Zyx (zyxin) - Rat Genome Database

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Gene: Zyx (zyxin) Rattus norvegicus
Analyze
Symbol: Zyx
Name: zyxin
RGD ID: 620698
Description: Predicted to enable metal ion binding activity. Predicted to be involved in cell surface receptor signaling pathway; cell-matrix adhesion; and stress fiber assembly. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in adherens junction; nucleus; and phagocytic vesicle. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human ZYX (zyxin); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,203,991 - 72,213,181 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl472,204,007 - 72,213,181 (+)EnsemblGRCr8
mRatBN7.2471,236,767 - 71,246,553 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,237,451 - 71,246,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx476,157,528 - 76,166,474 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0472,070,785 - 72,079,733 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,490,387 - 70,499,150 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,740,188 - 71,749,386 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,740,532 - 71,749,386 (+)Ensemblrn6Rnor6.0
Rnor_5.04136,544,775 - 136,553,784 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4470,119,162 - 70,128,016 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera466,168,190 - 66,177,032 (+)NCBICelera
RGSC_v3.1470,401,995 - 70,403,616 (+)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
fenamidone  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methotrexate  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IEA,ISO)
adherens junction  (IEA,ISO)
cytoplasm  (IBA,IEA)
cytoskeleton  (IEA)
focal adhesion  (IBA,IEA,ISO)
nucleus  (IEA,ISO)
phagocytic vesicle  (IEA,ISO)
stress fiber  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. Cattaruzza M, etal., J Biol Chem 2002 Feb 22;277(8):6582-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8940160   PMID:12417594   PMID:12658439   PMID:14967842   PMID:18297730   PMID:19144319   PMID:21423176   PMID:22658674   PMID:24036928   PMID:24841562   PMID:30361391  


