Rps21 (ribosomal protein S21) - Rat Genome Database

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Gene: Rps21 (ribosomal protein S21) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rps21
Name: ribosomal protein S21
RGD ID: 621038
Description: Predicted to enable ribosome binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic small ribosomal subunit. Orthologous to human RPS21 (ribosomal protein S21); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 40S ribosomal protein S21; small ribosomal subunit protein eS21
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Rps21-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,724,038 - 187,725,060 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,670,116 - 158,670,490 (+)EnsemblGRCr8
GRCr8 Ensembl3187,723,995 - 187,725,071 (+)EnsemblGRCr8
mRatBN7.23167,346,437 - 167,347,459 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,387,176 - 153,387,427 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl3167,346,201 - 167,347,470 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3171,722,880 - 171,723,902 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,681,969 - 180,682,991 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,347,380 - 177,348,402 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,629,176 - 175,630,198 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,629,374 - 175,630,048 (+)Ensemblrn6Rnor6.0
Rnor_5.03181,484,784 - 181,485,902 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43169,311,205 - 169,312,227 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3165,232,803 - 165,233,825 (-)NCBICelera
RGSC_v3.13169,217,240 - 169,218,262 (+)NCBI
Cytogenetic Map3q43NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures of the human and Drosophila 80S ribosome. Anger AM, etal., Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.
2. The primary structures of rat ribosomal proteins: the characterization of the cDNAs for S21 and L39, corrections in the sequences of L7 and L18a, and the identification of L33. Chan YL, etal., Biochem Biophys Res Commun 1995 Aug 24;213(3):1042-50.
3. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. Collatz E, etal., J Biol Chem. 1977 Dec 25;252(24):9071-80.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, etal., J Cell Biol. 2010 Sep 6;190(5):853-66. doi: 10.1083/jcb.201005117.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:3910104   PMID:15489334   PMID:16751776   PMID:22871113  


Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000008458
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat

Markers in Region
RH141919  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,347,605 - 167,347,820 (+)MAPPERmRatBN7.2
Rnor_6.03175,630,345 - 175,630,559NCBIRnor6.0
Rnor_5.03181,484,430 - 181,484,644UniSTSRnor5.0
RGSC_v3.43169,312,374 - 169,312,588UniSTSRGSC3.4
Celera3165,232,442 - 165,232,656UniSTS
RH 3.4 Map31527.8UniSTS
Cytogenetic Map3q43UniSTS
AI232413  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83187,724,185 - 187,724,628 (+)Marker Load Pipeline
mRatBN7.23167,346,584 - 167,347,027 (+)MAPPERmRatBN7.2
Rnor_6.03175,629,324 - 175,629,766NCBIRnor6.0
Rnor_5.03181,485,223 - 181,485,665UniSTSRnor5.0
RGSC_v3.43169,311,353 - 169,311,795UniSTSRGSC3.4
Celera3165,233,235 - 165,233,677UniSTS
RH 3.4 Map31525.0UniSTS
Cytogenetic Map3q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ610337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB462029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB867501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB868380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB871637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB879498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB889343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC924910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC925789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC929046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC936907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC946752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000084027   ⟹   ENSRNOP00000070217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3187,723,995 - 187,725,071 (+)Ensembl
mRatBN7.2 Ensembl3167,346,201 - 167,347,470 (+)Ensembl
Rnor_6.0 Ensembl3175,629,374 - 175,630,048 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118161   ⟹   ENSRNOP00000096052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,346,334 - 167,347,468 (+)Ensembl
RefSeq Acc Id: NM_031111   ⟹   NP_112373
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,724,038 - 187,725,060 (+)NCBI
mRatBN7.23167,346,437 - 167,347,459 (+)NCBI
Rnor_6.03175,629,176 - 175,630,198 (+)NCBI
Rnor_5.03181,484,784 - 181,485,902 (-)NCBI
RGSC_v3.43169,311,205 - 169,312,227 (+)RGD
Celera3165,232,803 - 165,233,825 (-)RGD
Sequence:
RefSeq Acc Id: NP_112373   ⟸   NM_031111
- UniProtKB: P05765 (UniProtKB/Swiss-Prot),   A6KMA7 (UniProtKB/TrEMBL),   D3ZSE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070217   ⟸   ENSRNOT00000084027
Ensembl Acc Id: ENSRNOP00000096052   ⟸   ENSRNOT00000118161

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05765-F1-model_v2 AlphaFold P05765 1-83 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621038 AgrOrtholog
BioCyc Gene G2FUF-46363 BioCyc
Ensembl Genes ENSRNOG00000033916 Ensembl
  ENSRNOG00000060449 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000084027 ENTREZGENE
Gene3D-CATH 3.30.1230.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918340 IMAGE-MGC_LOAD
InterPro Ribosomal_S21e UniProtKB/Swiss-Prot
  Ribosomal_S21e_CS UniProtKB/Swiss-Prot
  Ribosomal_S21e_sf UniProtKB/Swiss-Prot
KEGG Report rno:81775 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72789 IMAGE-MGC_LOAD
NCBI Gene 81775 ENTREZGENE
PANTHER PTHR10442 UniProtKB/Swiss-Prot
Pfam Ribosomal_S21e UniProtKB/Swiss-Prot
PhenoGen Rps21 PhenoGen
PIRSF Ribosomal_S21e UniProtKB/Swiss-Prot
PROSITE RIBOSOMAL_S21E UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033916 RatGTEx
  ENSRNOG00000060449 RatGTEx
UniProt A0A0G2JXC3_RAT UniProtKB/TrEMBL
  A6KMA7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSE0 ENTREZGENE, UniProtKB/TrEMBL
  P05765 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rps21  ribosomal protein S21      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rps21  ribosomal protein S21      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 83 amino acids and a molecular weight of 9,121 633962