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Gene: Nell1 (neural EGFL like 1) Rattus norvegicus

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Symbol:

Nell1

Name:

neural EGFL like 1

RGD ID:

620998

Description:

Enables heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in positive regulation of apoptotic process; positive regulation of ossification; and regulation of osteoblast differentiation. Located in extracellular space. Used to study craniosynostosis. Orthologous to human NELL1 (neural EGFL like 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

NEL-like 1; NEL-like protein 1; protein kinase C-binding protein NELL1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NELL1 (neural EGFL like 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Nell1 (NEL-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nell1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nell1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NELL1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nell1 (neural EGFL like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NELL2 (neural EGFL like 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	NELL1 (neural EGFL like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nell1 (NEL-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F19C6.3	Alliance	DIOPT (OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	nell1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nell1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Nell1^{Tn(sb-T2/Bart3)2.195Mcwi}

Genetic Models:

F344-Nell1^{Tn(sb-T2/Bart3)2.195Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	108,845,462 - 109,709,858 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	108,845,462 - 109,709,858 (+)	Ensembl				GRCr8
mRatBN7.2	1	99,709,305 - 100,573,872 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	99,709,793 - 100,573,860 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	105,063,381 - 105,953,646 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	113,535,301 - 114,425,557 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	106,857,549 - 107,748,146 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	105,348,577 - 106,218,970 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	105,349,069 - 106,218,958 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	106,397,933 - 107,260,905 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	99,805,922 - 100,758,002 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	93,902,928 - 94,754,650 (+)	NCBI		Celera
RGSC_v3.1	1	100,639,657 - 100,836,113 (+)	NCBI
Cytogenetic Map	1	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

craniosynostosis (IMP,ISO)

esophagus adenocarcinoma (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

7,12-dimethyltetraphene (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

bathocuproine disulfonic acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP,ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

decabromodiphenyl ether (EXP)

dibutyl phthalate (EXP)

dichlorine (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dimethylarsinic acid (EXP)

dorsomorphin (ISO)

ethanol (ISO)

flavonoids (EXP)

fonofos (ISO)

genistein (ISO)

hypochlorous acid (ISO)

ionomycin (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

ozone (EXP)

panobinostat (ISO)

paracetamol (ISO)

paraquat (EXP)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

permethrin (EXP)

phorbol 13-acetate 12-myristate (ISO)

profenofos (EXP)

pyrrolidine dithiocarbamate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

sodium arsenite (ISO)

terbufos (ISO)

titanium dioxide (ISO)

triclosan (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

negative regulation of osteoblast proliferation (ISO,ISS)

negative regulation of protein catabolic process (ISO,ISS)

positive regulation of apoptotic process (IDA)

positive regulation of bone mineralization (ISO,ISS)

positive regulation of ossification (IBA,IEA,IMP)

positive regulation of osteoblast differentiation (ISO,ISS)

regulation of gene expression (ISO,ISS)

regulation of osteoblast differentiation (IBA,IEA,IMP)

Cellular Component

cytoplasm (IBA,IEA,ISO)

extracellular region (IEA)

extracellular space (IBA,IDA)

nuclear envelope (IEA,ISO,ISS)

perinuclear region of cytoplasm (ISO,ISS)

Molecular Function

calcium ion binding (IEA)

heparin binding (IBA,IDA,IEA)

identical protein binding (IEA,IPI)

metal ion binding (IEA)

protein binding (ISO)

protein kinase C binding (IBA,IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal craniofacial bone morphology (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	An ectopic study of tissue-engineered bone with Nell-1 gene modified rat bone marrow stromal cells in nude mice.	Hu JZ, etal., Chin Med J (Engl). 2009 Apr 20;122(8):972-9.
4.	Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C.	Kuroda S and Tanizawa K, Biochem Biophys Res Commun 1999 Nov 30;265(3):752-7.
5.	Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2.	Kuroda S, etal., Biochem Biophys Res Commun 1999 Nov;265(1):79-86.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.	Zhang X, etal., J Bone Miner Res 2003 Dec;18(12):2126-34.
11.	Craniosynostosis in transgenic mice overexpressing Nell-1.	Zhang X, etal., J Clin Invest 2002 Sep;110(6):861-70.

