Acvr1c (activin A receptor type 1C) - Rat Genome Database

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Gene: Acvr1c (activin A receptor type 1C) Rattus norvegicus
Analyze
Symbol: Acvr1c
Name: activin A receptor type 1C
RGD ID: 621789
Description: Enables several functions, including ATP binding activity; BMP receptor binding activity; and activin binding activity. Involved in several processes, including brain development; cell surface receptor protein serine/threonine kinase signaling pathway; and response to aldosterone. Located in cell surface. Part of activin receptor complex. Biomarker of retinal degeneration. Orthologous to human ACVR1C (activin A receptor type 1C); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activin A receptor, type IC; activin receptor type IC; activin receptor type-1C; activin receptor-like kinase 7; ACTR-IC; Alk-7; Alk7; habrec1; TGF-beta type 1 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,224,322 - 63,301,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl363,227,559 - 63,301,205 (-)EnsemblGRCr8
mRatBN7.2342,815,490 - 42,892,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,822,610 - 42,892,327 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx346,155,042 - 46,224,767 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,750,410 - 54,820,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,529,199 - 52,598,998 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,272,859 - 44,342,501 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,270,653 - 44,342,355 (-)Ensemblrn6Rnor6.0
Rnor_5.0349,392,012 - 49,462,621 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4340,027,228 - 40,102,303 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera340,890,441 - 40,959,920 (-)NCBICelera
RGSC_v3.1339,923,599 - 39,998,675 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
carboplatin  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDD  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dieldrin  (ISO)
diuron  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
itraconazole  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
melphalan  (ISO)
methimazole  (EXP)
methylmercury(1+)  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
nickel atom  (ISO)
ozone  (ISO)
parathion  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
terbufos  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
activin receptor complex  (IBA,IDA,IEA,ISO)
cell surface  (IDA)
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Inman GJ, etal., Mol Pharmacol. 2002 Jul;62(1):65-74.
4. The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line. Jornvall H, etal., J Biol Chem. 2001 Feb 16;276(7):5140-6. Epub 2000 Nov 17.
5. Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells. Kim BC, etal., J Biol Chem. 2004 Jul 2;279(27):28458-65. doi: 10.1074/jbc.M313277200. Epub 2004 Apr 23.
6. Habrec1, a novel serine/threonine kinase TGF-beta type I-like receptor, has a specific cellular expression suggesting function in the developing organism and adult brain. Lorentzon M, etal., Exp Neurol. 1996 Dec;142(2):351-60.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system. Ryden M, etal., J Biol Chem 1996 Nov 29;271(48):30603-9.
14. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Tsuchida K, etal., Mol Cell Endocrinol. 2004 May 31;220(1-2):59-65.
15. Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain. Tsuchida K, etal., Mol Cell Neurosci 1996 Jun;7(6):467-78.
16. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Wang H, etal., Mol Endocrinol. 2006 Oct;20(10):2469-82. Epub 2006 May 18.
17. Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines. Zhang N, etal., Diabetologia. 2006 Mar;49(3):506-18. Epub 2006 Jan 27.
