Srm (spermidine synthase) - Rat Genome Database

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Gene: Srm (spermidine synthase) Rattus norvegicus
Analyze
Symbol: Srm (Ensembl: Masp2)
Name: spermidine synthase (Ensembl:MBL associated serine protease 2)
RGD ID: 620796
Description: Enables spermidine synthase activity. Involved in response to testosterone and spermidine biosynthetic process. Predicted to be active in cytosol. Orthologous to human SRM (spermidine synthase); PARTICIPATES IN spermidine metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100912604; LOC689673; similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY); spermidine synthase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,309,002 - 164,312,203 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5164,308,991 - 164,332,705 (+)EnsemblGRCr8
mRatBN7.25159,025,875 - 159,029,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,025,873 - 159,029,405 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5161,742,582 - 161,745,783 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,565,057 - 163,568,258 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,521,402 - 163,524,603 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,405,168 - 165,408,325 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,405,168 - 165,408,320 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl314,588,870 - 14,591,974 (+)Ensemblrn6Rnor6.0
Rnor_5.05169,061,769 - 169,064,926 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45165,672,516 - 165,675,673 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5157,302,130 - 157,305,203 (+)NCBICelera
RGSC_v3.15165,682,703 - 165,685,859 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
beauvericin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
pyrazinecarboxamide  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Androgen regulation of spermidine synthase expression in the rat prostate. Cyriac J, etal., Prostate. 2002 Mar 1;50(4):252-61. doi: 10.1002/pros.10052.
2. Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for aminopropyl transferases. Dejima H, etal., Biol Pharm Bull 2003 Jul;26(7):1005-8.
3. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
4. Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide. Fiori LM, etal., PLoS One. 2010 Nov 30;5(11):e15146. doi: 10.1371/journal.pone.0015146.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Hypusine Signaling Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension. Lemay SE, etal., Am J Respir Crit Care Med. 2024 Jun 1;209(11):1376-1391. doi: 10.1164/rccm.202305-0909OC.
9. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Assay for spermidine synthase activity by micellar electrokinetic chromatography with laser-induced fluorescence detection. Sano M and Nishino I, J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jan 1;845(1):80-3. Epub 2006 Aug 23.
16. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Shirahata A, etal., Biochem Pharmacol. 1993 May 5;45(9):1897-903.
17. A perspective of polyamine metabolism. Wallace HM, etal., Biochem J. 2003 Nov 15;376(Pt 1):1-14.
Additional References at PubMed
PMID:12477932   PMID:16515550   PMID:17585781   PMID:20439489   PMID:29892012   PMID:31515488   PMID:38928162  


Genomics

Comparative Map Data
Srm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,309,002 - 164,312,203 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5164,308,991 - 164,332,705 (+)EnsemblGRCr8
mRatBN7.25159,025,875 - 159,029,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,025,873 - 159,029,405 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5161,742,582 - 161,745,783 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,565,057 - 163,568,258 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,521,402 - 163,524,603 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,405,168 - 165,408,325 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,405,168 - 165,408,320 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl314,588,870 - 14,591,974 (+)Ensemblrn6Rnor6.0
Rnor_5.05169,061,769 - 169,064,926 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45165,672,516 - 165,675,673 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5157,302,130 - 157,305,203 (+)NCBICelera
RGSC_v3.15165,682,703 - 165,685,859 (+)NCBI
Cytogenetic Map5q36NCBI
SRM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,054,589 - 11,060,018 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,054,584 - 11,060,053 (-)Ensemblhg38GRCh38
GRCh37111,114,646 - 11,120,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,037,236 - 11,042,678 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34111,048,942 - 11,054,347NCBI
Celera110,226,954 - 10,232,396 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,266,094 - 10,271,363 (-)NCBIHuRef
CHM1_1111,102,556 - 11,108,076 (-)NCBICHM1_1
T2T-CHM13v2.0110,596,153 - 10,601,582 (-)NCBIT2T-CHM13v2.0
Srm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,675,970 - 148,679,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,675,960 - 148,679,450 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384148,591,513 - 148,594,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,591,503 - 148,594,993 (+)Ensemblmm10GRCm38
MGSCv374147,965,622 - 147,968,728 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364147,435,313 - 147,438,419 (+)NCBIMGSCv36mm8
Celera4150,853,070 - 150,856,182 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.76NCBI
Srm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,631,586 - 2,634,527 (+)Ensembl
ChiLan1.0NW_0049554862,631,579 - 2,634,779 (+)NCBIChiLan1.0ChiLan1.0
SRM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,164,133 - 217,169,647 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,810,098 - 215,815,576 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,817,765 - 9,823,244 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,038,452 - 11,043,186 (-)NCBIPanPan1.1PanPan1.1panPan2
SRM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,968,833 - 84,973,111 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,967,570 - 84,973,087 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha281,499,046 - 81,502,445 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0285,631,078 - 85,634,460 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,631,106 - 85,636,493 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,379,185 - 82,382,581 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,380,647 - 83,384,031 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,443,471 - 84,446,868 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,294,112 - 34,300,103 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474118,000 - 124,963 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936474121,135 - 124,894 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,246,876 - 71,253,508 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1671,246,895 - 71,253,534 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,154,834 - 65,158,866 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,718,265 - 120,723,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,718,424 - 120,723,944 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605424,626,079 - 24,631,446 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,725,480 - 1,732,186 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248181,725,614 - 1,729,374 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Srm
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1112,179,957 - 12,183,141 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srm
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:56
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000014934, ENSRNOT00000071712
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
AA858619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,028,823 - 159,029,024 (+)MAPPERmRatBN7.2
Rnor_6.0314,591,720 - 14,591,920NCBIRnor6.0
Rnor_6.05165,408,073 - 165,408,273NCBIRnor6.0
Rnor_5.05169,064,674 - 169,064,874UniSTSRnor5.0
Rnor_5.0319,903,052 - 19,903,252UniSTSRnor5.0
RGSC_v3.45165,675,421 - 165,675,621UniSTSRGSC3.4
Celera5157,304,951 - 157,305,151UniSTS
RH 3.4 Map51114.4UniSTS
Cytogenetic Map5q36UniSTS
Srm  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,028,206 - 159,028,887 (+)MAPPERmRatBN7.2
Rnor_6.0314,591,103 - 14,591,783NCBIRnor6.0
Rnor_6.05165,407,456 - 165,408,136NCBIRnor6.0
Rnor_5.0319,902,435 - 19,903,115UniSTSRnor5.0
Rnor_5.05169,064,057 - 169,064,737UniSTSRnor5.0
Celera5157,304,334 - 157,305,014UniSTS
Celera313,422,895 - 13,423,336UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
24 14 95 258 149 145 100 100 100 12 487 243 11 224 112 136 45 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014934   ⟹   ENSRNOP00000014934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,308,991 - 164,312,490 (+)Ensembl
mRatBN7.2 Ensembl5159,025,873 - 159,029,069 (+)Ensembl
Rnor_6.0 Ensembl5165,405,168 - 165,408,320 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000016317   ⟹   ENSRNOP00000016317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,319,038 - 164,332,705 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071712   ⟹   ENSRNOP00000067465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,308,991 - 164,312,532 (+)Ensembl
mRatBN7.2 Ensembl5159,025,873 - 159,029,405 (+)Ensembl
Rnor_6.0 Ensembl314,588,870 - 14,591,974 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079407   ⟹   ENSRNOP00000072546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,319,052 - 164,332,698 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133523   ⟹   ENSRNOP00000109450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,308,991 - 164,319,672 (+)Ensembl
RefSeq Acc Id: NM_053464   ⟹   NP_445916
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,309,002 - 164,312,203 (+)NCBI
mRatBN7.25159,025,875 - 159,029,076 (+)NCBI
Rnor_6.05165,405,168 - 165,408,325 (+)NCBI
Rnor_5.05169,061,769 - 169,064,926 (+)NCBI
RGSC_v3.45165,672,516 - 165,675,673 (+)RGD
Celera5157,302,130 - 157,305,203 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445916 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI28734 (Get FASTA)   NCBI Sequence Viewer  
  AAK21288 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014934
  ENSRNOP00000014934.2
  ENSRNOP00000067465.2
  ENSRNOP00000109450.1
RefSeq Acc Id: NP_445916   ⟸   NM_053464
- UniProtKB: Q99MI5 (UniProtKB/TrEMBL),   M0RCX8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014934   ⟸   ENSRNOT00000014934
Ensembl Acc Id: ENSRNOP00000067465   ⟸   ENSRNOT00000071712
Ensembl Acc Id: ENSRNOP00000016317   ⟸   ENSRNOT00000016317
Ensembl Acc Id: ENSRNOP00000109450   ⟸   ENSRNOT00000133523
Ensembl Acc Id: ENSRNOP00000072546   ⟸   ENSRNOT00000079407
Protein Domains
PABS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MI5-F1-model_v2 AlphaFold Q99MI5 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694263
Promoter ID:EPDNEW_R4788
Type:initiation region
Name:Srm_1
Description:spermidine synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05165,405,160 - 165,405,220EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620796 AgrOrtholog
BioCyc Gene G2FUF-39160 BioCyc
BioCyc Pathway BSUBPOLYAMSYN-PWY [spermidine biosynthesis I] BioCyc
BioCyc Pathway Image BSUBPOLYAMSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000011078 Ensembl
  ENSRNOG00000011258 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046379 Ensembl
Ensembl Transcript ENSRNOT00000014934 ENTREZGENE
  ENSRNOT00000014934.6 UniProtKB/TrEMBL
  ENSRNOT00000071712.4 UniProtKB/TrEMBL
  ENSRNOT00000133523.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.140.10 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8366755 IMAGE-MGC_LOAD
InterPro PABS UniProtKB/TrEMBL
  PABS_CS UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
  Spermi_synthase_euk UniProtKB/TrEMBL
  Spermidine_synt_N UniProtKB/TrEMBL
  Spermidine_synt_N_sf UniProtKB/TrEMBL
  Sprmine_synthase UniProtKB/TrEMBL
KEGG Report rno:84596 UniProtKB/TrEMBL
MGC_CLONE MGC:156617 IMAGE-MGC_LOAD
NCBI Gene 84596 ENTREZGENE
PANTHER PTHR11558 UniProtKB/TrEMBL
  SPERMIDINE SYNTHASE UniProtKB/TrEMBL
Pfam Spermine_synt_N UniProtKB/TrEMBL
  Spermine_synth UniProtKB/TrEMBL
PhenoGen Srm PhenoGen
PIRSF Spermidine_synth UniProtKB/TrEMBL
PROSITE SPERMIDINE_SYNTHASE_1 UniProtKB/TrEMBL
  SPERMIDINE_SYNTHASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011078 RatGTEx
  ENSRNOG00000011258 RatGTEx
  ENSRNOG00000046379 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0ABK0M2R6_RAT UniProtKB/TrEMBL
  M0RCX8 ENTREZGENE, UniProtKB/TrEMBL
  Q99MI5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Srm  spermidine synthase  LOC100912604  spermidine synthase-like  Data merged from RGD:6485978 737654 PROVISIONAL
2015-07-29 LOC100912604  spermidine synthase-like  LOC689673  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)  Data merged from RGD:1589905 737654 PROVISIONAL
2012-07-05 LOC100912604  spermidine synthase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC689673  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)  LOC687838  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)  Data merged from RGD:1596265 1643240 APPROVED
2006-11-20 LOC689673  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC687838  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Srm  spermidine synthase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Srm  spermidine synthase      Symbol and Name status set to provisional 70820 PROVISIONAL