Stau2 (staufen double-stranded RNA binding protein 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Stau2 (staufen double-stranded RNA binding protein 2) Rattus norvegicus
Analyze
Symbol: Stau2
Name: staufen double-stranded RNA binding protein 2
RGD ID: 621479
Description: Enables several functions, including Hsp70 protein binding activity; kinesin binding activity; and mitogen-activated protein kinase binding activity. Involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Located in several cellular components, including cytoplasmic stress granule; dendritic shaft; and nuclear membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Used to study microphthalmia. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: double-stranded RNA-binding protein Staufen homolog 2; MGC93196; r-staufen protein; staufen, RNA binding protein, homolog 2; staufen, RNA binding protein, homolog 2 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr857,623,528 - 7,868,206 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl57,624,019 - 7,868,204 (+)EnsemblGRCr8
mRatBN7.252,840,741 - 3,084,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl52,840,765 - 3,084,929 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx54,956,947 - 5,202,341 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.056,595,823 - 6,841,200 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.056,301,201 - 6,537,576 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,257,910 - 2,497,429 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.052,255,014 - 2,485,906 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.452,084,331 - 2,182,359 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera52,454,153 - 2,687,606 (+)NCBICelera
RGSC_v3.152,084,330 - 2,086,001 (+)NCBI
Cytogenetic Map5q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
choline  (ISO)
chrysene  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (EXP)
ozone  (ISO)
PCB138  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
venlafaxine hydrochloride  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The double-stranded RNA-binding protein Staufen 2 regulates eye size. Cockburn DM, etal., Mol Cell Neurosci. 2012 Nov;51(3-4):101-11. doi: 10.1016/j.mcn.2012.08.008. Epub 2012 Aug 24.
2. Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. Duchaine TF, etal., J Cell Sci. 2002 Aug 15;115(Pt 16):3285-95.
3. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons. Elvira G, etal., J Neurochem. 2006 Jan;96(1):105-17. Epub 2005 Nov 8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The brain-specific double-stranded RNA-binding protein Staufen2 is required for dendritic spine morphogenesis. Goetze B, etal., J Cell Biol. 2006 Jan 16;172(2):221-31.
6. Staufen2 regulates neuronal target RNAs. Heraud-Farlow JE, etal., Cell Rep. 2013 Dec 26;5(6):1511-8. doi: 10.1016/j.celrep.2013.11.039. Epub 2013 Dec 19.
7. The transport of Staufen2-containing ribonucleoprotein complexes involves kinesin motor protein and is modulated by mitogen-activated protein kinase pathway. Jeong JH, etal., J Neurochem. 2007 Sep;102(6):2073-84. Epub 2007 Jun 22.
8. Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons. Lebeau G, etal., Learn Mem. 2011 Apr 20;18(5):314-26. doi: 10.1101/lm.2100611. Print 2011.
9. Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain. Maher-Laporte M, etal., PLoS One. 2010 Jun 28;5(6):e11350. doi: 10.1371/journal.pone.0011350.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Alternative splicing of Staufen2 creates the nuclear export signal for CRM1 (Exportin 1). Miki T and Yoneda Y, J Biol Chem. 2004 Nov 12;279(46):47473-9. Epub 2004 Sep 10.
12. The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. Monshausen M, etal., Neuromolecular Med. 2004;6(2-3):127-44.
13. Role of mitogen-activated protein kinase (MAPK) docking sites on Staufen2 protein in dendritic mRNA transport. Nam YJ, etal., Biochem Biophys Res Commun. 2008 Aug 8;372(4):525-9. doi: 10.1016/j.bbrc.2008.05.047. Epub 2008 May 19.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Price TJ, etal., Neuroscience. 2006 Sep 15;141(4):2107-16. Epub 2006 Jun 30.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. A role for a rat homolog of staufen in the transport of RNA to neuronal dendrites. Tang SJ, etal., Neuron 2001 Nov 8;32(3):463-75.
19. Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes. Thomas MG, etal., Mol Biol Cell. 2005 Jan;16(1):405-20. Epub 2004 Nov 3.
