Npy2r (neuropeptide Y receptor Y2) - Rat Genome Database

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Gene: Npy2r (neuropeptide Y receptor Y2) Rattus norvegicus
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Symbol: Npy2r
Name: neuropeptide Y receptor Y2
RGD ID: 620475
Description: Used to study absence epilepsy and depressive disorder. Biomarker of obesity. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (neuropeptide Y receptor Y2); INTERACTS WITH 1D-myo-inositol 1,4,5-trisphosphate; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100360265; neuropeptide Y receptor type 2; neuropeptide Y receptor Y2-like; neuropeptide Y-Y2 receptor; neuropeptide Y/peptide YY-Y2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Niddm38
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,200,027 - 170,210,286 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2170,200,027 - 170,210,448 (-)EnsemblGRCr8
mRatBN7.22167,901,999 - 167,912,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,903,879 - 167,905,024 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2175,099,298 - 175,100,444 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,120,230 - 173,121,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,713,107 - 167,714,253 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,528,949 - 181,538,145 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,530,832 - 181,531,978 (-)Ensemblrn6Rnor6.0
Rnor_5.02200,942,882 - 200,952,072 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42150,554,962 - 150,556,108 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2161,929,373 - 161,930,519 (-)NCBICelera
RGSC_v3.12174,209,622 - 174,210,769 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors. Adewale AS, etal., Neuropharmacology. 2007 May;52(6):1396-402. Epub 2007 Feb 20.
2. Neuropeptide-Y Y2-receptor agonist, PYY3-36 promotes non-rapid eye movement sleep in rat. Akanmu MA, etal., Neurosci Res. 2006 Mar;54(3):165-70. Epub 2005 Dec 27.
3. Vulnerability to nicotine abstinence-related social anxiety-like behavior: molecular correlates in neuropeptide Y, Y2 receptor and corticotropin releasing factor. Aydin C, etal., Neurosci Lett. 2011 Mar 3;490(3):220-5. doi: 10.1016/j.neulet.2010.12.056. Epub 2010 Dec 30.
4. PYY3-36 infused systemically or directly into the VTA attenuates fentanyl seeking in male rats. Caffrey A, etal., Neuropharmacology. 2023 Nov 15;239:109686. doi: 10.1016/j.neuropharm.2023.109686. Epub 2023 Aug 10.
5. Expression of neuropeptide Y and its receptors Y1 and Y2 in the rat heart and its supplying autonomic and spinal sensory ganglia in experimentally induced diabetes. Chottova Dvorakova M, etal., Neuroscience. 2008 Feb 19;151(4):1016-28. doi: 10.1016/j.neuroscience.2007.07.069. Epub 2007 Dec 8.
6. The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety. Cippitelli A, etal., Alcohol. 2011 Sep;45(6):567-76. doi: 10.1016/j.alcohol.2010.09.003. Epub 2010 Dec 10.
7. BODIPY-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. Dumont Y, etal., Br J Pharmacol. 2005 Dec;146(8):1069-81.
8. Blockade of neuropeptide Y(2) receptors and suppression of NPY's anti-epileptic actions in the rat hippocampal slice by BIIE0246. El Bahh B, etal., Br J Pharmacol. 2002 Jun;136(4):502-9.
9. The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors. El Bahh B, etal., Eur J Neurosci. 2005 Sep;22(6):1417-30.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors. Gibbs JL, etal., Br J Pharmacol. 2007 Jan;150(1):72-9. Epub 2006 Dec 4.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. Goumain M, etal., Mol Pharmacol 2001 Jul;60(1):124-34.
14. Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. Igura K, etal., Rejuvenation Res. 2011 Aug;14(4):393-403. doi: 10.1089/rej.2010.1129. Epub 2011 May 19.
15. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Kallupi M, etal., Addict Biol. 2014 Sep;19(5):755-7. doi: 10.1111/adb.12059. Epub 2013 May 3.
16. Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R. Kloster E, etal., J Mol Med (Berl). 2014 Feb;92(2):177-84.
17. Involvement of NPY Y2 receptor subtype in the control of the spontaneous NO/GnRH release at the rat median eminence. Knauf C, etal., Neuroreport. 2001 Oct 29;12(15):3365-9.
18. Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. Li L, etal., J Cardiovasc Transl Res. 2011 Jun;4(3):351-62. doi: 10.1007/s12265-011-9271-5. Epub 2011 Apr 6.
19. Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Ma L, etal., Diabetes. 2005 May;54(5):1598-602.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Role of neuropeptide Y Y(1) and Y(2) receptors on behavioral despair in a rat model of depression with co-morbid anxiety. Morales-Medina JC, etal., Neuropharmacology. 2012 Jan;62(1):200-8. doi: 10.1016/j.neuropharm.2011.06.030. Epub 2011 Jul 23.
22. Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. Moran TD, etal., J Neurophysiol. 2004 Dec;92(6):3266-75. Epub 2004 Aug 4.
23. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Morris MJ, etal., Eur J Neurosci. 2007 Feb;25(4):1136-43.
24. Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation. Nave H, etal., J Neuroimmunol. 2004 Oct;155(1-2):1-12.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. The neuropeptide Y receptors, Y1 and Y2, are transiently and differentially expressed in the developing cerebellum. Neveu I, etal., Neuroscience 2002;113(4):767-77.
27. A Novel Long-Acting Selective Neuropeptide Y2 Receptor PEGylated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents. Ortiz AA, etal., J Pharmacol Exp Ther. 2007 Aug 1;.
28. A pool of Y2 neuropeptide Y receptors activated by modifiers of membrane sulfhydryl or cholesterol balance. Parker SL, etal., Eur J Biochem. 2002 May;269(9):2315-22.
29. Neuropeptide Y-induced contraction is mediated by neuropeptide Y Y2 and Y4 receptors in the rat colon. Pheng LH, etal., Eur J Pharmacol. 1999 Jun 11;374(1):85-91.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. Rimondini R, etal., Neurosci Lett. 2005 Feb 28;375(2):129-33. Epub 2004 Nov 30.
34. Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala. Sajdyk TJ, etal., Pharmacol Biochem Behav 2002 Mar;71(3):419-23.
35. Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. Sanchez-Marin L, etal., Eur Neuropsychopharmacol. 2020 Apr;33:126-138. doi: 10.1016/j.euroneuro.2020.01.012. Epub 2020 Feb 10.
36. Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. Sato N, etal., J Hum Genet. 2010 Nov;55(11):755-60. doi: 10.1038/jhg.2010.108. Epub 2010 Sep 2.
37. Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus. Silva AP, etal., J Neurochem. 2001 Oct;79(2):286-96. doi: 10.1046/j.1471-4159.2001.00560.x.
38. Ultrastructural Characterization of Corticotropin-Releasing Factor and Neuropeptide Y in the Rat Locus Coeruleus: Anatomical Evidence for Putative Interactions. Theisen CC, etal., Neuroscience. 2018 Aug 1;384:21-40. doi: 10.1016/j.neuroscience.2018.04.043. Epub 2018 May 22.
39. Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Thorsell A, etal., Neurosci Lett. 2002 Oct 25;332(1):1-4. doi: 10.1016/s0304-3940(02)00904-7.
40. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. Torekov SS, etal., Diabetologia. 2006 Nov;49(11):2653-8. Epub 2006 Sep 22.
41. Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder. Treutlein J, etal., Psychiatr Genet. 2017 Feb;27(1):34-37. doi: 10.1097/YPG.0000000000000149.
42. Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy? Vezzani A and Sperk G, Neuropeptides. 2004 Aug;38(4):245-52.
43. Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. Wang C, etal., Horm Metab Res. 2007 Apr;39(4):262-7.
44. Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. Wetherill L, etal., Alcohol Clin Exp Res. 2008 Dec;32(12):2031-40. doi: 10.1111/j.1530-0277.2008.00790.x. Epub 2008 Sep 25.
Additional References at PubMed
PMID:9636652   PMID:10698177   PMID:14615027   PMID:15544855   PMID:19119448   PMID:19593212   PMID:19953226   PMID:20451563   PMID:21658765   PMID:22074679   PMID:23074243   PMID:23548582  
PMID:24316073   PMID:25146309   PMID:27847128   PMID:28057538   PMID:28154160   PMID:28438668   PMID:35313782   PMID:37501148  


Genomics

Comparative Map Data
Npy2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,200,027 - 170,210,286 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2170,200,027 - 170,210,448 (-)EnsemblGRCr8
mRatBN7.22167,901,999 - 167,912,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,903,879 - 167,905,024 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2175,099,298 - 175,100,444 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,120,230 - 173,121,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,713,107 - 167,714,253 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,528,949 - 181,538,145 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,530,832 - 181,531,978 (-)Ensemblrn6Rnor6.0
Rnor_5.02200,942,882 - 200,952,072 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42150,554,962 - 150,556,108 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2161,929,373 - 161,930,519 (-)NCBICelera
RGSC_v3.12174,209,622 - 174,210,769 (-)NCBI
Cytogenetic Map2q34NCBI
NPY2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384155,173,723 - 155,217,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4155,208,636 - 155,217,078 (+)Ensemblhg38GRCh38
GRCh374156,094,875 - 156,138,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364156,349,232 - 156,357,678 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344156,487,385 - 156,495,832NCBI
Celera4153,460,186 - 153,468,632 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4151,868,438 - 151,876,885 (+)NCBIHuRef
CHM1_14156,107,896 - 156,116,343 (+)NCBICHM1_1
T2T-CHM13v2.04158,505,608 - 158,548,978 (+)NCBIT2T-CHM13v2.0
Npy2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,445,688 - 82,455,404 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,445,690 - 82,455,391 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38382,538,383 - 82,548,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,538,383 - 82,548,084 (-)Ensemblmm10GRCm38
MGSCv37382,342,305 - 82,352,007 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36382,624,310 - 82,634,013 (-)NCBIMGSCv36mm8
Celera382,557,426 - 82,567,083 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.49NCBI
Npy2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,796,278 - 11,804,114 (-)Ensembl
ChiLan1.0NW_00495547111,796,278 - 11,804,114 (-)NCBIChiLan1.0ChiLan1.0
NPY2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23153,087,172 - 153,132,447 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14153,442,534 - 153,487,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04147,542,551 - 147,586,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14159,360,854 - 159,404,224 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4159,401,080 - 159,402,231 (+)EnsemblpanPan2panpan1.1
NPY2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,790,136 - 52,797,785 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,794,671 - 52,795,818 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1553,131,265 - 53,141,184 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01553,475,002 - 53,484,515 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1553,481,383 - 53,484,128 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,727,621 - 52,737,421 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,836,294 - 52,846,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01553,149,800 - 53,159,345 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npy2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530137,606,621 - 37,615,131 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,932,870 - 1,938,703 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,932,526 - 1,939,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPY2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,039,616 - 74,047,817 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1874,039,959 - 74,048,398 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,331,707 - 78,340,148 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPY2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,696,081 - 101,773,782 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,770,551 - 101,771,696 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603781,413,529 - 81,421,886 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npy2r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248483,048,413 - 3,054,495 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248483,049,009 - 3,054,548 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Npy2r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1370,981,528 - 70,990,377 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npy2r
51 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000072029
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
AU047259  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82170,203,931 - 170,204,112 (+)Marker Load Pipeline
mRatBN7.22167,905,855 - 167,906,036 (+)MAPPERmRatBN7.2
Rnor_6.02181,532,810 - 181,532,990NCBIRnor6.0
Rnor_5.02200,946,732 - 200,946,912UniSTSRnor5.0
RGSC_v3.42174,261,495 - 174,261,675UniSTSRGSC3.4
Celera2161,931,351 - 161,931,531UniSTS
Cytogenetic Map2q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 3 17 115 31 21 14 3 14 4 94 35 99 33 79 7 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000072029   ⟹   ENSRNOP00000067147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2167,903,879 - 167,905,024 (-)Ensembl
Rnor_6.0 Ensembl2181,530,832 - 181,531,978 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169329   ⟹   ENSRNOP00000108738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2170,200,027 - 170,210,448 (-)Ensembl
RefSeq Acc Id: NM_023968   ⟹   NP_076458
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82170,201,954 - 170,203,100 (-)NCBI
mRatBN7.22167,903,878 - 167,905,024 (-)NCBI
Rnor_6.02181,530,832 - 181,531,978 (-)NCBI
Rnor_5.02200,942,882 - 200,952,072 (-)NCBI
RGSC_v3.42150,554,962 - 150,556,108 (+)RGD
Celera2161,929,373 - 161,930,519 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232534   ⟹   XP_006232596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82170,200,027 - 170,210,286 (-)NCBI
mRatBN7.22167,901,999 - 167,912,165 (-)NCBI
Rnor_6.02181,528,949 - 181,538,145 (-)NCBI
Rnor_5.02200,942,882 - 200,952,072 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_076458 (Get FASTA)   NCBI Sequence Viewer  
  XP_006232596 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40138 (Get FASTA)   NCBI Sequence Viewer  
  AAF89094 (Get FASTA)   NCBI Sequence Viewer  
  EDM00847 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000108738
  ENSRNOP00000108738.1
RefSeq Acc Id: NP_076458   ⟸   NM_023968
- UniProtKB: Q9ERC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232596   ⟸   XM_006232534
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000067147   ⟸   ENSRNOT00000072029
Ensembl Acc Id: ENSRNOP00000108738   ⟸   ENSRNOT00000169329
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERC0-F1-model_v2 AlphaFold Q9ERC0 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620475 AgrOrtholog
BioCyc Gene G2FUF-52679 BioCyc
Ensembl Genes ENSRNOG00000049213 Ensembl
  ENSRNOG00000083533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000169329 ENTREZGENE
  ENSRNOT00000169329.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  NPY2_rcpt UniProtKB/TrEMBL
  NPY_rcpt UniProtKB/TrEMBL
KEGG Report rno:66024 UniProtKB/TrEMBL
NCBI Gene 66024 ENTREZGENE
PANTHER NEUROPEPTIDE Y RECEPTOR UniProtKB/TrEMBL
  NEUROPEPTIDE Y RECEPTOR TYPE 2 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Npy2r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  NRPEPTIDEY2R UniProtKB/TrEMBL
  NRPEPTIDEYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049213 RatGTEx
  ENSRNOG00000083533 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0ABK0LRW4_RAT UniProtKB/TrEMBL
  Q9ERC0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Npy2r  neuropeptide Y receptor Y2  LOC100360265  neuropeptide Y receptor Y2-like  Data merged from RGD:2322486 737654 PROVISIONAL
2010-05-06 LOC100360265  neuropeptide Y receptor Y2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Npy2r  neuropeptide Y receptor Y2    neuropeptide Y/peptide YY-Y2 receptor  Name updated 1299863 APPROVED
2002-08-07 Npy2r  neuropeptide Y/peptide YY-Y2 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL