Kpna2 (karyopherin subunit alpha 2) - Rat Genome Database

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Gene: Kpna2 (karyopherin subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Kpna2
Name: karyopherin subunit alpha 2
RGD ID: 621419
Description: Predicted to enable several functions, including histone deacetylase binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway and regulation of transcription by glucose. Predicted to be located in cytoplasmic stress granule. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in several cellular components, including glutamatergic synapse; nuclear membrane; and postsynaptic density. Orthologous to human KPNA2 (karyopherin subunit alpha 2); PARTICIPATES IN influenza A pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: importin; importin subunit alpha-1; importin subunit alpha-2; karyopherin (importin) alpha 2; karyopherin alpha 2; MGC108637; nuclear import protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,433,678 - 92,445,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1092,433,679 - 92,445,937 (-)EnsemblGRCr8
mRatBN7.21091,933,951 - 91,946,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,933,951 - 91,946,150 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,991,813 - 97,004,201 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,454,982 - 96,467,370 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,856,366 - 91,868,402 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,200,029 - 95,212,111 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,200,030 - 95,212,111 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,940,856 - 94,952,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41096,342,214 - 96,352,613 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1090,599,417 - 90,611,576 (-)NCBICelera
RGSC_v3.11096,356,583 - 96,366,983 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-amphetamine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (EXP)
cytarabine  (ISO)
DDE  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dopamine  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
finasteride  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. Dieterich DC, etal., PLoS Biol. 2008 Feb;6(2):e34. doi: 10.1371/journal.pbio.0060034.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells. Guillemain G, etal., Biochem J 2002 May 15;364(Pt 1):201-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10869435   PMID:12695505   PMID:14675421   PMID:15603742   PMID:15689618   PMID:15719015   PMID:16906019   PMID:17324944   PMID:19946888   PMID:22681889   PMID:26340948   PMID:26526450  
PMID:27430620   PMID:28189564   PMID:31904090   PMID:36400309  


