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Gene: Gucy2f (guanylate cyclase 2F) Rattus norvegicus

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Symbol:

Gucy2f

Name:

guanylate cyclase 2F

RGD ID:

620439

Description:

Enables guanylate cyclase activity and identical protein binding activity. Involved in cGMP-mediated signaling. Located in plasma membrane. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal); PARTICIPATES IN visual phototransduction pathway; purine metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GC-F; guanylate cyclase 2F, retinal; guanylate cyclase F; RETGC-2; retinal guanylyl cyclase 2; rod outer segment membrane guanylate cyclase 2; ROS-GC2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GUCY2F (guanylate cyclase 2F, retinal)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gucy2f (guanylate cyclase 2f)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gucy2f (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GUCY2F (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GUCY2F (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gucy2f (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GUCY2F (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GUCY2F (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gucy2f (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gucy2f (guanylate cyclase 2F, retinal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DDX21 (DExD-box helicase 21)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GUCY2F (guanylate cyclase 2F, retinal)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gucy2f (guanylate cyclase 2f)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gc2 (guanylyl cyclase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gc2 (guanylyl cyclase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	gucy2f (guanylate cyclase 2F, retinal)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG34357	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG34357	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	gcy-14	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	gcy-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	gcy-20	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	gcy-22	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	gcy-27	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	gcy-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	odr-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gucy2f	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gucy2f	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	110,507,183 - 110,605,017 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	110,507,183 - 110,605,017 (-)	Ensembl				GRCr8
mRatBN7.2	X	105,710,356 - 105,808,183 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	105,710,356 - 105,808,183 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	107,848,258 - 107,946,084 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	111,347,446 - 111,445,266 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	108,912,156 - 109,010,662 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	113,372,240 - 113,474,210 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	113,372,240 - 113,474,164 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	111,822,417 - 111,920,459 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	36,367,528 - 36,469,112 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	105,123,834 - 105,223,272 (-)	NCBI		Celera
RGSC_v3.1	X	36,420,996 - 36,522,581 (+)	NCBI
Cytogenetic Map	X	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

retinal degeneration (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

copper(II) sulfate (ISO)

dextran sulfate (ISO)

hyaluronic acid (EXP)

hydrogen peroxide (EXP)

Moniliformin (ISO)

Rebamipide (EXP)

silicon dioxide (ISO)

titanium dioxide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cGMP biosynthetic process (IBA,IEA)

cGMP metabolic process (IDA)

cyclic nucleotide biosynthetic process (IEA)

detection of light stimulus involved in visual perception (IEA,ISO)

intracellular signal transduction (IEA)

receptor guanylyl cyclase signaling pathway (IBA)

visual perception (IBA,IEA)

Cellular Component

membrane (IEA)

photoreceptor outer segment membrane (IDA)

plasma membrane (IBA,IDA)

rod photoreceptor disc membrane (IDA)

rod photoreceptor outer segment (IBA,IEA,ISO,ISS)

Molecular Function

ATP binding (IEA)

GTP binding (IEA)

guanylate cyclase activity (IBA,IDA,IEA)

identical protein binding (IPI)

lyase activity (IEA)

nucleotide binding (IEA)

peptide receptor activity (IBA)

phosphorus-oxygen lyase activity (IEA)

protein binding (ISO)

protein heterodimerization activity (IDA)

protein kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

visual phototransduction pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Photoreceptor signaling: supporting vision across a wide range of light intensities.	Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	Application of functional genomic technologies in a mouse model of retinal degeneration.	Shearstone JR, etal., Genomics. 2005 Mar;85(3):309-21.
13.	Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers.	Yang RB and Garbers DL, J Biol Chem. 1997 May 23;272(21):13738-42.
14.	Two membrane forms of guanylyl cyclase found in the eye.	Yang RB, etal., Proc Natl Acad Sci U S A 1995 Jan 17;92(2):602-6.

Additional References at PubMed

PMID:17255100	PMID:21078983

Genomics

Comparative Map Data

Gucy2f
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	110,507,183 - 110,605,017 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	110,507,183 - 110,605,017 (-)	Ensembl				GRCr8
mRatBN7.2	X	105,710,356 - 105,808,183 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	105,710,356 - 105,808,183 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	107,848,258 - 107,946,084 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	111,347,446 - 111,445,266 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	108,912,156 - 109,010,662 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	113,372,240 - 113,474,210 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	113,372,240 - 113,474,164 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	111,822,417 - 111,920,459 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	36,367,528 - 36,469,112 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	105,123,834 - 105,223,272 (-)	NCBI		Celera
RGSC_v3.1	X	36,420,996 - 36,522,581 (+)	NCBI
Cytogenetic Map	X	q33	NCBI

GUCY2F
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	109,372,906 - 109,482,086 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	109,372,906 - 109,482,086 (-)	Ensembl			hg38	GRCh38
GRCh37	X	108,616,135 - 108,725,315 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	108,502,791 - 108,611,941 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	108,422,279 - 108,531,432	NCBI
Celera	X	109,095,739 - 109,204,892 (-)	NCBI		Celera
Cytogenetic Map	X	q22.3-q23	NCBI
HuRef	X	98,238,823 - 98,346,954 (-)	NCBI		HuRef
CHM1_1	X	108,527,410 - 108,636,553 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	107,820,404 - 107,929,552 (-)	NCBI		T2T-CHM13v2.0

Gucy2f
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	140,862,282 - 140,980,399 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	140,864,156 - 140,979,927 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	142,079,286 - 142,197,276 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	142,081,160 - 142,196,931 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	138,515,703 - 138,631,474 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	137,327,528 - 137,443,299 (-)	NCBI		MGSCv36	mm8
Celera	X	126,078,100 - 126,191,808 (-)	NCBI		Celera
Cytogenetic Map	X	F2	NCBI
cM Map	X	62.85	NCBI

Gucy2f
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955490	6,331,247 - 6,437,563 (+)	Ensembl
ChiLan1.0	NW_004955490	6,331,247 - 6,437,563 (+)	NCBI	ChiLan1.0	ChiLan1.0

GUCY2F
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	108,864,549 - 108,973,618 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	108,868,153 - 108,977,222 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	98,481,609 - 98,590,680 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	108,952,200 - 109,061,441 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	108,952,200 - 109,061,441 (-)	Ensembl			panPan2	panpan1.1

GUCY2F
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	82,648,673 - 82,751,394 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	82,649,601 - 82,751,394 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	68,727,019 - 68,829,988 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	84,298,609 - 84,401,821 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	84,299,418 - 84,401,821 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	81,778,827 - 81,877,294 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	83,469,984 - 83,573,170 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	83,301,901 - 83,400,620 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gucy2f
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	81,905,232 - 82,004,580 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936499	5,653,384 - 5,752,732 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GUCY2F
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	X	89,557,952 - 89,653,491 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	105,222,491 - 105,268,453 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GUCY2F
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	97,234,564 - 97,349,105 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	97,239,846 - 97,348,853 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666065	22,440,973 - 22,541,598 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gucy2f
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624803	6,509,114 - 6,683,046 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624803	6,510,264 - 6,683,046 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gucy2f
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	94,237,490 - 94,330,466 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gucy2f
422 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	36
Count of miRNA genes:	29
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000046804
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	97528096	142528096	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	105359969	157758123	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	80434318	125434318	Rat
738029	Stresp2	Stress response QTL 2	3.4	0.0004	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	92979612	117740458	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	105468858	125434318	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	45182909	117740458	Rat
2302047	Pia34	Pristane induced arthritis QTL 34	5.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	19	96916163	141916163	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	1	8	113	31	20	6	19	6	6	63	46	98	3	33	14	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001842591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L36030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000046804 ⟹ ENSRNOP00000049500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	110,507,183 - 110,605,017 (-)	Ensembl
mRatBN7.2 Ensembl	X	105,710,356 - 105,808,183 (-)	Ensembl
Rnor_6.0 Ensembl	X	113,372,240 - 113,474,164 (-)	Ensembl

RefSeq Acc Id:

NM_053831 ⟹ NP_446283

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	110,507,183 - 110,605,017 (-)	NCBI
mRatBN7.2	X	105,710,356 - 105,808,183 (-)	NCBI
Rnor_6.0	X	113,372,240 - 113,474,164 (-)	NCBI
Rnor_5.0	X	111,822,417 - 111,920,459 (-)	NCBI
RGSC_v3.4	X	36,367,528 - 36,469,112 (+)	RGD
Celera	X	105,123,834 - 105,223,272 (-)	RGD

Sequence:

show sequence

TAAAGGTTTACAATGCCTCACAATTATTTACTCTTTCAATGGAATTTGTCAACAGACTGGAGTC
CTTGGTGGGATTATGACAGCCCAAAAGATGGGTGCATTGGAGTAGCTGTGCCTGAGATCTGCAT
GTTCAGGCTGTCCACTGGAGATGATTGAATGGTGATTTACATGGCACTCAGAAACACCACTGTT
CATGTCCAGAGGGCAGAGTAATCCTCCAGTATCTCATCACTAACTTGCTGAAGGGCAGCAAGGC
TATGTTCCTCGGACCCTGGCCTTTTTCTCGCCTTCTGTCCTGGTTTGCCATTTCCAGCAGACTG
TCAGGACAGCATGGCCTCACTTCCTCCAAGTTCCTGAGATACTTGTGCCTCCTGGCCCTATTAC
CTCTCATATGGTGGGGGCAAGCACTCCCCTACAAGATAGGGGTCATAGGTCCCTGGACATGTGA
TCCGTTCTTTTCCAAGGCCCTGCCTGAGGTTGCTGCCGCTTTAGCAATTGAACGAATCAGCCGG
GACATGTCATTTGACAGAAGTTACTCCTTCGAATATGTGATTCTTAACGAAGATTGCCAGACTT
CAAAGGCCCTCACCAGTTTTATTTCCCACCAGCAGATGGCCTCAGGATTTGTTGGGCCTGCCAA
CCCTGGCTACTGTGAGGCAGCCTCACTCCTGGGAAACAGCTGGGACAAAGGGATTTTCTCTTGG
GCTTGTGTGAATCATGAATTAGATAACAAACATAGCTACCCGACTTTTTCTCGGACACTTCCTT
CTCCTATCCGGGTGCTTGTAACCGTCATGAAGTATTTCCAGTGGGCTCATGCTGGGGTCATTTC
CTCAGATGAAGACATTTGGGTGCATACAGCCAATCAAGTCTCAAGTGCTCTTCGGAGCCACGGC
CTACCTGTAGGGGTCGTCCTGACCTCGGGACAAGACAGCCGTAGCATTCAGAAAGCTCTGCAGC
AGATTCGCCAGGCAGACAGAATTCGCATAATCATCATGTGTATGCATTCAGCCTTGATTGGGGG
AGAGACTCAGACACACTTCTTGGAATTGGCTCATGATCTGAAAATGACGGATGGGACTTACGTC
TTTGTCCCCTATGATGTACTGCTCTACAGTTTACCTTATAAGCACAGCCCCTACCAGGTCCTGA
GGAACAATCAAAAGCTCCGGGAAGCCTATGATGCTGTGTTGACTATTACAGTGGAGTCCCATGA
AAAGACCTTCTATGAAGCCTTTACAGAAGCAGCAGCCGGTGGAGAGATTCCTGAGAAGCTTGAC
TCACACCAAGTTTCACCGTTGTTTGGAACCATCTACAATTCAATTTACTTTATCGCACAAGCCA
TGAGTAATGCTCTGAAAGAAAATGGACAGGCTAGCGCTGCCAGCCTGACTCGGCATTCCAGAAA
CATGCAGTTCTATGGATTCAACCAGTTGATAAGGACAGACTCAAATGGAAATGGAATTTCTGAA
TACGTAATCCTGGACACCAATGGGAAAGAATGGGAACTCCGTGGCACCTACACTGTGGACATGG
AAACTGAACTGCTAAGGTTCAGAGGGACCCCCATTCATTTCCCAGGTGGCAGGCCTACTAGCGC
AGATGCAAAATGCTGGTTTGCACAAGGGAAGATCTGCCAAGGAGGTATTGACCCTGCCTTAGCC
ATGATGGTCTGCTTTGCTTTGCTTCTAGCCTTGCTGTCTATCAATGGATTTGCTTACTTTATCA
GGCGACGTATAAATAAAATCCAGTTGATTAAAGGACCCAACAGAATCCTGCTGACTTTGGAAGA
TGTGACATTTATTAACCCCCACTTTGGCAGTAAGAGAGGAAGCCGTGCCAGTGTAAGCTTCCAG
ATTATCTCAGAAGTTCAAAGTGGGAGGTCTCCAAGGCTGTCATTTTCTTCAGGTAGTTTAACTC
CAGCTACTTATGAGAACTCCAACATAGCAATCTACCAGGGTGACTGGGTATGGCTGAAAAAGTT
CCCTCCTGGAGATTTTGGGGACATTAAGTCTATCAAATCAAGTGCAAGTGATGTGTTTGAAATG
ATGAAGGACCTGCGGCATGAAAATGTCAACCCTTTATTGGGCTTCTTCTATGATTCGGGGATGT
TTGCCATCGTGTCAGAATTTTGTTCTCGAAGGAGCCTAGAAGACATACTTACACAAGACGATGT
GAAACTTGATTGGATGTTCAAATCATCACTGCTGCTTGACCTCATCAAGGGAATGAAATACTTA
CACCACAGAGAATTTATTCATGGGAGGCTAAAGTCTCGGAACTGTGTGGTAGACGGACGTTTTG
TACTAAAAGTGACAGATTATGGCTTTAATAACATTTTAGAAATGCTGAGACTCTCTGAAGAGGA
ACCTTCTGAAGAAGAGCTGCTGTGGACGGCCCCTGAACTGTTAAGAGCCCCTGGGGGTATCAGG
TTAGGTTCATTTGCAGGAGACGTCTATAGCTTTGCCATCATCATGCAAGAAGTGATGGTCCGGG
GTGCTCCTTTCTGCATGATGGATCTGTCTGCCAAAGAAGTCATAGACAGACTTAAAATGCCTCC
CCCTGTGTATAGACCAGTGGTTTCTCCTGAGTTTGCCCCTCCAGAGTGTCTCCAGCTGATGAAG
CAATGCTGGGCCGAGGCTGCAGAACAGCGACCAACTTTTGATGAAATATTTAACCAGTTTAAAA
CTTTCAACAAAGGGAAAAAAACTAATATTATTGATTCTATGCTCCGGATGTTGGAGCAGTATTC
TAGCAACTTGGAAGATTTGATCCGGGAACGGACTGAAGAACTGGAAATTGAAAAACAGAAAACG
GAAAAGCTTCTAACACAGATGCTACCACCATCAGTTGCTGAATCCCTCAAAAAGGGCTGTACAG
TGGAACCTGAGGGATTTGACTTGGTCACCTTGTACTTCAGTGACATTGTGGGCTTCACCACCAT
CTCAGCCATGAGTGAGCCCATTGAAGTGGTGGACCTTCTGAATGACCTGTACACACTCTTTGAT
GCCATCATTGGCAGTCATGATGTCTATAAGGTAGAGACCATTGGAGATGCCTATATGGTGGCCT
CAGGCCTCCCAAAGAGGAACGGCAGTAGGCATGCAGCTGAGATTGCAAACATGTCCCTGGATAT
TCTGAGCTCTGTGGGTACCTTTAAGATGCGACACATGCCAGAGGTGCCAGTCCGGATTCGAATA
GGTCTGCACACAGGGCCTGTTGTTGCTGGAGTGGTGGGCCTTACCATGCCTAGATATTGCTTGT
TTGGTGATACTGTGAATACAGCTTCTCGAATGGAATCAACGGGGCTACCATACCGAATTCATGT
CAGTCTCAGCACAGTAACAATTCTTCGGACTCTGAGTGAAGGCTATGAAGTAGAGCTTCGTGGA
AGAACAGAGCTCAAGGGTAAAGGCACAGAGGAGACCTTCTGGCTTGTTGGAAAAAAGGGTTTCA
CCAAACCTCTTCCTGTACCCCCACCAGTGGGCAAAGATGGGCAAGTGGGTCATGGCTTGCAACC
AGCGGAGATTGCAGCATTCCAAAGAAGAAAAGCAGAAAGGCAGTTGGTGCGAAACAAGCCATAA
GATGGAAAGAACTCCAGCATTTGAATCTCCTCTTGACAAAGCAACGCTGAAGCTCATTACAGAT
CAAGGATATTCTTCTTCTTGAGCAAGATATTAGTGAATGATTGTTCTTCTGAGGTTGCCTAATG
TCCAGGGATGGGTCAAGCCTAGTGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_446283	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA65511	(Get FASTA)	NCBI Sequence Viewer
	EDL85212	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000049500
	ENSRNOP00000049500.2
GenBank Protein	P51842	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446283 ⟸ NM_053831
- Peptide Label:	precursor
- UniProtKB:	P51842 (UniProtKB/Swiss-Prot), A6KG67 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFLGPWPFSRLLSWFAISSRLSGQHGLTSSKFLRYLCLLALLPLIWWGQALPYKIGVIGPWTCD PFFSKALPEVAAALAIERISRDMSFDRSYSFEYVILNEDCQTSKALTSFISHQQMASGFVGPAN PGYCEAASLLGNSWDKGIFSWACVNHELDNKHSYPTFSRTLPSPIRVLVTVMKYFQWAHAGVIS SDEDIWVHTANQVSSALRSHGLPVGVVLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSALIGG ETQTHFLELAHDLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLRNNQKLREAYDAVLTITVESHE KTFYEAFTEAAAGGEIPEKLDSHQVSPLFGTIYNSIYFIAQAMSNALKENGQASAASLTRHSRN MQFYGFNQLIRTDSNGNGISEYVILDTNGKEWELRGTYTVDMETELLRFRGTPIHFPGGRPTSA DAKCWFAQGKICQGGIDPALAMMVCFALLLALLSINGFAYFIRRRINKIQLIKGPNRILLTLED VTFINPHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIYQGDWVWLKKF PPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTQDDV KLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNNILEMLRLSEEE PSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLSAKEVIDRLKMPP PVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYS SNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTI SAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDI LSSVGTFKMRHMPEVPVRIRIGLHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV SLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDGQVGHGLQP AEIAAFQRRKAERQLVRNKP hide sequence

Ensembl Acc Id:

ENSRNOP00000049500 ⟸ ENSRNOT00000046804

Protein Domains

Guanylate cyclase Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P51842-F1-model_v2	AlphaFold	P51842	1-1108	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620439	AgrOrtholog
BioCyc Gene	G2FUF-1520	BioCyc
Ensembl Genes	ENSRNOG00000019086	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000046804	ENTREZGENE
	ENSRNOT00000046804.3	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.70.1230	UniProtKB/Swiss-Prot
	3.40.50.2300	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	A/G_cyclase	UniProtKB/Swiss-Prot
	A/G_cyclase_CS	UniProtKB/Swiss-Prot
	ANF_lig-bd_rcpt	UniProtKB/Swiss-Prot
	Cyclic_nucleotide_synthase	UniProtKB/Swiss-Prot
	HNOB_dom_associated	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Nucleotide_cyclase	UniProtKB/Swiss-Prot
	Peripla_BP_I	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:116556	UniProtKB/Swiss-Prot
NCBI Gene	116556	ENTREZGENE
PANTHER	GUANYLYL CYCLASE	UniProtKB/Swiss-Prot
	PTHR11920:SF349	UniProtKB/Swiss-Prot
Pfam	ANF_receptor	UniProtKB/Swiss-Prot
	Guanylate_cyc	UniProtKB/Swiss-Prot
	HNOBA	UniProtKB/Swiss-Prot
	Pkinase_Tyr	UniProtKB/Swiss-Prot
PhenoGen	Gucy2f	PhenoGen
PROSITE	GUANYLATE_CYCLASE_1	UniProtKB/Swiss-Prot
	GUANYLATE_CYCLASE_2	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019086	RatGTEx
SMART	CYCc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53822	UniProtKB/Swiss-Prot
	SSF55073	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A6KG67	ENTREZGENE, UniProtKB/TrEMBL
	GUC2F_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-02-26	Gucy2f	guanylate cyclase 2F	Gucy2f	guanylate cyclase 2f	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Gucy2f	guanylate cyclase 2f		guanylate cyclase 2F, retinal	Name updated	1299863	APPROVED
2002-08-07	Gucy2f	guanylate cyclase 2F, retinal			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains an extracellular domain, a single membrane-spanning domain, a protein kinase-like domain, and a cyclase catalytic domain	632891
gene_expression	mRNA expressed only in the eye	632891
gene_process	may be involved with photoreceptor signal transduction	632891
gene_product	member of the guanylyl cyclase membrane receptor family	632891

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)