Additional References at PubMed

PMID:16243593	PMID:21285762	PMID:21723284	PMID:23083222	PMID:25376942	PMID:26772960	PMID:30937700	PMID:30979495

Genomics

Comparative Map Data

Nell1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	108,845,462 - 109,709,858 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	108,845,462 - 109,709,858 (+)	Ensembl				GRCr8
mRatBN7.2	1	99,709,305 - 100,573,872 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	99,709,793 - 100,573,860 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	105,063,381 - 105,953,646 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	113,535,301 - 114,425,557 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	106,857,549 - 107,748,146 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	105,348,577 - 106,218,970 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	105,349,069 - 106,218,958 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	106,397,933 - 107,260,905 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	99,805,922 - 100,758,002 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	93,902,928 - 94,754,650 (+)	NCBI		Celera
RGSC_v3.1	1	100,639,657 - 100,836,113 (+)	NCBI
Cytogenetic Map	1	q22	NCBI

NELL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	20,669,551 - 21,575,686 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	20,669,551 - 21,577,711 (+)	Ensembl			hg38	GRCh38
GRCh37	11	20,691,097 - 21,597,232 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	20,647,712 - 21,553,577 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	20,647,711 - 21,553,576	NCBI
Celera	11	20,823,987 - 21,729,999 (+)	NCBI		Celera
Cytogenetic Map	11	p15.1	NCBI
HuRef	11	20,382,761 - 21,279,982 (+)	NCBI		HuRef
CHM1_1	11	20,691,076 - 21,597,225 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	20,790,315 - 21,696,309 (+)	NCBI		T2T-CHM13v2.0

Nell1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	49,625,098 - 50,513,037 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	49,624,612 - 50,516,356 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	49,975,350 - 50,863,289 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	49,974,864 - 50,866,608 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	57,230,720 - 58,118,659 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	39,598,885 - 40,491,802 (+)	NCBI		MGSCv36	mm8
MGSCv36	7	49,843,371 - 50,731,308 (+)	NCBI		MGSCv36	mm8
Celera	7	45,425,847 - 46,113,619 (+)	NCBI		Celera
Cytogenetic Map	7	B4	NCBI
cM Map	7	31.79	NCBI

Nell1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	1,445,353 - 2,233,146 (+)	Ensembl
ChiLan1.0	NW_004955476	1,445,234 - 2,236,954 (+)	NCBI	ChiLan1.0	ChiLan1.0

NELL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	22,974,054 - 23,877,736 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	22,933,560 - 23,837,166 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	20,697,153 - 21,600,601 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	20,607,371 - 21,508,938 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	20,607,526 - 21,508,486 (+)	Ensembl			panPan2	panpan1.1

NELL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	42,654,925 - 43,468,806 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	42,656,339 - 43,468,806 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	42,126,909 - 42,948,580 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	43,772,115 - 44,588,353 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	43,772,165 - 44,596,808 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	42,773,602 - 43,589,728 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	42,949,431 - 43,761,387 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	43,331,499 - 44,154,079 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nell1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	41,532,506 - 42,335,524 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936654	1,591,847 - 2,394,692 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936654	1,591,016 - 2,392,496 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NELL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	37,809,008 - 38,754,525 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	37,809,080 - 38,754,520 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	41,071,490 - 41,565,325 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NELL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	43,416,052 - 44,335,894 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	43,415,553 - 44,335,381 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	140,734,465 - 141,671,260 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nell1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	11,921,650 - 12,737,576 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624766	11,921,570 - 12,734,032 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Nell1
5739 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	227
Count of miRNA genes:	162
Interacting mature miRNAs:	183
Transcripts:	ENSRNOT00000056030
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	102780511	182384005	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	101228864	146228864	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	108680016	153680016	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	102359314	153680016	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	99645382	182701046	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	109493780	193400781	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	97582336	142582336	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	101594089	146594089	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	100345976	145345976	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat

Markers in Region

D1Rat30

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	109,493,780 - 109,494,029 (+)	Marker Load Pipeline
mRatBN7.2	1	100,357,752 - 100,358,001 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	106,002,252 - 106,002,500	NCBI	Rnor6.0
Rnor_5.0	1	107,049,754 - 107,050,002	UniSTS	Rnor5.0
RGSC_v3.4	1	100,539,980 - 100,540,384	RGD	RGSC3.4
RGSC_v3.4	1	100,540,030 - 100,540,278	UniSTS	RGSC3.4
Celera	1	94,544,373 - 94,544,621	UniSTS
RGSC_v3.1	1	100,618,141 - 100,618,389	RGD
RH 3.4 Map	1	929.2	UniSTS
RH 3.4 Map	1	929.2	RGD
RH 2.0 Map	1	605.1	RGD
SHRSP x BN Map	1	51.4199	RGD
Cytogenetic Map	1	q22	UniSTS

D1Rat222

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	109,181,450 - 109,181,660 (+)	Marker Load Pipeline
mRatBN7.2	1	100,045,425 - 100,045,634 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	105,682,142 - 105,682,350	NCBI	Rnor6.0
Rnor_5.0	1	106,729,050 - 106,729,258	UniSTS	Rnor5.0
RGSC_v3.4	1	100,220,444 - 100,220,654	RGD	RGSC3.4
RGSC_v3.4	1	100,220,446 - 100,220,654	UniSTS	RGSC3.4
Celera	1	94,235,500 - 94,235,708	UniSTS
RGSC_v3.1	1	100,298,555 - 100,298,765	RGD
RH 3.4 Map	1	927.2	UniSTS
RH 3.4 Map	1	927.2	RGD
RH 2.0 Map	1	607.4	RGD
FHH x ACI Map	1	51.1299	RGD
Cytogenetic Map	1	q22	UniSTS

D1Rat206

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	100,125,741 - 100,125,944 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	105,762,678 - 105,762,880	NCBI	Rnor6.0
Rnor_5.0	1	106,808,728 - 106,808,930	UniSTS	Rnor5.0
RGSC_v3.4	1	100,302,006 - 100,302,208	UniSTS	RGSC3.4
RGSC_v3.4	1	100,302,005 - 100,302,208	RGD	RGSC3.4
Celera	1	94,313,970 - 94,314,174	UniSTS
RGSC_v3.1	1	100,380,117 - 100,380,319	RGD
RH 3.4 Map	1	931.89	RGD
RH 3.4 Map	1	931.89	UniSTS
FHH x ACI Map	1	51.1299	RGD
FHH x ACI Map	1	51.1299	UniSTS
Cytogenetic Map	1	q22	UniSTS

D1Rat214

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	99,862,096 - 99,862,196 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	105,499,947 - 105,500,046	NCBI	Rnor6.0
Rnor_5.0	1	106,548,488 - 106,548,587	UniSTS	Rnor5.0
RGSC_v3.4	1	100,034,564 - 100,034,664	RGD	RGSC3.4
RGSC_v3.4	1	100,034,565 - 100,034,664	UniSTS	RGSC3.4
RGSC_v3.1	1	100,112,676 - 100,112,775	RGD
RH 3.4 Map	1	924.1	RGD
RH 3.4 Map	1	924.1	UniSTS
RH 2.0 Map	1	604.2	RGD
FHH x ACI Map	1	51.1299	RGD
Cytogenetic Map	1	q22	UniSTS

D1Got310

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	99,998,296 - 99,998,444 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	105,635,027 - 105,635,174	NCBI	Rnor6.0
Rnor_5.0	1	106,681,945 - 106,682,092	UniSTS	Rnor5.0
RGSC_v3.4	1	100,173,737 - 100,173,884	UniSTS	RGSC3.4
Celera	1	94,188,636 - 94,188,783	UniSTS
Cytogenetic Map	1	q22	UniSTS

D1Got309

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	109,134,328 - 109,134,492 (+)	Marker Load Pipeline
mRatBN7.2	1	99,998,300 - 99,998,464 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	105,635,031 - 105,635,194	NCBI	Rnor6.0
Rnor_5.0	1	106,681,949 - 106,682,112	UniSTS	Rnor5.0
RGSC_v3.4	1	100,173,741 - 100,173,904	UniSTS	RGSC3.4
Celera	1	94,188,640 - 94,188,803	UniSTS
Cytogenetic Map	1	q22	UniSTS

AU047621

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	100,447,153 - 100,447,293 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	106,092,436 - 106,092,575	NCBI	Rnor6.0
Rnor_5.0	1	107,134,853 - 107,134,992	UniSTS	Rnor5.0
RGSC_v3.4	1	100,631,230 - 100,631,369	UniSTS	RGSC3.4
Celera	1	94,628,022 - 94,628,161	UniSTS
Cytogenetic Map	1	q22	UniSTS

RH138223

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	100,573,694 - 100,573,869 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	106,218,793 - 106,218,967	NCBI	Rnor6.0
Rnor_5.0	1	107,260,742 - 107,260,916	UniSTS	Rnor5.0
RGSC_v3.4	1	100,757,839 - 100,758,013	UniSTS	RGSC3.4
Celera	1	94,754,487 - 94,754,661	UniSTS
RH 3.4 Map	1	929.2	UniSTS
Cytogenetic Map	1	q22	UniSTS

AU048880

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	99,708,186 - 99,708,459 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	105,347,463 - 105,347,735	NCBI	Rnor6.0
Rnor_5.0	1	106,396,328 - 106,396,600	UniSTS	Rnor5.0
RGSC_v3.4	1	99,804,316 - 99,804,588	UniSTS	RGSC3.4
Celera	1	93,901,329 - 93,901,595	UniSTS
Cytogenetic Map	1	q22	UniSTS

Genetic Models

This gene Nell1 is modified in the following models/strains:

F344-Nell1^{Tn(sb-T2/Bart3)2.195Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	67	145	59	58	27	19	27	6	228	117	9	125	60	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U48246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000056030 ⟹ ENSRNOP00000052883

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	108,845,790 - 109,709,858 (+)	Ensembl
mRatBN7.2 Ensembl	1	99,709,793 - 100,573,860 (+)	Ensembl
Rnor_6.0 Ensembl	1	105,349,069 - 106,218,958 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094328 ⟹ ENSRNOP00000083529

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	108,845,663 - 109,709,846 (+)	Ensembl
mRatBN7.2 Ensembl	1	99,709,793 - 100,573,860 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000145487 ⟹ ENSRNOP00000112278

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	108,845,462 - 109,709,858 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000149591 ⟹ ENSRNOP00000106461

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	108,845,462 - 109,709,858 (+)	Ensembl

RefSeq Acc Id:

NM_031069 ⟹ NP_112331

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	108,845,462 - 109,709,858 (+)	NCBI
mRatBN7.2	1	99,709,306 - 100,573,872 (+)	NCBI
Rnor_6.0	1	105,349,069 - 106,218,956 (+)	NCBI
Rnor_5.0	1	106,397,933 - 107,260,905 (+)	NCBI
RGSC_v3.4	1	99,805,922 - 100,758,002 (+)	RGD
Celera	1	93,902,928 - 94,754,650 (+)	RGD

Sequence:

show sequence

AAGCACTGGTTTCTTGTTAGCGTTGGTGCGCCCTGCTTGGCGGGGGTTCTCCGGAGCGATGCCG
ATGGATGTGATTTTAGTTTTGTGGTTCTGTGTATGCACCGCCAGGACAGTGTTGGGCTTTGGGA
TGGACCCTGACCTTCAGCTGGACATCATCTCAGAGCTCGACCTGGTGAACACCACCCTGGGAGT
CACGCAGGTGGCTGGACTGCACAACGCCAGTAAAGCATTTCTATTTCAAGATGTACAGAGAGAG
ATCCATTCGGCCCCTCACGTGAGTGAGAAGCTGATCCAGCTATTCCGGAATAAGAGCGAGTTCA
CCTTTTTGGCTACAGTGCAGCAGAAACCATCCACCTCAGGGGTGATACTGTCCATCCGGGAGCT
GGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCCAAGAGAAGAGATACGCTACCATTACATA
CATGGTGGAAAGCCCAGGACTGAGGCCCTTCCCTACCGCATGGCAGACGGACAATGGCACAAGG
TCGCGCTGTCAGTGAGCGCCTCTCACCTCCTGCTCCACATCGACTGCAATAGGATTTACGAGCG
TGTGATAGACCCTCCGGAGACCAACCTTCCTCCAGGAAGCAATCTGTGGCTTGGGCAACGTAAC
CAAAAGCATGGCTTTTTCAAAGGAATCATCCAAGATGGTAAGATCATCTTCATGCCGAATGGTT
TCATCACACAGTGTCCCAACCTCAATCGCACTTGCCCAACATGCAGTGACTTCCTGAGCCTGGT
TCAAGGAATAATGGATTTGCAAGAGCTTTTGGCCAAGATGACTGCAAAACTGAATTATGCAGAG
ACGAGACTTGGTCAACTGGAAAATTGCCACTGTGAGAAGACCTGCCAAGTGAGTGGGCTGCTCT
ACAGGGACCAAGACTCCTGGGTGGATGGTGACAACTGTGGGAACTGCACGTGCAAAAGTGGTGC
CGTGGAGTGCCGCAGGATGTCCTGTCCCCCGCTCAACTGTTCCCCGGACTCACTTCCTGTGCAC
ATTTCCGGCCAGTGTTGTAAAGTTTGCAGACCAAAATGTATCTATGGAGGAAAAGTTCTTGCTG
AGGGCCAGCGGATTTTAACCAAGACCTGCCGGGAATGTCGAGGTGGAGTCTTGGTAAAAATCAC
AGAAGCTTGCCCTCCTTTGAACTGCTCAGCAAAGGATCATATTCTTCCAGAGAATCAGTGCTGC
AGGGTCTGCCCAGGTCATAACTTCTGTGCAGAAGCACCTAAGTGCGGAGAAAACTCGGAATGCA
AAAATTGGAATACAAAAGCAACCTGTGAGTGCAAGAATGGATACATCTCTGTCCAGGGCAACTC
TGCATACTGTGAAGATATTGATGAGTGTGCAGCTAAAATGCACTATTGTCATGCCAACACCGTG
TGTGTCAACTTGCCGGGGTTGTATCGCTGTGACTGCGTCCCAGGGTACATCCGTGTGGATGACT
TCTCTTGTACGGAGCATGATGATTGTGGCAGCGGACAACACAACTGCGACAAAAATGCCATCTG
TACCAACACAGTCCAGGGACACAGCTGCACCTGCCAGCCGGGTTACGTGGGAAATGGCACCATC
TGCAAAGCATTCTGTGAAGAGGGTTGCAGATACGGAGGTACCTGTGTGGCTCCTAACAAGTGTG
TCTGTCCTTCTGGATTCACGGGAAGCCACTGTGAGAAAGATATTGATGAATGCGCAGAGGGATT
CGTTGAATGCCACAACTACTCCCGCTGTGTTAACCTGCCAGGGTGGTACCACTGTGAGTGCAGA
AGCGGTTTCCATGACGATGGGACCTACTCACTGTCCGGGGAGTCCTGCATTGATATCGATGAAT
GTGCCTTAAGAACTCACACTTGTTGGAATGACTCTGCCTGCATCAACTTAGCAGGAGGATTTGA
CTGCCTGTGTCCCTCTGGGCCCTCCTGCTCTGGTGACTGTCCCCACGAAGGAGGGCTGAAGCAT
AATGGGCAGGTGTGGATTCTGAGAGAAGACAGGTGTTCAGTCTGTTCCTGCAAGGATGGGAAGA
TATTCTGCCGGCGGACAGCTTGTGATTGCCAGAATCCAAATGTTGACCTTTTTTGCTGCCCAGA
GTGCGATACCAGGGTCACCAGCCAATGTTTAGATCAAAGTGGACAGAAGCTCTATCGAAGTGGA
GACAACTGGACCCACAGCTGCCAGCAGTGCCGATGTCTGGAAGGAGAGGCAGACTGCTGGCCTC
TGGCTTGCCCTAGTTTGGGCTGTGAATACACAGCCATGTTTGAAGGGGAGTGTTGTCCCCGATG
TGTCAGTGACCCCTGCCTGGCTGGTAATATTGCCTATGACATCAGAAAAACTTGCCTGGACAGC
TTTGGTGTTTCGAGGCTGAGCGGAGCCGTGTGGACAATGGCTGGATCTCCTTGTACAACCTGCA
AATGCAAGAATGGGAGAGTCTGCTGCTCTGTGGATCTGGAGTGTATTGAGAATAACTGAAGATT
TTAAATGGACTCGTCACGTGAGAAAATGGGCAAAATGATCATCCCACCTGAGGAAGAAGAGGGG
CTGATTTCTTTTTCTTTTTAACCACAGTCAATTACCAAAGTCTCCATCTGAGGAAGGCGTTTGG
ATTGCCTTTGCCACTTTGCTCATCCTTGCTGACCTAGTCTAGATGCCTGCAGTACCGTGCATTT
CGGTCGATGGTTGTTGAGTCTCAGTGTTGTAAATCGCATTTCCCTCGTCAGATCATTTACAGAT
ACATTTAAAGGGGTTCCATGATAAATGTTAATGTAACTTTTGTTTATTTTGTGTACTGACATAA
TAGAGACTTGGCACCATTTATTTATTTTTCTTGATTTTTGGATCAAATTCTAAAAATAAAGTTG
CCTGTTGCGAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017589771 ⟹ XP_017445260

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	108,845,470 - 109,709,847 (+)	NCBI
mRatBN7.2	1	99,709,306 - 100,573,872 (+)	NCBI
Rnor_6.0	1	105,348,577 - 106,218,970 (+)	NCBI

Sequence:

show sequence

GTTGTTCCCCAAAGAGGGTCTGGGAGCACTCGGTGACACCGCCTAGGTCTGGTTTCCCTAGGAA
ACAACCCACGCACCAGGGTTGGGCTGCTTCGGACACGGCCCGGATGAACTGTTGCAACTTGGGC
AGCCCGCAGCGCGGCGCAGTGGCAGAGGCGGGGGCGTGAAGCCGGGAGGCGCGTGTAACCAGGA
TCCTCGAAGCTCCGGAGACCCGGAGGCGAAAGGATCCGCACAGGAACCCAGGGCAACCTGCGCG
AGTGGCGGAGCCCCGCGCTCCCGCCCTAGCTCAAGGGGAGCGCAGTCGTAGCGGGGTTCAGAGC
CCCAGCCCCGTGCCACCGCCACCCGCGGTGGGGGGTGGGCTGGGGGCGGGGCAGCTGGGGTTGC
CTTCCCGGGCGCGATCCCCGAGCGCGGCACCCGGCGCCGCCGAGCCACCTCCCCTGCCGCCCGC
CAGCAAGTTTGGCGGCTTCGAGCCCAGAGAGCCACGGCTTTCTGAAGCACTGGTTTCTTGTTAG
CGTTGGTGCGCCCTGCTTGGCGGGGGTTCTCCGGAGCGATGCCGATGGATGTGATTTTAGTTTT
GTGGTTCTGTGTATGCACCGCCAGGACAGTGTTGGGCTTTGGGATGGACCCTGACCTTCAGCTG
GACATCATCTCAGAGCTCGACCTGGTGAACACCACCCTGGGAGTCACGCAGGTGGCTGGACTGC
ACAACGCCAGTAAAGCATTTCTATTTCAAGATGTACAGAGAGAGATCCATTCGGCCCCTCACGT
GAGTGAGAAGCTGATCCAGCTATTCCGAAATAAGAGCGAGTTCACCTTTTTGGCTACAGTGCAG
CAGAAACCATCCACCTCAGGGGTGATACTGTCCATCCGGGAGCTGGAGCACAGCTATTTTGAAC
TGGAGAGCAGTGGCCCAAGAGAAGAGATACGCTACCATTACATACATGGTGGAAAGCCCAGGAC
TGAGGCCCTTCCCTACCGCATGGCAGACGGACAATGGCACAAGGTCGCGCTGTCAGTGAGCGCC
TCTCACCTCCTGCTCCACATCGACTGCAATAGGATTTACGAGCGTGTGATAGACCCTCCGGAGA
CCAACCTTCCTCCAGGAAGCAATCTGTGGCTTGGGCAACGTAACCAAAAGCATGGCTTTTTCAA
AGGAATCATCCAAGATGGTAAGATCATCTTCATGCCGAATGGTTTCATCACACAGTGTCCCAAC
CTCAATCGCACTTGCCCAACATGCAGTGACTTCCTGAGCCTGGTTCAAGGAATAATGGATTTGC
AAGAGCTTTTGGCCAAGATGACTGCAAAACTGAATTATGCAGAGACGAGACTTGGTCAACTGGA
AAATTGCCACTGTGAGAAGACCTGCCAAGTGAGTGGGCTGCTCTACAGGGACCAAGACTCCTGG
GTGGATGGTGACAACTGTAGGAACTGCACGTGCAAAAGTGGTGCCGTGGAGTGCCGCAGGATGT
CCTGTCCCCCGCTCAACTGTTCCCCAGACTCACTTCCTGTGCACATTTCCGGCCAGTGTTGTAA
AGTTTGCAGACCAAAATGTATCTATGGAGGAAAAGTTCTTGCTGAGGGCCAGCGGATTTTAACC
AAGACCTGCCGGGAATGTCGAGGTGGAGTCTTGGTAAAAATCACAGAAGCTTGCCCTCCTTTGA
ACTGCTCAGCAAAGGATCATATTCTTCCAGAGAATCAGTGCTGCAGGGTCTGCCCAGGTCATAA
CTTCTGTGCAGAAGCACCTAAGTGCGGAGAAAACTCGGAATGCAAAAATTGGAATACAAAAGCA
ACCTGTGAGTGCAAGAATGGATACATCTCTGTCCAGGGCAACTCTGCATACTGTGAAGATATTG
ATGAGTGTGCAGCTAAAATGCACTATTGTCATGCCAACACCGTGTGTGTCAACTTGCCGGGGTT
GTATCGCTGTGACTGCGTCCCAGGATACATCCGTGTGGATGACTTCTCTTGTACGGAGCATGAT
GATTGTGGCAGCGGACAACACAACTGCGACAAAAATGCCATCTGTACCAACACAGTCCAGGGAC
ACAGCTGCACCTGCCAGCCGGGTTACGTGGGAAATGGCACCATCTGCAAAGCATTCTGTGAAGA
GGGTTGCAGATACGGAGGTACCTGTGTGGCTCCTAACAAGTGTGTCTGTCCTTCTGGATTCACG
GGAAGCCACTGTGAGAAAGATATCGATGAATGTGCCTTAAGAACTCACACTTGTTGGAATGACT
CTGCCTGCATCAACTTAGCAGGAGGATTTGACTGCCTGTGTCCCTCTGGGCCCTCCTGCTCTGG
TGACTGTCCCCACGAAGGAGGGCTGAAGCATAATGGGCAGGTGTGGATTCTGAGAGAAGACAGG
TGTTCAGTCTGTTCCTGCAAGGATGGGAAGATATTCTGCCGGCGGACAGCTTGTGATTGCCAGA
ATCCAAATGTTGACCTTTTTTGCTGCCCAGAGTGCGATACCAGGGTCACCAGCCAATGTTTAGA
TCAAAGTGGACAGAAGCTCTATCGAAGTGGAGACAACTGGACCCACAGCTGCCAGCAGTGCCGA
TGTCTGGAAGGAGAGGCAGACTGCTGGCCTCTGGCTTGCCCTAGTTTGGGCTGTGAATACACAG
CCATGTTTGAAGGGGAGTGTTGTCCCCGATGTGTCAGTGACCCCTGCCTGGCTGATAATATTGC
CTATGACATCAGAAAAACTTGCCTGGACAGCTTTGGTGTTTCGAGGCTGAGCGGAGCCGTGTGG
ACAATGGCTGGATCTCCTTGTACAACCTGCAAATGCAAGAATGGGAGAGTCTGCTGCTCTGTGG
ATCTGGAGTGTATTGAGAATAACTGAAGATTTTAAATGGACTCGTCACGTGAGAAAATGGACAA
AATGATCATCCCACCTGAGGAAGAAGAGGGGCTGATTTCTTTTTCTTTTTAACCACAGTCAATT
ACCAAAGTCTCCATCTGAGGAAGGCGTTTGGATTGCCTTTGCCACTTTGCTCATCCTTGCTGAC
CTAGTCTAGATGCCTGCAGTACCGTGCATTTCGGTCGATGGTTGTTGAGTCTCAGTGTTGTAAA
TCGCATTTCCCTCGTCAGATCATTTACAGATACATTTAAAGGGGTTCCATGATAAATGTTAATG
TAACTTTTGTTTATTTTGTGTACTGACATAATAGAGACTTGGCACCATTTATTTATTTTTCTTG
ATTTTTGGATCAAATTCTAAAAATAAAGTTGCCTGTTGTGACTTTCGTCTCA

hide sequence

RefSeq Acc Id:

XM_039092192 ⟹ XP_038948120

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	108,845,470 - 109,360,887 (+)	NCBI
mRatBN7.2	1	99,709,305 - 100,217,083 (+)	NCBI

RefSeq Acc Id:

XM_039092195 ⟹ XP_038948123

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	108,845,470 - 109,265,882 (+)	NCBI
mRatBN7.2	1	99,709,306 - 100,129,858 (+)	NCBI

RefSeq Acc Id:

XM_039092200 ⟹ XP_038948128

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	108,845,471 - 109,132,767 (+)	NCBI
mRatBN7.2	1	99,709,307 - 100,008,480 (+)	NCBI

RefSeq Acc Id:

XM_063275215 ⟹ XP_063131285

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	108,845,469 - 109,611,936 (+)	NCBI

RefSeq Acc Id:

XM_063275221 ⟹ XP_063131291

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	108,845,467 - 109,338,397 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_112331	(Get FASTA)	NCBI Sequence Viewer
	XP_017445260	(Get FASTA)	NCBI Sequence Viewer
	XP_038948120	(Get FASTA)	NCBI Sequence Viewer
	XP_038948123	(Get FASTA)	NCBI Sequence Viewer
	XP_038948128	(Get FASTA)	NCBI Sequence Viewer
	XP_063131285	(Get FASTA)	NCBI Sequence Viewer
	XP_063131291	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC72252	(Get FASTA)	NCBI Sequence Viewer
	EDM07213	(Get FASTA)	NCBI Sequence Viewer
	EDM07214	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052883.4
	ENSRNOP00000083529
	ENSRNOP00000112278
GenBank Protein	Q62919	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112331 ⟸ NM_031069
- Peptide Label:	precursor
- UniProtKB:	Q62919 (UniProtKB/Swiss-Prot), D4A284 (UniProtKB/TrEMBL), A6JBG8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPMDVILVLWFCVCTARTVLGFGMDPDLQLDIISELDLVNTTLGVTQVAGLHNASKAFLFQDVQ REIHSAPHVSEKLIQLFRNKSEFTFLATVQQKPSTSGVILSIRELEHSYFELESSGPREEIRYH YIHGGKPRTEALPYRMADGQWHKVALSVSASHLLLHIDCNRIYERVIDPPETNLPPGSNLWLGQ RNQKHGFFKGIIQDGKIIFMPNGFITQCPNLNRTCPTCSDFLSLVQGIMDLQELLAKMTAKLNY AETRLGQLENCHCEKTCQVSGLLYRDQDSWVDGDNCGNCTCKSGAVECRRMSCPPLNCSPDSLP VHISGQCCKVCRPKCIYGGKVLAEGQRILTKTCRECRGGVLVKITEACPPLNCSAKDHILPENQ CCRVCPGHNFCAEAPKCGENSECKNWNTKATCECKNGYISVQGNSAYCEDIDECAAKMHYCHAN TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDDCGSGQHNCDKNAICTNTVQGHSCTCQPGYVGNG TICKAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECAEGFVECHNYSRCVNLPGWYHCE CRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGL KHNGQVWILREDRCSVCSCKDGKIFCRRTACDCQNPNVDLFCCPECDTRVTSQCLDQSGQKLYR SGDNWTHSCQQCRCLEGEADCWPLACPSLGCEYTAMFEGECCPRCVSDPCLAGNIAYDIRKTCL DSFGVSRLSGAVWTMAGSPCTTCKCKNGRVCCSVDLECIENN hide sequence

RefSeq Acc Id:	XP_017445260 ⟸ XM_017589771
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A059 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPMDVILVLWFCVCTARTVLGFGMDPDLQLDIISELDLVNTTLGVTQVAGLHNASKAFLFQDVQ REIHSAPHVSEKLIQLFRNKSEFTFLATVQQKPSTSGVILSIRELEHSYFELESSGPREEIRYH YIHGGKPRTEALPYRMADGQWHKVALSVSASHLLLHIDCNRIYERVIDPPETNLPPGSNLWLGQ RNQKHGFFKGIIQDGKIIFMPNGFITQCPNLNRTCPTCSDFLSLVQGIMDLQELLAKMTAKLNY AETRLGQLENCHCEKTCQVSGLLYRDQDSWVDGDNCRNCTCKSGAVECRRMSCPPLNCSPDSLP VHISGQCCKVCRPKCIYGGKVLAEGQRILTKTCRECRGGVLVKITEACPPLNCSAKDHILPENQ CCRVCPGHNFCAEAPKCGENSECKNWNTKATCECKNGYISVQGNSAYCEDIDECAAKMHYCHAN TVCVNLPGLYRCDCVPGYIRVDDFSCTEHDDCGSGQHNCDKNAICTNTVQGHSCTCQPGYVGNG TICKAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCL CPSGPSCSGDCPHEGGLKHNGQVWILREDRCSVCSCKDGKIFCRRTACDCQNPNVDLFCCPECD TRVTSQCLDQSGQKLYRSGDNWTHSCQQCRCLEGEADCWPLACPSLGCEYTAMFEGECCPRCVS DPCLADNIAYDIRKTCLDSFGVSRLSGAVWTMAGSPCTTCKCKNGRVCCSVDLECIENN hide sequence

Ensembl Acc Id:

ENSRNOP00000052883 ⟸ ENSRNOT00000056030

RefSeq Acc Id:	XP_038948120 ⟸ XM_039092192
- Peptide Label:	isoform X4
- UniProtKB:	A6JBG9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038948123 ⟸ XM_039092195
- Peptide Label:	isoform X5
- UniProtKB:	A6JBG9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038948128 ⟸ XM_039092200
- Peptide Label:	isoform X6
- UniProtKB:	A6JBG9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000083529 ⟸ ENSRNOT00000094328

RefSeq Acc Id:	XP_063131291 ⟸ XM_063275221
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063131285 ⟸ XM_063275215
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000106461 ⟸ ENSRNOT00000149591

Ensembl Acc Id:

ENSRNOP00000112278 ⟸ ENSRNOT00000145487

Protein Domains

EGF-like Laminin G Laminin G-like Thrombospondin-like N-terminal VWFC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62919-F1-model_v2	AlphaFold	Q62919	1-810	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620998	AgrOrtholog
BioCyc Gene	G2FUF-59555	BioCyc
Ensembl Genes	ENSRNOG00000015675	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000056030.5	UniProtKB/Swiss-Prot
	ENSRNOT00000094328	ENTREZGENE
	ENSRNOT00000145487	ENTREZGENE
Gene3D-CATH	2.60.120.200	UniProtKB/Swiss-Prot
	6.20.200.20	UniProtKB/Swiss-Prot
	Complement Module, domain 1	UniProtKB/Swiss-Prot
	Laminin	UniProtKB/Swiss-Prot
InterPro	ConA-like_dom_sf	UniProtKB/Swiss-Prot
	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/Swiss-Prot
	EGF_Ca-bd_CS	UniProtKB/Swiss-Prot
	EGF_dom	UniProtKB/Swiss-Prot
	Growth_fac_rcpt_cys_sf	UniProtKB/Swiss-Prot
	Laminin_G	UniProtKB/Swiss-Prot
	NOTCH1_EGF-like	UniProtKB/Swiss-Prot
	PKC-binding_NELL	UniProtKB/Swiss-Prot
	TSPN-like_N	UniProtKB/Swiss-Prot
	VWF_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:81733	UniProtKB/Swiss-Prot
NCBI Gene	81733	ENTREZGENE
PANTHER	NEL HOMOLOG	UniProtKB/Swiss-Prot
	PROTEIN KINASE C-BINDING PROTEIN NELL1	UniProtKB/Swiss-Prot
Pfam	EGF_3	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	Laminin_G_2	UniProtKB/Swiss-Prot
	VWC	UniProtKB/Swiss-Prot
PhenoGen	Nell1	PhenoGen
PROSITE	ASX_HYDROXYL	UniProtKB/Swiss-Prot
	EGF_1	UniProtKB/Swiss-Prot
	EGF_2	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	VWFC_1	UniProtKB/Swiss-Prot
	VWFC_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000015675	RatGTEx
SMART	EGF	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	LamG	UniProtKB/Swiss-Prot
	TSPN	UniProtKB/Swiss-Prot
	VWC	UniProtKB/Swiss-Prot
	VWC_out	UniProtKB/Swiss-Prot
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot
	FnI-like domain	UniProtKB/Swiss-Prot
	SSF49899	UniProtKB/Swiss-Prot
	SSF57184	UniProtKB/Swiss-Prot
UniProt	A0A8I6A059	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LVW7_RAT	UniProtKB/TrEMBL
	A6JBG8	ENTREZGENE
	A6JBG9	ENTREZGENE, UniProtKB/TrEMBL
	D4A284	ENTREZGENE
	NELL1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A6JBG8	UniProtKB/Swiss-Prot
	D4A284	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Nell1	NEL-like 1 (chicken)		protein kinase C-binding protein NELL1	Name updated	1299863	APPROVED
2002-08-07	Nell1	protein kinase C-binding protein NELL1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_mutations_overexpression	overexpression induces calvarial overgrowth resulting in premature suture closure	633405

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

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Mammalian Phenotype