Espn (espin) - Rat Genome Database

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Gene: Espn (espin) Rattus norvegicus
Analyze
Symbol: Espn
Name: espin
RGD ID: 620652
Description: Enables SH3 domain binding activity and actin filament binding activity. Predicted to be involved in microvillar actin bundle assembly and negative regulation of cytoskeleton organization. Predicted to act upstream of or within locomotory behavior; parallel actin filament bundle assembly; and positive regulation of filopodium assembly. Located in several cellular components, including actin cytoskeleton; brush border; and microvillus. Part of filamentous actin. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to human ESPN (espin); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH acrylamide; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin cytoskeletal regulatory protein; ectoplasmic specialization protein; Je; Jerker deafness locus; Jerker, deafness locus
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,909,271 - 167,943,168 (-)NCBIGRCr8
mRatBN7.25162,626,560 - 162,660,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,626,560 - 162,660,256 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,329,492 - 165,363,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,151,038 - 167,185,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,113,244 - 167,147,401 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,293,356 - 169,331,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,293,904 - 169,331,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,851,807 - 172,885,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,349,723 - 169,382,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,359,914 - 169,392,264 (-)NCBI
Celera5160,858,704 - 160,892,256 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
DDE  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diquat  (ISO)
endosulfan  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycitein  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
thiram  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli. Bartles JR, etal., J Cell Biol 1998 Oct 5;143(1):107-19.
2. Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations. Bartles JR, etal., J Cell Sci 1996 Jun;109 ( Pt 6):1229-39.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mechanotransduction by hair cells: models, molecules, and mechanisms. Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Review series: The cell biology of hearing. Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
11. Differential expression of espin isoforms during epithelial morphogenesis, stereociliogenesis and postnatal maturation in the developing inner ear. Sekerkova G, etal., Dev Biol. 2006 Mar 1;291(1):83-95. Epub 2006 Jan 17.
12. Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53. Sekerkova G, etal., J Neurosci 2003 Feb 15;23(4):1310-9.
13. The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins. Zheng L, etal., Cell 2000 Aug 4;102(3):377-85.
Additional References at PubMed
PMID:10588661   PMID:15190118   PMID:15477377   PMID:16962269   PMID:17409466   PMID:18551532   PMID:19287378   PMID:20016102   PMID:20510926   PMID:22114352   PMID:22264607   PMID:26754646  
PMID:29572253  


Genomics

Comparative Map Data
Espn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,909,271 - 167,943,168 (-)NCBIGRCr8
mRatBN7.25162,626,560 - 162,660,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,626,560 - 162,660,256 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,329,492 - 165,363,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,151,038 - 167,185,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,113,244 - 167,147,401 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,293,356 - 169,331,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,293,904 - 169,331,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,851,807 - 172,885,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,349,723 - 169,382,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,359,914 - 169,392,264 (-)NCBI
Celera5160,858,704 - 160,892,256 (-)NCBICelera
Cytogenetic Map5q36NCBI
ESPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,424,776 - 6,461,370 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,424,776 - 6,461,367 (+)EnsemblGRCh38hg38GRCh38
GRCh3716,484,836 - 6,521,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,407,435 - 6,443,591 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416,419,113 - 6,455,255NCBI
Celera15,599,359 - 5,635,452 (+)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,632,355 - 5,668,547 (+)NCBIHuRef
CHM1_116,473,408 - 6,509,542 (+)NCBICHM1_1
T2T-CHM13v2.015,950,417 - 5,987,012 (+)NCBIT2T-CHM13v2.0
Espn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,204,788 - 152,236,871 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,204,788 - 152,236,828 (-)EnsemblGRCm39 Ensembl
GRCm384152,120,331 - 152,152,414 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,120,331 - 152,152,371 (-)EnsemblGRCm38mm10GRCm38
MGSCv374151,494,985 - 151,526,316 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364150,964,677 - 150,996,007 (-)NCBIMGSCv36mm8
Celera4154,407,406 - 154,438,512 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map482.9NCBI
Espn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554866,130,190 - 6,156,859 (-)NCBIChiLan1.0ChiLan1.0
ESPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,766,953 - 221,804,885 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,409,018 - 220,446,247 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015,184,666 - 5,222,473 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,440,951 - 6,475,253 (+)NCBIpanpan1.1PanPan1.1panPan2
ESPN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,285,185 - 60,316,261 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,285,312 - 60,315,676 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,295,201 - 60,325,841 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,501,302 - 60,531,937 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,501,302 - 60,531,352 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,500,632 - 60,531,235 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,367,399 - 60,398,004 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,768,952 - 60,799,595 (+)NCBIUU_Cfam_GSD_1.0
Espn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,735,187 - 30,764,505 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366231,220,593 - 1,248,993 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366231,220,435 - 1,249,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESPN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,284,079 - 67,316,591 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,284,106 - 67,316,577 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,236,643 - 62,268,608 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,282,283 - 125,320,436 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,278,313 - 125,320,365 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,337,935 - 29,376,129 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Espn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248185,016,019 - 5,042,724 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248185,015,275 - 5,042,862 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Espn
206 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:312
Count of miRNA genes:109
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000000084, ENSRNOT00000013646, ENSRNOT00000042301, ENSRNOT00000047601
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 29 85 68 71 40 25 40 6 169 72 69 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF076856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF540946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF540947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF540948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF540949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY587568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY587569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013646   ⟹   ENSRNOP00000013645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,627,108 - 162,634,934 (-)Ensembl
Rnor_6.0 Ensembl5169,293,904 - 169,301,728 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000042301   ⟹   ENSRNOP00000039445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,627,350 - 162,660,256 (-)Ensembl
Rnor_6.0 Ensembl5169,293,904 - 169,331,163 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116345   ⟹   ENSRNOP00000080896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,626,560 - 162,642,512 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117287   ⟹   ENSRNOP00000097437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,626,560 - 162,660,256 (-)Ensembl
RefSeq Acc Id: NM_019622   ⟹   NP_062568
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,909,271 - 167,942,984 (-)NCBI
mRatBN7.25162,626,560 - 162,660,256 (-)NCBI
Rnor_6.05169,293,356 - 169,331,163 (-)NCBI
Rnor_5.05172,851,807 - 172,885,845 (-)NCBI
RGSC_v3.45169,349,723 - 169,382,076 (-)RGD
Celera5160,858,704 - 160,892,256 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764377   ⟹   XP_008762599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,909,271 - 167,943,168 (-)NCBI
mRatBN7.25162,626,560 - 162,660,439 (-)NCBI
Rnor_6.05169,293,356 - 169,331,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764380   ⟹   XP_008762602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,909,271 - 167,943,168 (-)NCBI
mRatBN7.25162,626,560 - 162,660,438 (-)NCBI
Rnor_6.05169,293,356 - 169,331,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110680   ⟹   XP_038966608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,909,271 - 167,943,168 (-)NCBI
mRatBN7.25162,626,560 - 162,660,439 (-)NCBI
RefSeq Acc Id: XM_039110681   ⟹   XP_038966609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,909,271 - 167,943,168 (-)NCBI
mRatBN7.25162,626,560 - 162,660,439 (-)NCBI
RefSeq Acc Id: XM_039110682   ⟹   XP_038966610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,909,271 - 167,943,168 (-)NCBI
mRatBN7.25162,626,560 - 162,660,439 (-)NCBI
RefSeq Acc Id: NP_062568   ⟸   NM_019622
- UniProtKB: F1LQ34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762602   ⟸   XM_008764380
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008762599   ⟸   XM_008764377
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ARF5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039445   ⟸   ENSRNOT00000042301
Ensembl Acc Id: ENSRNOP00000013645   ⟸   ENSRNOT00000013646
RefSeq Acc Id: XP_038966609   ⟸   XM_039110681
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038966610   ⟸   XM_039110682
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038966608   ⟸   XM_039110680
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000097437   ⟸   ENSRNOT00000117287
Ensembl Acc Id: ENSRNOP00000080896   ⟸   ENSRNOT00000116345
Protein Domains
WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63618-F1-model_v2 AlphaFold Q63618 1-837 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694298
Promoter ID:EPDNEW_R4823
Type:multiple initiation site
Name:Espn_1
Description:espin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,301,756 - 169,301,816EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620652 AgrOrtholog
BioCyc Gene G2FUF-39020 BioCyc
Ensembl Genes ENSRNOG00000010270 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013646.5 UniProtKB/Swiss-Prot
  ENSRNOT00000042301.6 UniProtKB/TrEMBL
  ENSRNOT00000116345.1 UniProtKB/TrEMBL
  ENSRNOT00000117287.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Espin/Espin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 56227 ENTREZGENE
PANTHER ESPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24153:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Espn PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010270 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQJ8_RAT UniProtKB/TrEMBL
  A0A8I6ARF5 ENTREZGENE, UniProtKB/TrEMBL
  A6IUH0_RAT UniProtKB/TrEMBL
  A6IUH2_RAT UniProtKB/TrEMBL
  ESPN_RAT UniProtKB/Swiss-Prot
  F1LQ34 ENTREZGENE, UniProtKB/TrEMBL
  Q63618 ENTREZGENE
UniProt Secondary Q6GYS2 UniProtKB/Swiss-Prot
  Q6GYS3 UniProtKB/Swiss-Prot
  Q80ZB6 UniProtKB/Swiss-Prot
  Q80ZB7 UniProtKB/Swiss-Prot
  Q80ZB8 UniProtKB/Swiss-Prot
  Q80ZB9 UniProtKB/Swiss-Prot
  Q9Z2B4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Espn  espin      Symbol and Name updated 629477 APPROVED
2003-03-07 Espn  espin  Je  Jerker, deafness locus  Data merged from RGD:2941 628472 PROVISIONAL
2002-08-07 Espn        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Je  Jerker, deafness locus      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the ectoplasmic specializations where Sertoli cells contact the heads of elongated spermatids 632658
gene_process responsible for function and organization of the ectoplasmic specialization 632658
gene_protein has a mass of 110 kDa with 8 ankyrin-like repeats in the N-terminal, a potential P-loop, two proline-rich peptides and two peptides with clusters of multiple glutamates 632658