Arf1 (ARF GTPase 1) - Rat Genome Database

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Gene: Arf1 (ARF GTPase 1) Rattus norvegicus
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Symbol: Arf1
Name: ARF GTPase 1 (Ensembl:ADP-ribosylation factor 1)
RGD ID: 621270
Description: Enables guanyl ribonucleotide binding activity; magnesium ion binding activity; and phospholipase D activator activity. Involved in several processes, including Golgi to transport vesicle transport; positive regulation of transport; and postsynapse organization. Located in Golgi apparatus; cytoplasmic vesicle; and peroxisomal membrane. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ARF GTPase 1); PARTICIPATES IN Arf family mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,4,6-trinitrotoluene; bexarotene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADP-ribosylation factor 1; MGC72830
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,497,543 - 44,513,994 (-)NCBIGRCr8
mRatBN7.21043,997,983 - 44,014,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,997,986 - 44,014,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,692,668 - 48,708,202 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,183,026 - 48,198,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,686,624 - 43,702,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,562,700 - 45,579,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,563,547 - 45,579,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,318,170 - 45,334,673 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,516,609 - 45,532,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,529,387 - 45,545,841 (-)NCBI
Celera1043,262,080 - 43,277,562 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Arf1Ratacute pancreatitis treatmentISOArf1 (Mus musculus)9684857 RGD 
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Arf1RatCharcot-Marie-Tooth disease  ISOARF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth diseaseClinVarPMID:12566280 and PMID:24078732
Arf1Ratgastrointestinal stromal tumor  ISOARF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Arf1Ratgenetic disease  ISOARF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Arf1Ratmultiple mitochondrial dysfunctions syndrome 3  ISOARF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Multiple mitochondrial dysfunctions syndrome 3ClinVarPMID:18094336 more ...
Arf1Ratparaplegia  ISOARF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:18094336 more ...
Arf1Ratparathyroid carcinoma  ISOARF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Arf1RatPeriventricular Nodular Heterotopia 8  ISOARF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Periventricular nodular heterotopia 8ClinVarPMID:25741868 more ...
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Arf1RatBreast Neoplasms  ISOARF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27517156
Arf1RatNeoplasm Invasiveness  ISOARF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27517156
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Arf1RatPeriventricular Nodular Heterotopia 8  ISOARF1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Arf1Rat(S)-nicotine multiple interactionsISOArf1 (Mus musculus)6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Arf1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOArf1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Arf1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOArf1 (Mus musculus)6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Arf1Rat17alpha-ethynylestradiol affects expressionISOArf1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of ARF1 mRNACTDPMID:17555576
Arf1Rat17alpha-ethynylestradiol increases expressionISOArf1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ARF1 mRNACTDPMID:17942748
Arf1Rat17beta-estradiol increases expressionISOArf1 (Mus musculus)6480464Estradiol results in increased expression of ARF1 mRNACTDPMID:39298647
Arf1Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOArf1 (Mus musculus)64804642 more ...CTDPMID:30294300