Additional References at PubMed
PMID:9920806   PMID:12063393   PMID:15150278   PMID:15485907   PMID:15531507   PMID:18480258   PMID:18480259   PMID:21356369   PMID:21805089   PMID:22550067   PMID:25577243   PMID:35666032  


Genomics

Comparative Map Data
Acvr1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,224,322 - 63,301,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl363,227,559 - 63,301,205 (-)EnsemblGRCr8
mRatBN7.2342,815,490 - 42,892,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,822,610 - 42,892,327 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx346,155,042 - 46,224,767 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,750,410 - 54,820,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,529,199 - 52,598,998 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,272,859 - 44,342,501 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,270,653 - 44,342,355 (-)Ensemblrn6Rnor6.0
Rnor_5.0349,392,012 - 49,462,621 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4340,027,228 - 40,102,303 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera340,890,441 - 40,959,920 (-)NCBICelera
RGSC_v3.1339,923,599 - 39,998,675 (-)NCBI
Cytogenetic Map3q21NCBI
ACVR1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382157,526,767 - 157,628,864 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2157,526,767 - 157,628,885 (-)Ensemblhg38GRCh38
GRCh372158,383,279 - 158,485,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362158,097,150 - 158,193,645 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342158,214,411 - 158,310,902NCBI
Celera2151,996,398 - 152,098,507 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2150,268,922 - 150,370,677 (-)NCBIHuRef
CHM1_12158,389,261 - 158,491,360 (-)NCBICHM1_1
T2T-CHM13v2.02157,980,200 - 158,081,964 (-)NCBIT2T-CHM13v2.0
Acvr1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39258,157,465 - 58,247,909 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl258,157,465 - 58,247,907 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38258,267,453 - 58,357,896 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl258,267,453 - 58,357,895 (-)Ensemblmm10GRCm38
MGSCv37258,119,864 - 58,210,169 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36258,087,208 - 58,140,193 (-)NCBIMGSCv36mm8
Celera260,022,538 - 60,113,847 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map233.05NCBI
Acvr1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544915,813,856 - 15,858,537 (+)Ensembl
ChiLan1.0NW_00495544915,814,230 - 15,864,747 (+)NCBIChiLan1.0ChiLan1.0
ACVR1C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21360,191,507 - 60,289,620 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B60,206,482 - 60,304,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B44,785,808 - 44,883,977 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B162,027,016 - 162,080,583 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B162,034,161 - 162,124,151 (-)EnsemblpanPan2panpan1.1
ACVR1C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1363,534,231 - 3,583,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl363,541,248 - 3,613,384 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha363,671,176 - 3,750,547 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0363,656,388 - 3,735,771 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl363,662,294 - 3,736,109 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1363,658,544 - 3,737,821 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0363,718,246 - 3,797,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0363,756,338 - 3,835,686 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acvr1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303120,653,036 - 120,725,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646920,892,466 - 20,960,098 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646920,892,715 - 20,964,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR1C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1564,455,989 - 64,529,107 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11564,452,632 - 64,529,329 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21571,381,954 - 71,455,690 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR1C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11042,935,085 - 43,030,581 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1042,942,284 - 42,994,488 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040156,542,844 - 156,643,373 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvr1c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247328,130,962 - 8,247,289 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247328,130,970 - 8,247,528 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acvr1c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1536,071,340 - 36,149,299 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acvr1c
853 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:40
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000059280
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)35860129171157804Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)35911940270710963Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat

Markers in Region
