Gap43 (growth associated protein 43) - Rat Genome Database

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Gene: Gap43 (growth associated protein 43) Rattus norvegicus
Analyze
Symbol: Gap43
Name: growth associated protein 43
RGD ID: 62071
Description: Enables lysophosphatidic acid binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylserine binding activity. Involved in several processes, including regulation of postsynaptic specialization assembly; response to auditory stimulus; and tissue regeneration. Is active in GABA-ergic synapse and presynapse. Biomarker of middle cerebral artery infarction. Orthologous to human GAP43 (growth associated protein 43); PARTICIPATES IN N-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: axonal membrane protein GAP-43; Basp2; brain abundant membrane attached signal protein 2; brain abundant, membrane attached signal protein 2; growth accentuating protein 43; growth-associated protein 43; MGC156666; neuromodulin; protein F1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81171,882,131 - 71,975,799 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1171,882,131 - 71,975,797 (+)EnsemblGRCr8
mRatBN7.21158,376,371 - 58,470,047 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1158,376,371 - 58,470,045 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1167,189,389 - 67,283,059 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01159,851,686 - 59,945,352 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01158,895,119 - 58,988,732 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01158,624,198 - 58,717,916 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1158,624,198 - 58,717,914 (+)Ensemblrn6Rnor6.0
Rnor_5.01162,777,623 - 62,870,998 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41159,989,085 - 60,083,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1157,921,205 - 58,014,789 (+)NCBICelera
RGSC_v3.11160,046,673 - 60,141,558 (+)NCBI
Cytogenetic Map11q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-methyladenine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arachidonic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azamethiphos  (EXP)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butan-1-ol  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcitonin gene-related peptide 1  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carvedilol  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
clobetasol  (ISO)
clorgyline  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dieldrin  (EXP)
dioxygen  (EXP)
diuron  (EXP)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
fasudil  (EXP)
fenpyroximate  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fructose  (EXP)
galactose  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
heptachlor  (EXP)
imipramine  (EXP)
isophthalic acid  (ISO)
kainic acid  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
Meclizine  (ISO)
megestrol  (ISO)
melatonin  (EXP)
melittin  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
Methazolamide  (ISO)
methimazole  (EXP)
Mipafox  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP)
nickel atom  (EXP)
nicotine  (ISO)
Oxadiazon  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (EXP)
PhIP  (EXP)
picoxystrobin  (ISO)
potassium chloride  (EXP)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
tebufenpyrad  (ISO)
Testosterone propionate  (EXP)
thapsigargin  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
trichlorfon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tris(2-chloroethyl) phosphate  (EXP)
Tryptanthrine  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Withanone  (ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO)
cell periphery  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
dendrite  (IEA)
filopodium membrane  (IEA,ISO)
GABA-ergic synapse  (IDA,IMP)
growth cone  (IEA,TAS)
growth cone membrane  (IEA)
perikaryon  (IEA)
plasma membrane  (IBA,IEA,ISO)
postsynaptic density  (IBA,IEA,ISO)
presynapse  (IDA,ISO)
synapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitional expression of OX-2 and GAP-43 glycoproteins in developing rat cochlear nerve fibers. Bartolome MV, etal., Histol Histopathol 2002 Jan;17(1):83-95.
2. Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin. Boczek T, etal., Mol Cell Biochem. 2012 Jan;360(1-2):89-102. doi: 10.1007/s11010-011-1047-3. Epub 2011 Sep 13.
3. Tracking the expression of excitatory and inhibitory neurotransmission-related proteins and neuroplasticity markers after noise induced hearing loss. Browne CJ, etal., PLoS One. 2012;7(3):e33272. doi: 10.1371/journal.pone.0033272. Epub 2012 Mar 12.
4. Neurogranin binds to phosphatidic acid and associates to cellular membranes. Dominguez-Gonzalez I, etal., Biochem J. 2007 May 15;404(1):31-43.
5. Intranasal Calcitonin Gene-Related Peptide Protects Against Focal Cerebral Ischemic Injury in Rats Through the Wnt/β-Catenin Pathway. Du Z, etal., Med Sci Monit. 2018 Dec 7;24:8860-8869. doi: 10.12659/MSM.913777.
6. The differential distribution of the growth-associated protein-43 in first and higher order thalamic nuclei of the adult rat. Feig SL, Neuroscience. 2005;136(4):1147-57. doi: 10.1016/j.neuroscience.2005.08.033. Epub 2005 Oct 3.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. The interactions of the brain-specific calmodulin-binding protein kinase C substrate, neuromodulin (GAP 43), with membrane phospholipids. Houbre D, etal., J Biol Chem. 1991 Apr 15;266(11):7121-31.
10. Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. Irwin N, etal., Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12427-31.
11. Cloning of complementary DNA for GAP-43, a neuronal growth-related protein. Karns LR, etal., Science 1987 May 1;236(4801):597-600.
12. Effects of elevated serotonin levels on patterns of GAP-43 expression during barrel development in rat somatosensory cortex. Kesterson KL, etal., Brain Res Dev Brain Res 2002 Dec 15;139(2):167-74.
13. Identification and characterization of the BRI2 interactome in the brain. Martins F, etal., Sci Rep. 2018 Feb 23;8(1):3548. doi: 10.1038/s41598-018-21453-3.
14. Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization. McNamara RK and Lenox RH, J Neurosci Res. 2000 Nov 1;62(3):416-26.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity. Nedivi E, etal., J Neurosci 1992 Mar;12(3):691-704.
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Expression of activating transcription factor 3 and growth-associated protein 43 in the rat geniculate ganglion neurons after chorda tympani injury. Tsuzuki K, etal., Acta Otolaryngol 2002 Mar;122(2):161-7.
23. The basic helix-loop-helix differentiation factor Nex1/MATH-2 functions as a key activator of the GAP-43 gene. Uittenbogaard M, etal., J Neurochem 2003 Feb;84(4):678-88.
24. Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat. Urdzíková LM, etal., Int J Mol Sci. 2014 Jun 25;15(7):11275-93. doi: 10.3390/ijms150711275.
25. Expression of neuropeptides and growth-associated protein 43 (GAP-43) in cutaneous and mucosal nerve structures of the adult rat lower lip after mental nerve section. Verze L, etal., Ann Anat 2003 Jan;185(1):35-44.
26. Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. Wang CY, etal., Mol Cell Biol. 2015 May;35(10):1712-26. doi: 10.1128/MCB.01332-14. Epub 2015 Mar 9.
27. Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm. Young E, etal., Hippocampus 2002;12(4):457-64.
Additional References at PubMed
PMID:1533624   PMID:3428269   PMID:3581170   PMID:7859286   PMID:8694767   PMID:8889548   PMID:10482234   PMID:10662636   PMID:10850491   PMID:11703425   PMID:11839359   PMID:12034726  
PMID:12105219   PMID:12106089   PMID:12210137   PMID:12477932   PMID:12485886   PMID:12631465   PMID:12701761   PMID:12814368   PMID:14519521   PMID:14559368   PMID:14598294   PMID:14637107  
PMID:14648693   PMID:14978216   PMID:15052664   PMID:15071120   PMID:15182364   PMID:15234344   PMID:15246990   PMID:15502978   PMID:15964096   PMID:16269460   PMID:16330713   PMID:16820009  
PMID:16892058   PMID:17114649   PMID:17146769   PMID:17287580   PMID:17601561   PMID:17845802   PMID:18019391   PMID:18184180   PMID:18455509   PMID:18502309   PMID:18724891   PMID:19235891  
PMID:19249369   PMID:19443652   PMID:19761692   PMID:19782125   PMID:19805073   PMID:20035832   PMID:20090303   PMID:20173666   PMID:20335141   PMID:20406666   PMID:20423852   PMID:20646586  
PMID:20667480   PMID:21046809   PMID:21137370   PMID:21167390   PMID:21210085   PMID:21436126   PMID:21671799   PMID:21687946   PMID:21695168   PMID:21723373   PMID:21752992   PMID:21821100  
PMID:21822733   PMID:21868332   PMID:21948316   PMID:22063813   PMID:22121776   PMID:22490962   PMID:22617637   PMID:22871113   PMID:23119112   PMID:23316631   PMID:23426659   PMID:23586486  
PMID:23666783   PMID:23938193   PMID:24023391   PMID:24244461   PMID:24350898   PMID:24458787   PMID:24567055   PMID:24582971   PMID:24665937   PMID:25165142   PMID:25686598   PMID:25868328  
PMID:26238991   PMID:26503622   PMID:26850084   PMID:26865625   PMID:27412933   PMID:28801169   PMID:28871047   PMID:29286154   PMID:29486290   PMID:30682386   PMID:30911273   PMID:31686426  
PMID:32095982   PMID:33356694   PMID:33953268   PMID:34643252   PMID:35715368   PMID:38168094   PMID:38288820  


Genomics

Comparative Map Data
Gap43
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81171,882,131 - 71,975,799 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1171,882,131 - 71,975,797 (+)EnsemblGRCr8
mRatBN7.21158,376,371 - 58,470,047 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1158,376,371 - 58,470,045 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1167,189,389 - 67,283,059 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01159,851,686 - 59,945,352 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01158,895,119 - 58,988,732 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01158,624,198 - 58,717,916 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1158,624,198 - 58,717,914 (+)Ensemblrn6Rnor6.0
