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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhcr7
Name: 7-dehydrocholesterol reductase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhcr7affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of DHCR7 mRNAPMID:22298810
Dhcr7decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of DHCR7 mRNAPMID:21215274 PMID:21724226 PMID:32109520
Dhcr7affects expressionISODhcr7 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of DHCR7 mRNAPMID:21570461 PMID:26377647
Dhcr7multiple interactionsISODhcr7 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of DHCR7 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHCR7 mRNAPMID:17942748 PMID:28433925
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