Arf1Rat2,4,6-trinitrotoluene affects expressionEXP 6480464Trinitrotoluene affects the expression of ARF1 mRNACTDPMID:21346803
Arf1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOARF1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARF1 mRNACTDPMID:28628672
Arf1Rat4,4'-sulfonyldiphenol increases expressionISOArf1 (Mus musculus)6480464bisphenol S results in increased expression of ARF1 mRNACTDPMID:39298647
Arf1Rat5-fluorouracil multiple interactionsISOARF1 (Homo sapiens)6480464ARF1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]CTDPMID:18927307
Arf1Rataflatoxin B1 decreases expressionISOArf1 (Mus musculus)6480464Aflatoxin B1 results in decreased expression of ARF1 mRNACTDPMID:19770486
Arf1Ratall-trans-retinoic acid decreases expressionISOARF1 (Homo sapiens)6480464Tretinoin results in decreased expression of ARF1 mRNACTDPMID:21934132
Arf1RatAroclor 1254 decreases expressionISOArf1 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of ARF1 mRNACTDPMID:23650126
Arf1Ratarsane multiple interactionsISOARF1 (Homo sapiens)6480464[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ARF1 mRNACTDPMID:32525701
Arf1Ratarsane affects methylationISOARF1 (Homo sapiens)6480464Arsenic affects the methylation of ARF1 geneCTDPMID:25304211
Arf1Ratarsenic atom multiple interactionsISOARF1 (Homo sapiens)6480464[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of ARF1 mRNACTDPMID:32525701
Arf1Ratarsenic atom affects methylationISOARF1 (Homo sapiens)6480464Arsenic affects the methylation of ARF1 geneCTDPMID:25304211
Arf1Ratarsenous acid increases expressionISOARF1 (Homo sapiens)6480464Arsenic Trioxide results in increased expression of ARF1 mRNACTDPMID:20458559
Arf1Ratbenzo[a]pyrene decreases methylationISOARF1 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of ARF1 5' UTRCTDPMID:27901495

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Biological Process
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Original Reference(s)
Arf1Ratactin filament organization  IMP 8553918 RGD 
Arf1Ratdendritic spine organization involved_inIMP 8553918PMID:23889934UniProt 
Arf1RatGolgi to transport vesicle transport  IDA 9684858 RGD 
Arf1Ratintracellular copper ion homeostasis involved_inISOARF1 (Homo sapiens)1624291 PMID:21034850RGDPMID:21034850
Arf1Ratintracellular protein transport involved_inIBACGD:CAL0000186453 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Arf1Ratlong-term synaptic depression involved_inIDA 8553918PMID:23889934UniProt 
Arf1Ratlysosomal membrane organization  IDA 9684948 RGD 
Arf1Ratmitotic cleavage furrow ingression involved_inISOArf1 (Mus musculus)1624291UniProtKB:P61209 and PMID:27535433RGDPMID:27535433
Arf1Ratpositive regulation of calcium ion-dependent exocytosis  IDA 9684853 RGD 
Arf1Ratpositive regulation of dendritic spine development  IMP 8553918 RGD 
Arf1Ratpositive regulation of endocytosis  IMP 9684859 RGD 
Arf1Ratpositive regulation of ER to Golgi vesicle-mediated transport  IMP 9684856 RGD 
Arf1Ratpositive regulation of late endosome to lysosome transport  IMP 9684860 RGD 
Arf1Ratpositive regulation of protein secretion  IMP 9684859 RGD 
Arf1Ratpositive regulation of sodium ion transmembrane transport  IMP 1302324 RGD 
Arf1Ratpostsynaptic actin cytoskeleton organization involved_inIMP 8553918PMID:23889934SynGO 
Arf1Ratpostsynaptic actin cytoskeleton organization involved_inIDA 8553918PMID:23889934SynGO 
Arf1Ratprotein transport involved_inIEAUniProtKB-KW:KW-06531600115GO_REF:0000043UniProtGO_REF:0000043
Arf1Ratregulation of Arp2/3 complex-mediated actin nucleation involved_inIDA 8553918PMID:23889934UniProt 
Arf1Ratregulation of phospholipid metabolic process  IDA 9684853 RGD 
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Cellular Component
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Arf1Ratcell leading edge located_inISOARF1 (Homo sapiens)1624291 PMID:22573891RGDPMID:22573891
Arf1RatCOPI-coated vesicle located_inIDA 9684998 RGD 
Arf1Ratcytoplasm is_active_inIBACGD:CAL0000186453 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Arf1Ratcytosol located_inISOArf1 (Mus musculus)1624291 PMID:14728599RGDPMID:14728599