Genomics

Comparative Map Data
Zyx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,203,991 - 72,213,181 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl472,204,007 - 72,213,181 (+)EnsemblGRCr8
mRatBN7.2471,236,767 - 71,246,553 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,237,451 - 71,246,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx476,157,528 - 76,166,474 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0472,070,785 - 72,079,733 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,490,387 - 70,499,150 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,740,188 - 71,749,386 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,740,532 - 71,749,386 (+)Ensemblrn6Rnor6.0
Rnor_5.04136,544,775 - 136,553,784 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4470,119,162 - 70,128,016 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera466,168,190 - 66,177,032 (+)NCBICelera
RGSC_v3.1470,401,995 - 70,403,616 (+)NCBI
Cytogenetic Map4q24NCBI
ZYX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,381,345 - 143,391,111 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,381,295 - 143,391,111 (+)Ensemblhg38GRCh38
GRCh377143,078,438 - 143,088,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,788,482 - 142,798,326 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347142,595,196 - 142,605,039NCBI
Celera7137,915,624 - 137,925,468 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7137,415,678 - 137,425,520 (+)NCBIHuRef
CHM1_17143,015,288 - 143,025,131 (+)NCBICHM1_1
T2T-CHM13v2.07144,736,772 - 144,746,538 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,480,492 - 142,490,336 (+)NCBI
Zyx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,326,507 - 42,337,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,326,564 - 42,337,147 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38642,349,511 - 42,360,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,349,630 - 42,360,213 (+)Ensemblmm10GRCm38
MGSCv37642,299,827 - 42,308,394 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36642,279,864 - 42,288,002 (+)NCBIMGSCv36mm8
Celera642,294,470 - 42,303,037 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.64NCBI
Zyx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494269,222 - 276,904 (-)Ensembl
ChiLan1.0NW_004955494268,844 - 277,381 (-)NCBIChiLan1.0ChiLan1.0
ZYX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,214,476 - 180,243,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,244,306 - 32,254,215 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,375,816 - 135,385,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,865,444 - 147,875,017 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,865,440 - 147,875,017 (+)EnsemblpanPan2panpan1.1
ZYX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,304,163 - 6,313,923 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,292,681 - 7,301,847 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0166,157,384 - 6,166,501 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,157,384 - 6,188,234 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,105,301 - 6,114,400 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,956,860 - 5,966,008 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,032,095 - 6,041,208 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zyx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,070,048 - 12,079,397 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527824,489 - 833,005 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936527823,973 - 833,387 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZYX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,861,077 - 6,870,265 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,861,072 - 6,870,256 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,099,073 - 7,111,110 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZYX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,266,880 - 112,277,083 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660729,012,426 - 9,022,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zyx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,381,178 - 11,389,271 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480011,380,787 - 11,389,418 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Zyx
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1697,858,737 - 97,867,746 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zyx
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:172
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000023537
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46796011273752811Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
D4Got51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,241,724 - 71,241,930 (+)MAPPERmRatBN7.2
Rnor_6.0471,744,558 - 71,744,763NCBIRnor6.0
Rnor_5.04136,548,956 - 136,549,161UniSTSRnor5.0
RGSC_v3.4470,123,187 - 70,123,393RGDRGSC3.4
RGSC_v3.4470,123,188 - 70,123,393UniSTSRGSC3.4
Celera466,172,214 - 66,172,409UniSTS
RGSC_v3.1470,399,318 - 70,399,523RGD
RH 3.4 Map4430.6UniSTS
RH 3.4 Map4430.6RGD
RH 2.0 Map4471.2RGD
Cytogenetic Map4q23UniSTS
RH141119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,246,091 - 71,246,282 (+)MAPPERmRatBN7.2
Rnor_6.0471,748,925 - 71,749,115NCBIRnor6.0
Rnor_5.04136,553,323 - 136,553,513UniSTSRnor5.0
RGSC_v3.4470,127,555 - 70,127,745UniSTSRGSC3.4
Celera466,176,571 - 66,176,761UniSTS
RH 3.4 Map12176.8UniSTS
Cytogenetic Map4q23UniSTS
RH125177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,238,089 - 71,238,205 (+)MAPPERmRatBN7.2
Rnor_6.0471,740,925 - 71,741,040NCBIRnor6.0
Rnor_5.04136,545,323 - 136,545,438UniSTSRnor5.0
RGSC_v3.4470,119,555 - 70,119,670UniSTSRGSC3.4
Celera466,168,583 - 66,168,698UniSTS
Cytogenetic Map4q23UniSTS
Zyx  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,239,040 - 71,239,115 (+)MAPPERmRatBN7.2
Rnor_6.0471,741,876 - 71,741,950NCBIRnor6.0
Rnor_5.04136,546,274 - 136,546,348UniSTSRnor5.0
RGSC_v3.4470,120,506 - 70,120,580UniSTSRGSC3.4
Celera466,169,534 - 66,169,608UniSTS
Cytogenetic Map4q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023537   ⟹   ENSRNOP00000023537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl472,204,007 - 72,213,181 (+)Ensembl
mRatBN7.2 Ensembl471,237,451 - 71,246,553 (+)Ensembl
Rnor_6.0 Ensembl471,740,532 - 71,749,386 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104565   ⟹   ENSRNOP00000097981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl472,204,435 - 72,213,181 (+)Ensembl
mRatBN7.2 Ensembl471,237,779 - 71,246,317 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115210   ⟹   ENSRNOP00000094013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl472,204,188 - 72,212,943 (+)Ensembl
mRatBN7.2 Ensembl471,237,451 - 71,246,314 (+)Ensembl
RefSeq Acc Id: NM_001398717   ⟹   NP_001385646
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,204,435 - 72,213,181 (+)NCBI
mRatBN7.2471,237,805 - 71,246,553 (+)NCBI
RefSeq Acc Id: NM_001398718   ⟹   NP_001385647
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,204,435 - 72,213,181 (+)NCBI
mRatBN7.2471,237,805 - 71,246,553 (+)NCBI
RefSeq Acc Id: NM_001415801   ⟹   NP_001402730
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,204,000 - 72,213,181 (+)NCBI
mRatBN7.2471,237,370 - 71,246,553 (+)NCBI
RefSeq Acc Id: NM_053761   ⟹   NP_446213
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,204,435 - 72,213,181 (+)NCBI
mRatBN7.2471,237,805 - 71,246,553 (+)NCBI
Rnor_6.0471,740,532 - 71,749,386 (+)NCBI
Rnor_5.04136,544,775 - 136,553,784 (+)NCBI
RGSC_v3.4470,119,162 - 70,128,016 (+)RGD
Celera466,168,190 - 66,177,032 (+)RGD
Sequence:
RefSeq Acc Id: XM_017592382   ⟹   XP_017447871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,203,991 - 72,212,947 (+)NCBI
mRatBN7.2471,236,767 - 71,246,393 (+)NCBI
Rnor_6.0471,740,188 - 71,749,238 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285399   ⟹   XP_063141469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,204,184 - 72,212,947 (+)NCBI
RefSeq Acc Id: NP_446213   ⟸   NM_053761
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GKY5 (UniProtKB/TrEMBL),   A6IF73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447871   ⟸   XM_017592382
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GKY5 (UniProtKB/TrEMBL),   A6IF73 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023537   ⟸   ENSRNOT00000023537
Ensembl Acc Id: ENSRNOP00000094013   ⟸   ENSRNOT00000115210
Ensembl Acc Id: ENSRNOP00000097981   ⟸   ENSRNOT00000104565
RefSeq Acc Id: NP_001402730   ⟸   NM_001415801
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GKY5 (UniProtKB/TrEMBL),   A6IF73 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385647   ⟸   NM_001398718
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AV84 (UniProtKB/TrEMBL),   A0A8I6GKY5 (UniProtKB/TrEMBL),   A6IF73 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385646   ⟸   NM_001398717
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GKY5 (UniProtKB/TrEMBL),   A6IF73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141469   ⟸   XM_063285399
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GKY5 (UniProtKB/TrEMBL),   A6IF73 (UniProtKB/TrEMBL)
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7U1-F1-model_v2 AlphaFold D4A7U1 1-564 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693010
Promoter ID:EPDNEW_R3534
Type:initiation region
Name:Zyx_1
Description:zyxin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0471,740,640 - 71,740,700EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620698 AgrOrtholog
BioCyc Gene G2FUF-45087 BioCyc
Ensembl Genes ENSRNOG00000017354 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023537 ENTREZGENE
  ENSRNOT00000023537.7 UniProtKB/TrEMBL
  ENSRNOT00000104565 ENTREZGENE
  ENSRNOT00000104565.2 UniProtKB/TrEMBL
  ENSRNOT00000115210 ENTREZGENE
  ENSRNOT00000115210.2 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
InterPro Znf_LIM UniProtKB/TrEMBL
NCBI Gene 114636 ENTREZGENE
PANTHER ZYXIN UniProtKB/TrEMBL
  ZYXIN/TRIP6 UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
PhenoGen Zyx PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017354 RatGTEx
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8I6AV84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKY5 ENTREZGENE, UniProtKB/TrEMBL
  A6IF73 ENTREZGENE, UniProtKB/TrEMBL
  A6IF74_RAT UniProtKB/TrEMBL
  A6IF75_RAT UniProtKB/TrEMBL
  D4A7U1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Zyx  zyxin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Zyx        Symbol and Name status set to provisional 70820 PROVISIONAL