Dhcr7 (7-dehydrocholesterol reductase) - Rat Genome Database

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Gene: Dhcr7 (7-dehydrocholesterol reductase) Rattus norvegicus
Analyze
Symbol: Dhcr7
Name: 7-dehydrocholesterol reductase
RGD ID: 621769
Description: Enables 7-dehydrocholesterol reductase activity. Involved in cholesterol biosynthetic process and regulation of cholesterol biosynthetic process. Predicted to be located in nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease and Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase); PARTICIPATES IN cholesterol biosynthetic pathway; steroid biosynthetic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 7-DHC reductase; cholesterol-5,6-epoxide hydrolase subunit DHCR7; MGC93039; sterol Delta(7)-reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,444,434 - 208,460,408 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1208,444,434 - 208,461,382 (+)EnsemblGRCr8
mRatBN7.21199,015,081 - 199,031,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,015,081 - 199,031,055 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1207,394,648 - 207,410,602 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,476,501 - 214,492,466 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,150,670 - 207,166,635 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,018,916 - 217,034,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,018,916 - 217,034,904 (+)Ensemblrn6Rnor6.0
Rnor_5.01223,874,935 - 223,890,913 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41204,245,562 - 204,258,913 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1196,577,886 - 196,593,821 (+)NCBICelera
RGSC_v3.11204,399,014 - 204,412,366 (+)NCBI
Cytogenetic Map1q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
Acetyl tributyl citrate  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cariprazine  (ISO)
cerium trichloride  (ISO)
chlorpyrifos  (ISO)
cholesta-5,7-dien-3beta-ol  (ISO)
cholesterol  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
Febrifugine  (ISO)
fenarimol  (EXP)
fenthion  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
galaxolide  (EXP)
Ganoderic acid A  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
linalool  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
motexafin gadolinium  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nitroglycerin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylpropanolamine  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
ritonavir  (EXP)
rotenone  (ISO)
selenium atom  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
triacsin C  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zinc acetate  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. Bae SH, etal., J Biol Chem 1999 May 21;274(21):14624-31.
2. Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population. Fang J, etal., Am J Ophthalmol. 2014 Feb;157(2):488-494.e6. doi: 10.1016/j.ajo.2013.10.010. Epub 2013 Nov 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
6. The human lamin B receptor/sterol reductase multigene family. Holmer L, etal., Genomics 1998 Dec 15;54(3):469-76.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Association of circulating 25-hydroxyvitamin D levels with hypertension and blood pressure values in Korean adults: A Mendelian randomization study on a subset of the Korea National Health and Nutrition Survey 2011-2012 population. Kwak SY, etal., Nutr Res Pract. 2019 Dec;13(6):498-508. doi: 10.4162/nrp.2019.13.6.498. Epub 2019 Aug 13.
9. Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene. Lee JN, etal., Biochim Biophys Acta 2002 Jun 7;1576(1-2):148-56.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Evidence for requirement of NADPH-cytochrome P450 oxidoreductase in the microsomal NADPH-sterol Delta7-reductase system. Nishino H and Ishibashi T, Arch Biochem Biophys. 2000 Feb 15;374(2):293-8.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation. Shefer S, etal., J Lipid Res. 1998 Dec;39(12):2471-6.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome. Wassif CA, etal., Hum Mol Genet 2001 Mar 15;10(6):555-64.
21. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
22. Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene. Waterham HR, etal., Am J Hum Genet. 1998 Aug;63(2):329-38.
