Sftpb (surfactant protein B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sftpb (surfactant protein B) Rattus norvegicus
Analyze
Symbol: Sftpb
Name: surfactant protein B
RGD ID: 621700
Description: Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to dexamethasone. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of asthma; congenital diaphragmatic hernia; lung disease (multiple); and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B); INTERACTS WITH (R)-lipoic acid; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pulmonary surfactant-associated protein B; pulmonary surfactant-associated proteolipid SPL(Phe); Sp-b; surfactant associated protein B; surfactant pulmonary-associated protein B; surfactant, pulmonary-associated protein B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84105,917,495 - 105,926,631 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4105,917,578 - 105,927,646 (+)EnsemblGRCr8
mRatBN7.24104,359,303 - 104,368,439 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,359,396 - 104,368,436 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4109,739,790 - 109,748,813 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,514,908 - 105,523,931 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,129,047 - 104,138,091 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,166,855 - 100,175,941 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,166,863 - 100,175,938 (+)Ensemblrn6Rnor6.0
Rnor_5.04164,937,638 - 164,946,703 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44105,609,410 - 105,618,452 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera493,513,449 - 93,522,486 (+)NCBICelera
RGSC_v3.14105,853,890 - 105,862,933 (+)NCBI
RH 3.4 Map4631.95RGD
Cytogenetic Map4q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinol  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
ATP  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bosentan  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
dichlorine  (ISO)
Didecyldimethylammonium  (ISO)
dioxygen  (EXP,ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
liraglutide  (EXP)
malathion  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-5'-carboxamidoadenosine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP,ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
Ro 31-8220  (EXP)
rosmarinic acid  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbutaline  (EXP,ISO)
theophylline  (ISO)
thiram  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
UTP  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
vitamin E  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Surfactant protein deficiency in familial interstitial lung disease. Amin RS, etal., J Pediatr. 2001 Jul;139(1):85-92.
2. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. Atochina EN, etal., J Lab Clin Med. 2001 Jun;137(6):429-39.
3. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Atochina EN, etal., Respir Res. 2003 Dec 8;4:15. Print 2003.
4. Immune reconstitution during Pneumocystis lung infection: disruption of surfactant component expression and function by S-nitrosylation. Atochina-Vasserman EN, etal., J Immunol. 2009 Feb 15;182(4):2277-87.
5. Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency. Barnett RC, etal., Exp Biol Med (Maywood). 2017 Jul;242(13):1345-1354. doi: 10.1177/1535370217713000. Epub 2017 Jun 5.
6. [Effect of intrauterine acute ischemic-hypoxia on the expression of lung SP-A and SP-B in neonatal rats] Cai XX, etal., Zhonghua Er Ke Za Zhi. 2003 Mar;41(3):208-11.
7. Mild vitamin A deficiency delays fetal lung maturation in the rat. Chailley-Heu B, etal., Am J Respir Cell Mol Biol. 1999 Jul;21(1):89-96.
8. High-dose vascular endothelial growth factor increases surfactant protein gene expressions in preterm rat lung. Chen CM and Wang LF, Early Hum Dev. 2007 Sep;83(9):581-4. Epub 2007 Jan 30.
9. Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration. Cleary GM, etal., Pediatrics. 1997 Dec;100(6):998-1003.
10. Surfactant proteins-A and -B are elevated in plasma of patients with acute respiratory failure. Doyle IR, etal., Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1217-29.
11. cDNA and deduced amino acid sequence for the rat hydrophobic pulmonary surfactant-associated protein, SP-B. Emrie PA, etal., Biochim Biophys Acta 1989 Feb 23;994(3):215-21.
12. Surfactant protein B inhibits endotoxin-induced lung inflammation. Epaud R, etal., Am J Respir Cell Mol Biol. 2003 Mar;28(3):373-8.
13. Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma. Erpenbeck VJ, etal., Allergy. 2006 May;61(5):598-604.
14. Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers. Ewis AA, etal., Am J Ind Med. 2006 May;49(5):367-73.
15. Hormonal effects on the surfactant protein B (SP-B) mRNA in cultured fetal rat lung. Floros J, etal., Am J Respir Cell Mol Biol. 1991 May;4(5):449-54. doi: 10.1165/ajrcmb/4.5.449.
16. Dinucleotide repeats in the human surfactant protein-B gene and respiratory-distress syndrome. Floros J, etal., Biochem J. 1995 Jan 15;305 ( Pt 2):583-90.
17. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Foreman MG, etal., Eur Respir J. 2008 Oct;32(4):938-44. Epub 2008 Jun 11.
18. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Fredenburgh LE, etal., Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):513-20.
19. [Expression of HoxB5 mRNA and their effect on lung development in premature rats with hyperoxia-induced chronic lung disease] Fu JH, etal., Zhonghua Er Ke Za Zhi. 2008 Jul;46(7):540-3.
20. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Fujita M, etal., Cytokine. 2005 Jul 7;31(1):25-33.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Regulation of SP-B and SP-C secretion in rat type II cells in primary culture. Gobran LI and Rooney SA, Am J Physiol Lung Cell Mol Physiol 2001 Dec;281(6):L1413-9.
24. Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS. Gong MN, etal., Chest. 2004 Jan;125(1):203-11.
25. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Griese M, etal., Am J Respir Crit Care Med. 2004 Nov 1;170(9):1000-5. Epub 2004 Jul 21.
26. Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease. Griese M, etal., Respir Res. 2005 Jul 22;6:80.
27. Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients. Griese M, etal., Respir Res. 2005 Nov 7;6:133.
28. Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats. Guarino N, etal., J Pediatr Surg. 2000 Oct;35(10):1468-73. doi: 10.1053/jpsu.2000.16416.
29. Surfactant protein gene A, B, and D marker alleles in chronic obstructive pulmonary disease of a Mexican population. Guo X, etal., Eur Respir J. 2001 Sep;18(3):482-90.
30. Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype. Gutierrez JA, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):81-7. Epub 2003 Jan 31.
31. Defective surfactant secretion in a mouse model of Hermansky-Pudlak syndrome. Guttentag SH, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):14-21. Epub 2005 Mar 24.
32. Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome. Haataja R, etal., Hum Mol Genet. 2000 Nov 1;9(18):2751-60.
33. Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice. Haczku A, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):45-50.
34. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Hersh CP, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):71-8. Epub 2005 Apr 7.
35. Surfactant protein B 1580 polymorphism is associated with susceptibility to chronic obstructive pulmonary disease in Chinese Han population. Hu R, etal., J Huazhong Univ Sci Technolog Med Sci. 2004;24(3):216-8, 238.
36. Reversibility of lung inflammation caused by SP-B deficiency. Ikegami M, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L962-70. Epub 2005 Jul 15.
37. Effects of intrauterine IL-6 and IL-8 on the expression of surfactant apoprotein mRNAs in the fetal rat lung. Ikegami T, etal., Eur J Obstet Gynecol Reprod Biol. 2000 Nov;93(1):97-103.
38. Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats. Inselman LS, etal., Lung. 2004;182(2):101-17.
39. Pulmonary alveolar proteinosis in SCID mice. Jennings VM, etal., Am J Respir Cell Mol Biol. 1995 Sep;13(3):297-306.
40. Surfactant protein levels in severe respiratory syncytial virus infection. Kerr MH and Paton JY, Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1115-8.
41. Circadian rhythm of surfactant protein A, B and C mRNA in rats. Kim CM, etal., Korean J Intern Med. 2003 Jun;18(2):76-82.
42. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
43. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Lee JW, etal., Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L950-7. Epub 2005 Jan 7.
44. Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production. Lee S, etal., Cell Physiol Biochem. 2017;42(4):1684-1700. doi: 10.1159/000479418. Epub 2017 Jul 25.
45. Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids. Losada A, etal., Endocrinology. 2000 Jun;141(6):2166-73.
46. Effect of epidermal growth factor and dexamethasone on fetal rat lung development. Ma L, etal., Chin Med J (Engl). 2009 Sep 5;122(17):2013-6.
47. Polymorphisms of surfactant protein B encoding gene: modifiers of the course of neonatal respiratory distress syndrome? Makri V, etal., Eur J Pediatr. 2002 Nov;161(11):604-8. Epub 2002 Sep 13.
48. SP-B deficiency causes respiratory failure in adult mice. Melton KR, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L543-9. Epub 2003 Mar 14.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds. Nogee LM, etal., J Clin Invest. 1994 Apr;93(4):1860-3.
51. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
52. Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia. Pavlovic J, etal., Dis Markers. 2006;22(5-6):277-91.
53. Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma. Puthothu B, etal., BMC Pulm Med. 2007 May 11;7:6.
54. Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. Quasney MW, etal., Crit Care Med. 2004 May;32(5):1115-9.
55. Glucose decreases steady state mRNA content of hydrophobic surfactant proteins B and C in fetal rat lung explants. Rayani HH, etal., Exp Lung Res. 1999 Jan-Feb;25(1):69-79.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Comprehensive gene review and curation RGD comprehensive gene curation
60. Data mining and multiparameter analysis of lung surfactant protein genes in bronchopulmonary dysplasia. Rova M, etal., Hum Mol Genet. 2004 Jun 1;13(11):1095-104. Epub 2004 Apr 21.
61. Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia. Russo TA, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L655-63.
62. Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C. Savani RC, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L685-96.
63. Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration. Schmidt R, etal., Respir Res. 2007 Jul 27;8:55.
64. Decrease of the surface fraction of surfactant proteins containing clara cells and type II pneumocytes in a rat asthma model. Schmiedl A, etal., Exp Toxicol Pathol. 2005 Mar;56(4-5):265-72.
65. Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study. Schmiedl A, etal., Histochem Cell Biol. 2005 Dec;124(6):465-76. Epub 2005 Sep 27.
66. Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients. Seifart C, etal., Br J Cancer. 2002 Jul 15;87(2):212-7. doi: 10.1038/sj.bjc.6600353.
67. Surfactant protein B intron 4 variation in German patients with COPD and acute respiratory failure. Seifart C, etal., Dis Markers. 2002;18(3):129-36.
68. Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis. Selman M, etal., Hum Genet. 2003 Nov;113(6):542-50. Epub 2003 Sep 6.
69. Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis. Seymour JF, etal., Thorax. 2003 Mar;58(3):252-7.
70. Relationship between surfactant proteins B and C and obstructive sleep apnea: is serum SP-B concentration a potential biomarker of obstructive sleep apnea? Shao L, etal., Sleep Breath. 2016 Mar;20(1):25-31. doi: 10.1007/s11325-015-1179-x. Epub 2015 May 8.
71. Pro-surfactant protein B as a biomarker for lung cancer prediction. Sin DD, etal., J Clin Oncol. 2013 Dec 20;31(36):4536-43. doi: 10.1200/JCO.2013.50.6105. Epub 2013 Nov 18.
72. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
73. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury. Sugahara K, etal., Lab Invest. 1996 Jan;74(1):209-20.
74. Genetic polymorphisms in the surfactant proteins in systemic sclerosis in Japanese: T/T genotype at 1580 C/T (Thr131Ile) in the SP-B gene reduces the risk of interstitial lung disease. Sumita Y, etal., Rheumatology (Oxford). 2008 Mar;47(3):289-91. Epub 2008 Feb 8.
75. Lung protein leakage in respiratory failure induced by a hybridoma making monoclonal antibody to the hydrophobic surfactant-associated polypeptide SP-B. Suzuki Y, etal., Int J Exp Pathol. 1992 Jun;73(3):325-33.
76. Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury. Tokieda K, etal., Am J Respir Cell Mol Biol. 1999 Oct;21(4):463-72.
77. Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. Torday JS, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Mar;282(3):L405-10. doi: 10.1152/ajplung.2002.282.3.L405.
78. Congenital alveolar proteinosis caused by a novel mutation of the surfactant protein B gene and misalignment of lung vessels in consanguineous kindred infants. Wallot M, etal., Eur J Pediatr. 1999 Jun;158(6):513-8. doi: 10.1007/s004310051132.
79. Dimeric surfactant protein B peptide sp-b(1-25) in neonatal and acute respiratory distress syndrome. Walther FJ, etal., Exp Lung Res. 2002 Dec;28(8):623-40.
80. Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients. Wang K, etal., J Cell Biochem. 2019 Sep;120(9):14804-14812. doi: 10.1002/jcb.28741. Epub 2019 Apr 23.
81. [Effects of hydrogen sulfide on pulmonary surfactant in rats with acute lung injury induced by lipopolysccharide]. Wang P, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Nov;27(4):485-9.
82. The localization of SP-B and influences of lipopolysaccharide on it. Wang WN, etal., Eur Rev Med Pharmacol Sci. 2016 Jun;20(11):2338-45.
83. Processing of hydrophobic pulmonary surfactant protein B in rat type II cells. Weaver TE and Whitsett JA, Am J Physiol. 1989 Aug;257(2 Pt 1):L100-8. doi: 10.1152/ajplung.1989.257.2.L100.
84. Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia. White CW, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):51-9.
85. Surfactant protein B detection and gene expression in chronic rhinosinusitis. Woodworth BA, etal., Laryngoscope. 2007 Jul;117(7):1296-301.
86. Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. Yang L, etal., J Immunol. 2010 Jan 15;184(2):975-83. doi: 10.4049/jimmunol.0900650. Epub 2009 Dec 9.
87. Zhonghua er ke za zhi. Chinese journal of pediatrics Yin XJ, etal., Zhonghua Er Ke Za Zhi. 2008 Jan;46(1):9-12.
88. Effect of inhaled budesonide on surfactant protein expression in asthmatic mice. Yu ZW and Zhang JH, Allergy Asthma Proc. 2008 Sep-Oct;29(5):486-92.
89. Surfactant protein B gene polymorphisms is associated with risk of bronchopulmonary dysplasia in Chinese Han population. Zhang S, etal., Int J Clin Exp Pathol. 2015 Mar 1;8(3):2971-8. eCollection 2015.
Additional References at PubMed
PMID:8813084   PMID:12904592   PMID:16794256   PMID:18344412   PMID:20023175   PMID:24191021   PMID:26196539   PMID:27155084   PMID:30341519   PMID:33248225   PMID:38483982  


Genomics

Comparative Map Data
Sftpb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84105,917,495 - 105,926,631 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4105,917,578 - 105,927,646 (+)EnsemblGRCr8
mRatBN7.24104,359,303 - 104,368,439 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,359,396 - 104,368,436 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4109,739,790 - 109,748,813 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,514,908 - 105,523,931 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,129,047 - 104,138,091 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,166,855 - 100,175,941 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,166,863 - 100,175,938 (+)Ensemblrn6Rnor6.0
Rnor_5.04164,937,638 - 164,946,703 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44105,609,410 - 105,618,452 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera493,513,449 - 93,522,486 (+)NCBICelera
RGSC_v3.14105,853,890 - 105,862,933 (+)NCBI
RH 3.4 Map4631.95RGD
Cytogenetic Map4q32NCBI
SFTPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,657,307 - 85,668,741 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,655,154 - 85,668,741 (-)Ensemblhg38GRCh38
GRCh37285,884,430 - 85,895,864 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,737,951 - 85,748,823 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34285,796,098 - 85,806,970NCBI
Celera285,712,739 - 85,724,163 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,781,765 - 85,793,199 (-)NCBIHuRef
CHM1_1285,814,217 - 85,825,673 (-)NCBICHM1_1
T2T-CHM13v2.0285,659,365 - 85,670,797 (-)NCBIT2T-CHM13v2.0
Sftpb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,281,594 - 72,291,354 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,281,594 - 72,291,354 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38672,304,610 - 72,314,373 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,304,610 - 72,314,371 (+)Ensemblmm10GRCm38
MGSCv37672,253,239 - 72,264,364 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36672,232,754 - 72,243,879 (+)NCBIMGSCv36mm8
Celera674,392,942 - 74,404,491 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Sftpb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,849,314 - 1,858,087 (+)Ensembl
ChiLan1.0NW_0049554241,849,313 - 1,858,087 (+)NCBIChiLan1.0ChiLan1.0
SFTPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,717,295 - 40,733,497 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,720,056 - 40,736,258 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,708,485 - 85,718,120 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,257,244 - 87,268,332 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,257,244 - 87,268,332 (-)EnsemblpanPan2panpan1.1
SFTPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,419,305 - 39,428,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,386,584 - 39,426,229 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1739,091,243 - 39,100,877 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01740,165,986 - 40,175,651 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,133,281 - 40,172,841 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,295,537 - 39,305,192 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,368,057 - 39,377,708 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,767,452 - 39,777,111 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sftpb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,235,909 - 79,243,514 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,614,979 - 1,622,466 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,614,979 - 1,621,207 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFTPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,101,981 - 59,112,396 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1359,101,940 - 59,113,442 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2361,901,846 - 61,913,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFTPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,487,424 - 21,497,491 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,488,387 - 21,499,850 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604590,974,475 - 90,981,286 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sftpb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,486,518 - 17,493,846 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474917,486,483 - 17,495,822 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Sftpb
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:42
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000014505
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
RH142439  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24104,368,194 - 104,368,365 (+)MAPPERmRatBN7.2
Rnor_6.04100,175,697 - 100,175,867NCBIRnor6.0
Rnor_5.04164,946,458 - 164,946,628UniSTSRnor5.0
RGSC_v3.44105,618,211 - 105,618,381UniSTSRGSC3.4
Celera493,522,245 - 93,522,415UniSTS
RH 3.4 Map4631.95UniSTS
Cytogenetic Map4q33UniSTS
PMC34520P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24104,361,112 - 104,361,502 (+)MAPPERmRatBN7.2
Rnor_6.04100,168,615 - 100,169,004NCBIRnor6.0
Rnor_5.04164,939,376 - 164,939,765UniSTSRnor5.0
RGSC_v3.44105,611,129 - 105,611,518UniSTSRGSC3.4
Celera493,515,169 - 93,515,558UniSTS
Cytogenetic Map4q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 11 28 53 55 54 23 46 23 6 149 103 8 27 8 37 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000014505   ⟹   ENSRNOP00000014505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4105,917,578 - 105,926,630 (+)Ensembl
mRatBN7.2 Ensembl4104,359,396 - 104,368,436 (+)Ensembl
Rnor_6.0 Ensembl4100,166,863 - 100,175,938 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150973   ⟹   ENSRNOP00000103580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4105,917,578 - 105,927,646 (+)Ensembl
RefSeq Acc Id: NM_138842   ⟹   NP_620197
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84105,917,588 - 105,926,630 (+)NCBI
mRatBN7.24104,359,396 - 104,368,436 (+)NCBI
Rnor_6.04100,166,896 - 100,175,938 (+)NCBI
Rnor_5.04164,937,638 - 164,946,703 (+)NCBI
RGSC_v3.44105,609,410 - 105,618,452 (+)RGD
Celera493,513,449 - 93,522,486 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236657   ⟹   XP_006236719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84105,917,495 - 105,926,631 (+)NCBI
mRatBN7.24104,359,303 - 104,368,439 (+)NCBI
Rnor_6.04100,166,855 - 100,175,941 (+)NCBI
Rnor_5.04164,937,638 - 164,946,703 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_620197 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236719 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH72466 (Get FASTA)   NCBI Sequence Viewer  
  CAA32885 (Get FASTA)   NCBI Sequence Viewer  
  EDL91019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000103580
GenBank Protein P22355 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620197   ⟸   NM_138842
- Peptide Label: precursor
- UniProtKB: P22355 (UniProtKB/Swiss-Prot),   Q6IN44 (UniProtKB/TrEMBL),   F7FPB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236719   ⟸   XM_006236657
- Peptide Label: isoform X1
- UniProtKB: P22355 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014505   ⟸   ENSRNOT00000014505
Ensembl Acc Id: ENSRNOP00000103580   ⟸   ENSRNOT00000150973
Protein Domains
Saposin A-type   Saposin B-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22355-F1-model_v2 AlphaFold P22355 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693123
Promoter ID:EPDNEW_R3648
Type:single initiation site
Name:Sftpb_1
Description:surfactant protein B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04100,166,886 - 100,166,946EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621700 AgrOrtholog
BioCyc Gene G2FUF-44154 BioCyc
Ensembl Genes ENSRNOG00000010761 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000150973 ENTREZGENE
Gene3D-CATH Saposin-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100971 IMAGE-MGC_LOAD
InterPro SAP_A UniProtKB/Swiss-Prot
  SapB_1 UniProtKB/Swiss-Prot
  SapB_2 UniProtKB/Swiss-Prot
  Saposin UniProtKB/Swiss-Prot
  Saposin-like UniProtKB/Swiss-Prot
  SaposinB_dom UniProtKB/Swiss-Prot
  Sphingo_Act-Surfact_Prot UniProtKB/Swiss-Prot
KEGG Report rno:192155 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91491 IMAGE-MGC_LOAD
NCBI Gene 192155 ENTREZGENE
PANTHER PULMONARY SURFACTANT-ASSOCIATED PROTEIN B UniProtKB/Swiss-Prot
  SAPOSIN-RELATED UniProtKB/Swiss-Prot
Pfam SapA UniProtKB/Swiss-Prot
  SapB_1 UniProtKB/Swiss-Prot
  SapB_2 UniProtKB/Swiss-Prot
PhenoGen Sftpb PhenoGen
PRINTS SAPOSIN UniProtKB/Swiss-Prot
PROSITE SAP_A UniProtKB/Swiss-Prot
  SAP_B UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010761 RatGTEx
SMART SAPA UniProtKB/Swiss-Prot
  SapB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47862 UniProtKB/Swiss-Prot
UniProt A0ABK0LPA7_RAT UniProtKB/TrEMBL
  F7FPB1 ENTREZGENE, UniProtKB/TrEMBL
  P22355 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6IN44 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Sftpb  surfactant protein B  Sftpb  surfactant associated protein B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Sftpb  surfactant associated protein B    surfactant, pulmonary-associated protein B  Name updated 1299863 APPROVED
2002-08-07 Sftpb  surfactant, pulmonary-associated protein B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in lung and particularly enriched in alveolar type II cells 729692
gene_process mediates biophysical functions of surfactant 628506
gene_protein a small hydrophobic protein 628506
gene_regulation secretion is stimulated by b-adrenergic, adenosine A2B, and purinergic P2Y2 receptor agonists, and by TPA and ionomycin in isolated type II cells 628506