Symbol:
Espn
Name:
espin
RGD ID:
620652
Description:
Enables SH3 domain binding activity and actin filament binding activity. Predicted to be involved in microvillar actin bundle assembly and negative regulation of cytoskeleton organization. Predicted to act upstream of or within locomotory behavior; parallel actin filament bundle assembly; and positive regulation of filopodium assembly. Located in several cellular components, including actin cytoskeleton; brush border; and microvillus. Part of filamentous actin. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to human ESPN (espin); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH acrylamide; alpha-Zearalanol; ammonium chloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
actin cytoskeletal regulatory protein; ectoplasmic specialization protein; Je; Jerker deafness locus; Jerker, deafness locus
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ESPN (espin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):
Espn (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Espn (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ESPN (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ESPN (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Espn (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ESPN (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
ESPN (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Espn (espin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TCF7L2 (transcription factor 7 like 2) HGNC
OMA
Alliance orthologs 3
Mus musculus (house mouse):
Espn (espin)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
ESPN (espin)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
espn (espin)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
f
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|PANTHER)
Xenopus tropicalis (tropical clawed frog):
espn
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 5 167,909,271 - 167,943,168 (-) NCBI GRCr8 mRatBN7.2 5 162,626,560 - 162,660,439 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 5 162,626,560 - 162,660,256 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 5 165,329,492 - 165,363,610 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 5 167,151,038 - 167,185,203 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 5 167,113,244 - 167,147,401 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 5 169,293,356 - 169,331,338 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 169,293,904 - 169,331,163 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 172,851,807 - 172,885,845 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 169,349,723 - 169,382,076 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 5 169,359,914 - 169,392,264 (-) NCBI Celera 5 160,858,704 - 160,892,256 (-) NCBI Celera Cytogenetic Map 5 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,2-dichloroethane (ISO) 1,2-dimethylhydrazine (ISO) 17beta-estradiol (ISO) 2,3,7,8-tetrachlorodibenzodioxine (ISO) 4,4'-sulfonyldiphenol (ISO) acrylamide (EXP) aflatoxin B1 (ISO) all-trans-retinoic acid (ISO) alpha-Zearalanol (EXP) ammonium chloride (EXP) aristolochic acid A (ISO) benzo[a]pyrene (ISO) benzo[e]pyrene (ISO) Benzo[ghi]perylene (ISO) beta-lapachone (ISO) bis(2-chloroethyl) sulfide (ISO) bis(2-ethylhexyl) phthalate (EXP) bisphenol A (EXP,ISO) butanal (ISO) Butylbenzyl phthalate (EXP) C60 fullerene (EXP) caffeine (ISO) carbon nanotube (ISO) carmustine (EXP) CGP 52608 (ISO) choline (ISO) chromium(6+) (ISO) copper(II) sulfate (ISO) cyclosporin A (ISO) daidzein (ISO) DDE (ISO) dibutyl phthalate (EXP) diethyl phthalate (EXP) diethylstilbestrol (ISO) diisobutyl phthalate (EXP) diisononyl phthalate (EXP) diquat (ISO) endosulfan (ISO) flavonoids (EXP) folic acid (ISO) furan (EXP) genistein (ISO) gentamycin (EXP) glycitein (ISO) inulin (ISO) L-methionine (ISO) lead(0) (ISO) Licochalcone B (ISO) methapyrilene (ISO) methotrexate (EXP,ISO) mono(2-ethylhexyl) phthalate (ISO) N-nitrosodiethylamine (ISO) N-Nitrosopyrrolidine (ISO) O-methyleugenol (ISO) paracetamol (EXP,ISO) perfluorooctane-1-sulfonic acid (ISO) perfluorooctanoic acid (EXP,ISO) quercetin (ISO) resveratrol (ISO) sodium arsenite (ISO) sulforaphane (ISO) thiram (ISO) tioguanine (EXP) titanium dioxide (ISO) triclosan (ISO) triptonide (ISO) urethane (ISO) valproic acid (ISO) vinclozolin (EXP) zearalenone (ISO)
1.
Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli.
Bartles JR, etal., J Cell Biol 1998 Oct 5;143(1):107-19.
2.
Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations.
Bartles JR, etal., J Cell Sci 1996 Jun;109 ( Pt 6):1229-39.