Rnor_5.01162,777,623 - 62,870,998 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41159,989,085 - 60,083,971 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1157,921,205 - 58,014,789 (+)NCBICelera
RGSC_v3.11160,046,673 - 60,141,558 (+)NCBI
Cytogenetic Map11q21NCBI
GAP43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383115,623,510 - 115,721,483 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3115,623,510 - 115,721,490 (+)Ensemblhg38GRCh38
GRCh373115,342,357 - 115,440,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363116,825,142 - 116,922,842 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343116,825,141 - 116,922,842NCBI
Celera3113,750,041 - 113,848,417 (+)NCBICelera
Cytogenetic Map3q13.31NCBI
HuRef3112,715,632 - 112,815,889 (+)NCBIHuRef
CHM1_13115,305,939 - 115,404,101 (+)NCBICHM1_1
T2T-CHM13v2.03118,343,657 - 118,441,697 (+)NCBIT2T-CHM13v2.0
Gap43
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391642,068,915 - 42,161,014 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1642,068,805 - 42,161,014 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381642,248,552 - 42,340,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1642,248,442 - 42,340,651 (-)Ensemblmm10GRCm38
MGSCv371642,248,665 - 42,340,764 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361642,167,884 - 42,259,983 (-)NCBIMGSCv36mm8
Celera1642,611,179 - 42,699,387 (-)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.37NCBI
Gap43
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542715,695,963 - 15,791,327 (+)Ensembl
ChiLan1.0NW_00495542715,696,549 - 15,791,279 (+)NCBIChiLan1.0ChiLan1.0
GAP43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22113,616,249 - 113,716,525 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13113,621,025 - 113,721,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03112,765,576 - 112,863,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13119,682,743 - 119,780,290 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3119,734,942 - 119,780,290 (+)EnsemblpanPan2panpan1.1
GAP43
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13319,668,491 - 19,770,509 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3319,656,835 - 19,770,408 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3319,775,530 - 19,877,471 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03319,917,865 - 20,017,414 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3319,917,886 - 20,017,410 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13319,722,015 - 19,823,783 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03319,768,803 - 19,870,740 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03320,313,727 - 20,415,899 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gap43
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602134,430,958 - 134,526,139 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365362,996,028 - 3,090,482 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365362,995,654 - 3,091,079 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAP43
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13144,364,317 - 144,629,174 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113144,364,314 - 144,458,136 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213153,842,841 - 153,937,719 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAP43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12265,142,472 - 65,242,185 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2265,142,039 - 65,242,222 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041101,151,539 - 101,250,605 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gap43
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473132,629,477 - 32,749,081 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473132,629,586 - 32,748,515 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gap43
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1427,176,383 - 27,270,177 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gap43
701 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:77
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000002091
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
GAP43  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81171,975,295 - 71,975,446 (+)Marker Load Pipeline
mRatBN7.21158,469,543 - 58,469,694 (+)MAPPERmRatBN7.2
Rnor_6.01158,717,413 - 58,717,563NCBIRnor6.0
Rnor_5.01162,870,495 - 62,870,645UniSTSRnor5.0
RGSC_v3.41160,083,468 - 60,083,618UniSTSRGSC3.4
Celera1158,014,286 - 58,014,436UniSTS
Cytogenetic Map11q21UniSTS
PMC17794P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21158,424,505 - 58,424,670 (+)MAPPERmRatBN7.2