Additional References at PubMed
PMID:12477932   PMID:12592035   PMID:15489334   PMID:19946888   PMID:20510018   PMID:21266579   PMID:22087843   PMID:22658674   PMID:22681889   PMID:28765142   PMID:28821679   PMID:29149906  
PMID:34884825  


Genomics

Comparative Map Data
Stau2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr857,623,528 - 7,868,206 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl57,624,019 - 7,868,204 (+)EnsemblGRCr8
mRatBN7.252,840,741 - 3,084,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl52,840,765 - 3,084,929 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx54,956,947 - 5,202,341 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.056,595,823 - 6,841,200 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.056,301,201 - 6,537,576 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,257,910 - 2,497,429 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.052,255,014 - 2,485,906 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.452,084,331 - 2,182,359 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera52,454,153 - 2,687,606 (+)NCBICelera
RGSC_v3.152,084,330 - 2,086,001 (+)NCBI
Cytogenetic Map5q11NCBI
STAU2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38873,420,369 - 73,747,480 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl873,420,369 - 73,747,708 (-)Ensemblhg38GRCh38
GRCh37874,332,604 - 74,659,715 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36874,624,394 - 74,821,611 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34874,624,397 - 74,821,611NCBI
Celera870,330,172 - 70,657,629 (-)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef869,823,519 - 70,150,737 (-)NCBIHuRef
CHM1_1874,385,185 - 74,712,036 (-)NCBICHM1_1
T2T-CHM13v2.0873,850,269 - 74,176,939 (-)NCBIT2T-CHM13v2.0
Stau2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,299,027 - 16,591,228 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,298,898 - 16,590,336 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38116,228,803 - 16,520,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,228,674 - 16,520,112 (-)Ensemblmm10GRCm38
MGSCv37116,218,891 - 16,509,383 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36116,329,412 - 16,360,609 (-)NCBIMGSCv36mm8
Celera116,163,216 - 16,444,255 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.05NCBI
Stau2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554446,538,310 - 6,778,708 (+)Ensembl
ChiLan1.0NW_0049554446,538,310 - 6,777,132 (+)NCBIChiLan1.0ChiLan1.0
STAU2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2789,167,182 - 89,492,005 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1864,796,944 - 65,121,802 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0869,958,735 - 70,283,591 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1871,605,582 - 71,929,331 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl871,606,583 - 71,929,167 (-)EnsemblpanPan2panpan1.1
STAU2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12921,995,229 - 22,292,107 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2921,996,108 - 22,283,355 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2922,259,472 - 22,555,897 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02922,105,311 - 22,402,291 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2922,104,509 - 22,402,788 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12922,163,044 - 22,459,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02922,199,867 - 22,496,340 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02922,481,150 - 22,777,972 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stau2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530356,978,148 - 57,276,321 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366482,171,957 - 2,469,869 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366482,172,263 - 2,470,494 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAU2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl462,139,464 - 62,455,499 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1462,139,456 - 62,455,509 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2467,846,349 - 68,043,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAU2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1869,025,827 - 69,360,760 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl869,025,436 - 69,322,539 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603972,011,270 - 72,345,819 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stau2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474417,434,686 - 17,727,127 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474417,434,733 - 17,726,348 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Stau2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11150,581,474 - 150,817,884 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stau2
