Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) - Rat Genome Database

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Gene: Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1) Rattus norvegicus
Analyze
Symbol: Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
RGD ID: 621308
Description: Enables protein serine/threonine phosphatase activity. Involved in circadian rhythm; hippocampus development; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1); PARTICIPATES IN protein kinase C (PKC) signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Circadian Oscillatory Protein (SCOP); PH domain and leucine rich repeat protein phosphatase; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; Phlpp; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; Plekhe1; SCN circadian oscillatory protein; Scop; suprachiasmatic nucleus circadian oscillatory protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81322,823,132 - 23,045,619 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1322,823,132 - 23,045,619 (+)EnsemblGRCr8
mRatBN7.21322,308,532 - 22,530,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,308,548 - 22,530,977 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1322,628,670 - 22,849,686 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01323,913,452 - 24,134,143 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01322,597,347 - 22,819,856 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01326,145,989 - 26,394,505 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,172,243 - 26,394,505 (+)Ensemblrn6Rnor6.0
Rnor_5.01331,302,241 - 31,550,366 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41312,315,824 - 12,565,692 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1322,176,081 - 22,397,222 (+)NCBICelera
RGSC_v3.11312,343,187 - 12,565,692 (+)NCBI
Cytogenetic Map13p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
ammonium chloride  (EXP)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nicotine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
PD173074  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
raloxifene  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA,IMP)
membrane  (IEA)
nuclear membrane  (IDA,IEA)
nucleoplasm  (IDA,IEA)
nucleus  (IEA)
plasma membrane  (IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PHLiPPing the switch on Akt and protein kinase C signaling. Brognard J and Newton AC, Trends Endocrinol Metab. 2008 Aug;19(6):223-30. Epub 2008 May 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
4. PHLPP1 splice variants differentially regulate AKT and PKCalpha signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. Jackson TC, etal., J Neurochem. 2010 Nov;115(4):941-55. doi: 10.1111/j.1471-4159.2010.06984.x. Epub 2010 Sep 28.
5. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. Kanan Y, etal., J Neurochem. 2010 Apr;113(2):477-88. Epub 2010 Jan 20.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. Shimizu K, etal., FEBS Lett 1999 Sep 24;458(3):363-9.
11. Signaling specificity in the Akt pathway in biology and disease. Toker A and Marmiroli S, Adv Biol Regul. 2014 May;55:28-38. doi: 10.1016/j.jbior.2014.04.001. Epub 2014 Apr 19.
Additional References at PubMed
PMID:12594205   PMID:17386267   PMID:20080691   PMID:20513427   PMID:21498666   PMID:22871113   PMID:24394804   PMID:24530606   PMID:29739983   PMID:29940243   PMID:30407372   PMID:30930055  
PMID:32150791   PMID:32480039   PMID:33164862   PMID:34868398  


Genomics

Comparative Map Data
Phlpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81322,823,132 - 23,045,619 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1322,823,132 - 23,045,619 (+)EnsemblGRCr8
mRatBN7.21322,308,532 - 22,530,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,308,548 - 22,530,977 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1322,628,670 - 22,849,686 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01323,913,452 - 24,134,143 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01322,597,347 - 22,819,856 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01326,145,989 - 26,394,505 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,172,243 - 26,394,505 (+)Ensemblrn6Rnor6.0
Rnor_5.01331,302,241 - 31,550,366 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41312,315,824 - 12,565,692 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1322,176,081 - 22,397,222 (+)NCBICelera
RGSC_v3.11312,343,187 - 12,565,692 (+)NCBI
Cytogenetic Map13p11NCBI
PHLPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381862,715,541 - 62,980,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1862,715,464 - 62,980,433 (+)Ensemblhg38GRCh38