Rnor_6.01158,672,417 - 58,672,581NCBIRnor6.0
Rnor_5.01162,825,652 - 62,825,816UniSTSRnor5.0
RGSC_v3.41160,037,625 - 60,037,789UniSTSRGSC3.4
Celera1157,969,327 - 57,969,491UniSTS
Cytogenetic Map11q21UniSTS
AU048143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21158,448,030 - 58,448,184 (+)MAPPERmRatBN7.2
Rnor_6.01158,695,940 - 58,696,093NCBIRnor6.0
Rnor_5.01162,849,175 - 62,849,328UniSTSRnor5.0
RGSC_v3.41160,062,186 - 60,062,339UniSTSRGSC3.4
Celera1157,992,815 - 57,992,968UniSTS
Cytogenetic Map11q21UniSTS
UniSTS:265709  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81171,975,180 - 71,975,528 (+)Marker Load Pipeline
mRatBN7.21158,469,428 - 58,469,776 (+)MAPPERmRatBN7.2
Rnor_6.01158,717,298 - 58,717,645NCBIRnor6.0
Rnor_5.01162,870,380 - 62,870,727UniSTSRnor5.0
RGSC_v3.41160,083,353 - 60,083,700UniSTSRGSC3.4
Celera1158,014,171 - 58,014,518UniSTS
Cytogenetic Map11q21UniSTS
PMC337033P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21158,469,539 - 58,469,694 (+)MAPPERmRatBN7.2
Rnor_6.01158,717,409 - 58,717,563NCBIRnor6.0
Rnor_5.01162,870,491 - 62,870,645UniSTSRnor5.0
RGSC_v3.41160,083,464 - 60,083,618UniSTSRGSC3.4
Celera1158,014,282 - 58,014,436UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 67 160 75 74 43 33 43 6 263 133 11 139 65 90 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002091   ⟹   ENSRNOP00000002091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1171,882,131 - 71,975,797 (+)Ensembl
mRatBN7.2 Ensembl1158,376,371 - 58,470,045 (+)Ensembl
Rnor_6.0 Ensembl1158,624,198 - 58,717,914 (+)Ensembl
RefSeq Acc Id: NM_017195   ⟹   NP_058891
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81171,882,131 - 71,975,799 (+)NCBI
mRatBN7.21158,376,371 - 58,470,047 (+)NCBI
Rnor_6.01158,624,198 - 58,717,916 (+)NCBI
Rnor_5.01162,777,623 - 62,870,998 (+)NCBI
RGSC_v3.41159,989,085 - 60,083,971 (+)RGD
Celera1157,921,205 - 58,014,789 (+)RGD
Sequence:
RefSeq Acc Id: NP_058891   ⟸   NM_017195
- UniProtKB: A0JPM4 (UniProtKB/Swiss-Prot),   P07936 (UniProtKB/Swiss-Prot),   A6IR38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002091   ⟸   ENSRNOT00000002091
Protein Domains
IQ   Neuromodulin (GAP-43) C-terminal   Neuromodulin gap junction N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07936-F1-model_v2 AlphaFold P07936 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698129
Promoter ID:EPDNEW_R8654
Type:single initiation site
Name:Gap43_1
Description:growth associated protein 43
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01158,624,291 - 58,624,351EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62071 AgrOrtholog
BioCyc Gene G2FUF-21310 BioCyc
Ensembl Genes ENSRNOG00000001528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002091 ENTREZGENE
  ENSRNOT00000002091.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.190 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8364847 IMAGE-MGC_LOAD
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  Neuromodulin UniProtKB/Swiss-Prot
  Neuromodulin_C UniProtKB/Swiss-Prot
  Neuromodulin_gap-junction_N UniProtKB/Swiss-Prot
  Neuromodulin_P_site UniProtKB/Swiss-Prot
  Neuromodulin_palmitoyl_site UniProtKB/Swiss-Prot
KEGG Report rno:29423 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156666 IMAGE-MGC_LOAD
NCBI Gene 29423 ENTREZGENE
PANTHER NEUROMODULIN UniProtKB/Swiss-Prot
  NEUROMODULIN UniProtKB/Swiss-Prot
Pfam Neuromodulin UniProtKB/Swiss-Prot
  Neuromodulin_N UniProtKB/Swiss-Prot
  PF00612 UniProtKB/Swiss-Prot
PhenoGen Gap43 PhenoGen
PRINTS NEUROMODULIN UniProtKB/Swiss-Prot
PROSITE NEUROMODULIN_1 UniProtKB/Swiss-Prot
  NEUROMODULIN_2 UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001528 RatGTEx
SMART SM00015 UniProtKB/Swiss-Prot
UniProt A0JPM4 ENTREZGENE
  A6IR38 ENTREZGENE, UniProtKB/TrEMBL
  A6IR39_RAT UniProtKB/TrEMBL
  NEUM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63212_RAT UniProtKB/TrEMBL
UniProt Secondary A0JPM4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Gap43  growth associated protein 43      Symbol and Name updated 629477 APPROVED
2003-03-14 Gap43  growth associated protein 43  Basp2  brain abundant, membrane attached signal protein 2  Data merged from RGD:621492 628472 PROVISIONAL
2002-08-07 Basp2  brain abundant, membrane attached signal protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gap43  growth associated protein 43      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates axon growth and synaptic plasticity 625586
gene_regulation mRNA increased by nerve growth factor (NGF) due to the ARPP-19 dependent increase of mRNA half-life 625586