Pold1 (DNA polymerase delta 1, catalytic subunit) - Rat Genome Database

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Gene: Pold1 (DNA polymerase delta 1, catalytic subunit) Rattus norvegicus
Analyze
Symbol: Pold1
Name: DNA polymerase delta 1, catalytic subunit
RGD ID: 621839
Description: Enables DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process and DNA-templated DNA replication. Part of delta DNA polymerase complex. Human ortholog(s) of this gene implicated in immunodeficiency 120. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3'-5' exodeoxyribonuclease; DAN polymerase delta 1, catalytic subunit; DNA polymerase delta catalytic subunit; DNA polymerase delta, catalytic subunit; DNA-directed DNA polymerase delta 1; polymerase (DNA directed), delta 1, catalytic subunit; polymerase (DNA) delta 1, catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,161,984 - 104,178,074 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,162,016 - 104,172,982 (-)EnsemblGRCr8
mRatBN7.2195,025,462 - 95,041,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,410,903 - 100,421,871 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,883,547 - 108,894,515 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,173,968 - 102,184,936 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,538,066 - 100,554,105 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)Ensemblrn6Rnor6.0
Rnor_5.01101,603,453 - 101,619,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,010,719 - 95,021,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,287,965 - 89,298,931 (-)NCBICelera
RGSC_v3.1195,088,829 - 95,099,797 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
furan  (EXP)
guanine  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
miconazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrates  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
progesterone  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*. Birkus G, etal., Antimicrob Agents Chemother. 2002 May;46(5):1610-3.
2. Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells. Fox G, etal., J Cancer Res Clin Oncol. 1997;123(11-12):659-68.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. Goldsby RE, etal., Proc Natl Acad Sci U S A 2002 Nov 26;99(24):15560-5. Epub 2002 Nov 12.
6. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.
7. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
8. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Lopez-Girona A, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):566-74.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme. Popanda O, etal., J Cancer Res Clin Oncol 1999 Nov;125(11):598-608.
14. DNA polymerases delta and epsilon in developing and aging rat brain. Prapurna DR and Rao KS, Int J Dev Neurosci. 1997 Feb;15(1):67-73.
15. Reactome: A Knowledgebase of Biological Processes Reactome
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. POLD1 and POLE Gene Mutations in Jewish Cohorts of Early-Onset Colorectal Cancer and of Multiple Colorectal Adenomas. Rosner G, etal., Dis Colon Rectum. 2018 Sep;61(9):1073-1079. doi: 10.1097/DCR.0000000000001150.
21. POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East. Siraj AK, etal., Mol Genet Genomic Med. 2020 Aug;8(8):e1368. doi: 10.1002/mgg3.1368. Epub 2020 Jun 22.
22. Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer. Song X, etal., Sci Rep. 2017 Sep 18;7(1):11785. doi: 10.1038/s41598-017-08257-7.
Additional References at PubMed
PMID:1730053   PMID:3335506   PMID:10559260   PMID:10559261   PMID:11595739   PMID:15177179   PMID:16762037   PMID:19946888   PMID:20070946   PMID:20227374   PMID:20713449   PMID:22465957  
PMID:23770608   PMID:24115439   PMID:24191025   PMID:24270157   PMID:24939902  


Genomics

Comparative Map Data
Pold1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,161,984 - 104,178,074 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,162,016 - 104,172,982 (-)EnsemblGRCr8
mRatBN7.2195,025,462 - 95,041,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,410,903 - 100,421,871 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,883,547 - 108,894,515 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,173,968 - 102,184,936 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,538,066 - 100,554,105 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)Ensemblrn6Rnor6.0
Rnor_5.01101,603,453 - 101,619,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,010,719 - 95,021,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,287,965 - 89,298,931 (-)NCBICelera
RGSC_v3.1195,088,829 - 95,099,797 (-)NCBI
Cytogenetic Map1q22NCBI
POLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,384,323 - 50,418,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,384,204 - 50,418,018 (+)Ensemblhg38GRCh38
GRCh371950,887,580 - 50,921,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,579,405 - 55,613,083 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341955,579,407 - 55,613,082NCBI
Celera1947,937,836 - 47,971,517 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,225,718 - 47,259,759 (+)NCBIHuRef
CHM1_11950,889,357 - 50,923,058 (+)NCBICHM1_1
T2T-CHM13v2.01953,471,875 - 53,505,574 (+)NCBIT2T-CHM13v2.0
Pold1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,182,168 - 44,198,239 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,182,170 - 44,198,273 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38744,532,744 - 44,548,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,532,746 - 44,548,849 (-)Ensemblmm10GRCm38
MGSCv37751,788,114 - 51,804,185 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36744,400,791 - 44,416,858 (-)NCBIMGSCv36mm8
Celera739,982,884 - 39,998,944 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.83NCBI
Pold1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559712,321 - 725,661 (-)Ensembl
ChiLan1.0NW_004955559712,375 - 730,551 (-)NCBIChiLan1.0ChiLan1.0
POLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,449,766 - 56,483,752 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,371,169 - 58,405,169 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,347,919 - 47,381,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,251,356 - 56,284,263 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,251,356 - 56,297,611 (+)EnsemblpanPan2panpan1.1
POLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,302,583 - 106,331,353 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,302,574 - 106,331,385 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1105,875,694 - 105,904,437 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01106,813,663 - 106,842,434 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11106,485,820 - 106,514,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,127,322 - 106,156,071 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,967,996 - 106,996,721 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pold1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,355,338 - 22,382,953 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889251,874 - 258,201 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936889231,373 - 250,987 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936889231,373 - 250,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,247,880 - 55,272,085 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1655,247,799 - 55,272,087 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,096,669 - 51,120,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pold1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,117,341 - 4,135,035 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248324,117,597 - 4,135,092 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pold1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,984,682 - 155,000,760 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pold1
191 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:140
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000026797
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH144354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,028,872 - 95,029,168 (+)MAPPERmRatBN7.2
Rnor_6.01100,541,472 - 100,541,767NCBIRnor6.0
Rnor_5.01101,606,859 - 101,607,154UniSTSRnor5.0
RGSC_v3.4195,014,093 - 95,014,388UniSTSRGSC3.4
Celera189,291,339 - 89,291,634UniSTS
RH 3.4 Map1903.69UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 13 79 203 91 90 59 148 59 6 454 270 21 178 98 112 31 29 29