GRCh371860,382,774 - 60,647,666 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,533,714 - 58,798,646 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341858,533,713 - 58,798,646NCBI
Celera1857,100,716 - 57,365,706 (+)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1857,092,100 - 57,356,438 (+)NCBIHuRef
CHM1_11860,377,900 - 60,642,909 (+)NCBICHM1_1
T2T-CHM13v2.01862,918,332 - 63,183,249 (+)NCBIT2T-CHM13v2.0
Phlpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391106,099,599 - 106,321,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1106,099,482 - 106,321,980 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381106,171,869 - 106,394,245 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1106,171,752 - 106,394,250 (+)Ensemblmm10GRCm38
MGSCv371108,068,446 - 108,290,822 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361107,999,416 - 108,221,797 (+)NCBIMGSCv36mm8
Celera1109,020,809 - 109,235,924 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.76NCBI
Phlpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540246,666,599 - 46,772,387 (+)Ensembl
ChiLan1.0NW_00495540246,563,918 - 46,773,349 (+)NCBIChiLan1.0ChiLan1.0
PHLPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21780,235,829 - 80,489,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11865,928,439 - 66,182,079 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01856,084,851 - 56,338,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11859,402,317 - 59,655,858 (+)NCBIPanPan1.1PanPan1.1panPan2
PHLPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1114,027,741 - 14,234,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,028,652 - 14,234,229 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha114,993,895 - 15,200,571 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0113,886,534 - 14,093,998 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,886,542 - 14,093,809 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,923,809 - 14,130,372 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,856,460 - 14,063,176 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0114,102,787 - 14,309,607 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Phlpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494427,228,741 - 27,444,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364972,467,684 - 2,683,799 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364972,467,776 - 2,683,794 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHLPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1158,642,818 - 158,862,106 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11158,642,810 - 158,863,643 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21176,119,433 - 176,234,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHLPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11816,786,128 - 17,051,250 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660608,634,577 - 8,901,660 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phlpp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247928,448,013 - 8,681,053 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247928,448,245 - 8,680,845 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Phlpp1
1562 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:510
Count of miRNA genes:244
Interacting mature miRNAs:287
Transcripts:ENSRNOT00000003840
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134785618Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131228551734884386Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13600200837088115Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
2303031Bp326Blood pressure QTL 326arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131228551723516549Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13143736554Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131228551734884386Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13134785618Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
D13Mco13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81323,039,911 - 23,040,080 (+)Marker Load Pipeline
mRatBN7.21322,525,269 - 22,525,438 (+)MAPPERmRatBN7.2
Rnor_6.01326,388,798 - 26,388,966NCBIRnor6.0
Rnor_5.01331,544,659 - 31,544,827UniSTSRnor5.0
RGSC_v3.41312,559,984 - 12,560,153RGDRGSC3.4
RGSC_v3.41312,559,985 - 12,560,153UniSTSRGSC3.4
Celera1322,391,515 - 22,391,683UniSTS
RGSC_v3.11312,559,984 - 12,560,153RGD
Cytogenetic Map13p13UniSTS
D13Uwm8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,284,038 - 22,284,156 (+)MAPPERmRatBN7.2
Rnor_6.01326,147,607 - 26,147,724NCBIRnor6.0
Rnor_5.01331,303,859 - 31,303,976UniSTSRnor5.0
RGSC_v3.41312,317,442 - 12,317,559UniSTSRGSC3.4
Cytogenetic Map13p13UniSTS
RH133278  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,179,481 - 28,179,633 (+)MAPPERmRatBN7.2
mRatBN7.21322,530,758 - 22,530,910 (-)MAPPERmRatBN7.2
mRatBN7.21528,179,481 - 28,179,633 (-)MAPPERmRatBN7.2
mRatBN7.21322,530,758 - 22,530,910 (+)MAPPERmRatBN7.2
Rnor_6.01533,365,714 - 33,365,865NCBIRnor6.0
Rnor_6.01326,394,287 - 26,394,438NCBIRnor6.0
Rnor_5.01537,250,377 - 37,250,528UniSTSRnor5.0
Rnor_5.01331,550,148 - 31,550,299UniSTSRnor5.0
RGSC_v3.41532,797,396 - 32,797,547UniSTSRGSC3.4
RGSC_v3.41312,565,474 - 12,565,625UniSTSRGSC3.4
Celera1322,397,004 - 22,397,155UniSTS
Celera1527,757,734 - 27,757,885UniSTS
Cytogenetic Map13p13UniSTS
AI555189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,338,314 - 22,338,512 (+)MAPPERmRatBN7.2
Rnor_6.01326,201,863 - 26,202,060NCBIRnor6.0
Rnor_5.01331,357,332 - 31,357,529UniSTSRnor5.0
RGSC_v3.41312,372,823 - 12,373,020UniSTSRGSC3.4
Celera1322,205,855 - 22,206,052UniSTS
Cytogenetic Map13p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003840   ⟹   ENSRNOP00000003840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1322,823,132 - 23,045,619 (+)Ensembl
mRatBN7.2 Ensembl1322,308,548 - 22,530,977 (+)Ensembl
Rnor_6.0 Ensembl1326,172,243 - 26,394,505 (+)Ensembl
RefSeq Acc Id: NM_021657   ⟹   NP_067689
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81322,823,132 - 23,045,619 (+)NCBI
mRatBN7.21322,308,536 - 22,530,977 (+)NCBI
Rnor_6.01326,145,989 - 26,394,505 (+)NCBI
Rnor_5.01331,302,241 - 31,550,366 (+)NCBI
RGSC_v3.41312,315,824 - 12,565,692 (+)RGD
Celera1322,176,081 - 22,397,222 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067689 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA77767 (Get FASTA)   NCBI Sequence Viewer  
  EDL91741 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003840
GenBank Protein Q9WTR8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067689   ⟸   NM_021657
- UniProtKB: Q9WTR8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003840   ⟸   ENSRNOT00000003840
Protein Domains
PH   PPM-type phosphatase   Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTR8-F1-model_v2 AlphaFold Q9WTR8 1-1696 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698748
Promoter ID:EPDNEW_R9273
Type:single initiation site
Name:Phlpp1_1
Description:PH domain and leucine rich repeat protein phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01326,172,264 - 26,172,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621308 AgrOrtholog
BioCyc Gene G2FUF-18611 BioCyc
Ensembl Genes ENSRNOG00000002821 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003840 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRR_domain-containing UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PPM-type_dom_sf UniProtKB/Swiss-Prot
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot
  RA_PHLPP-like UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:59265 UniProtKB/Swiss-Prot
NCBI Gene 59265 ENTREZGENE
PANTHER PH DOMAIN AND LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1 UniProtKB/Swiss-Prot
  PTHR48051 UniProtKB/Swiss-Prot
Pfam LRR_1 UniProtKB/Swiss-Prot
  LRR_6 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  PP2C UniProtKB/Swiss-Prot
  RA_3 UniProtKB/Swiss-Prot
PhenoGen Phlpp1 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PPM_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002821 RatGTEx
SMART LRR_BAC UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  PP2Cc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  PH domain-like UniProtKB/Swiss-Prot
  SSF81606 UniProtKB/Swiss-Prot
UniProt F1LNC3_RAT UniProtKB/TrEMBL
  PHLP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Phlpp1  PH domain and leucine rich repeat protein phosphatase 1  Phlpp  PH domain and leucine rich repeat protein phosphatase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Phlpp  PH domain and leucine rich repeat protein phosphatase  Plekhe1  pleckstrin homology domain containing, family E (with leucine rich repeats) member 1  Symbol and Name updated 1299863 APPROVED
2004-09-10 Plekhe1  pleckstrin homology domain containing, family E (with leucine rich repeats) member 1  Scop  Circadian Oscillatory Protein (SCOP)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Scop  Circadian Oscillatory Protein (SCOP)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region 633914
gene_expression mainly expressed in the brain 633914