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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621700
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sftpb
Name: surfactant protein B
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sftpbincreases expressionEXP 6480464CTDDexamethasone results in increased expression of SFTPB mRNAPMID:11792629 PMID:23354098
Sftpbmultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]; Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]; Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]PMID:10830305 PMID:11051153
Sftpbincreases expressionISOSFTPB (Homo sapiens)6480464CTDDexamethasone results in increased expression of SFTPB mRNAPMID:16857225 PMID:21398497 PMID:2539393
Sftpbincreases stabilityISOSFTPB (Homo sapiens)6480464CTDDexamethasone results in increased stability of SFTPB mRNAPMID:21398497
Sftpbmultiple interactionsISOSFTPB (Homo sapiens)6480464CTD[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SFTPB mRNA; Thiram inhibits the reaction [Dexamethasone results in increased expression of SFTPB mRNA]PMID:16857225 PMID:16997883
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