Csnk2a1 (casein kinase 2 alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Csnk2a1 (casein kinase 2 alpha 1) Rattus norvegicus
Analyze
Symbol: Csnk2a1
Name: casein kinase 2 alpha 1
RGD ID: 621663
Description: Enables ribonucleoprotein complex binding activity. Involved in several processes, including liver regeneration; regulation of protein localization to plasma membrane; and response to testosterone. Located in chromatin. Biomarker of myocardial infarction. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1); PARTICIPATES IN E-cadherin signaling pathway; mitochondrial autophagy pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: casein kinase 2, alpha 1 polypeptide; casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide; CK II alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,170,295 - 161,217,073 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,170,405 - 161,215,698 (+)EnsemblGRCr8
mRatBN7.23140,709,984 - 140,756,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,709,991 - 140,756,696 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,614,755 - 144,658,895 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,198,587 - 153,242,728 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,938,676 - 150,982,746 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,713,808 - 147,760,375 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,713,821 - 147,757,862 (+)Ensemblrn6Rnor6.0
Rnor_5.03154,061,948 - 154,108,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,564,754 - 142,609,311 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,476,391 - 139,506,459 (+)NCBICelera
RGSC_v3.13142,470,349 - 142,514,931 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
ammonium chloride  (EXP)
AMP-PNP  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
ATP  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
budesonide  (ISO)
Bufotalin  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
chloroprene  (EXP)
cilostazol  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cyclopamine  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP,ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
guanosine 5'-[beta,gamma-imido]triphosphate  (ISO)
haloperidol  (EXP)
ionomycin  (ISO)
ivermectin  (ISO)
KT 5720  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
potassium dichromate  (ISO)
pyrithione  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silmitasertib  (ISO)
sodium arsenite  (EXP,ISO)
staurosporine  (ISO)
sulindac  (EXP,ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate. Ahmed K, etal., Cell Mol Biol Res 1993;39(5):451-62.
2. Differential localization of alpha' and beta subunits of protein kinase CK2 during rat spermatogenesis. Alvarado-Diaz CP, etal., Cell Tissue Res. 2009 Oct;338(1):139-49. doi: 10.1007/s00441-009-0847-1. Epub 2009 Aug 27.
3. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. De Felice FG, etal., Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2.
4. Regulation of protein kinase CK2 isoform expression during rat brain development. Diaz-Nido J, etal., Cell Mol Biol Res. 1994;40(5-6):581-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Kramerov AA, etal., Am J Pathol. 2006 May;168(5):1722-36.
7. Role of autophosphorylation in regulation of protein kinase CK2 from rat neuronal chromatin. Kulikova OG and Reikhardt BA, Biochemistry (Mosc). 1998 Dec;63(12):1400-6.
8. Protein kinase CK2: signaling and tumorigenesis in the mammary gland. Landesman-Bollag E, etal., Mol Cell Biochem 2001 Nov;227(1-2):153-65.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Changes in the activity of nuclear protein kinase CK2 during rat liver regeneration. Pancetti F, etal., Biochem Biophys Res Commun. 1996 Jan 5;218(1):35-9.
12. Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2. Pancetti F, etal., Biochem Biophys Res Commun. 1999 Jun 24;260(1):17-22.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory beta-subunit. Sarrouilhe D, etal., Biochim Biophys Acta. 1998 Jun 22;1403(2):199-210.
20. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
21. Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
Additional References at PubMed
PMID:2752008   PMID:8598227   PMID:8940188   PMID:9268364   PMID:11035045   PMID:11704824   PMID:11972058   PMID:12432063   PMID:12477932   PMID:12700239   PMID:15284227   PMID:15342635  
PMID:15723517   PMID:16193064   PMID:17728463   PMID:17827154   PMID:18191828   PMID:18413716   PMID:18548200   PMID:19542537   PMID:19662498   PMID:19765564   PMID:20067794   PMID:20387789  
PMID:20625391   PMID:20864032   PMID:21282530   PMID:21559479   PMID:21630459   PMID:22206666   PMID:22406621   PMID:24013921   PMID:24457960   PMID:25931508   PMID:28031292   PMID:28927755  
PMID:29476059   PMID:30699359   PMID:33065005  


Genomics

Comparative Map Data
Csnk2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,170,295 - 161,217,073 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,170,405 - 161,215,698 (+)EnsemblGRCr8
mRatBN7.23140,709,984 - 140,756,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,709,991 - 140,756,696 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,614,755 - 144,658,895 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,198,587 - 153,242,728 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,938,676 - 150,982,746 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,713,808 - 147,760,375 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,713,821 - 147,757,862 (+)Ensemblrn6Rnor6.0
Rnor_5.03154,061,948 - 154,108,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,564,754 - 142,609,311 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,476,391 - 139,506,459 (+)NCBICelera
RGSC_v3.13142,470,349 - 142,514,931 (+)NCBI
Cytogenetic Map3q41NCBI
CSNK2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3820472,498 - 543,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl20472,498 - 543,835 (-)Ensemblhg38GRCh38
GRCh3720453,142 - 524,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3620411,338 - 472,482 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3420411,337 - 472,482NCBI
Celera20558,168 - 619,315 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef20414,534 - 475,783 (-)NCBIHuRef
CHM1_120463,361 - 524,481 (-)NCBICHM1_1
T2T-CHM13v2.020516,232 - 587,494 (-)NCBIT2T-CHM13v2.0
Csnk2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,068,468 - 152,123,772 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,068,759 - 152,123,772 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382152,226,535 - 152,281,856 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,226,839 - 152,281,852 (+)Ensemblmm10GRCm38
MGSCv372152,052,576 - 152,107,588 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362151,918,392 - 151,973,288 (+)NCBIMGSCv36mm8
Celera2158,043,147 - 158,095,936 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
Csnk2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955597315,793 - 397,112 (-)Ensembl
ChiLan1.0NW_004955597326,601 - 397,112 (-)NCBIChiLan1.0ChiLan1.0
CSNK2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,569,710 - 1,632,281 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1201,568,135 - 1,629,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v020689,494 - 752,092 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.120459,070 - 521,126 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl20456,629 - 521,126 (-)EnsemblpanPan2panpan1.1
CSNK2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,333,593 - 20,390,341 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2419,985,091 - 20,044,278 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02421,024,162 - 21,083,612 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,024,195 - 21,083,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,299,232 - 20,358,675 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,405,477 - 20,464,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,835,744 - 20,895,178 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Csnk2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640169,535,585 - 169,588,246 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648517,966,961 - 18,019,607 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648517,966,993 - 18,021,191 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSNK2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11734,692,960 - 34,748,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,413,860 - 39,467,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CSNK2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,982,259 - 56,047,023 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660787,905,841 - 7,970,771 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csnk2a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247411,566,380 - 1,635,365 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Csnk2a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15131,563,975 - 131,610,422 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Csnk2a1
413 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:117