Genomics

Comparative Map Data
Kpna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,433,678 - 92,445,841 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1092,433,679 - 92,445,937 (-)EnsemblGRCr8
mRatBN7.21091,933,951 - 91,946,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,933,951 - 91,946,150 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,991,813 - 97,004,201 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,454,982 - 96,467,370 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,856,366 - 91,868,402 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,200,029 - 95,212,111 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,200,030 - 95,212,111 (-)Ensemblrn6Rnor6.0
Rnor_5.01094,940,856 - 94,952,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41096,342,214 - 96,352,613 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1090,599,417 - 90,611,576 (-)NCBICelera
RGSC_v3.11096,356,583 - 96,366,983 (-)NCBI
Cytogenetic Map10q32.1NCBI
KPNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381768,035,735 - 68,046,854 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1768,035,636 - 68,047,364 (+)Ensemblhg38GRCh38
GRCh371766,031,851 - 66,042,970 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361763,462,310 - 63,473,432 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1762,601,848 - 62,612,972 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1761,416,714 - 61,427,908 (+)NCBIHuRef
CHM1_11766,096,665 - 66,107,785 (+)NCBICHM1_1
T2T-CHM13v2.01768,911,511 - 68,922,628 (+)NCBIT2T-CHM13v2.0
Kpna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,879,455 - 106,890,351 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,879,455 - 106,890,367 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811106,988,629 - 106,999,525 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,988,629 - 106,999,541 (-)Ensemblmm10GRCm38
MGSCv3711106,849,943 - 106,860,839 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611106,804,719 - 106,815,615 (-)NCBIMGSCv36mm8
Celera11118,719,792 - 118,733,297 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.08NCBI
Kpna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,121,432 - 7,134,327 (+)Ensembl
ChiLan1.0NW_0049554787,121,432 - 7,134,327 (+)NCBIChiLan1.0ChiLan1.0
KPNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21984,035,576 - 84,071,181 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11788,856,717 - 88,892,339 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01761,968,807 - 61,979,954 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11767,161,908 - 67,173,410 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1767,161,908 - 67,173,410 (+)EnsemblpanPan2panpan1.1
KPNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1912,546,912 - 12,556,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha913,442,712 - 13,451,963 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0914,205,539 - 14,214,799 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl914,205,541 - 14,214,742 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1913,154,710 - 13,163,965 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,370,477 - 14,379,722 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,369,408 - 14,378,660 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kpna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560213,965,860 - 13,977,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365415,217,362 - 5,228,846 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365415,217,389 - 5,228,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,283,087 - 14,296,746 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11214,283,092 - 14,296,749 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KPNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11653,422,792 - 53,434,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1653,423,040 - 53,433,290 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607724,363,548 - 24,375,627 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624870444,558 - 457,872 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624870444,551 - 457,986 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kpna2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1972,134,399 - 72,148,166 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kpna2
103 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:36
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000020795
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109090424595604677Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109112727095604677Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)9090424595604677Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)9090424595604677Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)109090424595604677Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)109090424595604677Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)109090424595604677Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
PMC109067P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q32.1UniSTS
RH133348  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020795   ⟹   ENSRNOP00000020795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1092,433,679 - 92,445,937 (-)Ensembl
mRatBN7.2 Ensembl1091,933,951 - 91,946,150 (-)Ensembl
Rnor_6.0 Ensembl1095,200,030 - 95,212,111 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100211   ⟹   ENSRNOP00000076768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1092,433,693 - 92,445,841 (-)Ensembl
mRatBN7.2 Ensembl1091,934,045 - 91,946,118 (-)Ensembl
RefSeq Acc Id: NM_001270802   ⟹   NP_001257731
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,433,678 - 92,445,841 (-)NCBI
mRatBN7.21091,933,951 - 91,946,115 (-)NCBI
Rnor_6.01095,200,029 - 95,212,111 (-)NCBI
Rnor_5.01094,940,856 - 94,952,938 (-)NCBI
Celera1090,599,417 - 90,611,576 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053483   ⟹   NP_445935
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,433,678 - 92,445,841 (-)NCBI
mRatBN7.21091,933,951 - 91,946,115 (-)NCBI
Rnor_6.01095,200,029 - 95,212,111 (-)NCBI
Rnor_5.01094,940,856 - 94,952,938 (-)NCBI
RGSC_v3.41096,342,214 - 96,352,613 (-)RGD
Celera1090,599,417 - 90,611,576 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270000   ⟹   XP_063126070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,433,678 - 92,445,631 (-)NCBI
RefSeq Acc Id: NP_445935   ⟸   NM_053483
- UniProtKB: Q6P6T9 (UniProtKB/TrEMBL),   A6HK66 (UniProtKB/TrEMBL),   Q9Z0N9 (UniProtKB/TrEMBL),   F7F4Z2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257731   ⟸   NM_001270802
- UniProtKB: Q6P6T9 (UniProtKB/TrEMBL),   A6HK66 (UniProtKB/TrEMBL),   Q9Z0N9 (UniProtKB/TrEMBL),   F7F4Z2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020795   ⟸   ENSRNOT00000020795
Ensembl Acc Id: ENSRNOP00000076768   ⟸   ENSRNOT00000100211
RefSeq Acc Id: XP_063126070   ⟸   XM_063270000
- Peptide Label: isoform X1
- UniProtKB: A6HK66 (UniProtKB/TrEMBL),   F7F4Z2 (UniProtKB/TrEMBL),   Q6P6T9 (UniProtKB/TrEMBL),   Q9Z0N9 (UniProtKB/TrEMBL)
Protein Domains
IBB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T9-F1-model_v2 AlphaFold Q6P6T9 1-529 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697848
Promoter ID:EPDNEW_R8373
Type:single initiation site
Name:Kpna2_1
Description:karyopherin subunit alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01095,212,113 - 95,212,173EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621419 AgrOrtholog
BioCyc Gene G2FUF-22916 BioCyc
Ensembl Genes ENSRNOG00000015329 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020795 ENTREZGENE
  ENSRNOT00000020795.8 UniProtKB/TrEMBL
  ENSRNOT00000100211.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.690 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621957 IMAGE-MGC_LOAD
  IMAGE:7326072 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Importin-a-like_IBB-bd_dom UniProtKB/TrEMBL
  Importin-a_IBB_sf UniProtKB/TrEMBL
  Importing_su_alpha UniProtKB/TrEMBL
KEGG Report rno:85245 UniProtKB/TrEMBL
MGC_CLONE MGC:108637 IMAGE-MGC_LOAD
  MGC:72360 IMAGE-MGC_LOAD
NCBI Gene 85245 ENTREZGENE
PANTHER IMPORTIN ALPHA UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
PhenoGen Kpna2 PhenoGen
PIRSF Importin_alpha UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015329 RatGTEx
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I5Y0C8_RAT UniProtKB/TrEMBL
  A0ABZ3NN64_RAT UniProtKB/TrEMBL
  A6HK66 ENTREZGENE
  F7F4Z2 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6T9 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0N9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6HK66 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kpna2  karyopherin subunit alpha 2  Kpna2  karyopherin alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kpna2  karyopherin alpha 2  Kpna2  karyopherin (importin) alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kpna2  karyopherin (importin) alpha 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kpna2  karyopherin (importin) alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function regulates glucose-sensitive gene expression by transmitting a signal to the nucleus 633087