Additional References at PubMed
PMID:9465114   PMID:11792727   PMID:15005800   PMID:15489334   PMID:19946888   PMID:37329988  


Genomics

Comparative Map Data
Dhcr7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,444,434 - 208,460,408 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1208,444,434 - 208,461,382 (+)EnsemblGRCr8
mRatBN7.21199,015,081 - 199,031,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,015,081 - 199,031,055 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1207,394,648 - 207,410,602 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,476,501 - 214,492,466 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,150,670 - 207,166,635 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,018,916 - 217,034,890 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,018,916 - 217,034,904 (+)Ensemblrn6Rnor6.0
Rnor_5.01223,874,935 - 223,890,913 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41204,245,562 - 204,258,913 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1196,577,886 - 196,593,821 (+)NCBICelera
RGSC_v3.11204,399,014 - 204,412,366 (+)NCBI
Cytogenetic Map1q42NCBI
DHCR7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,427,287 - 71,449,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,428,193 - 71,452,868 (-)Ensemblhg38GRCh38
GRCh371171,138,333 - 71,160,089 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,823,105 - 70,837,125 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341170,823,110 - 70,837,047NCBI
Celera1168,438,984 - 68,453,003 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1167,439,049 - 67,453,070 (-)NCBIHuRef
CHM1_11171,029,428 - 71,043,448 (-)NCBICHM1_1
T2T-CHM13v2.01171,354,234 - 71,375,999 (-)NCBIT2T-CHM13v2.0
Dhcr7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,376,827 - 143,402,147 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,376,882 - 143,402,147 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387143,823,167 - 143,848,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,823,145 - 143,848,410 (+)Ensemblmm10GRCm38
MGSCv377151,009,072 - 151,034,315 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367143,632,557 - 143,657,800 (+)NCBIMGSCv36mm8
Celera7143,579,742 - 143,604,212 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.33NCBI
Dhcr7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542215,119,173 - 15,136,771 (+)Ensembl
ChiLan1.0NW_00495542215,119,155 - 15,136,771 (+)NCBIChiLan1.0ChiLan1.0
DHCR7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2972,320,577 - 72,334,547 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11173,363,320 - 73,376,738 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01166,450,230 - 66,464,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11169,721,741 - 69,735,715 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1169,721,741 - 69,735,715 (-)EnsemblpanPan2panpan1.1
DHCR7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11847,257,750 - 47,277,436 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1847,261,730 - 47,274,236 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1845,862,457 - 45,882,527 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,935,184 - 47,955,313 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,938,180 - 47,955,305 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11847,376,200 - 47,396,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,962,021 - 46,982,089 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01847,708,851 - 47,728,938 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101971285
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049473,490,627 - 3,493,336 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367941,432,379 - 1,468,966 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHCR7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl22,377,416 - 2,391,447 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.122,377,352 - 2,391,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22851,404 - 864,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHCR7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.113,243,263 - 3,257,332 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl13,243,313 - 3,257,487 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038100,430,412 - 100,444,448 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhcr7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476716,118,052 - 16,132,834 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476716,118,157 - 16,132,225 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dhcr7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v125,862,552 - 5,879,800 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dhcr7
154 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:89
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000028195
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH128054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,030,690 - 199,030,900 (+)MAPPERmRatBN7.2
Rnor_6.01217,034,526 - 217,034,735NCBIRnor6.0
Rnor_5.01223,890,549 - 223,890,758UniSTSRnor5.0
RGSC_v3.41204,258,549 - 204,258,758UniSTSRGSC3.4