3.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.
Mechanotransduction by hair cells: models, molecules, and mechanisms.
Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
5.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
6.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
8.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
10.
Review series: The cell biology of hearing.
Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
11.
Differential expression of espin isoforms during epithelial morphogenesis, stereociliogenesis and postnatal maturation in the developing inner ear.
Sekerkova G, etal., Dev Biol. 2006 Mar 1;291(1):83-95. Epub 2006 Jan 17.
12.
Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.
Sekerkova G, etal., J Neurosci 2003 Feb 15;23(4):1310-9.
13.
The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins.
Zheng L, etal., Cell 2000 Aug 4;102(3):377-85.
Espn Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 5 167,909,271 - 167,943,168 (-) NCBI GRCr8 mRatBN7.2 5 162,626,560 - 162,660,439 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 5 162,626,560 - 162,660,256 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 5 165,329,492 - 165,363,610 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 5 167,151,038 - 167,185,203 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 5 167,113,244 - 167,147,401 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 5 169,293,356 - 169,331,338 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 169,293,904 - 169,331,163 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 172,851,807 - 172,885,845 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 169,349,723 - 169,382,076 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 5 169,359,914 - 169,392,264 (-) NCBI Celera 5 160,858,704 - 160,892,256 (-) NCBI Celera Cytogenetic Map 5 q36 NCBI
ESPN Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 1 6,424,776 - 6,461,370 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 1 6,424,776 - 6,461,367 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 1 6,484,836 - 6,521,004 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 1 6,407,435 - 6,443,591 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 1 6,419,113 - 6,455,255 NCBI Celera 1 5,599,359 - 5,635,452 (+) NCBI Celera Cytogenetic Map 1 p36.31 NCBI HuRef 1 5,632,355 - 5,668,547 (+) NCBI HuRef CHM1_1 1 6,473,408 - 6,509,542 (+) NCBI CHM1_1 T2T-CHM13v2.0 1 5,950,417 - 5,987,012 (+) NCBI T2T-CHM13v2.0
Espn Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 4 152,204,788 - 152,236,871 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 4 152,204,788 - 152,236,828 (-) Ensembl GRCm39 Ensembl GRCm38 4 152,120,331 - 152,152,414 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 4 152,120,331 - 152,152,371 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 4 151,494,985 - 151,526,316 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 4 150,964,677 - 150,996,007 (-) NCBI MGSCv36 mm8 Celera 4 154,407,406 - 154,438,512 (-) NCBI Celera Cytogenetic Map 4 E2 NCBI cM Map 4 82.9 NCBI
Espn Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 NW_004955486 6,130,190 - 6,156,859 (-) NCBI ChiLan1.0 ChiLan1.0
ESPN Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 1 221,766,953 - 221,804,885 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 1 220,409,018 - 220,446,247 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 1 5,184,666 - 5,222,473 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 1 6,440,951 - 6,475,253 (+) NCBI panpan1.1 PanPan1.1 panPan2
ESPN Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 5 60,285,185 - 60,316,261 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 5 60,285,312 - 60,315,676 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 5 60,295,201 - 60,325,841 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 5 60,501,302 - 60,531,937 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 5 60,501,302 - 60,531,352 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 5 60,500,632 - 60,531,235 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 5 60,367,399 - 60,398,004 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 5 60,768,952 - 60,799,595 (+) NCBI UU_Cfam_GSD_1.0
Espn Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405058 30,735,187 - 30,764,505 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936623 1,220,593 - 1,248,993 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936623 1,220,435 - 1,249,743 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
ESPN Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 6 67,284,079 - 67,316,591 (+) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 6 67,284,106 - 67,316,577 (+) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 6 62,236,643 - 62,268,608 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
ESPN Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 20 125,282,283 - 125,320,436 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 20 125,278,313 - 125,320,365 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666054 29,337,935 - 29,376,129 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Espn
.
Predicted Target Of
Count of predictions: 312 Count of miRNA genes: 109 Interacting mature miRNAs: 120 Transcripts: ENSRNOT00000000084, ENSRNOT00000013646, ENSRNOT00000042301, ENSRNOT00000047601 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
631272 Lanf1 Left ventricular atrial natriuretic factor QTL 1 12 heart left ventricle natriuretic peptide A amount (VT:0010596) heart left ventricle natriuretic peptide A level (CMO:0002165) 5 151113452 166875058 Rat 10053720 Scort26 Serum corticosterone level QTL 26 2.06 0.0147 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 5 124965598 166875058 Rat 1576314 Eutr1 Estrogen induced uterine response QTL 1 uterus integrity trait (VT:0010575) pyometritis severity score (CMO:0002009) 5 2138965 166875058 Rat 631562 Apr2 Acute phase response QTL 2 3.7 blood murinoglobulin 1 amount (VT:0010597) plasma murinoglobulin 1 level (CMO:0001931) 5 135927956 166875058 Rat 61444 Strs2 Sensitivity to stroke QTL 2 4.7 cerebrum integrity trait (VT:0010549) post-insult time to onset of cerebrovascular lesion (CMO:0002343) 5 135929696 166875058 Rat 634349 Bp139 Blood pressure QTL 139 0.001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 5 128924607 166875058 Rat 724525 Bp147 Blood pressure QTL 147 4.3 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 5 126424772 166875058 Rat 1549904 Neuinf1 Neuroinflammation QTL 1 3 0 nervous system integrity trait (VT:0010566) blood T lymphocyte count (CMO:0000110) 5 154828214 166875058 Rat 738018 Anxrr4 Anxiety related response QTL 4 5.1 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) 5 130130159 166875058 Rat 8552908 Pigfal4 Plasma insulin-like growth factor 1 level QTL 4 6.6 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 5 128506074 166875058 Rat 7794791 Mcs33 Mammary carcinoma susceptibility QTL 33 1.93 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) 5 131345754 166875058 Rat 1354631 Swd2 Spike wave discharge measurement QTL 2 3.64 0.0002 brain electrophysiology trait (VT:0010557) brain total spike-and-wave discharge duration (CMO:0001740) 5 151113452 164465185 Rat 1302790 Scl20 Serum cholesterol level QTL 20 6.4 0.0001 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 5 82394392 166664054 Rat 1598861 Cm64 Cardiac mass QTL 64 2.9 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 5 127798274 166875058 Rat 631505 Bp103 Blood pressure QTL 103 3.2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 5 132717196 165560427 Rat 1641920 Colcs1 Colorectal carcinoma susceptibility QTL 1 2.99 0.0055 intestine integrity trait (VT:0010554) benign colorectal tumor surface area measurement (CMO:0001799) 5 121846814 166846814 Rat 1598819 Bp292 Blood pressure QTL 292 4.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 5 127798274 166875058 Rat 1331721 Bp210 Blood pressure QTL 210 3.413 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) 5 143069996 166846814 Rat 8694169 Bw148 Body weight QTL 148 5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 5 128506074 166875058 Rat
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
5
29
85
68
71
40
25
40
6
169
72
69
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000013646 ⟹ ENSRNOP00000013645
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 5 162,627,108 - 162,634,934 (-) Ensembl Rnor_6.0 Ensembl 5 169,293,904 - 169,301,728 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000042301 ⟹ ENSRNOP00000039445
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 5 162,627,350 - 162,660,256 (-) Ensembl Rnor_6.0 Ensembl 5 169,293,904 - 169,331,163 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000116345 ⟹ ENSRNOP00000080896
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 5 162,626,560 - 162,642,512 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000117287 ⟹ ENSRNOP00000097437
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 5 162,626,560 - 162,660,256 (-) Ensembl
RefSeq Acc Id:
NM_019622 ⟹ NP_062568
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 5 167,909,271 - 167,942,984 (-) NCBI mRatBN7.2 5 162,626,560 - 162,660,256 (-) NCBI Rnor_6.0 5 169,293,356 - 169,331,163 (-) NCBI Rnor_5.0 5 172,851,807 - 172,885,845 (-) NCBI RGSC_v3.4 5 169,349,723 - 169,382,076 (-) RGD Celera 5 160,858,704 - 160,892,256 (-) NCBI
Sequence:
GCCGAGGGTGACACCATGGCCCTGGAACAGGCGATGCAGGCGGCACGGCGGGGCGACCTGGACGTGCTGAGGTCCCTGCACGCCGCCGGCCTGCTGGGGCCTTCTCTGCGCGACCCGCTAGACGCCCT
hide sequence
RefSeq Acc Id:
XM_008764377 ⟹ XP_008762599
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 5 167,909,271 - 167,943,168 (-) NCBI mRatBN7.2 5 162,626,560 - 162,660,439 (-) NCBI Rnor_6.0 5 169,293,356 - 169,331,338 (-) NCBI
Sequence:
CCAGAGCGCCGCTGAGCTGGAGTTGAGTCCCCGGGATCGCAGAGCCGGAGCCGGCTGGCAGCCGCTCTGCCTCCCGGGTCCGCACTCCTCCTCCGACTGCACCGCCGGGTTGCTCTTGGAGCCCGGGG
hide sequence
RefSeq Acc Id:
XM_008764380 ⟹ XP_008762602
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 5 167,909,271 - 167,943,168 (-) NCBI mRatBN7.2 5 162,626,560 - 162,660,438 (-) NCBI Rnor_6.0 5 169,293,356 - 169,331,338 (-) NCBI
Sequence:
CCAGAGCGCCGCTGAGCTGGAGTTGAGTCCCCGGGATCGCAGAGCCGGAGCCGGCTGGCAGCCG
hide sequence
RefSeq Acc Id:
XM_039110680 ⟹ XP_038966608
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 5 167,909,271 - 167,943,168 (-) NCBI mRatBN7.2 5 162,626,560 - 162,660,439 (-) NCBI
RefSeq Acc Id:
XM_039110681 ⟹ XP_038966609
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 5 167,909,271 - 167,943,168 (-) NCBI mRatBN7.2 5 162,626,560 - 162,660,439 (-) NCBI
RefSeq Acc Id:
XM_039110682 ⟹ XP_038966610
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 5 167,909,271 - 167,943,168 (-) NCBI mRatBN7.2 5 162,626,560 - 162,660,439 (-) NCBI
RefSeq Acc Id:
NP_062568 ⟸ NM_019622
- UniProtKB:
F1LQ34 (UniProtKB/TrEMBL)
- Sequence:
MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGG
hide sequence
RefSeq Acc Id:
XP_008762602 ⟸ XM_008764380
- Peptide Label:
isoform X5
- Sequence:
MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGG
hide sequence
RefSeq Acc Id:
XP_008762599 ⟸ XM_008764377
- Peptide Label:
isoform X3
- UniProtKB:
A0A8I6ARF5 (UniProtKB/TrEMBL)
- Sequence:
MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGG
hide sequence
Ensembl Acc Id:
ENSRNOP00000039445 ⟸ ENSRNOT00000042301
Ensembl Acc Id:
ENSRNOP00000013645 ⟸ ENSRNOT00000013646
RefSeq Acc Id:
XP_038966609 ⟸ XM_039110681
- Peptide Label:
isoform X2
RefSeq Acc Id:
XP_038966610 ⟸ XM_039110682
- Peptide Label:
isoform X4
RefSeq Acc Id:
XP_038966608 ⟸ XM_039110680
- Peptide Label:
isoform X1
Ensembl Acc Id:
ENSRNOP00000097437 ⟸ ENSRNOT00000117287
Ensembl Acc Id:
ENSRNOP00000080896 ⟸ ENSRNOT00000116345
RGD ID: 13694298 Promoter ID: EPDNEW_R4823 Type: multiple initiation site Name: Espn_1 Description: espin SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 5 169,301,756 - 169,301,816 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2003-04-09
Espn
espin
Symbol and Name updated
629477 APPROVED
2003-03-07
Espn
espin
Je
Jerker, deafness locus
Data merged from RGD:2941
628472 PROVISIONAL
2002-08-07
Espn
Symbol and Name status set to provisional
70820 PROVISIONAL
2002-06-10
Je
Jerker, deafness locus
Symbol and Name status set to approved
70586 APPROVED
Note Type
Note
Reference
gene_cellular_localization
localized to the ectoplasmic specializations where Sertoli cells contact the heads of elongated spermatids
632658
gene_process
responsible for function and organization of the ectoplasmic specialization
632658
gene_protein
has a mass of 110 kDa with 8 ankyrin-like repeats in the N-terminal, a potential P-loop, two proline-rich peptides and two peptides with clusters of multiple glutamates
632658