Sequence


Ensembl Acc Id: ENSRNOT00000026797   ⟹   ENSRNOP00000026797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,162,016 - 104,172,982 (-)Ensembl
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)Ensembl
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162699   ⟹   ENSRNOP00000104224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,162,443 - 104,172,982 (-)Ensembl
RefSeq Acc Id: NM_021662   ⟹   NP_067694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,162,016 - 104,172,982 (-)NCBI
mRatBN7.2195,025,499 - 95,036,465 (-)NCBI
Rnor_6.01100,538,098 - 100,549,064 (-)NCBI
Rnor_5.01101,603,453 - 101,619,471 (-)NCBI
RGSC_v3.4195,010,719 - 95,021,686 (-)RGD
Celera189,287,965 - 89,298,931 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229142   ⟹   XP_006229204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,161,984 - 104,178,074 (-)NCBI
mRatBN7.2195,025,462 - 95,041,559 (-)NCBI
Rnor_6.01100,538,066 - 100,554,105 (-)NCBI
Rnor_5.01101,603,453 - 101,619,471 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272283   ⟹   XP_063128353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,161,984 - 104,177,938 (-)NCBI
RefSeq Acc Id: NP_067694   ⟸   NM_021662
- UniProtKB: O54747 (UniProtKB/Swiss-Prot),   A6JAQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229204   ⟸   XM_006229142
- Peptide Label: isoform X1
- UniProtKB: G3V8M1 (UniProtKB/TrEMBL),   A6JAQ6 (UniProtKB/TrEMBL),   A6JAQ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026797   ⟸   ENSRNOT00000026797
RefSeq Acc Id: XP_063128353   ⟸   XM_063272283
- Peptide Label: isoform X1
- UniProtKB: A6JAQ5 (UniProtKB/TrEMBL),   A6JAQ6 (UniProtKB/TrEMBL),   G3V8M1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104224   ⟸   ENSRNOT00000162699
Protein Domains
C4-type zinc-finger of DNA polymerase delta   DNA polymerase delta/zeta catalytic subunit N-   DNA-directed DNA polymerase family B   DNA-directed DNA polymerase family B exonuclease

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54747-F1-model_v2 AlphaFold O54747 1-1103 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621839 AgrOrtholog
BioCyc Gene G2FUF-59763 BioCyc
Ensembl Genes ENSRNOG00000019681 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026797 ENTREZGENE
Gene3D-CATH 1.10.132.60 UniProtKB/Swiss-Prot
  3.30.420.10 UniProtKB/Swiss-Prot
  3.90.1600.10 UniProtKB/Swiss-Prot
  6.10.140.1540 UniProtKB/Swiss-Prot
  DNA Polymerase, chain B, domain 1 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
InterPro DNA-dir_DNA_pol_B UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_B_CS UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_B_exonuc UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_B_multi_dom UniProtKB/Swiss-Prot
  DNA/RNA_pol_sf UniProtKB/Swiss-Prot
  DNA_pol_B_C UniProtKB/Swiss-Prot
  DNA_pol_palm_dom_sf UniProtKB/Swiss-Prot
  DNA_pol_type-B UniProtKB/Swiss-Prot
  DPOD/Z_N UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
  RNaseH_sf UniProtKB/Swiss-Prot
  Znf-C4pol UniProtKB/Swiss-Prot
KEGG Report rno:59294 UniProtKB/Swiss-Prot
NCBI Gene 59294 ENTREZGENE
PANTHER DNA POLYMERASE CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
  DNA POLYMERASE DELTA CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
Pfam DNA_pol_B UniProtKB/Swiss-Prot
  DNA_pol_B_exo1 UniProtKB/Swiss-Prot
  POL3_N UniProtKB/Swiss-Prot
  zf-C4pol UniProtKB/Swiss-Prot
PhenoGen Pold1 PhenoGen
PRINTS DNAPOLB UniProtKB/Swiss-Prot
PROSITE DNA_POLYMERASE_B UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019681 RatGTEx
SMART POLBc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot
  SSF56672 UniProtKB/Swiss-Prot
UniProt A0ABK0LKY1_RAT UniProtKB/TrEMBL
  A6JAQ5 ENTREZGENE, UniProtKB/TrEMBL
  A6JAQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JAQ9_RAT UniProtKB/TrEMBL
  A6JAR0_RAT UniProtKB/TrEMBL
  DPOD1_RAT UniProtKB/Swiss-Prot
  G3V8M1 ENTREZGENE, UniProtKB/TrEMBL
  O54747 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Pold1  DNA polymerase delta 1, catalytic subunit  Pold1  DAN polymerase delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Pold1  DAN polymerase delta 1, catalytic subunit  Pold1  polymerase (DNA) delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Pold1  polymerase (DNA) delta 1, catalytic subunit  Pold1  polymerase (DNA directed), delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pold1  polymerase (DNA directed), delta 1, catalytic subunit    DNA polymerase delta, catalytic subunit  Name updated 1299863 APPROVED
2002-08-07 Pold1  DNA polymerase delta, catalytic subunit      Symbol and Name status set to provisional 70820 PROVISIONAL