1747 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:22
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000066590
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)519895442Rat
631551Vetf1Vascular elastic tissue fragility QTL 150.0001aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)5706553510687501Rat

Markers in Region
RH135083  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.252,989,293 - 2,989,473 (+)MAPPERmRatBN7.2
Rnor_6.052,402,279 - 2,402,458NCBIRnor6.0
Rnor_5.052,391,083 - 2,391,262UniSTSRnor5.0
RGSC_v3.452,086,451 - 2,086,630UniSTSRGSC3.4
Celera52,593,681 - 2,593,860UniSTS
Cytogenetic Map5q11UniSTS
RH137896  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.252,957,627 - 2,957,801 (+)MAPPERmRatBN7.2
Rnor_6.052,371,362 - 2,371,535NCBIRnor6.0
Rnor_5.052,361,347 - 2,361,520UniSTSRnor5.0
Celera52,561,904 - 2,562,077UniSTS
Cytogenetic Map5q11UniSTS
RH138848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.253,080,338 - 3,080,490 (+)MAPPERmRatBN7.2
Rnor_6.052,493,317 - 2,493,468NCBIRnor6.0
Rnor_5.052,481,794 - 2,481,945UniSTSRnor5.0
RGSC_v3.452,178,247 - 2,178,398UniSTSRGSC3.4
Celera52,683,492 - 2,683,643UniSTS
Cytogenetic Map5q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 51 68 149 96 11 50 46 32 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001007150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF483620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF483621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY549445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY549446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY549447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY549448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY684789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY684790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000066590   ⟹   ENSRNOP00000060092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl52,840,765 - 2,987,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090346   ⟹   ENSRNOP00000074008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl52,840,769 - 2,988,841 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100311   ⟹   ENSRNOP00000087673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl52,840,769 - 3,084,929 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120142   ⟹   ENSRNOP00000092247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl52,840,801 - 3,084,467 (+)Ensembl
RefSeq Acc Id: NM_001007149   ⟹   NP_001007150
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,624,019 - 7,868,203 (+)NCBI
mRatBN7.252,840,741 - 3,084,935 (+)NCBI
Rnor_6.052,257,910 - 2,497,429 (+)NCBI
Rnor_5.052,255,014 - 2,485,906 (+)NCBI
RGSC_v3.452,084,331 - 2,182,359 (+)RGD
Celera52,454,153 - 2,687,606 (+)RGD
Sequence:
RefSeq Acc Id: NM_001007150   ⟹   NP_001007151
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,624,019 - 7,772,821 (+)NCBI
mRatBN7.252,840,741 - 2,989,546 (+)NCBI
Rnor_6.052,296,894 - 2,401,833 (+)NCBI
Rnor_5.052,255,014 - 2,485,906 (+)NCBI
RGSC_v3.452,084,331 - 2,182,359 (+)RGD
Celera52,506,948 - 2,593,235 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001393676   ⟹   NP_001380605
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,624,019 - 7,772,821 (+)NCBI
mRatBN7.252,840,741 - 2,989,546 (+)NCBI
RefSeq Acc Id: NM_134466   ⟹   NP_604461
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,624,019 - 7,772,821 (+)NCBI
mRatBN7.252,840,741 - 2,989,546 (+)NCBI
Rnor_6.052,278,357 - 2,401,833 (+)NCBI
Rnor_5.052,255,014 - 2,485,906 (+)NCBI
RGSC_v3.452,084,331 - 2,182,359 (+)RGD
Celera52,480,810 - 2,593,235 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287123   ⟹   XP_063143193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,624,108 - 7,868,206 (+)NCBI
RefSeq Acc Id: XM_063287124   ⟹   XP_063143194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,650,477 - 7,868,206 (+)NCBI
RefSeq Acc Id: XM_063287125   ⟹   XP_063143195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,624,032 - 7,868,206 (+)NCBI
RefSeq Acc Id: XM_063287126   ⟹   XP_063143196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,623,528 - 7,868,206 (+)NCBI
