Arhgef7 (Rho guanine nucleotide exchange factor 7) - Rat Genome Database

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Gene: Arhgef7 (Rho guanine nucleotide exchange factor 7) Rattus norvegicus
Analyze
Symbol: Arhgef7
Name: Rho guanine nucleotide exchange factor 7
RGD ID: 620624
Description: Enables protein kinase binding activity. Contributes to small GTPase binding activity. Involved in actin cytoskeleton organization; astrocyte cell migration; and small GTPase-mediated signal transduction. Located in focal adhesion and growth cone. Part of protein-containing complex. Is active in GABA-ergic synapse. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7); PARTICIPATES IN adenosine signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-Pix; P85spr; PAK-interacting exchange factor beta; Pak3bp; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor (GEF7)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81684,373,123 - 84,484,759 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1684,373,123 - 84,484,597 (-)EnsemblGRCr8
mRatBN7.21677,671,021 - 77,782,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1682,951,484 - 83,030,424 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01686,404,129 - 86,483,069 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01681,646,838 - 81,725,963 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,006,732 - 83,117,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)Ensemblrn6Rnor6.0
Rnor_5.01682,479,277 - 82,605,606 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41682,521,224 - 82,603,338 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1675,472,865 - 75,551,301 (-)NCBICelera
RGSC_v3.11682,517,165 - 82,563,059 (-)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
inulin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
propiconazole  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA)
centrosome  (ISO,ISS)
cytoplasm  (IBA)
cytosol  (IEA,ISO,TAS)
focal adhesion  (IDA,IEA)
GABA-ergic synapse  (IDA,IMP)
growth cone  (IDA)
lamellipodium  (IBA,IEA,ISO,ISS)
mitotic spindle pole  (ISO,ISS)
neuron projection  (ISO)
neuronal cell body  (ISO)
plasma membrane  (IEA,ISO)
postsynapse  (IEA,ISO,ISS)
protein-containing complex  (IDA,ISO)
ruffle  (IEA)
storage vacuole  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Fiuza M, etal., Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12. doi: 10.1073/pnas.1312211110. Epub 2013 Dec 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2. Hoelz A, etal., J Mol Biol. 2006 Apr 28;358(2):509-22. Epub 2006 Feb 28.
5. N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Hua KT, etal., Cancer Cell. 2011 Feb 15;19(2):218-31. doi: 10.1016/j.ccr.2010.11.010. Epub 2011 Feb 3.
6. Cbl promotes clustering of endocytic adaptor proteins. Jozic D, etal., Nat Struct Mol Biol. 2005 Nov;12(11):972-9.
7. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. Kim S, etal., J Biol Chem. 2003 Feb 21;278(8):6291-300. Epub 2002 Dec 6.
8. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
9. BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction. Lee JS, etal., J Biol Chem. 2010 Mar 12;285(11):8104-13. doi: 10.1074/jbc.M109.055079. Epub 2010 Jan 14.
10. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Manser E, etal., Mol Cell 1998 Jan;1(2):183-92.
11. Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX. Martin HG, etal., J Cell Biochem. 2006 Nov 1;99(4):1203-15. doi: 10.1002/jcb.20998.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration. Osmani N, etal., Curr Biol. 2006 Dec 19;16(24):2395-405. Epub 2006 Nov 2.
15. Analysis of the subcellular distribution of avian p95-APP2, an ARF-GAP orthologous to mammalian paxillin kinase linker. Paris S, etal., Int J Biochem Cell Biol. 2002 Jul;34(7):826-37.
16. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. Park E, etal., J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7.
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. Shin EY, etal., J Biol Chem 2002 Nov 15;277(46):44417-30.
22. GIT1 and ßPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission. Smith KR, etal., Cell Rep. 2014 Oct 9;9(1):298-310. doi: 10.1016/j.celrep.2014.08.061. Epub 2014 Oct 2.
23. ß-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses. Sun Y and Bamji SX, J Neurosci. 2011 Nov 23;31(47):17123-33. doi: 10.1523/JNEUROSCI.2359-11.2011.
