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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhcr7
Name: 7-dehydrocholesterol reductase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhcr7affects expressionEXP 6480464CTDbisphenol A affects the expression of DHCR7 mRNAPMID:25181051 PMID:30903817 PMID:32145629
Dhcr7decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of DHCR7 mRNAPMID:15901920
Dhcr7increases expressionEXP 6480464CTDbisphenol A results in increased expression of DHCR7 mRNAPMID:31771501
Dhcr7increases methylationEXP 6480464CTDbisphenol A results in increased methylation of DHCR7 genePMID:28505145
Dhcr7affects expressionISODHCR7 (Homo sapiens)6480464CTDbisphenol A affects the expression of DHCR7 proteinPMID:37567409
Dhcr7affects expressionISODhcr7 (Mus musculus)6480464CTDbisphenol A affects the expression of DHCR7 mRNAPMID:21636974
Dhcr7increases expressionISODHCR7 (Homo sapiens)6480464CTDbisphenol A results in increased expression of DHCR7 mRNA; bisphenol A results in increased expression of DHCR7 proteinPMID:29275510 PMID:34186270
Dhcr7increases expressionISODhcr7 (Mus musculus)6480464CTDbisphenol A results in increased expression of DHCR7 mRNAPMID:25270620
Dhcr7multiple interactionsISODhcr7 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of DHCR7 mRNAPMID:28433925
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