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000007558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH143208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23140,736,366 - 140,736,600 (+)MAPPERmRatBN7.2
Rnor_6.03147,739,986 - 147,740,219NCBIRnor6.0
Rnor_5.03154,088,127 - 154,088,360UniSTSRnor5.0
RGSC_v3.43142,591,544 - 142,591,777UniSTSRGSC3.4
Celera3139,488,691 - 139,488,924UniSTS
RH 3.4 Map31267.6UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC091130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007558   ⟹   ENSRNOP00000007558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,170,405 - 161,215,698 (+)Ensembl
mRatBN7.2 Ensembl3140,710,040 - 140,755,226 (+)Ensembl
Rnor_6.0 Ensembl3147,713,821 - 147,757,862 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113326   ⟹   ENSRNOP00000092799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,170,405 - 161,215,698 (+)Ensembl
mRatBN7.2 Ensembl3140,709,991 - 140,756,696 (+)Ensembl
RefSeq Acc Id: NM_053824   ⟹   NP_446276
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,170,391 - 161,214,447 (+)NCBI
mRatBN7.23140,710,075 - 140,754,135 (+)NCBI
Rnor_6.03147,713,883 - 147,757,753 (+)NCBI
Rnor_5.03154,061,948 - 154,108,516 (+)NCBI
RGSC_v3.43142,564,754 - 142,609,311 (+)RGD
Celera3139,476,391 - 139,506,459 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235220   ⟹   XP_006235282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,170,295 - 161,217,073 (+)NCBI
mRatBN7.23140,709,984 - 140,756,757 (+)NCBI
Rnor_6.03147,713,808 - 147,760,375 (+)NCBI
Rnor_5.03154,061,948 - 154,108,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235221   ⟹   XP_006235283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,170,306 - 161,217,073 (+)NCBI
mRatBN7.23140,709,999 - 140,754,206 (+)NCBI
Rnor_6.03147,713,808 - 147,757,794 (+)NCBI
Rnor_5.03154,061,948 - 154,108,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104110   ⟹   XP_038960038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,170,362 - 161,217,073 (+)NCBI
mRatBN7.23140,710,169 - 140,754,206 (+)NCBI
RefSeq Acc Id: XM_039104112   ⟹   XP_038960040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,170,303 - 161,217,073 (+)NCBI
mRatBN7.23140,709,988 - 140,754,206 (+)NCBI
RefSeq Acc Id: XM_063282998   ⟹   XP_063139068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,170,336 - 161,217,073 (+)NCBI
RefSeq Acc Id: XM_063282999   ⟹   XP_063139069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,170,308 - 161,217,073 (+)NCBI
RefSeq Acc Id: NP_446276   ⟸   NM_053824
- UniProtKB: Q5BKC1 (UniProtKB/Swiss-Prot),   P19139 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235283   ⟸   XM_006235221
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006235282   ⟸   XM_006235220
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000007558   ⟸   ENSRNOT00000007558
RefSeq Acc Id: XP_038960040   ⟸   XM_039104112
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960038   ⟸   XM_039104110
- Peptide Label: isoform X1
- UniProtKB: P19139 (UniProtKB/Swiss-Prot),   Q5BKC1 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092799   ⟸   ENSRNOT00000113326
RefSeq Acc Id: XP_063139069   ⟸   XM_063282999
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139068   ⟸   XM_063282998
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19139-F1-model_v2 AlphaFold P19139 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692531
Promoter ID:EPDNEW_R3056
Type:initiation region
Name:Csnk2a1_1
Description:casein kinase 2 alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03147,713,827 - 147,713,887EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621663 AgrOrtholog
BioCyc Gene G2FUF-47279 BioCyc
Ensembl Genes ENSRNOG00000005276 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000113326 ENTREZGENE
  ENSRNOT00000113326.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7367296 IMAGE-MGC_LOAD
InterPro CK2_alpha UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:116549 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108626 IMAGE-MGC_LOAD
NCBI Gene 116549 ENTREZGENE
PANTHER CASEIN KINASE II SUBUNIT ALPHA-RELATED UniProtKB/Swiss-Prot
  PTHR24054 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Csnk2a1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005276 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2Q2R7 ENTREZGENE, UniProtKB/TrEMBL
  A6KHM3 ENTREZGENE, UniProtKB/TrEMBL
  CSK21_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKC1 ENTREZGENE
UniProt Secondary Q5BKC1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Csnk2a1  casein kinase 2 alpha 1  Csnk2a1  casein kinase 2, alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Csnk2a1  casein kinase 2, alpha 1 polypeptide  Csnk2a1  casein kinase II, alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Csnk2a1  casein kinase II, alpha 1 polypeptide      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Csnk2a1  casein kinase II, alpha 1 polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation transcription is regulated by androgen, regulation is not an early androgen response but occurs in later stages of androgen mediated cell proliferation 727982