BE118782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2342,860,767 - 42,860,923 (+)MAPPERmRatBN7.2
Rnor_6.0344,310,935 - 44,311,090NCBIRnor6.0
Rnor_5.0349,431,376 - 49,431,531UniSTSRnor5.0
RGSC_v3.4340,067,971 - 40,068,126UniSTSRGSC3.4
Celera340,928,507 - 40,928,662UniSTS
RH 3.4 Map3555.5UniSTS
Cytogenetic Map3q21UniSTS
BF390693  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2342,834,749 - 42,834,906 (+)MAPPERmRatBN7.2
Rnor_6.0344,285,018 - 44,285,174NCBIRnor6.0
Rnor_5.0349,404,375 - 49,404,531UniSTSRnor5.0
RGSC_v3.4340,039,286 - 40,039,442UniSTSRGSC3.4
Celera340,902,581 - 40,902,737UniSTS
RH 3.4 Map3556.4UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 59 130 91 90 59 73 59 6 326 162 10 104 81 89 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000059280   ⟹   ENSRNOP00000056047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,231,442 - 63,301,154 (-)Ensembl
mRatBN7.2 Ensembl342,822,610 - 42,892,327 (-)Ensembl
Rnor_6.0 Ensembl344,270,653 - 44,342,355 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099861   ⟹   ENSRNOP00000088735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,231,442 - 63,301,154 (-)Ensembl
mRatBN7.2 Ensembl342,822,610 - 42,892,327 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101769   ⟹   ENSRNOP00000083168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,231,442 - 63,301,205 (-)Ensembl
mRatBN7.2 Ensembl342,822,610 - 42,892,327 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107627   ⟹   ENSRNOP00000094234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,231,442 - 63,270,994 (-)Ensembl
mRatBN7.2 Ensembl342,822,610 - 42,862,166 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125981   ⟹   ENSRNOP00000104089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl363,227,559 - 63,301,154 (-)Ensembl
RefSeq Acc Id: NM_139090   ⟹   NP_620790
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,231,442 - 63,301,154 (-)NCBI
mRatBN7.2342,822,610 - 42,892,327 (-)NCBI
Rnor_6.0344,272,859 - 44,342,501 (-)NCBI
Rnor_5.0349,392,012 - 49,462,621 (-)NCBI
RGSC_v3.4340,027,228 - 40,102,303 (-)RGD
Celera340,890,441 - 40,959,920 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104246   ⟹   XP_038960174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8363,224,322 - 63,301,252 (-)NCBI
mRatBN7.2342,815,490 - 42,892,423 (-)NCBI
Protein Sequences
Protein RefSeqs NP_620790 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960174 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB04813 (Get FASTA)   NCBI Sequence Viewer  
  AAC52803 (Get FASTA)   NCBI Sequence Viewer  
  AAC52919 (Get FASTA)   NCBI Sequence Viewer  
  EDM00404 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056047
GenBank Protein P70539 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620790   ⟸   NM_139090
- Peptide Label: precursor
- UniProtKB: P70603 (UniProtKB/Swiss-Prot),   P70539 (UniProtKB/Swiss-Prot),   F1LQM3 (UniProtKB/TrEMBL),   A6JF56 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056047   ⟸   ENSRNOT00000059280
RefSeq Acc Id: XP_038960174   ⟸   XM_039104246
- Peptide Label: isoform X1
- UniProtKB: P70603 (UniProtKB/Swiss-Prot),   P70539 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000094234   ⟸   ENSRNOT00000107627
Ensembl Acc Id: ENSRNOP00000088735   ⟸   ENSRNOT00000099861
Ensembl Acc Id: ENSRNOP00000083168   ⟸   ENSRNOT00000101769
Ensembl Acc Id: ENSRNOP00000104089   ⟸   ENSRNOT00000125981
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70539-F1-model_v2 AlphaFold P70539 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621789 AgrOrtholog
BioCyc Gene G2FUF-49658 BioCyc
Ensembl Genes ENSRNOG00000004828 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000059280 ENTREZGENE
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Activin_recp UniProtKB/Swiss-Prot
  GS_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Snake_toxin-like_sf UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:245921 UniProtKB/Swiss-Prot
NCBI Gene 245921 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-1C UniProtKB/Swiss-Prot
  PTHR23255 UniProtKB/Swiss-Prot
Pfam Activin_recp UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  TGF_beta_GS UniProtKB/Swiss-Prot
PhenoGen Acvr1c PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS51256 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004828 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
  SM00467 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF57302 UniProtKB/Swiss-Prot
UniProt A0A8I5ZUX4_RAT UniProtKB/TrEMBL
  A0A8I6A748_RAT UniProtKB/TrEMBL
  A0A8I6AKH6_RAT UniProtKB/TrEMBL
  A0ABK0LKP7_RAT UniProtKB/TrEMBL
  A6JF56 ENTREZGENE, UniProtKB/TrEMBL
  ACV1C_RAT UniProtKB/Swiss-Prot
  F1LQM3 ENTREZGENE, UniProtKB/TrEMBL
  P70539 ENTREZGENE
  P70603 ENTREZGENE
UniProt Secondary P70603 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvr1c  activin A receptor type 1C  Acvr1c  activin A receptor, type IC  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Acvr1c  activin A receptor, type IC    activin receptor-like kinase 7  Name updated 1299863 APPROVED
2004-09-10 Acvr1c  activin receptor-like kinase 7  Alk7    Symbol and Name updated 1299863 APPROVED
2002-08-07 Alk7  activin receptor-like kinase 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons of various regions of the adult central nervous system 631880