Nrp2 (neuropilin 2) - Rat Genome Database

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Gene: Nrp2 (neuropilin 2) Rattus norvegicus
Analyze
Symbol: Nrp2
Name: neuropilin 2
RGD ID: 621442
Description: Predicted to enable identical protein binding activity and semaphorin receptor activity. Involved in axon guidance. Predicted to be located in membrane. Predicted to be active in axon; glutamatergic synapse; and postsynaptic membrane. Orthologous to human NRP2 (neuropilin 2); PARTICIPATES IN vascular endothelial growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neuropilin-2; vascular endothelial cell growth factor 165 receptor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8971,616,602 - 71,731,869 (+)NCBIGRCr8
mRatBN7.2964,122,815 - 64,238,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl964,123,132 - 64,237,958 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx972,622,149 - 72,733,999 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0977,743,432 - 77,855,324 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0976,053,061 - 76,165,010 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0969,496,875 - 69,609,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl969,497,121 - 69,612,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0969,307,221 - 69,420,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4961,348,529 - 61,460,457 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1961,495,510 - 61,607,439 (+)NCBI
Celera961,541,966 - 61,654,219 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorthalidone  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
inulin  (ISO)
kainic acid  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
pentetrazol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
procymidone  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sphingosine 1-phosphate  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA,IEA,ISO)
glutamatergic synapse  (IBA,IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA)
postsynaptic membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. Cloutier JF, etal., Neuron 2002 Mar 14;33(6):877-92.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Neuropilin is a semaphorin III receptor. Kolodkin AL, etal., Cell 1997 Aug 22;90(4):753-62.
5. Identifying New COVID-19 Receptor Neuropilin-1 in Severe Alzheimer's Disease Patients Group Brain Using Genome-Wide Association Study Approach. Lim KH, etal., Front Genet. 2021 Oct 21;12:741175. doi: 10.3389/fgene.2021.741175. eCollection 2021.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Neuropilin-2 is overexpressed in the rat brain after limbic seizures. Shimakawa S, etal., Brain Res 2002 Nov 22;956(1):67-73.
Additional References at PubMed
PMID:12852851   PMID:15239958   PMID:15635621   PMID:15677725   PMID:15814794   PMID:16319111   PMID:18356247   PMID:18632792   PMID:19386662   PMID:19855168   PMID:20010807   PMID:20439489  
PMID:20524965   PMID:21059704   PMID:22790009   PMID:25143608   PMID:25752543   PMID:26030152   PMID:26053665   PMID:26410366   PMID:31211440   PMID:36044155  


Genomics

Comparative Map Data
Nrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8971,616,602 - 71,731,869 (+)NCBIGRCr8
mRatBN7.2964,122,815 - 64,238,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl964,123,132 - 64,237,958 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx972,622,149 - 72,733,999 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0977,743,432 - 77,855,324 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0976,053,061 - 76,165,010 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0969,496,875 - 69,609,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl969,497,121 - 69,612,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0969,307,221 - 69,420,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4961,348,529 - 61,460,457 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1961,495,510 - 61,607,439 (+)NCBI
Celera961,541,966 - 61,654,219 (+)NCBICelera
Cytogenetic Map9q32NCBI
NRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382205,682,501 - 205,798,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2205,681,990 - 205,798,133 (+)EnsemblGRCh38hg38GRCh38
GRCh372206,547,225 - 206,662,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362206,255,469 - 206,371,102 (+)NCBINCBI36Build 36hg18NCBI36
Build 342206,372,729 - 206,488,362NCBI
Celera2200,305,001 - 200,420,624 (+)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2198,395,758 - 198,511,368 (+)NCBIHuRef
CHM1_12206,553,933 - 206,669,559 (+)NCBICHM1_1
T2T-CHM13v2.02206,164,595 - 206,280,478 (+)NCBIT2T-CHM13v2.0
Nrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39162,742,476 - 62,857,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl162,742,444 - 62,857,854 (+)EnsemblGRCm39 Ensembl
GRCm38162,703,317 - 62,818,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl162,703,285 - 62,818,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv37162,749,891 - 62,865,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36162,637,986 - 62,750,163 (+)NCBIMGSCv36mm8