RefSeq Acc Id: XM_063287127   ⟹   XP_063143197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,624,109 - 7,772,123 (+)NCBI
RefSeq Acc Id: XM_063287128   ⟹   XP_063143198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr857,632,359 - 7,868,206 (+)NCBI
RefSeq Acc Id: NP_001007150   ⟸   NM_001007149
- Peptide Label: isoform LL (A)
- UniProtKB: Q8R4C9 (UniProtKB/Swiss-Prot),   Q68SB4 (UniProtKB/Swiss-Prot),   Q68SB3 (UniProtKB/Swiss-Prot),   Q68SB2 (UniProtKB/Swiss-Prot),   Q68SB1 (UniProtKB/Swiss-Prot),   Q8R4D0 (UniProtKB/Swiss-Prot),   A6JFB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_604461   ⟸   NM_134466
- Peptide Label: isoform LS (B)
- UniProtKB: Q68SB1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001007151   ⟸   NM_001007150
- Peptide Label: isoform SS
- UniProtKB: A6JFB3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000092247   ⟸   ENSRNOT00000120142
Ensembl Acc Id: ENSRNOP00000074008   ⟸   ENSRNOT00000090346
Ensembl Acc Id: ENSRNOP00000060092   ⟸   ENSRNOT00000066590
Ensembl Acc Id: ENSRNOP00000087673   ⟸   ENSRNOT00000100311
RefSeq Acc Id: NP_001380605   ⟸   NM_001393676
- Peptide Label: isoform LS (B)
RefSeq Acc Id: XP_063143196   ⟸   XM_063287126
- Peptide Label: isoform X3
- UniProtKB: A6JFB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143195   ⟸   XM_063287125
- Peptide Label: isoform X3
- UniProtKB: A6JFB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143193   ⟸   XM_063287123
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143197   ⟸   XM_063287127
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063143198   ⟸   XM_063287128
- Peptide Label: isoform X5
- UniProtKB: A6JFB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143194   ⟸   XM_063287124
- Peptide Label: isoform X2
- UniProtKB: Q8R4D0 (UniProtKB/Swiss-Prot),   Q8R4C9 (UniProtKB/Swiss-Prot),   Q68SB4 (UniProtKB/Swiss-Prot),   Q68SB3 (UniProtKB/Swiss-Prot),   Q68SB2 (UniProtKB/Swiss-Prot),   Q68SB1 (UniProtKB/Swiss-Prot),   A6JFB1 (UniProtKB/TrEMBL)
Protein Domains
DRBM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LN29-F1-model_v2 AlphaFold F1LN29 1-510 view protein structure
AF-Q68SB1-F1-model_v2 AlphaFold Q68SB1 1-571 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621479 AgrOrtholog
BioCyc Gene G2FUF-42310 BioCyc
Ensembl Genes ENSRNOG00000042458 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000066590.4 UniProtKB/Swiss-Prot
  ENSRNOT00000090346 ENTREZGENE
  ENSRNOT00000090346.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100311 ENTREZGENE
  ENSRNOT00000100311.1 UniProtKB/Swiss-Prot
  ENSRNOT00000120142.1 UniProtKB/Swiss-Prot
  ENSRNOT00000155543 ENTREZGENE
Gene3D-CATH 3.30.160.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190916 IMAGE-MGC_LOAD
InterPro DRBM-containing_protein UniProtKB/Swiss-Prot
  dsRBD_dom UniProtKB/Swiss-Prot
  STAU2_DSRM_2 UniProtKB/Swiss-Prot
  STAU2_DSRM_3 UniProtKB/Swiss-Prot
  STAU2_DSRM_4 UniProtKB/Swiss-Prot
  Staufen_C UniProtKB/Swiss-Prot
KEGG Report rno:171500 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93196 IMAGE-MGC_LOAD
NCBI Gene 171500 ENTREZGENE
PANTHER DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2 UniProtKB/Swiss-Prot
  MATERNAL EFFECT PROTEIN STAUFEN UniProtKB/Swiss-Prot
Pfam dsrm UniProtKB/Swiss-Prot
  Staufen_C UniProtKB/Swiss-Prot
PhenoGen Stau2 PhenoGen
PROSITE DS_RBD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000042458 RatGTEx
SMART DSRM UniProtKB/Swiss-Prot
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/Swiss-Prot
UniProt A0A0G2K703_RAT UniProtKB/TrEMBL
  A0ABK0L9B2_RAT UniProtKB/TrEMBL
  A0ABK0LD33_RAT UniProtKB/TrEMBL
  A6JFB1 ENTREZGENE, UniProtKB/TrEMBL
  A6JFB3 ENTREZGENE, UniProtKB/TrEMBL
  F1LN29_RAT UniProtKB/TrEMBL
  Q68SB1 ENTREZGENE
  Q68SB2 ENTREZGENE
  Q68SB3 ENTREZGENE
  Q68SB4 ENTREZGENE
  Q8R4C9 ENTREZGENE
  Q8R4D0 ENTREZGENE
  STAU2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q68SB2 UniProtKB/Swiss-Prot
  Q68SB3 UniProtKB/Swiss-Prot
  Q68SB4 UniProtKB/Swiss-Prot
  Q8R4C9 UniProtKB/Swiss-Prot
  Q8R4D0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-14 Stau2  staufen double-stranded RNA binding protein 2  Stau2  staufen, RNA binding protein, homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Stau2  staufen, RNA binding protein, homolog 2 (Drosophila)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Stau2  staufen, RNA binding protein, homolog 2 (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL