Pcsk5 (proprotein convertase subtilisin/kexin type 5) - Rat Genome Database

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Gene: Pcsk5 (proprotein convertase subtilisin/kexin type 5) Rattus norvegicus
Analyze
Symbol: Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
RGD ID: 620326
Description: Predicted to enable peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of integrin-mediated signaling pathway; and positive regulation of smooth muscle cell-matrix adhesion. Located in Golgi apparatus subcompartment; perikaryon; and proximal dendrite. Biomarker of sciatic neuropathy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pc5; PC6; proprotein convertase 5; proprotein convertase 6; proprotein convertase PC5; rPC5; subtilisin/kexin-like protease PC5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,263,823 - 224,694,350 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1224,264,678 - 224,694,347 (-)EnsemblGRCr8
mRatBN7.21214,837,847 - 215,267,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,837,927 - 215,267,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,320,598 - 223,601,308 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01230,257,142 - 230,537,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,075,150 - 223,355,852 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,031,988 - 236,313,858 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,031,988 - 236,313,858 (+)Ensemblrn6Rnor6.0
Rnor_5.01243,339,259 - 243,768,026 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,961,912 - 221,405,907 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1212,298,555 - 212,578,355 (-)NCBICelera
RGSC_v3.11221,283,956 - 221,569,937 (-)NCBI
Cytogenetic Map1q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
ferric oxide  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
ketoconazole  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Hormonal regulation of proprotein convertase subtilisin/kexin type 5 expression during ovarian follicle development in the rat. Bae JA, etal., Mol Cell Endocrinol. 2008 Jul 16;289(1-2):29-37. doi: 10.1016/j.mce.2008.04.006. Epub 2008 Apr 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells. Lusson J, etal., Proc Natl Acad Sci U S A 1993 Jul 15;90(14):6691-5.
5. The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing. Marcinkiewicz M, etal., Brain Res Mol Brain Res. 1998 Aug 31;59(2):229-46.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling. Stawowy P, etal., Circulation. 2004 Feb 17;109(6):770-6.
13. Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo. Stawowy P, etal., Histochem Cell Biol. 2003 Mar;119(3):239-45. Epub 2003 Feb 20.
14. Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells. Stawowy P, etal., Hypertension. 2002 Feb;39(2 Pt 2):399-404.
15. Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro. Stawowy P, etal., J Histochem Cytochem. 2001 Mar;49(3):323-32.
16. The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. Sun X, etal., Mol Cancer. 2009 Sep 8;8:73. doi: 10.1186/1476-4598-8-73.
17. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Szumska D, etal., Genes Dev. 2008 Jun 1;22(11):1465-77. doi: 10.1101/gad.479408.
18. PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations. Tsuda T, etal., Eur J Pediatr Surg. 2011 Aug;21(4):238-41. doi: 10.1055/s-0031-1273691. Epub 2011 Apr 8.
19. Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain. Villeneuve P, etal., J Comp Neurol. 2000 Aug 28;424(3):461-75.
20. Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain. Villeneuve P, etal., Neuroscience. 1999;92(2):641-54.
Additional References at PubMed
PMID:8468318   PMID:8901832   PMID:8940009   PMID:8947550   PMID:9013936   PMID:9242664   PMID:10749928   PMID:14608596   PMID:15358140   PMID:15601911   PMID:15606899   PMID:16109723  
PMID:16912035   PMID:20581395   PMID:21147780   PMID:21700711   PMID:23686857   PMID:24006456   PMID:25807483   PMID:28975535   PMID:33313955  


Genomics

Comparative Map Data
Pcsk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,263,823 - 224,694,350 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1224,264,678 - 224,694,347 (-)EnsemblGRCr8
mRatBN7.21214,837,847 - 215,267,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,837,927 - 215,267,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,320,598 - 223,601,308 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01230,257,142 - 230,537,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,075,150 - 223,355,852 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,031,988 - 236,313,858 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,031,988 - 236,313,858 (+)Ensemblrn6Rnor6.0
Rnor_5.01243,339,259 - 243,768,026 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41220,961,912 - 221,405,907 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1212,298,555 - 212,578,355 (-)NCBICelera
RGSC_v3.11221,283,956 - 221,569,937 (-)NCBI
Cytogenetic Map1q43NCBI
PCSK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38975,889,809 - 76,362,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl975,890,644 - 76,362,975 (+)Ensemblhg38GRCh38
GRCh37978,505,589 - 78,977,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36977,695,441 - 77,998,164 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34975,735,174 - 76,037,889NCBI
Celera949,083,010 - 49,551,972 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef948,336,126 - 48,806,234 (+)NCBIHuRef
CHM1_1978,651,993 - 79,121,401 (+)NCBICHM1_1
T2T-CHM13v2.0988,048,502 - 88,519,580 (+)NCBIT2T-CHM13v2.0
Pcsk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391917,409,678 - 17,815,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1917,409,683 - 17,814,996 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381917,432,314 - 17,837,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1917,432,319 - 17,837,632 (-)Ensemblmm10GRCm38
MGSCv371917,507,322 - 17,912,122 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361917,499,851 - 17,993,244 (-)NCBIMGSCv36mm8
Celera1918,108,836 - 18,517,555 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1912.86NCBI
Pcsk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555122,917,243 - 3,333,688 (-)Ensembl
ChiLan1.0NW_0049555122,914,834 - 3,333,440 (-)NCBIChiLan1.0ChiLan1.0
PCSK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,063,314 - 75,524,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1975,069,756 - 75,532,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0948,480,607 - 48,943,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1974,745,187 - 75,224,347 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl974,745,761 - 75,220,502 (+)EnsemblpanPan2panpan1.1
PCSK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1182,088,090 - 82,506,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl182,090,664 - 82,555,145 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha182,554,152 - 83,012,101 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0182,504,812 - 82,963,105 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl182,506,866 - 82,963,633 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1182,293,218 - 82,750,127 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0182,009,456 - 82,467,391 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,737,312 - 83,195,037 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcsk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947129,415,166 - 129,706,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650311,466,950 - 11,896,887 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650311,466,955 - 11,896,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1228,854,595 - 229,308,906 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11228,854,587 - 229,308,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,618,184 - 255,748,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11286,907,173 - 87,367,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1287,042,557 - 87,367,033 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603875,357,152 - 75,822,509 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248113,453,218 - 3,862,970 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pcsk5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1217,525,179 - 17,934,302 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pcsk5
2812 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:40
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000016164
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1221820316234540296Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1223964326236074012Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
WI-15571  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01243,620,894 - 243,621,018NCBIRnor5.0
RGSC_v3.41221,117,553 - 221,117,676UniSTSRGSC3.4
Celera1212,298,590 - 212,298,713UniSTS
Cytogenetic Map1q43UniSTS
D1Bda56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21214,838,009 - 214,838,227 (-)MAPPERmRatBN7.2
Rnor_6.01236,463,116 - 236,463,333NCBIRnor6.0
Rnor_5.01243,767,646 - 243,767,863UniSTSRnor5.0
RGSC_v3.41220,962,676 - 220,962,893UniSTSRGSC3.4
Celera1212,153,579 - 212,153,796UniSTS
Cytogenetic Map1q43UniSTS
RH137520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21215,113,055 - 215,113,207 (-)MAPPERmRatBN7.2
Rnor_6.01236,187,308 - 236,187,459NCBIRnor6.0
Rnor_5.01243,494,174 - 243,494,325UniSTSRnor5.0
RGSC_v3.41221,245,252 - 221,245,403UniSTSRGSC3.4
Celera1212,423,976 - 212,424,127UniSTS
Cytogenetic Map1q43UniSTS
BF390451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21215,029,096 - 215,029,264 (-)MAPPERmRatBN7.2
Rnor_6.01236,271,388 - 236,271,555NCBIRnor6.0
Rnor_5.01243,578,583 - 243,578,750UniSTSRnor5.0
RGSC_v3.41221,159,182 - 221,159,349UniSTSRGSC3.4
Celera1212,340,809 - 212,340,976UniSTS
RH 3.4 Map9759.09UniSTS
Cytogenetic Map1q43UniSTS
D19Dcr4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21214,924,277 - 214,924,324 (-)MAPPERmRatBN7.2
Rnor_6.01236,378,896 - 236,378,942NCBIRnor6.0
Rnor_5.01243,682,944 - 243,682,990UniSTSRnor5.0
RGSC_v3.41221,049,791 - 221,049,837UniSTSRGSC3.4
Celera1212,236,451 - 212,236,497UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 151 91 90 59 28 59 6 292 128 11 130 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016164   ⟹   ENSRNOP00000016164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1224,413,648 - 224,694,347 (-)Ensembl
mRatBN7.2 Ensembl1214,986,922 - 215,267,600 (-)Ensembl
Rnor_6.0 Ensembl1236,031,988 - 236,313,858 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100985   ⟹   ENSRNOP00000089163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1224,264,678 - 224,694,347 (-)Ensembl
mRatBN7.2 Ensembl1214,837,927 - 215,267,600 (-)Ensembl
RefSeq Acc Id: NM_053823   ⟹   NP_446275
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,413,648 - 224,694,347 (-)NCBI
mRatBN7.21214,986,922 - 215,267,600 (-)NCBI
Rnor_6.01236,031,988 - 236,313,858 (+)NCBI
Rnor_5.01243,339,259 - 243,768,026 (+)NCBI
Celera1212,298,555 - 212,578,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109692   ⟹   XP_038965620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,263,823 - 224,694,350 (-)NCBI
mRatBN7.21214,837,847 - 215,267,626 (-)NCBI
RefSeq Acc Id: XM_039109729   ⟹   XP_038965657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,263,823 - 224,694,350 (-)NCBI
mRatBN7.21214,837,847 - 215,267,626 (-)NCBI
RefSeq Acc Id: XM_039109772   ⟹   XP_038965700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,263,823 - 224,468,364 (-)NCBI
mRatBN7.21214,837,847 - 215,041,606 (-)NCBI
RefSeq Acc Id: XM_039109807   ⟹   XP_038965735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,263,823 - 224,393,988 (-)NCBI
mRatBN7.21214,837,847 - 214,974,625 (-)NCBI
RefSeq Acc Id: XM_063264264   ⟹   XP_063120334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,372,010 - 224,694,350 (-)NCBI
RefSeq Acc Id: NP_446275   ⟸   NM_053823
- Peptide Label: preproprotein
- UniProtKB: A6I0J8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016164   ⟸   ENSRNOT00000016164
RefSeq Acc Id: XP_038965657   ⟸   XM_039109729
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965620   ⟸   XM_039109692
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AKB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965700   ⟸   XM_039109772
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965735   ⟸   XM_039109807
- Peptide Label: isoform X4
- UniProtKB: A6I0J7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089163   ⟸   ENSRNOT00000100985
RefSeq Acc Id: XP_063120334   ⟸   XM_063264264
- Peptide Label: isoform X5
Protein Domains
EGF-like   P/Homo B   Peptidase S8   PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41413-F1-model_v2 AlphaFold P41413 1-1809 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690809
Promoter ID:EPDNEW_R1334
Type:single initiation site
Name:Pcsk5_1
Description:proprotein convertase subtilisin/kexin type 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01236,031,944 - 236,032,004EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620326 AgrOrtholog
BioCyc Gene G2FUF-56209 BioCyc
Ensembl Genes ENSRNOG00000012036 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016164 ENTREZGENE
  ENSRNOT00000016164.8 UniProtKB/Swiss-Prot
  ENSRNOT00000100985 ENTREZGENE
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
  Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2 UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  Furin_repeat UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  GF_recep_IV UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Kexin/furin UniProtKB/Swiss-Prot
  P_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  Rspo_Fu-CRD_dom UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
  S8_pro-domain_sf UniProtKB/Swiss-Prot
KEGG Report rno:116548 UniProtKB/Swiss-Prot
NCBI Gene 116548 ENTREZGENE
PANTHER FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2 UniProtKB/Swiss-Prot
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot
Pfam Furin-like_2 UniProtKB/Swiss-Prot
  GF_recep_IV UniProtKB/Swiss-Prot
  P_proprotein UniProtKB/Swiss-Prot
  Peptidase_S8 UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
PhenoGen Pcsk5 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE P_HOMO_B UniProtKB/Swiss-Prot
  SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_ASP UniProtKB/Swiss-Prot
  SUBTILASE_HIS UniProtKB/Swiss-Prot
  SUBTILASE_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012036 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  Ephrin_rec_like UniProtKB/Swiss-Prot
  SM00261 UniProtKB/Swiss-Prot
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot
  SSF49785 UniProtKB/Swiss-Prot
  SSF52743 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A8I6AKB3 ENTREZGENE, UniProtKB/TrEMBL
  A6I0J7 ENTREZGENE, UniProtKB/TrEMBL
  A6I0J8 ENTREZGENE, UniProtKB/TrEMBL
  P41413 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3ZVZ3 UniProtKB/Swiss-Prot
  Q62914 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pcsk5  proprotein convertase subtilisin/kexin type 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pcsk5        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the subtilisin/kexin like proprotein convertase family 729485