RGD Reference Report - Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain. - Rat Genome Database

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Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain.

Authors: Tsuchida, K  Sawchenko, PE  Nishikawa, S  Vale, WW 
Citation: Tsuchida K, etal., Mol Cell Neurosci 1996 Jun;7(6):467-78.
RGD ID: 631881
Pubmed: PMID:8875430   (View Abstract at PubMed)

Growth factors belonging to the TGF beta superfamily bind to and signal through a receptor complex comprising two transmembrane serine/threonine kinases, called type I and type II. Each receptor is responsible for the signaling of the individual TGF beta superfamily members. So far, five type II and six type I receptors have been cloned from mammalian sources. We report here the molecular cloning of a novel type I receptor serine/threonine kinase, ALK7 (activin receptor-like kinase 7), from rat brain. ALK7 shows a significant sequence similarity with TGF beta RI and ActRIB in the intracellular kinase domain and is quite distinct from other type I receptors in the extracellular domain. ALK7 mRNA is expressed in embryonic and in adult rat brain, where it was localized in superficial layers of the forebrain, the CA3 pyramidal subfield of hippocampus, the basal ganglia, the thalamus, and the cerebellar cortex. The functionality of the receptor was demonstrated by the identification of a constitutively active point mutant of ALK7 that activates the TGF beta/activin-responsive reporter without any ligand stimulation. Although the endogenous ligand for ALK7 has yet to be identified, its extensive anatomic distribution in brain, gut, spleen, and lung suggests important roles for this orphan receptor.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
activin receptor activity, type I enablesIDA 631881PMID:8875430UniProt 
metal ion binding enablesICGO:0016361631881PMID:8875430UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Acvr1c  (activin A receptor type 1C)


Additional Information