Celera1196,593,457 - 196,593,666UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 91 59 6 355 191 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001438360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001438361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001438362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001438363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB016800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC094001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF272393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF279892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028195   ⟹   ENSRNOP00000028194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1208,444,434 - 208,460,408 (+)Ensembl
mRatBN7.2 Ensembl1199,015,081 - 199,031,055 (+)Ensembl
Rnor_6.0 Ensembl1217,018,916 - 217,034,890 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078979   ⟹   ENSRNOP00000071939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1208,446,632 - 208,461,382 (+)Ensembl
mRatBN7.2 Ensembl1199,017,279 - 199,031,055 (+)Ensembl
Rnor_6.0 Ensembl1217,019,051 - 217,034,904 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162673   ⟹   ENSRNOP00000103661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1208,450,912 - 208,461,382 (+)Ensembl
RefSeq Acc Id: NM_022389   ⟹   NP_071784
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,434 - 208,460,408 (+)NCBI
mRatBN7.21199,015,081 - 199,031,055 (+)NCBI
Rnor_6.01217,018,916 - 217,034,890 (+)NCBI
Rnor_5.01223,874,935 - 223,890,913 (+)NCBI
RGSC_v3.41204,245,562 - 204,258,913 (+)RGD
Celera1196,577,886 - 196,593,821 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230893   ⟹   XP_006230955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,546 - 208,460,408 (+)NCBI
mRatBN7.21199,015,133 - 199,031,055 (+)NCBI
Rnor_6.01217,019,017 - 217,034,890 (+)NCBI
Rnor_5.01223,874,935 - 223,890,913 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230894   ⟹   XP_006230956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,566 - 208,460,408 (+)NCBI
mRatBN7.21199,015,234 - 199,031,055 (+)NCBI
Rnor_6.01217,019,041 - 217,034,890 (+)NCBI
Rnor_5.01223,874,935 - 223,890,913 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089500   ⟹   XP_038945428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,564 - 208,460,408 (+)NCBI
mRatBN7.21199,015,188 - 199,031,055 (+)NCBI
RefSeq Acc Id: XM_063272737   ⟹   XP_063128807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,505 - 208,460,408 (+)NCBI
RefSeq Acc Id: XM_063272738   ⟹   XP_063128808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,953 - 208,460,408 (+)NCBI
RefSeq Acc Id: XM_063272739   ⟹   XP_063128809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,951 - 208,460,408 (+)NCBI
RefSeq Acc Id: NP_071784   ⟸   NM_022389
- UniProtKB: Q9Z2Z8 (UniProtKB/Swiss-Prot),   A6HYE0 (UniProtKB/TrEMBL),   A0A8L2R4U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230955   ⟸   XM_006230893
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006230956   ⟸   XM_006230894
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000028194   ⟸   ENSRNOT00000028195
Ensembl Acc Id: ENSRNOP00000071939   ⟸   ENSRNOT00000078979
RefSeq Acc Id: XP_038945428   ⟸   XM_039089500
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128807   ⟸   XM_063272737
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128809   ⟸   XM_063272739
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Z8 (UniProtKB/Swiss-Prot),   A6HYE0 (UniProtKB/TrEMBL),   A0A8L2R4U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128808   ⟸   XM_063272738
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Z8 (UniProtKB/Swiss-Prot),   A6HYE0 (UniProtKB/TrEMBL),   A0A8L2R4U0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103661   ⟸   ENSRNOT00000162673

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2Z8-F1-model_v2 AlphaFold Q9Z2Z8 1-471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690582
Promoter ID:EPDNEW_R1105
Type:initiation region
Name:Dhcr7_1
Description:7-dehydrocholesterol reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,019,083 - 217,019,143EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621769 AgrOrtholog
BioCyc Gene G2FUF-56855 BioCyc
BioCyc Pathway PWY66-4 [cholesterol biosynthesis III (via desmosterol)] BioCyc
BioCyc Pathway Image PWY66-4 BioCyc
Ensembl Genes ENSRNOG00000020776 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028195 ENTREZGENE
  ENSRNOT00000028195.6 UniProtKB/Swiss-Prot
  ENSRNOT00000078979 ENTREZGENE
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109221 IMAGE-MGC_LOAD
InterPro Ergosterol_biosynth_ERG4_ERG24 UniProtKB/Swiss-Prot
  Sterol_reductase_CS UniProtKB/Swiss-Prot
KEGG Report rno:64191 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93039 IMAGE-MGC_LOAD
NCBI Gene 64191 ENTREZGENE
PANTHER 7-DEHYDROCHOLESTEROL REDUCTASE UniProtKB/Swiss-Prot
  DELTA(14)-STEROL REDUCTASE UniProtKB/Swiss-Prot
Pfam ERG4_ERG24 UniProtKB/Swiss-Prot
PhenoGen Dhcr7 PhenoGen
PROSITE STEROL_REDUCT_1 UniProtKB/Swiss-Prot
  STEROL_REDUCT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020776 RatGTEx
UniProt A0A8L2R4U0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LL20_RAT UniProtKB/TrEMBL
  A6HYE0 ENTREZGENE, UniProtKB/TrEMBL
  A6HYE4_RAT UniProtKB/TrEMBL
  DHCR7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dhcr7  7-dehydrocholesterol reductase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dhcr7  7-dehydrocholesterol reductase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog involved in Smith-Lemli-Opitz syndrome 632010
gene_expression expressed in liver, kidney and brain 632010
gene_protein 471 amino acid; 54 kDa 632010