Celera163,214,234 - 63,328,949 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map131.35NCBI
Nrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554579,197,405 - 9,316,787 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554579,197,621 - 9,316,789 (-)NCBIChiLan1.0ChiLan1.0
NRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213108,283,734 - 108,399,945 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B108,299,569 - 108,414,927 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B92,911,721 - 93,027,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B211,042,324 - 211,157,547 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B211,042,324 - 211,157,547 (+)Ensemblpanpan1.1panPan2
NRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13714,293,545 - 14,408,984 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3714,293,614 - 14,406,949 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3715,172,096 - 15,287,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03714,230,443 - 14,345,834 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3714,230,535 - 14,345,832 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13714,184,082 - 14,299,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03714,156,464 - 14,271,604 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03714,150,952 - 14,266,106 (+)NCBIUU_Cfam_GSD_1.0
Nrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303162,471,295 - 162,587,007 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366312,106,453 - 2,222,088 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366312,106,378 - 2,222,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15108,974,816 - 109,092,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115108,974,246 - 109,092,316 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap15q21-q26NCBI
NRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11091,460,179 - 91,575,408 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1091,460,373 - 91,557,430 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040107,804,373 - 107,919,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476510,372,099 - 10,484,963 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476510,372,172 - 10,484,766 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrp2
435 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:34
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000042562
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1578659Tspe1Trichinella spiralis expulsion QTL 14.8parasite quantity (VT:0010441)logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)96138143465691299Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat

Markers in Region
D9Got64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2964,229,147 - 64,229,355 (+)MAPPERmRatBN7.2
Rnor_6.0969,603,235 - 69,603,440NCBIRnor6.0
Rnor_5.0969,413,192 - 69,413,397UniSTSRnor5.0
RGSC_v3.4961,454,319 - 61,454,525RGDRGSC3.4
RGSC_v3.4961,454,320 - 61,454,525UniSTSRGSC3.4
RGSC_v3.1961,601,302 - 61,601,507RGD
Celera961,647,464 - 61,647,669UniSTS
RH 3.4 Map9517.5UniSTS
RH 3.4 Map9517.5RGD
RH 2.0 Map9580.4RGD
Cytogenetic Map9q31UniSTS
BF406209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2964,204,318 - 64,204,564 (+)MAPPERmRatBN7.2
Rnor_6.0969,578,406 - 69,578,651NCBIRnor6.0
Rnor_5.0969,388,363 - 69,388,608UniSTSRnor5.0
RGSC_v3.4961,429,491 - 61,429,736UniSTSRGSC3.4
Celera961,622,635 - 61,622,880UniSTS
RH 3.4 Map9518.8UniSTS
Cytogenetic Map9q31UniSTS
BE097230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2964,219,159 - 64,219,317 (+)MAPPERmRatBN7.2
Rnor_6.0969,593,248 - 69,593,405NCBIRnor6.0
Rnor_5.0969,403,205 - 69,403,362UniSTSRnor5.0
RGSC_v3.4961,444,333 - 61,444,490UniSTSRGSC3.4
Celera961,637,477 - 61,637,634UniSTS
RH 3.4 Map9518.8UniSTS
Cytogenetic Map9q31UniSTS
BF396291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2964,211,029 - 64,211,182 (+)MAPPERmRatBN7.2
Rnor_6.0969,585,116 - 69,585,268NCBIRnor6.0
Rnor_5.0969,395,073 - 69,395,225UniSTSRnor5.0
RGSC_v3.4961,436,201 - 61,436,353UniSTSRGSC3.4
Celera961,629,345 - 61,629,497UniSTS
RH 3.4 Map9518.1UniSTS
Cytogenetic Map9q31UniSTS
BF397549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2964,235,472 - 64,235,682 (+)MAPPERmRatBN7.2
Rnor_6.0969,609,558 - 69,609,767NCBIRnor6.0
Rnor_5.0969,419,515 - 69,419,724UniSTSRnor5.0
RGSC_v3.4961,460,643 - 61,460,852UniSTSRGSC3.4
Celera961,654,405 - 61,654,614UniSTS
RH 3.4 Map9518.8UniSTS
Cytogenetic Map9q31UniSTS
Nrp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2964,138,946 - 64,139,013 (+)MAPPERmRatBN7.2
Rnor_6.0969,513,002 - 69,513,068NCBIRnor6.0
Rnor_5.0969,323,318 - 69,323,384UniSTSRnor5.0
Cytogenetic Map9q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 22 22 7 18 7 1 1 56 23 30 11 1
Low 21 35 34 1 34 7 10 18 12 11 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042562   ⟹   ENSRNOP00000047206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl964,123,132 - 64,237,958 (+)Ensembl
Rnor_6.0 Ensembl969,497,121 - 69,612,087 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105009   ⟹   ENSRNOP00000090812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl964,123,132 - 64,236,683 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119267   ⟹   ENSRNOP00000094102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl964,123,132 - 64,217,279 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119960   ⟹   ENSRNOP00000086265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl964,123,132 - 64,236,683 (+)Ensembl
RefSeq Acc Id: NM_030869   ⟹   NP_110496
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8971,617,254 - 71,729,152 (+)NCBI
mRatBN7.2964,123,377 - 64,235,287 (+)NCBI
Rnor_6.0969,497,434 - 69,609,372 (+)NCBI
Rnor_5.0969,307,221 - 69,420,379 (+)NCBI
RGSC_v3.4961,348,529 - 61,460,457 (+)RGD
Celera961,541,966 - 61,654,219 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245039   ⟹   XP_006245101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8971,616,602 - 71,731,869 (+)NCBI
mRatBN7.2964,122,815 - 64,238,007 (+)NCBI
Rnor_6.0969,496,875 - 69,609,802 (+)NCBI
Rnor_5.0969,307,221 - 69,420,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245040   ⟹   XP_006245102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8971,616,602 - 71,731,869 (+)NCBI
mRatBN7.2964,122,816 - 64,238,007 (+)NCBI
Rnor_6.0969,496,876 - 69,609,802 (+)NCBI
Rnor_5.0969,307,221 - 69,420,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245041   ⟹   XP_006245103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8971,616,602 - 71,713,377 (+)NCBI
mRatBN7.2964,122,815 - 64,219,510 (+)NCBI
Rnor_6.0969,496,875 - 69,593,598 (+)NCBI
Rnor_5.0969,307,221 - 69,420,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245042   ⟹   XP_006245104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8971,616,602 - 71,713,377 (+)NCBI
mRatBN7.2964,122,815 - 64,219,510 (+)NCBI
Rnor_6.0969,496,875 - 69,593,598 (+)NCBI
Rnor_5.0969,307,221 - 69,420,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767137   ⟹   XP_008765359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8971,616,602 - 71,731,869 (+)NCBI
mRatBN7.2964,122,815 - 64,238,007 (+)NCBI
Rnor_6.0969,496,876 - 69,609,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084243   ⟹   XP_038940171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8971,616,602 - 71,709,732 (+)NCBI
mRatBN7.2964,122,816 - 64,213,828 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_110496   ⟸   NM_030869
- Peptide Label: precursor
- UniProtKB: O35276 (UniProtKB/Swiss-Prot),   A0A8I6A5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245101   ⟸   XM_006245039
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AF12 (UniProtKB/TrEMBL),   A0A8I6A5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245102   ⟸   XM_006245040
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245103   ⟸   XM_006245041
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AH16 (UniProtKB/TrEMBL),   A0A8I6A5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245104   ⟸   XM_006245042
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765359   ⟸   XM_008767137
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UM12 (UniProtKB/TrEMBL),   A0A8I6A5P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047206   ⟸   ENSRNOT00000042562
RefSeq Acc Id: XP_038940171   ⟸   XM_039084243
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A5P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090812   ⟸   ENSRNOT00000105009
RefSeq Acc Id: ENSRNOP00000086265   ⟸   ENSRNOT00000119960
RefSeq Acc Id: ENSRNOP00000094102   ⟸   ENSRNOT00000119267
Protein Domains
CUB   F5/8 type C   MAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35276-F1-model_v2 AlphaFold O35276 1-925 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621442 AgrOrtholog
BioCyc Gene G2FUF-27360 BioCyc
Ensembl Genes ENSRNOG00000031232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042562.4 UniProtKB/TrEMBL
  ENSRNOT00000105009.1 UniProtKB/TrEMBL
  ENSRNOT00000119267.1 UniProtKB/TrEMBL
  ENSRNOT00000119960.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuropilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuropilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81527 UniProtKB/Swiss-Prot
NCBI Gene 81527 ENTREZGENE
PANTHER F5/8 TYPE C DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46806:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3481 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nrp2 PhenoGen
PIRSF Neuropilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MAMDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031232 RatGTEx
SMART CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A5P1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH16 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UM12 ENTREZGENE, UniProtKB/TrEMBL
  A6IPE6_RAT UniProtKB/TrEMBL
  A6IPE7_RAT UniProtKB/TrEMBL
  A6IPE8_RAT UniProtKB/TrEMBL
  NRP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nrp2  neuropilin 2    neuropilin-2  Name updated 1299863 APPROVED
2002-08-07 Nrp2  neuropilin-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression upregulated following seizures in mature rats 729118