Pfn1 (profilin 1) - Rat Genome Database

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Gene: Pfn1 (profilin 1) Rattus norvegicus
Analyze
Symbol: Pfn1
Name: profilin 1
RGD ID: 621825
Description: Enables phosphatidylinositol-4,5-bisphosphate binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of nucleobase-containing compound metabolic process; positive regulation of stress fiber assembly; and positive regulation of viral transcription. Is active in several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: profilin; profilin I; profilin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,863,882 - 55,866,587 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,863,881 - 55,868,611 (-)EnsemblGRCr8
mRatBN7.21055,365,263 - 55,367,968 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,365,262 - 55,527,631 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1060,045,873 - 60,048,577 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,534,379 - 59,537,083 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,033,485 - 55,036,189 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,273,003 - 57,275,708 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,273,005 - 57,275,708 (-)Ensemblrn6Rnor6.0
Rnor_5.01057,018,597 - 57,021,302 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41057,531,661 - 57,534,366 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1054,510,819 - 54,513,524 (-)NCBICelera
RGSC_v3.11057,545,285 - 57,547,989 (-)NCBI
RH 3.4 Map9783.99RGD
Cytogenetic Map10q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dimethoxyphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dihydroartemisinin  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
graphite  (ISO)
GSK-J4  (ISO)
haloperidol  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
malathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
neomycin  (EXP)
nicotine  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
quercetin  (EXP,ISO)
rhosin  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tanespimycin  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Profilin is required for viral morphogenesis, syncytium formation, and cell-specific stress fiber induction by respiratory syncytial virus. Bitko V, etal., BMC Microbiol. 2003 May 9;3:9.
2. Endothelin-1 mobilizes profilin-1-bound PIP2 in cardiac muscle. Evans NJ and Walker JW, Exp Biol Med (Maywood). 2006 Jun;231(6):882-7.
3. Location of profilin at presynaptic sites in the cerebellar cortex; implication for the regulation of the actin-polymerization state during axonal elongation and synaptogenesis. Faivre-Sarrailh C, etal., J Neurocytol. 1993 Dec;22(12):1060-72.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system. Giesemann T, etal., J Neurosci. 2003 Sep 10;23(23):8330-9.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Gronborg M, etal., Mol Cell Proteomics. 2006 Jan;5(1):157-71. Epub 2005 Oct 8.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Increase of hepatic mRNAS of profilin, actin and extracellular matrix proteins after carbon tetrachloride treatment and partial hepatectomy in rats. Nakamura H, etal., Biochem Biophys Res Commun. 1994 Jan 28;198(2):568-73.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner. Neuhoff H, etal., Eur J Neurosci. 2005 Jan;21(1):15-25. doi: 10.1111/j.1460-9568.2004.03814.x.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. Tamura M, etal., Biochem Biophys Res Commun 1996 May 24;222(3):683-7.
19. Expression of profilin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells. Tamura M, etal., J Am Soc Nephrol. 2000 Mar;11(3):423-33.
20. Activation of DNA synthesis and AP-1 by profilin, an actin-binding protein, via binding to a cell surface receptor in cultured rat mesangial cells. Tamura M, etal., J Am Soc Nephrol. 2000 Sep;11(9):1620-30.
Additional References at PubMed
PMID:7758455   PMID:10069337   PMID:10445846   PMID:11274401   PMID:15174098   PMID:15489334   PMID:15615774   PMID:16547510   PMID:17021034   PMID:17914456   PMID:18230613   PMID:18573880  
PMID:19056867   PMID:19946888   PMID:20458337   PMID:21423176   PMID:21586339   PMID:21700703   PMID:22082260   PMID:22516433   PMID:22681889   PMID:23106098   PMID:23153535   PMID:23376485  
PMID:23533145   PMID:23578580   PMID:23615214   PMID:24006456   PMID:24700464   PMID:25468996   PMID:26951674   PMID:27185630   PMID:29238726   PMID:29476059   PMID:30392913   PMID:31599437  
PMID:36989867  


Genomics

Comparative Map Data
Pfn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,863,882 - 55,866,587 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,863,881 - 55,868,611 (-)EnsemblGRCr8
mRatBN7.21055,365,263 - 55,367,968 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,365,262 - 55,527,631 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1060,045,873 - 60,048,577 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,534,379 - 59,537,083 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,033,485 - 55,036,189 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,273,003 - 57,275,708 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,273,005 - 57,275,708 (-)Ensemblrn6Rnor6.0
Rnor_5.01057,018,597 - 57,021,302 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41057,531,661 - 57,534,366 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1054,510,819 - 54,513,524 (-)NCBICelera
RGSC_v3.11057,545,285 - 57,547,989 (-)NCBI
RH 3.4 Map9783.99RGD
Cytogenetic Map10q24NCBI
PFN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,945,652 - 4,948,530 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,945,652 - 4,950,517 (-)Ensemblhg38GRCh38
GRCh37174,848,947 - 4,851,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,789,692 - 4,792,570 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34174,789,693 - 4,792,570NCBI
Celera174,863,758 - 4,866,636 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,736,535 - 4,739,971 (-)NCBIHuRef
CHM1_1174,858,279 - 4,861,714 (-)NCBICHM1_1
T2T-CHM13v2.0174,836,000 - 4,838,878 (-)NCBIT2T-CHM13v2.0
Pfn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,542,670 - 70,547,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,542,676 - 70,545,470 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381170,651,844 - 70,656,799 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,651,850 - 70,654,644 (-)Ensemblmm10GRCm38
MGSCv371170,465,349 - 70,468,152 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361170,468,044 - 70,470,830 (-)NCBIMGSCv36mm8
Celera1178,202,791 - 78,205,594 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1143.21NCBI
Pfn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,357,838 - 10,360,651 (-)Ensembl
ChiLan1.0NW_00495546710,357,838 - 10,360,651 (-)NCBIChiLan1.0ChiLan1.0
PFN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,555,720 - 12,559,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,524,079 - 14,526,976 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,993,853 - 4,996,811 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,981,765 - 4,984,676 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,981,765 - 4,985,022 (-)EnsemblpanPan2panpan1.1
PFN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,670,483 - 31,671,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,670,194 - 31,671,895 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha531,807,352 - 31,810,011 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0531,772,763 - 31,775,424 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,772,755 - 31,775,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,739,303 - 31,741,962 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,699,008 - 31,701,668 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,875,384 - 31,878,044 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pfn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,134,909 - 53,137,871 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,762,971 - 2,766,149 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,762,971 - 2,766,038 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,961,952 - 51,965,464 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11251,962,642 - 51,965,570 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,031,353 - 54,034,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,426,853 - 4,430,259 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,426,962 - 4,429,713 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605917,203,582 - 17,206,997 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247868,803,118 - 8,805,960 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247868,803,247 - 8,805,958 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pfn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1950,262,820 - 50,266,063 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pfn1
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:283
Count of miRNA genes:164
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000005370
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AV328608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21055,364,779 - 55,364,876 (+)MAPPERmRatBN7.2
Rnor_6.01057,272,520 - 57,272,616NCBIRnor6.0
Rnor_5.01057,018,114 - 57,018,210UniSTSRnor5.0
RGSC_v3.41057,531,178 - 57,531,274UniSTSRGSC3.4
Celera1054,510,336 - 54,510,432UniSTS
Cytogenetic Map10q24UniSTS
RH94647  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map9783.99UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005370   ⟹   ENSRNOP00000005370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,365,263 - 55,527,631 (-)Ensembl
Rnor_6.0 Ensembl1057,273,005 - 57,275,708 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104684   ⟹   ENSRNOP00000093393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,863,881 - 55,868,611 (-)Ensembl
mRatBN7.2 Ensembl1055,365,262 - 55,370,492 (-)Ensembl
RefSeq Acc Id: NM_022511   ⟹   NP_071956
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,863,882 - 55,866,587 (-)NCBI
mRatBN7.21055,365,263 - 55,367,968 (-)NCBI
Rnor_6.01057,273,003 - 57,275,708 (-)NCBI
Rnor_5.01057,018,597 - 57,021,302 (-)NCBI
RGSC_v3.41057,531,661 - 57,534,366 (-)RGD
Celera1054,510,819 - 54,513,524 (-)RGD
Sequence:
RefSeq Acc Id: NP_071956   ⟸   NM_022511
- UniProtKB: P62963 (UniProtKB/Swiss-Prot),   A6HG86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005370   ⟸   ENSRNOT00000005370
Ensembl Acc Id: ENSRNOP00000093393   ⟸   ENSRNOT00000104684

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62963-F1-model_v2 AlphaFold P62963 1-140 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697372
Promoter ID:EPDNEW_R7895
Type:initiation region
Name:Pfn1_1
Description:profilin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01057,275,741 - 57,275,801EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621825 AgrOrtholog
BioCyc Gene G2FUF-24439 BioCyc
Ensembl Genes ENSRNOG00000003975 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005370.7 UniProtKB/Swiss-Prot
Gene3D-CATH Dynein light chain 2a, cytoplasmic UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623232 IMAGE-MGC_LOAD
InterPro PFN UniProtKB/Swiss-Prot
  PFN UniProtKB/Swiss-Prot
  PFN_sf UniProtKB/Swiss-Prot
  Profilin1/2/3_vertebrate UniProtKB/Swiss-Prot
  Profilin_CS UniProtKB/Swiss-Prot
KEGG Report rno:64303 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72445 IMAGE-MGC_LOAD
NCBI Gene 64303 ENTREZGENE
PANTHER PROFILIN UniProtKB/Swiss-Prot
  PTHR13936:SF14 UniProtKB/Swiss-Prot
Pfam Profilin UniProtKB/Swiss-Prot
PhenoGen Pfn1 PhenoGen
PRINTS PROFILINMAML UniProtKB/Swiss-Prot
PROSITE PROFILIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003975 RatGTEx
SMART PROF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55770 UniProtKB/Swiss-Prot
UniProt A0A8I6AKB2_RAT UniProtKB/TrEMBL
  A6HG80_RAT UniProtKB/TrEMBL
  A6HG83_RAT UniProtKB/TrEMBL
  A6HG86 ENTREZGENE, UniProtKB/TrEMBL
  P62963 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P10924 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pfn1  profilin 1    profilin  Name updated 1299863 APPROVED
2002-08-07 Pfn1  profilin      Symbol and Name status set to provisional 70820 PROVISIONAL