RGD Reference Report - Role of mitogen-activated protein kinase (MAPK) docking sites on Staufen2 protein in dendritic mRNA transport. - Rat Genome Database

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Role of mitogen-activated protein kinase (MAPK) docking sites on Staufen2 protein in dendritic mRNA transport.

Authors: Nam, YJ  Cheon, HS  Choi, YK  Kim, SY  Shin, EY  Kim, EG  Kim, HK 
Citation: Nam YJ, etal., Biochem Biophys Res Commun. 2008 Aug 8;372(4):525-9. doi: 10.1016/j.bbrc.2008.05.047. Epub 2008 May 19.
RGD ID: 10043172
Pubmed: PMID:18492489   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2008.05.047   (Journal Full-text)

Although transport and subsequent translation of dendritic mRNA play an important role in neuronal synaptic plasticity, the underlying mechanisms for modulating dendritic mRNA transport are almost completely unknown. In this study, we identified and characterized an interaction between Staufen2 and mitogen-activated protein kinase (MAPK) with co-immunoprecipitation assays. Staufen2 utilized a docking (D) site to interact with ERK1/2; deleting the D-site decreased colocalization of Staufen2 with immunoreactive ERK1/2 in the cell body regions of cultured hippocampal neurons, and it reduced the amount of Staufen2-containing RNP complexes in the distal dendrites. In addition, the deletion completely abolished the depolarization-induced increase of Staufen2-containing RNP complexes. These results suggest that the MAPK pathway could modulate dendritic mRNA transport through its interaction with Staufen2.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mitogen-activated protein kinase binding  IDA 10043172 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Stau2  (staufen double-stranded RNA binding protein 2)


Additional Information