Additional References at PubMed
PMID:8889548   PMID:10896954   PMID:11864573   PMID:12477932   PMID:12695502   PMID:16954223   PMID:17310244   PMID:18325335   PMID:18385518   PMID:19041750   PMID:19136011   PMID:19322025  
PMID:20117114   PMID:20338996   PMID:21048939   PMID:21088884   PMID:21423176   PMID:21828338   PMID:24029230   PMID:24752242   PMID:25009260   PMID:25500533   PMID:29191942   PMID:30053369  
PMID:34006608   PMID:34154701   PMID:36044673  


Genomics

Comparative Map Data
Arhgef7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81684,373,123 - 84,484,759 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1684,373,123 - 84,484,597 (-)EnsemblGRCr8
mRatBN7.21677,671,021 - 77,782,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1682,951,484 - 83,030,424 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01686,404,129 - 86,483,069 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01681,646,838 - 81,725,963 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,006,732 - 83,117,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)Ensemblrn6Rnor6.0
Rnor_5.01682,479,277 - 82,605,606 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41682,521,224 - 82,603,338 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1675,472,865 - 75,551,301 (-)NCBICelera
RGSC_v3.11682,517,165 - 82,563,059 (-)NCBI
Cytogenetic Map16q12.5NCBI
ARHGEF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813111,114,619 - 111,305,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13111,114,559 - 111,305,737 (+)Ensemblhg38GRCh38
GRCh3713111,766,966 - 111,958,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613110,565,783 - 110,756,079 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3413110,565,782 - 110,745,543NCBI
Celera1392,614,729 - 92,805,032 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1392,335,232 - 92,556,608 (+)NCBIHuRef
CHM1_113111,735,565 - 111,925,520 (+)NCBICHM1_1
T2T-CHM13v2.013110,344,517 - 110,535,326 (+)NCBIT2T-CHM13v2.0
Arhgef7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,778,053 - 11,885,219 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl811,777,721 - 11,885,219 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38811,728,001 - 11,835,219 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl811,727,721 - 11,835,219 (+)Ensemblmm10GRCm38
MGSCv37811,728,105 - 11,835,219 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36811,758,319 - 11,835,191 (+)NCBIMGSCv36mm8
Celera811,933,357 - 12,010,286 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Arhgef7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554041,748,665 - 1,814,575 (-)Ensembl
ChiLan1.0NW_0049554041,749,051 - 1,835,455 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214112,605,805 - 112,795,972 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113111,285,530 - 111,475,913 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01392,246,107 - 92,436,173 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113111,427,905 - 111,545,413 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13111,427,905 - 111,545,413 (+)EnsemblpanPan2panpan1.1
ARHGEF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12259,207,278 - 59,305,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2259,206,868 - 59,303,049 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2258,888,587 - 59,015,004 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02259,801,684 - 59,928,168 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2259,801,654 - 59,928,162 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12259,303,236 - 59,429,725 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02259,295,788 - 59,422,676 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02259,330,969 - 59,457,416 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgef7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945194,095,753 - 194,167,935 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364721,784,195 - 1,874,774 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364721,784,215 - 1,857,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1177,427,368 - 77,530,993 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11177,427,352 - 77,531,001 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,902,021 - 85,006,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1389,287,663 - 89,467,846 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl389,287,863 - 89,468,511 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604646,054,615 - 46,237,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247931,880,382 - 1,995,610 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247931,880,681 - 1,995,604 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgef7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11372,016,421 - 72,123,101 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgef7
459 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:925
Count of miRNA genes:290
Interacting mature miRNAs:364
Transcripts:ENSRNOT00000017947, ENSRNOT00000043449
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat

Markers in Region
D16Rat126  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81684,403,417 - 84,403,620 (+)Marker Load Pipeline
mRatBN7.21677,701,318 - 77,701,521 (+)MAPPERmRatBN7.2
Rnor_6.01683,037,016 - 83,037,218NCBIRnor6.0
Rnor_5.01682,509,634 - 82,509,836UniSTSRnor5.0
RGSC_v3.41682,553,695 - 82,553,897UniSTSRGSC3.4
FHH x ACI Map1645.9899UniSTS
FHH x ACI Map1645.9899RGD
Cytogenetic Map16q12.5UniSTS
RH136837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,671,176 - 77,671,318 (+)MAPPERmRatBN7.2
Rnor_6.01683,006,888 - 83,007,029NCBIRnor6.0
Rnor_5.01682,479,433 - 82,479,574UniSTSRnor5.0
RGSC_v3.41682,521,380 - 82,521,521UniSTSRGSC3.4
Celera1675,473,021 - 75,473,162UniSTS
RH 3.4 Map16746.2UniSTS
Cytogenetic Map16q12.5UniSTS
RH143440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,693,890 - 77,694,140 (+)MAPPERmRatBN7.2
Rnor_6.01683,029,590 - 83,029,839NCBIRnor6.0
Rnor_5.01682,502,208 - 82,502,457UniSTSRnor5.0
RGSC_v3.41682,546,269 - 82,546,518UniSTSRGSC3.4
Celera1675,495,980 - 75,496,229UniSTS
RH 3.4 Map16752.8UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF044673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY034823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY996221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM390964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB792685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017947   ⟹   ENSRNOP00000017947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1684,373,123 - 84,484,539 (-)Ensembl
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)Ensembl
Rnor_6.0 Ensembl1683,006,734 - 83,084,975 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000043449   ⟹   ENSRNOP00000043761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1684,373,123 - 84,433,047 (-)Ensembl
mRatBN7.2 Ensembl1677,671,023 - 77,782,695 (-)Ensembl
Rnor_6.0 Ensembl1683,006,718 - 83,132,785 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100639   ⟹   ENSRNOP00000095285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1684,373,123 - 84,484,597 (-)Ensembl
mRatBN7.2 Ensembl1677,671,023 - 77,782,697 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119685   ⟹   ENSRNOP00000084089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1684,373,123 - 84,484,388 (-)Ensembl
mRatBN7.2 Ensembl1677,671,023 - 77,782,695 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171130   ⟹   ENSRNOP00000103841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1684,380,818 - 84,484,597 (-)Ensembl
RefSeq Acc Id: NM_001113521   ⟹   NP_001106993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,123 - 84,484,388 (-)NCBI
mRatBN7.21677,671,021 - 77,782,277 (-)NCBI
Rnor_6.01683,006,732 - 83,084,975 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,472,865 - 75,551,301 (-)RGD
Sequence:
RefSeq Acc Id: NM_001113522   ⟹   NP_001106994
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,123 - 84,484,388 (-)NCBI
mRatBN7.21677,671,021 - 77,782,277 (-)NCBI
Rnor_6.01683,006,732 - 83,084,975 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,472,865 - 75,551,301 (-)RGD
Sequence:
RefSeq Acc Id: NM_053740   ⟹   NP_446192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,380,818 - 84,484,388 (-)NCBI
mRatBN7.21677,678,716 - 77,782,277 (-)NCBI
Rnor_6.01683,016,821 - 83,058,844 (-)NCBI
Rnor_5.01682,479,277 - 82,605,606 (-)NCBI
RGSC_v3.41682,521,224 - 82,603,338 (-)RGD
Celera1675,482,954 - 75,525,170 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771376   ⟹   XP_008769598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,434,575 (-)NCBI
mRatBN7.21677,671,025 - 77,732,469 (-)NCBI
Rnor_6.01683,006,736 - 83,076,976 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771380   ⟹   XP_008769602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,484,759 (-)NCBI
mRatBN7.21677,671,025 - 77,782,585 (-)NCBI
Rnor_6.01683,006,736 - 83,117,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094099   ⟹   XP_038950027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,484,759 (-)NCBI
mRatBN7.21677,671,025 - 77,782,593 (-)NCBI
RefSeq Acc Id: XM_039094100   ⟹   XP_038950028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,451,754 (-)NCBI
mRatBN7.21677,671,025 - 77,749,646 (-)NCBI
RefSeq Acc Id: XM_063274984   ⟹   XP_063131054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,484,759 (-)NCBI
RefSeq Acc Id: XM_063274985   ⟹   XP_063131055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,484,759 (-)NCBI
RefSeq Acc Id: XM_063274986   ⟹   XP_063131056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,434,462 (-)NCBI
RefSeq Acc Id: XM_063274987   ⟹   XP_063131057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,434,577 (-)NCBI
RefSeq Acc Id: XM_063274988   ⟹   XP_063131058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,373,127 - 84,414,564 (-)NCBI
RefSeq Acc Id: NP_446192   ⟸   NM_053740
- Peptide Label: isoform c
- UniProtKB: A0A0G2QC21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106993   ⟸   NM_001113521
- Peptide Label: isoform a
- UniProtKB: A0A0G2QC21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106994   ⟸   NM_001113522
- Peptide Label: isoform b
- UniProtKB: A0A0G2QC21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769602   ⟸   XM_008771380
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769598   ⟸   XM_008771376
- Peptide Label: isoform X4
- UniProtKB: A3KMH4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043761   ⟸   ENSRNOT00000043449
Ensembl Acc Id: ENSRNOP00000017947   ⟸   ENSRNOT00000017947
RefSeq Acc Id: XP_038950027   ⟸   XM_039094099
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AP31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950028   ⟸   XM_039094100
- Peptide Label: isoform X7
- UniProtKB: A3KMH4 (UniProtKB/TrEMBL),   F1LNB0 (UniProtKB/TrEMBL),   Q52NK0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095285   ⟸   ENSRNOT00000100639
Ensembl Acc Id: ENSRNOP00000084089   ⟸   ENSRNOT00000119685
RefSeq Acc Id: XP_063131054   ⟸   XM_063274984
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q927 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131055   ⟸   XM_063274985
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q927 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131057   ⟸   XM_063274987
- Peptide Label: isoform X8
- UniProtKB: O55043 (UniProtKB/Swiss-Prot),   A6IWN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131056   ⟸   XM_063274986
- Peptide Label: isoform X6
- UniProtKB: O55043 (UniProtKB/Swiss-Prot),   A6IWN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131058   ⟸   XM_063274988
- Peptide Label: isoform X9
- UniProtKB: A3KMH4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103841   ⟸   ENSRNOT00000171130
Protein Domains
DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55043-F1-model_v2 AlphaFold O55043 1-646 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700241
Promoter ID:EPDNEW_R10765
Type:initiation region
Name:Arhgef7_1
Description:Rho guanine nucleotide exchange factor 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,084,945 - 83,085,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620624 AgrOrtholog
BioCyc Gene G2FUF-10664 BioCyc
Ensembl Genes ENSRNOG00000012934 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017947 ENTREZGENE
  ENSRNOT00000043449 ENTREZGENE
  ENSRNOT00000100639 ENTREZGENE
  ENSRNOT00000171130 ENTREZGENE
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  L1 transposable element, trimerization domain UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8364481 IMAGE-MGC_LOAD
InterPro BetaPIX_SH3 UniProtKB/Swiss-Prot
  DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  GEF_CC UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_Cool_Pix UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:114559 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156613 IMAGE-MGC_LOAD
NCBI Gene 114559 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7 UniProtKB/Swiss-Prot
  RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F UniProtKB/Swiss-Prot
Pfam betaPIX_CC UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  RhoGEF67_u2 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Arhgef7 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012934 RatGTEx
SMART RhoGEF UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A0G2QC21 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWI0_RAT UniProtKB/TrEMBL
  A0A8I6AP31 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q927 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LGU4_RAT UniProtKB/TrEMBL
  A3KMH4 ENTREZGENE, UniProtKB/TrEMBL
  A6IWN1 ENTREZGENE, UniProtKB/TrEMBL
  A6IWN3_RAT UniProtKB/TrEMBL
  ARHG7_RAT UniProtKB/Swiss-Prot
  F1LNB0 ENTREZGENE
  O55043 ENTREZGENE
  Q52NK0 ENTREZGENE, UniProtKB/TrEMBL
  Q923I5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef7  Rho guanine nucleotide exchange factor 7  Arhgef7  Rho guanine nucleotide exchange factor (GEF) 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-25 Arhgef7  Rho guanine nucleotide exchange factor (GEF) 7   Arhgef7  Rho guanine nucleotide exchange factor (GEF7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Arhgef7  Rho guanine nucleotide exchange factor (GEF7)  Arhgef7  Rho guanine nucleotide exchange factor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Arhgef7  Rho guanine nucleotide exchange factor 7  Pak3bp  PAK-interacting exchange factor beta  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pak3bp  PAK-interacting exchange factor beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of PIX (PAK-interacting exchange factor)/Cool (cloned out of library) protein family 633693
gene_regulation phosphorylated via the Ras/ERK cascade 633693