Arhgef1 (Rho guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Arhgef1 (Rho guanine nucleotide exchange factor 1) Rattus norvegicus
Analyze
Symbol: Arhgef1
Name: Rho guanine nucleotide exchange factor 1
RGD ID: 620951
Description: Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in microtubule depolymerization. Predicted to be located in membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1); PARTICIPATES IN eicosanoid signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lbc's second cousin; Lbcl2; Lsc; Lymphoid blast crisis-like 2; MGC108950; Rho guanine nucleotide exchange factor (GEF) 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,626,884 - 89,648,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,628,266 - 89,649,067 (+)EnsemblGRCr8
mRatBN7.2180,499,026 - 80,520,954 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,499,131 - 80,520,953 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,891,659 - 85,913,491 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,442,476 - 94,464,309 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,647,420 - 87,669,252 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,769,212 - 81,797,237 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,779,380 - 81,797,236 (+)Ensemblrn6Rnor6.0
Rnor_5.0183,025,520 - 83,053,989 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,209,459 - 80,226,353 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,946,561 - 74,968,150 (+)NCBICelera
RGSC_v3.1180,287,569 - 80,304,463 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. Eisenhaure TM, etal., J Biol Chem 2003 Aug 15;278(33):30975-84. Epub 2003 May 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Information Derived from GenBank Report RGD, Sept. 2003
8. Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. Varma H, etal., J Biol Chem. 2010 Nov 26;285(48):37445-57. doi: 10.1074/jbc.M110.125542. Epub 2010 Sep 21.
Additional References at PubMed
PMID:12477932   PMID:12634853   PMID:17971419   PMID:18569527   PMID:22658674   PMID:28673614  


Genomics

Comparative Map Data
Arhgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,626,884 - 89,648,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,628,266 - 89,649,067 (+)EnsemblGRCr8
mRatBN7.2180,499,026 - 80,520,954 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,499,131 - 80,520,953 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,891,659 - 85,913,491 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,442,476 - 94,464,309 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,647,420 - 87,669,252 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,769,212 - 81,797,237 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,779,380 - 81,797,236 (+)Ensemblrn6Rnor6.0
Rnor_5.0183,025,520 - 83,053,989 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,209,459 - 80,226,353 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,946,561 - 74,968,150 (+)NCBICelera
RGSC_v3.1180,287,569 - 80,304,463 (+)NCBI
Cytogenetic Map1q21NCBI
ARHGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,883,184 - 41,930,141 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,883,079 - 41,930,150 (+)Ensemblhg38GRCh38
GRCh371942,387,251 - 42,434,293 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,079,107 - 47,103,444 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341947,080,285 - 47,103,443NCBI
Celera1939,186,950 - 39,211,282 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,818,551 - 38,842,545 (+)NCBIHuRef
CHM1_11942,388,735 - 42,412,987 (+)NCBICHM1_1
T2T-CHM13v2.01944,702,671 - 44,749,424 (+)NCBIT2T-CHM13v2.0
Arhgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,601,762 - 24,626,019 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,602,337 - 24,626,019 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38724,902,986 - 24,926,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,902,912 - 24,926,594 (+)Ensemblmm10GRCm38
MGSCv37725,688,005 - 25,711,611 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36724,611,816 - 24,635,352 (+)NCBIMGSCv36mm8
Celera719,518,885 - 19,542,623 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.52NCBI
Arhgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555938,491 - 961,142 (-)Ensembl
ChiLan1.0NW_004955555941,539 - 961,407 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,988,151 - 48,013,022 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,857,135 - 49,882,019 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,771,343 - 38,796,174 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,276,407 - 47,299,663 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,277,420 - 47,299,663 (+)EnsemblpanPan2panpan1.1
ARHGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,391,670 - 112,410,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,827,451 - 111,846,482 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,015,057 - 113,034,087 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,015,059 - 113,033,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,568,393 - 112,587,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,204,579 - 112,223,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,131,063 - 113,150,095 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,193,641 - 16,211,488 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706540,748 - 558,823 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936706540,987 - 558,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,975,876 - 49,995,339 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,975,957 - 49,995,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,030,643 - 46,046,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,091,158 - 36,115,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,091,204 - 36,115,626 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607314,326,794 - 14,351,774 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907783,214 - 802,150 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624907783,404 - 802,205 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef1
49 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000065865
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
AU047514  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0181,781,927 - 81,782,049NCBIRnor6.0
Rnor_5.0183,037,866 - 83,037,988UniSTSRnor5.0
RGSC_v3.4180,211,871 - 80,211,993UniSTSRGSC3.4
Celera174,953,664 - 74,953,786UniSTS
Cytogenetic Map1q21UniSTS
AU047512  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8189,634,112 - 89,634,265 (+)Marker Load Pipeline
mRatBN7.2180,506,238 - 80,506,393 (+)MAPPERmRatBN7.2
Rnor_6.0181,781,929 - 81,782,081NCBIRnor6.0
Rnor_5.0183,037,868 - 83,038,020UniSTSRnor5.0
RGSC_v3.4180,211,873 - 80,212,025UniSTSRGSC3.4
Celera174,953,666 - 74,953,818UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001440131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF314539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ236911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000065865   ⟹   ENSRNOP00000059325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl180,499,131 - 80,520,951 (+)Ensembl
Rnor_6.0 Ensembl181,779,380 - 81,797,236 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080143   ⟹   ENSRNOP00000068908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,628,266 - 89,649,067 (+)Ensembl
mRatBN7.2 Ensembl180,500,418 - 80,520,953 (+)Ensembl
Rnor_6.0 Ensembl181,779,465 - 81,797,236 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080840   ⟹   ENSRNOP00000072904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,634,963 - 89,648,056 (+)Ensembl
mRatBN7.2 Ensembl180,507,091 - 80,520,187 (+)Ensembl
Rnor_6.0 Ensembl181,779,482 - 81,796,900 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089592   ⟹   ENSRNOP00000073086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl181,779,478 - 81,796,572 (+)Ensembl
RefSeq Acc Id: NM_021694   ⟹   NP_067726
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,626,990 - 89,648,823 (+)NCBI
mRatBN7.2180,499,113 - 80,520,954 (+)NCBI
Rnor_6.0181,769,212 - 81,797,237 (+)NCBI
Rnor_5.0183,025,520 - 83,053,989 (+)NCBI
RGSC_v3.4180,209,459 - 80,226,353 (+)RGD
Celera174,946,561 - 74,968,150 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088933   ⟹   XP_038944861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,626,884 - 89,648,823 (+)NCBI
mRatBN7.2180,499,029 - 80,520,954 (+)NCBI
RefSeq Acc Id: XM_063272358   ⟹   XP_063128428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,627,146 - 89,648,823 (+)NCBI
RefSeq Acc Id: XM_063272361   ⟹   XP_063128431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,626,914 - 89,648,823 (+)NCBI
RefSeq Acc Id: XM_063272364   ⟹   XP_063128434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,627,147 - 89,648,823 (+)NCBI
RefSeq Acc Id: XM_063272365   ⟹   XP_063128435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,627,144 - 89,648,823 (+)NCBI
RefSeq Acc Id: XM_063272369   ⟹   XP_063128439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,626,884 - 89,645,894 (+)NCBI
RefSeq Acc Id: XM_063272371   ⟹   XP_063128441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,626,884 - 89,645,338 (+)NCBI
RefSeq Acc Id: NP_067726   ⟸   NM_021694
- UniProtKB: Q9Z1I6 (UniProtKB/Swiss-Prot),   Q5BK37 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068908   ⟸   ENSRNOT00000080143
Ensembl Acc Id: ENSRNOP00000072904   ⟸   ENSRNOT00000080840
Ensembl Acc Id: ENSRNOP00000073086   ⟸   ENSRNOT00000089592
Ensembl Acc Id: ENSRNOP00000059325   ⟸   ENSRNOT00000065865
RefSeq Acc Id: XP_038944861   ⟸   XM_039088933
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128439   ⟸   XM_063272369
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063128441   ⟸   XM_063272371
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063128431   ⟸   XM_063272361
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JU01 (UniProtKB/TrEMBL),   E9PTJ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128435   ⟸   XM_063272365
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128428   ⟸   XM_063272358
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128434   ⟸   XM_063272364
- Peptide Label: isoform X3
Protein Domains
DH   PH   RGSL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1I6-F1-model_v2 AlphaFold Q9Z1I6 1-919 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620951 AgrOrtholog
BioCyc Gene G2FUF-60410 BioCyc
Ensembl Genes ENSRNOG00000020130 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080143 ENTREZGENE
  ENSRNOT00000080840 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107802 IMAGE-MGC_LOAD
InterPro DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  p115RhoGEF_RGS UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_16 UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  RGS-like_dom UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108950 IMAGE-MGC_LOAD
NCBI Gene 60323 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 UniProtKB/Swiss-Prot
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D UniProtKB/Swiss-Prot
Pfam PH_16 UniProtKB/Swiss-Prot
  RGS-like UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
PhenoGen Arhgef1 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020130 RatGTEx
SMART RhoGEF UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF48097 UniProtKB/Swiss-Prot
UniProt A0A0G2JU01 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K446_RAT UniProtKB/TrEMBL
  ARHG1_RAT UniProtKB/Swiss-Prot
  E9PTJ8 ENTREZGENE
  Q5BK37 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1I6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef1  Rho guanine nucleotide exchange factor 1  Arhgef1  Rho guanine nucleotide exchange factor (GEF) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Arhgef1  Rho guanine nucleotide exchange factor (GEF) 1  Lsc  lsc protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Lsc  lsc protein      Symbol and Name status set to provisional 70820 PROVISIONAL