)	NCBI Sequence Viewer
	EDM14762	(Get FASTA)	NCBI Sequence Viewer
	EDM14763	(Get FASTA)	NCBI Sequence Viewer
	EDM14764	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000102791
	ENSRNOP00000102791.1
	ENSRNOP00000103024
	ENSRNOP00000103024.1
	ENSRNOP00000103356
	ENSRNOP00000103356.1
	ENSRNOP00000110155
	ENSRNOP00000110155.1
	ENSRNOP00000111537
	ENSRNOP00000111537.1

RefSeq Acc Id:

NP_001093961 ⟸ NM_001100491

- UniProtKB:

G3V848 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), Q8CIX6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKHIINSYEHTNNTARNNSDCPDVVVPEEIFFTISIIGVLENLIVLLAVIKNKNLQSPVYFFIC
SLAISDMLGSLYKILENILIMFRNMGYLKPRGSLESTADDIIDCMFVLSLLGSIFSLSVIAADR
YITIFHALQYHSIVTMRRTVITLTVIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCL
YIHMFLLARSHARKISTLPRANMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMS
LFQVNGMLIMCNAVIDPFIYAFRSPELREAFKKMLFCNRY

hide sequence

RefSeq Acc Id:	XP_008770316 ⟸ XM_008772094
- Peptide Label:	isoform X1
- UniProtKB:	G3V848 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), Q8CIX6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKHIINSYEHTNNTARNNSDCPDVVVPEEIFFTISIIGVLENLIVLLAVIKNKNLQSPVYFFIC SLAISDMLGSLYKILENILIMFRNMGYLKPRGSLESTADDIIDCMFVLSLLGSIFSLSVIAADR YITIFHALQYHSIVTMRRTVITLTVIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCL YIHMFLLARSHARKISTLPRANMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMS LFQVNGMLIMCNAVIDPFIYAFRSPELREAFKKMLFCNRY hide sequence

RefSeq Acc Id:	XP_008770317 ⟸ XM_008772095
- Peptide Label:	isoform X1
- UniProtKB:	G3V848 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), Q8CIX6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKHIINSYEHTNNTARNNSDCPDVVVPEEIFFTISIIGVLENLIVLLAVIKNKNLQSPVYFFIC SLAISDMLGSLYKILENILIMFRNMGYLKPRGSLESTADDIIDCMFVLSLLGSIFSLSVIAADR YITIFHALQYHSIVTMRRTVITLTVIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCL YIHMFLLARSHARKISTLPRANMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMS LFQVNGMLIMCNAVIDPFIYAFRSPELREAFKKMLFCNRY hide sequence

Ensembl Acc Id:

ENSRNOP00000022347 ⟸ ENSRNOT00000022347

RefSeq Acc Id:	XP_063133206 ⟸ XM_063277136
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133205 ⟸ XM_063277135
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133210 ⟸ XM_063277140
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133207 ⟸ XM_063277137
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133208 ⟸ XM_063277138
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133209 ⟸ XM_063277139
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133211 ⟸ XM_063277141
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133214 ⟸ XM_063277144
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133213 ⟸ XM_063277143
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133212 ⟸ XM_063277142
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133215 ⟸ XM_063277145
- Peptide Label:	isoform X1
- UniProtKB:	Q8CIX6 (UniProtKB/TrEMBL), A6IXY0 (UniProtKB/TrEMBL), G3V848 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000102791 ⟸ ENSRNOT00000126493

Ensembl Acc Id:

ENSRNOP00000111537 ⟸ ENSRNOT00000164299

Ensembl Acc Id:

ENSRNOP00000103024 ⟸ ENSRNOT00000134916

Ensembl Acc Id:

ENSRNOP00000103356 ⟸ ENSRNOT00000135912

Ensembl Acc Id:

ENSRNOP00000110155 ⟸ ENSRNOT00000148665

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V848-F1-model_v2	AlphaFold	G3V848	1-296	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628649	AgrOrtholog
BioCyc Gene	G2FUF-7102	BioCyc
Ensembl Genes	ENSRNOG00000016681	Ensembl
	ENSRNOG00000072071	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000126493	ENTREZGENE
	ENSRNOT00000126493.1	UniProtKB/TrEMBL
	ENSRNOT00000134916	ENTREZGENE
	ENSRNOT00000134916.1	UniProtKB/TrEMBL
	ENSRNOT00000135912	ENTREZGENE
	ENSRNOT00000135912.1	UniProtKB/TrEMBL
	ENSRNOT00000148665	ENTREZGENE
	ENSRNOT00000148665.1	UniProtKB/TrEMBL
	ENSRNOT00000164299	ENTREZGENE
	ENSRNOT00000164299.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	ACTH_rcpt	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
	Melcrt_ACTH_rcpt	UniProtKB/TrEMBL
KEGG Report	rno:282839	UniProtKB/TrEMBL
NCBI Gene	282839	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Mc2r	PhenoGen
PRINTS	ACTROPHINR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
	MCRFAMILY	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016681	RatGTEx
	ENSRNOG00000072071	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0ABK0M454_RAT	UniProtKB/TrEMBL
	A6IXY0	ENTREZGENE, UniProtKB/TrEMBL
	G3V848	ENTREZGENE
	Q8CIX6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Mc2r	melanocortin 2 receptor	Mc2r	melanocortin 2 receptor (adrenocorticotropic hormone)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-05	Mc2r	melanocortin 2 receptor (adrenocorticotropic hormone)	Mc2r	melanocortin 2 receptor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-01-19	Mc2r	melanocortin 2 receptor	Mc2r	melanocortin 2 receptor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Mc2r	melanocortin 2 receptor			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Mc2r	melanocortin 2 receptor			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in sympathetic ganglia	724417

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB