P2rx4 (purinergic receptor P2X 4) - Rat Genome Database

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Gene: P2rx4 (purinergic receptor P2X 4) Rattus norvegicus
Analyze
Symbol: P2rx4
Name: purinergic receptor P2X 4
RGD ID: 62073
Description: Enables several functions, including ATP binding activity; ligand-gated monoatomic cation channel activity; and transition metal ion binding activity. Involved in several processes, including cellular response to zinc ion; neuronal action potential; and positive regulation of microglial cell migration. Located in several cellular components, including dendritic spine; lysosomal membrane; and neuronal cell body. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density membrane. Biomarker of congestive heart failure. Orthologous to human P2RX4 (purinergic receptor P2X 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP receptor; P2X purinoceptor 4; P2X4; purinergic receptor P2X ligand-gated ion channel 4; purinergic receptor P2X, ligand-gated ion channel 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,505,438 - 39,523,349 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1239,505,438 - 39,523,094 (-)EnsemblGRCr8
mRatBN7.21233,844,609 - 33,862,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,844,396 - 33,862,253 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,022,338 - 35,040,001 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,633,773 - 35,651,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,686,065 - 34,703,728 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,308,022 - 39,325,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,308,025 - 39,325,673 (-)Ensemblrn6Rnor6.0
Rnor_5.01241,196,777 - 41,214,428 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,943,900 - 34,961,551 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1235,521,444 - 35,539,095 (-)NCBICelera
RGSC_v3.11234,807,290 - 34,824,939 (-)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (EXP,ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
diclofenac  (EXP)
dieldrin  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Fast green FCF  (ISO)
fenthion  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
ginsenoside C-K  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Rd  (ISO)
heptachlor  (EXP)
hydroquinone  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
neohesperidin  (EXP)
nitrogen dioxide  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (ISO)
behavioral response to pain  (IMP)
calcium ion transmembrane transport  (IBA,IDA,ISO)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cell surface receptor signaling pathway  (IEA)
cellular response to ATP  (IDA,IEA,ISO,ISS)
cellular response to zinc ion  (IDA)
excitatory postsynaptic potential  (IEA,ISO)
membrane depolarization  (ISO)
monoatomic cation transmembrane transport  (IEA)
monoatomic cation transport  (IDA)
monoatomic ion transmembrane transport  (IEA,ISO)
monoatomic ion transport  (IEA)
negative regulation of cardiac muscle hypertrophy  (ISO)
nervous system process  (IEA)
neuronal action potential  (IDA)
nitric oxide biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of microglial cell migration  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
purinergic nucleotide receptor signaling pathway  (IEA,ISO)
regulation of blood pressure  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of chemotaxis  (IEA,IMP)
regulation of membrane potential  (IEA)
regulation of metal ion transport  (IEA)
regulation of ruffle assembly  (IMP)
regulation of sodium ion transport  (IDA)
relaxation of cardiac muscle  (ISO)
response to ATP  (IEA,ISO)
response to axon injury  (IMP)
response to fluid shear stress  (ISO)
response to ischemia  (IMP)
response to stress  (IEA)
sensory perception of pain  (IMP)
sensory perception of touch  (IMP)
signal transduction  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2. Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging. Antonio LS, etal., FEBS Lett. 2014 Jun 5;588(12):2125-8. doi: 10.1016/j.febslet.2014.04.048. Epub 2014 May 8.
3. Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. Aschrafi A, etal., J Mol Biol. 2004 Sep 3;342(1):333-43.
4. Electron microscopic localisation of P2X4 receptor subunit immunoreactivity to pre- and post-synaptic neuronal elements and glial processes in the dorsal vagal complex of the rat. Ashour F and Deuchars J, Brain Res. 2004 Nov 5;1026(1):44-55.
5. A P2X purinoceptor cDNA conferring a novel pharmacological profile. Bo X, etal., FEBS Lett 1995 Nov 13;375(1-2):129-33.
6. An antagonist-insensitive P2X receptor expressed in epithelia and brain. Buell G, etal., EMBO J 1996 Jan 2;15(1):55-62.
7. Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists. Cavaliere F, etal., Neuroscience. 2003;120(1):85-98.
8. Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc. Coddou C, etal., J Biol Chem. 2003 Sep 19;278(38):36777-85. Epub 2003 Jun 20.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Evidence for functional P2X4/P2X7 heteromeric receptors. Guo C, etal., Mol Pharmacol. 2007 Dec;72(6):1447-56. Epub 2007 Sep 4.
11. P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. Huang P, etal., J Biol Chem. 2014 Jun 20;289(25):17658-67. doi: 10.1074/jbc.M114.552158. Epub 2014 May 9.
12. ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. Inoue K, etal., J Pharmacol Sci. 2004 Feb;94(2):112-4.
13. Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel alpha beta-methylene ATP-sensitive phenotype. Jones CA, etal., Mol Pharmacol. 2004 Apr;65(4):979-85. doi: 10.1124/mol.65.4.979.
14. Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons. Luo J, etal., Brain Res. 2006 Oct 18;1115(1):9-15. Epub 2006 Aug 24.
15. Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats. Mapplebeck JCS, etal., Pain. 2018 Sep;159(9):1752-1763. doi: 10.1097/j.pain.0000000000001265.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Ohsawa K, etal., Glia. 2007 Apr 15;55(6):604-16. doi: 10.1002/glia.20489.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Distinct Localization of P2X receptors at excitatory postsynaptic specializations. Rubio ME and Soto F, J Neurosci. 2001 Jan 15;21(2):641-53.
23. A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. Seguela P, etal., J Neurosci 1996 Jan 15;16(2):448-55.
24. Direct observation of ATP-induced conformational changes in single P2X(4) receptors. Shinozaki Y, etal., PLoS Biol. 2009 May;7(5):e1000103. doi: 10.1371/journal.pbio.1000103. Epub 2009 May 5.
25. P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Soto F, etal., Proc Natl Acad Sci U S A 1996 Apr 16;93(8):3684-8.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin. Toulme E, etal., Mol Pharmacol. 2006 Feb;69(2):576-87. Epub 2005 Nov 10.
28. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Tsuda M, etal., Nature. 2003 Aug 14;424(6950):778-83. doi: 10.1038/nature01786.
29. Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. Wang CZ, etal., Biochem Biophys Res Commun 1996 Mar 7;220(1):196-202.
Additional References at PubMed
PMID:9016352   PMID:10515189   PMID:10899068   PMID:10969036   PMID:11606481   PMID:12077178   PMID:12088286   PMID:12105201   PMID:12600825   PMID:12788520   PMID:15081800   PMID:15130891  
PMID:15489334   PMID:15528255   PMID:15795310   PMID:15885321   PMID:15890753   PMID:15985462   PMID:16327800   PMID:16534777   PMID:16943557   PMID:16949036   PMID:16973131   PMID:17264311  
PMID:17560948   PMID:17897319   PMID:17918263   PMID:17940064   PMID:17990272   PMID:18427835   PMID:18675255   PMID:18837052   PMID:18938136   PMID:19056867   PMID:19084381   PMID:19283779  
PMID:19295157   PMID:19298529   PMID:19304656   PMID:19351603   PMID:19447505   PMID:19562525   PMID:19767540   PMID:19946888   PMID:20009029   PMID:20026202   PMID:20056605   PMID:20406028  
PMID:20407394   PMID:20590593   PMID:21106936   PMID:21378451   PMID:21482824   PMID:21844344   PMID:21907716   PMID:22053919   PMID:22222817   PMID:22230887   PMID:22393055   PMID:22785548  
PMID:23220420   PMID:23303206   PMID:23524095   PMID:23533145   PMID:23555667   PMID:23771671   PMID:24254916   PMID:24569146   PMID:24798490   PMID:24943126   PMID:24997270   PMID:25070962  
PMID:25074385   PMID:25398027   PMID:25662851   PMID:25680470   PMID:26481522   PMID:26946358   PMID:27506813   PMID:27545450   PMID:28306606   PMID:28461136   PMID:29973381   PMID:29997254  
PMID:30306657   PMID:30507759   PMID:30537520   PMID:32198702   PMID:32428626   PMID:32979222   PMID:33398365   PMID:33639220   PMID:33966147   PMID:34638832   PMID:35218450   PMID:35290938  
PMID:35594248   PMID:39019229  


Genomics

Comparative Map Data
P2rx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,505,438 - 39,523,349 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1239,505,438 - 39,523,094 (-)EnsemblGRCr8
mRatBN7.21233,844,609 - 33,862,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,844,396 - 33,862,253 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,022,338 - 35,040,001 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,633,773 - 35,651,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,686,065 - 34,703,728 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,308,022 - 39,325,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,308,025 - 39,325,673 (-)Ensemblrn6Rnor6.0
Rnor_5.01241,196,777 - 41,214,428 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,943,900 - 34,961,551 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1235,521,444 - 35,539,095 (-)NCBICelera
RGSC_v3.11234,807,290 - 34,824,939 (-)NCBI
Cytogenetic Map12q16NCBI
P2RX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812121,210,129 - 121,234,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,210,065 - 121,234,112 (+)Ensemblhg38GRCh38
GRCh3712121,647,932 - 121,671,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,132,047 - 120,156,292 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412120,110,383 - 120,134,627NCBI
Celera12121,285,420 - 121,309,664 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,657,246 - 118,681,512 (+)NCBIHuRef
CHM1_112121,616,508 - 121,640,746 (+)NCBICHM1_1
T2T-CHM13v2.012121,200,899 - 121,224,872 (+)NCBIT2T-CHM13v2.0
P2rx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,845,581 - 122,867,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,845,607 - 122,867,801 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385122,707,518 - 122,729,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,707,544 - 122,729,738 (+)Ensemblmm10GRCm38
MGSCv375123,157,566 - 123,179,053 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365122,968,240 - 122,989,661 (+)NCBIMGSCv36mm8
Celera5119,785,375 - 119,806,787 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.53NCBI
P2rx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,031,874 - 7,039,220 (-)Ensembl
ChiLan1.0NW_0049554827,031,874 - 7,039,026 (-)NCBIChiLan1.0ChiLan1.0
P2RX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210129,294,836 - 129,319,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112129,291,253 - 129,315,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,807,961 - 118,832,267 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112122,178,668 - 122,202,959 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,178,672 - 122,202,959 (+)EnsemblpanPan2panpan1.1
P2RX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1267,897,528 - 7,914,279 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,898,015 - 7,914,234 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha268,062,300 - 8,079,042 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0268,155,694 - 8,172,441 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,155,705 - 8,172,399 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,115,630 - 8,132,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,174,205 - 8,190,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,130,559 - 8,147,306 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
P2rx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118156,402,015 - 156,417,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,059,886 - 3,077,451 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365583,062,279 - 3,077,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,368,303 - 31,387,905 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11431,368,542 - 31,387,960 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,232,162 - 33,251,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,585,276 - 116,609,401 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,585,586 - 116,609,511 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037128,472,594 - 128,496,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2rx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,783,381 - 21,796,260 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474721,783,445 - 21,796,501 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
P2rx4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11631,098,792 - 31,116,945 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in P2rx4
134 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:170
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000001752
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH137366  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,844,643 - 33,844,833 (+)MAPPERmRatBN7.2
Rnor_6.01239,308,055 - 39,308,244NCBIRnor6.0
Rnor_5.01241,196,810 - 41,196,999UniSTSRnor5.0
RGSC_v3.41234,943,933 - 34,944,122UniSTSRGSC3.4
Celera1235,521,477 - 35,521,666UniSTS
RH 3.4 Map12595.6UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
25 13 86 231 91 90 59 167 59 6 506 296 22 209 118 125 31 45 45

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY749415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X93565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001752   ⟹   ENSRNOP00000001752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1239,505,438 - 39,523,089 (-)Ensembl
mRatBN7.2 Ensembl1233,844,613 - 33,862,253 (-)Ensembl
Rnor_6.0 Ensembl1239,308,025 - 39,325,673 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098463   ⟹   ENSRNOP00000084396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1239,505,438 - 39,523,089 (-)Ensembl
mRatBN7.2 Ensembl1233,844,396 - 33,862,234 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102812   ⟹   ENSRNOP00000092796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1239,505,438 - 39,523,089 (-)Ensembl
mRatBN7.2 Ensembl1233,844,613 - 33,862,253 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110480   ⟹   ENSRNOP00000086475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1239,505,438 - 39,523,089 (-)Ensembl
mRatBN7.2 Ensembl1233,844,616 - 33,862,234 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152277   ⟹   ENSRNOP00000102850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1239,505,455 - 39,523,094 (-)Ensembl
RefSeq Acc Id: NM_031594   ⟹   NP_113782
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,523,089 (-)NCBI
mRatBN7.21233,844,611 - 33,862,265 (-)NCBI
Rnor_6.01239,308,022 - 39,325,673 (-)NCBI
Rnor_5.01241,196,777 - 41,214,428 (-)NCBI
RGSC_v3.41234,943,900 - 34,961,551 (-)RGD
Celera1235,521,444 - 35,539,095 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089300   ⟹   XP_038945228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,514,634 (-)NCBI
mRatBN7.21233,844,609 - 33,853,812 (-)NCBI
RefSeq Acc Id: XM_039089303   ⟹   XP_038945231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,513,872 (-)NCBI
mRatBN7.21233,844,609 - 33,851,353 (-)NCBI
RefSeq Acc Id: XM_063271235   ⟹   XP_063127305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,523,097 (-)NCBI
RefSeq Acc Id: XM_063271236   ⟹   XP_063127306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,523,349 (-)NCBI
RefSeq Acc Id: XM_063271237   ⟹   XP_063127307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,522,835 (-)NCBI
RefSeq Acc Id: XM_063271238   ⟹   XP_063127308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,514,634 (-)NCBI
RefSeq Acc Id: XM_063271240   ⟹   XP_063127310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,514,634 (-)NCBI
RefSeq Acc Id: XM_063271241   ⟹   XP_063127311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81239,505,438 - 39,513,889 (-)NCBI
RefSeq Acc Id: NP_113782   ⟸   NM_031594
- UniProtKB: P51577 (UniProtKB/Swiss-Prot),   A6J182 (UniProtKB/TrEMBL),   A6J181 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001752   ⟸   ENSRNOT00000001752
RefSeq Acc Id: XP_038945228   ⟸   XM_039089300
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038945231   ⟸   XM_039089303
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000086475   ⟸   ENSRNOT00000110480
Ensembl Acc Id: ENSRNOP00000084396   ⟸   ENSRNOT00000098463
Ensembl Acc Id: ENSRNOP00000092796   ⟸   ENSRNOT00000102812
RefSeq Acc Id: XP_063127306   ⟸   XM_063271236
- Peptide Label: isoform X2
- UniProtKB: A6J183 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127305   ⟸   XM_063271235
- Peptide Label: isoform X1
- UniProtKB: A6J181 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127307   ⟸   XM_063271237
- Peptide Label: isoform X2
- UniProtKB: A6J183 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127310   ⟸   XM_063271240
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063127308   ⟸   XM_063271238
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127311   ⟸   XM_063271241
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000102850   ⟸   ENSRNOT00000152277

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51577-F1-model_v2 AlphaFold P51577 1-388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698641
Promoter ID:EPDNEW_R9164
Type:initiation region
Name:P2rx4_1
Description:purinergic receptor P2X 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,325,605 - 39,325,665EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62073 AgrOrtholog
BioCyc Gene G2FUF-19267 BioCyc
Ensembl Genes ENSRNOG00000001300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001752 ENTREZGENE
  ENSRNOT00000001752.6 UniProtKB/Swiss-Prot
  ENSRNOT00000152277 ENTREZGENE
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot
  atp-gated p2x4 ion channel UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7123247 IMAGE-MGC_LOAD
InterPro P2X4_purnocptor UniProtKB/Swiss-Prot
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot
  P2X_purnocptor UniProtKB/Swiss-Prot
  P2X_RECEPTOR_CS UniProtKB/Swiss-Prot
KEGG Report rno:29659 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93356 IMAGE-MGC_LOAD
NCBI Gene 29659 ENTREZGENE
PANTHER P2X PURINOCEPTOR UniProtKB/Swiss-Prot
  P2X PURINOCEPTOR 4 UniProtKB/Swiss-Prot
Pfam P2X_receptor UniProtKB/Swiss-Prot
PhenoGen P2rx4 PhenoGen
PIRSF P2X_purinoceptor UniProtKB/Swiss-Prot
PRINTS P2X4RECEPTOR UniProtKB/Swiss-Prot
  P2XRECEPTOR UniProtKB/Swiss-Prot
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001300 RatGTEx
UniProt A0A8I5ZYY2_RAT UniProtKB/TrEMBL
  A0A8I6A3Q3_RAT UniProtKB/TrEMBL
  A0A8I6GKC6_RAT UniProtKB/TrEMBL
  A0ABK0LIR9_RAT UniProtKB/TrEMBL
  A6J179_RAT UniProtKB/TrEMBL
  A6J180_RAT UniProtKB/TrEMBL
  A6J181 ENTREZGENE, UniProtKB/TrEMBL
  A6J182 ENTREZGENE, UniProtKB/TrEMBL
  A6J183 ENTREZGENE, UniProtKB/TrEMBL
  P2RX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2rx4  purinergic receptor P2X 4  P2rx4  purinergic receptor P2X, ligand-gated ion channel 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P2rx4  purinergic receptor P2X, ligand-gated ion channel, 4       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pancreatic islet cells 729194
gene_regulation channel is highly permeable to Ca2+ and is modulated by extracellular Zn2+ 729054