Arhgef1 (Rho guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Arhgef1 (Rho guanine nucleotide exchange factor 1) Heterocephalus glaber
Analyze
Symbol: Arhgef1
Name: Rho guanine nucleotide exchange factor 1
RGD ID: 18929172
Description: ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN microtubule depolymerization (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ASSOCIATED WITH Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); craniosynostosis (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907783,214 - 802,150 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907783,404 - 802,205 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
membrane  (IEA)
plasma membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Arhgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907783,214 - 802,150 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907783,404 - 802,205 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ARHGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,883,184 - 41,930,141 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,883,173 - 41,930,150 (+)EnsemblGRCh38hg38GRCh38
GRCh371942,387,251 - 42,434,293 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,079,107 - 47,103,444 (+)NCBINCBI36Build 36hg18NCBI36
Build 341947,080,285 - 47,103,443NCBI
Celera1939,186,950 - 39,211,282 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,818,551 - 38,842,545 (+)NCBIHuRef
CHM1_11942,388,735 - 42,412,987 (+)NCBICHM1_1
T2T-CHM13v2.01944,702,671 - 44,749,424 (+)NCBIT2T-CHM13v2.0
Arhgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,601,762 - 24,626,019 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,602,337 - 24,626,019 (+)EnsemblGRCm39 Ensembl
GRCm38724,902,986 - 24,926,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,902,912 - 24,926,594 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,688,005 - 25,711,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,611,816 - 24,635,352 (+)NCBIMGSCv36mm8
Celera719,518,885 - 19,542,623 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.52NCBI
Arhgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,626,884 - 89,648,823 (+)NCBIGRCr8
mRatBN7.2180,499,026 - 80,520,954 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,499,131 - 80,520,953 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,891,659 - 85,913,491 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,442,476 - 94,464,309 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,647,420 - 87,669,252 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,769,212 - 81,797,237 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,779,380 - 81,797,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,025,520 - 83,053,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,209,459 - 80,226,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,287,569 - 80,304,463 (+)NCBI
Celera174,946,561 - 74,968,150 (+)NCBICelera
Cytogenetic Map1q21NCBI
Arhgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955555941,539 - 961,407 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,988,151 - 48,013,022 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,857,135 - 49,882,019 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,771,343 - 38,796,174 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,276,407 - 47,299,663 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,277,420 - 47,299,663 (+)Ensemblpanpan1.1panPan2
ARHGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,391,670 - 112,410,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,827,451 - 111,846,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,015,057 - 113,034,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,015,059 - 113,033,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,568,393 - 112,587,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,204,579 - 112,223,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,131,063 - 113,150,095 (-)NCBIUU_Cfam_GSD_1.0
Arhgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,193,641 - 16,211,488 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706540,748 - 558,823 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706540,987 - 558,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,975,876 - 49,995,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,975,957 - 49,995,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,030,643 - 46,046,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,091,158 - 36,115,355 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,091,204 - 36,115,626 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,326,794 - 14,351,774 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000004220   ⟹   ENSHGLP00000004162
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624907783,214 - 802,150 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000004221   ⟹   ENSHGLP00000004163
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624907783,214 - 801,203 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000004222   ⟹   ENSHGLP00000004164
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624907783,828 - 797,145 (-)Ensembl
RefSeq Acc Id: XM_004873063   ⟹   XP_004873120
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 802,205 (-)NCBI
RefSeq Acc Id: XM_013068598   ⟹   XP_012924052
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 802,143 (-)NCBI
RefSeq Acc Id: XM_013068599   ⟹   XP_012924053
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 801,994 (-)NCBI
RefSeq Acc Id: XM_013068603   ⟹   XP_012924057
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 802,205 (-)NCBI
RefSeq Acc Id: XM_013068604   ⟹   XP_012924058
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 800,903 (-)NCBI
RefSeq Acc Id: XM_013068605   ⟹   XP_012924059
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 801,994 (-)NCBI
RefSeq Acc Id: XM_013068608   ⟹   XP_012924062
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 802,205 (-)NCBI
RefSeq Acc Id: XM_013068609   ⟹   XP_012924063
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 800,878 (-)NCBI
RefSeq Acc Id: XM_021250873   ⟹   XP_021106532
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 801,994 (-)NCBI
RefSeq Acc Id: XM_021250874   ⟹   XP_021106533
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 801,994 (-)NCBI
RefSeq Acc Id: XM_021250875   ⟹   XP_021106534
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 797,258 (-)NCBI
RefSeq Acc Id: XM_021250877   ⟹   XP_021106536
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 801,993 (-)NCBI
RefSeq Acc Id: XM_021250878   ⟹   XP_021106537
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 800,865 (-)NCBI
RefSeq Acc Id: XM_021250879   ⟹   XP_021106538
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624907783,404 - 800,874 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004873120   ⟸   XM_004873063
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924062   ⟸   XM_013068608
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924057   ⟸   XM_013068603
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924052   ⟸   XM_013068598
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924059   ⟸   XM_013068605
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106532   ⟸   XM_021250873
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106533   ⟸   XM_021250874
- Peptide Label: isoform X2
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924053   ⟸   XM_013068599
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106536   ⟸   XM_021250877
- Peptide Label: isoform X4
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924058   ⟸   XM_013068604
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924063   ⟸   XM_013068609
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106538   ⟸   XM_021250879
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106537   ⟸   XM_021250878
- Peptide Label: isoform X1
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106534   ⟸   XM_021250875
- Peptide Label: isoform X3
- UniProtKB: G5AZQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000004162   ⟸   ENSHGLT00000004220
RefSeq Acc Id: ENSHGLP00000004164   ⟸   ENSHGLT00000004222
RefSeq Acc Id: ENSHGLP00000004163   ⟸   ENSHGLT00000004221


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003059 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004221 ENTREZGENE
  ENSHGLT00000004222 ENTREZGENE
Gene3D-CATH Dbl homology (DH) domain UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  Regulator of G-protein Signalling 4, domain 2 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  p115RhoGEF_RGS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_16 UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  RGS-like_dom UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
NCBI Gene Arhgef1 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D UniProtKB/TrEMBL
Pfam PH_16 UniProtKB/TrEMBL
  RGS-like UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DBL homology domain (DH-domain) UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Regulator of G-protein signaling, RGS UniProtKB/TrEMBL
UniProt G5AZQ3 ENTREZGENE, UniProtKB/TrEMBL