Arf1Ratendomembrane system located_inISOArf1 (Mus musculus)1624291 PMID:14728599RGDPMID:14728599
Arf1Ratglutamatergic synapse is_active_inIDA 8553918PMID:23889934SynGO 
Arf1Ratglutamatergic synapse is_active_inIMP 8553918PMID:23889934SynGO 
Arf1RatGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01321600115GO_REF:0000044UniProtGO_REF:0000044
Arf1RatGolgi apparatus located_inIEAUniRule:UR0016277551600115GO_REF:0000104UniProtGO_REF:0000104
Arf1RatGolgi apparatus located_inIEAUniProtKB:Q8BSL7 and ensembl:ENSMUSP000001026221600115GO_REF:0000107EnsemblGO_REF:0000107
Arf1RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Arf1RatGolgi apparatus located_inISOArf1 (Mus musculus)1624291 PMID:11092755 and PMID:8947846RGDPMID:11092755 and PMID:8947846
Arf1RatGolgi membrane located_inIDA 9684998 RGD 
Arf1RatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
Arf1Ratlate endosome  IDA 9684860 RGD 
Arf1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Arf1Ratneuron projection located_inIEAUniProtKB-KW:KW-07711600115GO_REF:0000043UniProtGO_REF:0000043
Arf1Ratperoxisomal membrane located_inIDA 9684997 RGD 
Arf1Ratplasma membrane is_active_inIBAFB:FBgn0010348 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Arf1Ratpostsynaptic density located_inIEAUniProtKB-SubCell:SL-02971600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Original Reference(s)
Arf1RatGDP binding  IDA 9684957 RGD 
Arf1RatGTP binding  IDA 9684957 RGD 
Arf1RatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Arf1RatGTP binding enablesIBACGD:CAL0000196747 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Arf1RatGTP binding enablesIEAInterPro:IPR005225 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Arf1RatGTP binding enablesIEAUniRule:UR0016277551600115GO_REF:0000104UniProtGO_REF:0000104
Arf1RatGTP binding enablesISOArf1 (Mus musculus)1624291 PMID:12679809RGDPMID:12679809
Arf1RatGTPase activity enablesIEAInterPro:IPR006689 and InterPro:IPR0458721600115GO_REF:0000002InterProGO_REF:0000002
Arf1RatGTPase activity enablesIEAUniRule:UR0016277551600115GO_REF:0000104UniProtGO_REF:0000104
Arf1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Arf1Ratmagnesium ion binding  IDA 9684957 RGD 
Arf1Ratmagnesium ion binding enablesISOArf1 (Mus musculus)1624291 PMID:12679809RGDPMID:12679809
Arf1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Arf1Ratphospholipase D activator activity  IDA 9685186 RGD 
Arf1Ratprotein binding  IPIPick1 (Rattus norvegicus)8553918 RGD 
Arf1Ratprotein binding enablesISOArf1 (Mus musculus)1624291UniProtKB:Q5T5U3 more ...RGDPMID:12679809 and PMID:17347647
Arf1Ratprotein binding enablesISOARF1 (Homo sapiens)1624291UniProtKB:O60271-2 more ...RGDPMID:10198630 more ...
Arf1Ratprotein domain specific binding enablesISOARF1 (Homo sapiens)1624291 PMID:12668765RGDPMID:12668765
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Imported Annotations - PID (archival)


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Reference Title
Reference Citation
1. ARF-induced lysosomal lysis in vitro. Arai K, etal., J Biochem. 1998 Apr;123(4):637-43.
2. Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins. Asp L, etal., Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):566-70. Epub 2004 Dec 23.
3. Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors. Austin CD and Shields D, J Cell Biol. 1996 Dec;135(6 Pt 1):1471-83.
4. Membrane curvature induced by Arf1-GTP is essential for vesicle formation. Beck R, etal., Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11731-6. doi: 10.1073/pnas.0805182105. Epub 2008 Aug 8.
5. Translocation of Arf1 to the secretory granules in rat parotid acinar cells. Dohke Y, etal., Arch Biochem Biophys. 1998 Sep 1;357(1):147-54.
6. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. El-Annan J, etal., Am J Physiol Cell Physiol. 2004 Apr;286(4):C768-78. Epub 2003 Dec 18.
7. A function for the AP3 coat complex in synaptic vesicle formation from endosomes. Faundez V, etal., Cell. 1998 May 1;93(3):423-32.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms. Greasley SE, etal., Nat Struct Biol. 1995 Sep;2(9):797-806.
10. Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes. Lay D, etal., J Biol Chem. 2005 Oct 14;280(41):34489-99. Epub 2005 Aug 12.
11. Effect of protein kinase A activity on the association of ADP-ribosylation factor 1 to golgi membranes. Martin ME, etal., J Biol Chem. 2000 Jun 23;275(25):19050-9.
12. Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes. Massenburg D, etal., Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11718-22.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis. Orlichenko L, etal., J Biol Chem. 2012 Jul 13;287(29):24284-93. doi: 10.1074/jbc.M111.328815. Epub 2012 May 8.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Price SR, etal., Mol Cell Biochem 1996 Jun 7;159(1):15-23.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity. Rocca DL, etal., Neuron. 2013 Jul 24;79(2):293-307. doi: 10.1016/j.neuron.2013.05.003.
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PMID:7890632   PMID:8947846   PMID:10022920   PMID:10623590   PMID:10747863   PMID:11092755   PMID:12477932   PMID:12668765   PMID:12679809   PMID:14728599   PMID:15489334   PMID:15616190  
PMID:16101683   PMID:17562717   PMID:17693410   PMID:18693248   PMID:19199708   PMID:20458337   PMID:21034850   PMID:21187408   PMID:21423176   PMID:22573891   PMID:22681889   PMID:23533145  
PMID:26446845   PMID:27535433   PMID:28389568  



Arf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,497,543 - 44,513,994 (-)NCBIGRCr8
mRatBN7.21043,997,983 - 44,014,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,997,986 - 44,014,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,692,668 - 48,708,202 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,183,026 - 48,198,560 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,686,624 - 43,702,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,562,700 - 45,579,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,563,547 - 45,579,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,318,170 - 45,334,673 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,516,609 - 45,532,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11045,529,387 - 45,545,841 (-)NCBI
Celera1043,262,080 - 43,277,562 (-)NCBICelera
Cytogenetic Map10q22NCBI
ARF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,082,708 - 228,099,212 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,082,708 - 228,099,212 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,270,409 - 228,286,913 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,336,984 - 226,353,536 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,577,163 - 224,593,645NCBI
Celera1201,460,593 - 201,477,145 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,785,590 - 198,802,034 (+)NCBIHuRef
CHM1_11229,542,706 - 229,559,258 (+)NCBICHM1_1
T2T-CHM13v2.01227,271,693 - 227,288,198 (+)NCBIT2T-CHM13v2.0
Arf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,102,237 - 59,119,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,102,238 - 59,119,096 (-)EnsemblGRCm39 Ensembl
GRCm381159,211,412 - 59,228,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,211,412 - 59,228,270 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,024,914 - 59,041,769 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,027,608 - 59,044,381 (-)NCBIMGSCv36mm8
Celera1163,976,432 - 63,993,249 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.05NCBI
Arf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581319,942 - 335,112 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955581319,942 - 335,112 (-)NCBIChiLan1.0ChiLan1.0
ARF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,507,248 - 21,523,835 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,445,519 - 21,462,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,484,803 - 203,501,395 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,695,615 - 208,712,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,695,615 - 208,712,105 (+)Ensemblpanpan1.1panPan2
ARF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114835,476 - 836,424 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14835,476 - 836,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14315,387 - 316,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014554,686 - 568,903 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14554,687 - 568,881 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114746,548 - 747,495 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014527,341 - 528,288 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014513,272 - 514,220 (-)NCBIUU_Cfam_GSD_1.0
Arf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,776,242 - 87,778,336 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936864117,510 - 119,612 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,219,667 - 51,237,639 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,219,597 - 51,237,640 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,874,559 - 53,892,570 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,628,836 - 1,644,502 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,628,751 - 1,644,499 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,510,307 - 1,525,996 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937857,795 - 871,089 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Arf1
58 total Variants

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:108
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000074900
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 64 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat

1 to 10 of 64 rows
RH134612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21043,997,921 - 43,998,116 (+)MAPPERmRatBN7.2
Rnor_6.01045,562,639 - 45,562,833NCBIRnor6.0
Rnor_5.01045,318,109 - 45,318,303UniSTSRnor5.0
RGSC_v3.41045,515,701 - 45,515,895UniSTSRGSC3.4
Celera1043,261,172 - 43,261,366UniSTS
RH 3.4 Map10503.4UniSTS
Cytogenetic Map10q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000080028   ⟹   ENSRNOP00000072575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1043,997,986 - 44,014,434 (-)Ensembl
Rnor_6.0 Ensembl1045,563,547 - 45,579,029 (-)Ensembl
RefSeq Acc Id: NM_001414037   ⟹   NP_001400966
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,497,543 - 44,513,994 (-)NCBI
mRatBN7.21043,997,983 - 44,014,434 (-)NCBI
RefSeq Acc Id: NM_001414038   ⟹   NP_001400967
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,497,543 - 44,513,994 (-)NCBI
mRatBN7.21043,997,983 - 44,014,434 (-)NCBI
RefSeq Acc Id: NM_022518   ⟹   NP_071963
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,497,543 - 44,513,994 (-)NCBI
mRatBN7.21043,997,983 - 44,014,434 (-)NCBI
Rnor_6.01045,563,547 - 45,579,029 (-)NCBI
Rnor_5.01045,318,170 - 45,334,673 (-)NCBI
RGSC_v3.41045,516,609 - 45,532,091 (-)RGD
Celera1043,262,080 - 43,277,562 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269815   ⟹   XP_063125885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81044,497,546 - 44,507,204 (-)NCBI
RefSeq Acc Id: NP_071963   ⟸   NM_022518
- UniProtKB: P84079 (UniProtKB/Swiss-Prot),   A6HEZ7 (UniProtKB/TrEMBL),   A0A8I5ZKF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072575   ⟸   ENSRNOT00000080028
RefSeq Acc Id: NP_001400967   ⟸   NM_001414038
- UniProtKB: P84079 (UniProtKB/Swiss-Prot),   A6HEZ7 (UniProtKB/TrEMBL),   A0A8I5ZKF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400966   ⟸   NM_001414037
- UniProtKB: P84079 (UniProtKB/Swiss-Prot),   A6HEZ7 (UniProtKB/TrEMBL),   A0A8I5ZKF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125885   ⟸   XM_063269815
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZKF2 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-P84079-F1-model_v2 AlphaFold P84079 1-181 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24906 BioCyc
Ensembl Genes ENSRNOG00000060229 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080028.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889332 IMAGE-MGC_LOAD
InterPro Arf1_5_like UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase_ARF UniProtKB/Swiss-Prot
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot
KEGG Report rno:64310 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72830 IMAGE-MGC_LOAD
NCBI Gene 64310 ENTREZGENE
PANTHER PTHR11711 UniProtKB/Swiss-Prot
Pfam Arf UniProtKB/Swiss-Prot
PhenoGen Arf1 PhenoGen
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot
PROSITE ARF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004807 RatGTEx
  ENSRNOG00000060229 RatGTEx
SMART ARF UniProtKB/Swiss-Prot
  RAB UniProtKB/Swiss-Prot
  SAR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZKF2 ENTREZGENE, UniProtKB/TrEMBL
  A6HEZ1_RAT UniProtKB/TrEMBL
  A6HEZ2_RAT UniProtKB/TrEMBL
  A6HEZ3_RAT UniProtKB/TrEMBL
  A6HEZ5_RAT UniProtKB/TrEMBL
  A6HEZ7 ENTREZGENE, UniProtKB/TrEMBL
  A6HF00_RAT UniProtKB/TrEMBL
  ARF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P10947 UniProtKB/Swiss-Prot
  P32889 UniProtKB/Swiss-Prot
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-11-07 Arf1  ARF GTPase 1  Arf1  ADP-ribosylation factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Arf1  ADP-ribosylation factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Arf1  ADP-ribosylation factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL