Sh3gl2 (SH3 domain containing GRB2 like 2, endophilin A1) - Rat Genome Database

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Gene: Sh3gl2 (SH3 domain containing GRB2 like 2, endophilin A1) Rattus norvegicus
Analyze
Symbol: Sh3gl2
Name: SH3 domain containing GRB2 like 2, endophilin A1
RGD ID: 620276
Description: Enables several functions, including identical protein binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including membrane bending; positive regulation of membrane tubulation; and vesicle scission. Located in presynapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 17beta-estradiol; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endophilin-1; endophilin-A1; SH3 domain protein 2A; SH3 domain-containing GRB2-like 2; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; Sh3d2a; Sh3p4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85104,699,270 - 104,874,724 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5104,698,929 - 105,159,896 (+)EnsemblGRCr8
mRatBN7.2599,653,189 - 99,827,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl599,653,152 - 100,113,843 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5102,036,367 - 102,216,379 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05103,824,073 - 103,998,825 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05103,847,211 - 104,027,230 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05103,479,767 - 103,654,507 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5103,479,767 - 103,654,247 (+)Ensemblrn6Rnor6.0
Rnor_5.05107,479,270 - 107,653,523 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45104,129,280 - 104,308,317 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera598,159,729 - 98,334,521 (+)NCBICelera
RGSC_v3.15104,300,491 - 104,313,320 (+)NCBI
Cytogenetic Map5q31NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation. Ambroso MR, etal., Proc Natl Acad Sci U S A. 2014 May 13;111(19):6982-7. doi: 10.1073/pnas.1402233111. Epub 2014 Apr 28.
2. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Intradimer/Intermolecular interactions suggest autoinhibition mechanism in endophilin A1. Chen Z, etal., J Am Chem Soc. 2014 Mar 26;136(12):4557-64. doi: 10.1021/ja411607b. Epub 2014 Mar 13.
4. Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Chowdhury S, etal., Neuron. 2006 Nov 9;52(3):445-59.
5. Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation. De Gois S, etal., Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):679-93. doi: 10.1007/s10571-006-9054-8. Epub 2006 May 19.
6. Identification of the major synaptojanin-binding proteins in brain. de Heuvel E, etal., J Biol Chem. 1997 Mar 28;272(13):8710-6.
7. Generation of high curvature membranes mediated by direct endophilin bilayer interactions. Farsad K, etal., J Cell Biol. 2001 Oct 15;155(2):193-200. doi: 10.1083/jcb.200107075. Epub 2001 Oct 15.
8. Mechanism of endophilin N-BAR domain-mediated membrane curvature. Gallop JL, etal., EMBO J. 2006 Jun 21;25(12):2898-910. doi: 10.1038/sj.emboj.7601174. Epub 2006 Jun 8.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Early increase of apoptosis-linked gene-2 interacting protein X in areas of kainate-induced neurodegeneration. Hemming FJ, etal., Neuroscience. 2004;123(4):887-95.
12. Interaction of SPIN90 with dynamin I and its participation in synaptic vesicle endocytosis. Kim Y, etal., J Neurosci. 2005 Oct 12;25(41):9515-23.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. Micheva KD, etal., J Biol Chem. 1997 Oct 24;272(43):27239-45. doi: 10.1074/jbc.272.43.27239.
15. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Milosevic I, etal., Neuron. 2011 Nov 17;72(4):587-601. doi: 10.1016/j.neuron.2011.08.029.
16. Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis. Mizuno N, etal., J Biol Chem. 2010 Jul 23;285(30):23351-8. doi: 10.1074/jbc.M110.143776. Epub 2010 May 18.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. Nemoto Y, etal., J Biol Chem 2001 Nov 2;276(44):41133-42.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Differential expression of endophilin 1 and 2 dimers at central nervous system synapses. Ringstad N, etal., J Biol Chem. 2001 Nov 2;276(44):40424-30. doi: 10.1074/jbc.M106338200. Epub 2001 Aug 22.
25. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Ringstad N, etal., Proc Natl Acad Sci U S A 1997 Aug 5;94(16):8569-74.
26. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
27. Inhibitory role of endophilin 3 in receptor-mediated endocytosis. Sugiura H, etal., J Biol Chem. 2004 May 28;279(22):23343-8. doi: 10.1074/jbc.M312607200. Epub 2004 Apr 5.
28. Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I. Tian Q, etal., Neurosci Bull. 2012 Oct;28(5):483-92. doi: 10.1007/s12264-012-1257-z. Epub 2012 Jul 13.
29. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Voglmaier SM, etal., Neuron. 2006 Jul 6;51(1):71-84. doi: 10.1016/j.neuron.2006.05.027.
30. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. Wuertenberger S and Groemping Y, FEBS Lett. 2015 Apr 28;589(10):1156-63. doi: 10.1016/j.febslet.2015.03.014. Epub 2015 Mar 24.
Additional References at PubMed
PMID:10908605   PMID:14704270   PMID:15821731   PMID:16115810   PMID:16164598   PMID:18391417   PMID:18940612   PMID:19481455   PMID:20404169   PMID:20418375   PMID:21849472   PMID:22768939  
PMID:23376485   PMID:23442862   PMID:23482561   PMID:23785143   PMID:24854121   PMID:25517094   PMID:26854628   PMID:28131823   PMID:28235806   PMID:28933693   PMID:29476059   PMID:31059028  


Genomics

Comparative Map Data
Sh3gl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85104,699,270 - 104,874,724 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5104,698,929 - 105,159,896 (+)EnsemblGRCr8
mRatBN7.2599,653,189 - 99,827,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl599,653,152 - 100,113,843 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5102,036,367 - 102,216,379 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05103,824,073 - 103,998,825 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05103,847,211 - 104,027,230 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05103,479,767 - 103,654,507 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5103,479,767 - 103,654,247 (+)Ensemblrn6Rnor6.0
Rnor_5.05107,479,270 - 107,653,523 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45104,129,280 - 104,308,317 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera598,159,729 - 98,334,521 (+)NCBICelera
RGSC_v3.15104,300,491 - 104,313,320 (+)NCBI
Cytogenetic Map5q31NCBI
SH3GL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38917,579,066 - 17,797,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl917,579,066 - 17,797,129 (+)Ensemblhg38GRCh38
GRCh37917,579,064 - 17,797,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36917,569,194 - 17,787,122 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34917,569,193 - 17,787,120NCBI
Celera917,507,463 - 17,725,658 (+)NCBICelera
Cytogenetic Map9p22.2NCBI
HuRef917,541,205 - 17,759,965 (+)NCBIHuRef
CHM1_1917,579,359 - 17,797,531 (+)NCBICHM1_1
T2T-CHM13v2.0917,591,797 - 17,809,924 (+)NCBIT2T-CHM13v2.0
Sh3gl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39485,123,663 - 85,307,617 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl485,123,363 - 85,557,432 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38485,205,456 - 85,389,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl485,205,126 - 85,639,195 (+)Ensemblmm10GRCm38
MGSCv37484,851,360 - 85,035,284 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36484,676,687 - 84,860,611 (+)NCBIMGSCv36mm8
Celera483,721,182 - 83,903,108 (+)NCBICelera
Cytogenetic Map4C4NCBI
cM Map440.23NCBI
Sh3gl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543420,331,779 - 20,381,376 (+)Ensembl
ChiLan1.0NW_00495543420,332,727 - 20,381,320 (+)NCBIChiLan1.0ChiLan1.0
SH3GL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211106,761,688 - 106,981,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19106,767,634 - 106,987,062 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0917,386,298 - 17,605,722 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1917,878,860 - 18,097,579 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl918,045,198 - 18,097,579 (+)EnsemblpanPan2panpan1.1
SH3GL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11137,720,793 - 37,769,027 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1137,577,053 - 37,767,572 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1136,210,473 - 36,429,450 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01138,479,939 - 38,699,050 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1138,479,865 - 38,844,393 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11137,183,251 - 37,402,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01136,975,724 - 37,194,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01137,613,946 - 37,832,890 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SH3GL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1205,081,231 - 205,285,364 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11205,081,227 - 205,285,359 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21228,802,236 - 229,005,151 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH3GL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11261,862,997 - 62,085,254 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1261,862,943 - 61,917,315 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603850,001,458 - 50,229,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3gl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473621,554,969 - 21,716,877 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473621,554,950 - 21,715,522 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sh3gl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1168,546,762 - 68,721,309 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sh3gl2
1230 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:152
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000008999
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Rat151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2599,753,548 - 99,753,708 (+)MAPPERmRatBN7.2
Rnor_6.05103,580,245 - 103,580,403NCBIRnor6.0
Rnor_5.05107,580,080 - 107,580,201NCBIRnor5.0
Rnor_5.05107,580,081 - 107,580,201NCBIRnor5.0
RGSC_v3.45104,231,741 - 104,231,900RGDRGSC3.4
RGSC_v3.45104,231,742 - 104,231,900UniSTSRGSC3.4
Celera598,259,651 - 98,259,809UniSTS
RGSC_v3.15104,236,968 - 104,237,126RGD
RH 3.4 Map5742.7RGD
RH 3.4 Map5742.7UniSTS
RH 2.0 Map5653.0RGD
Cytogenetic Map5q31UniSTS
AU047584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2599,800,893 - 99,801,089 (+)MAPPERmRatBN7.2
mRatBN7.2599,800,932 - 99,801,089 (+)MAPPERmRatBN7.2
Rnor_6.05103,628,140 - 103,628,296NCBIRnor6.0
Rnor_6.05103,628,101 - 103,628,296NCBIRnor6.0
Rnor_5.05107,627,416 - 107,627,572UniSTSRnor5.0
Rnor_5.05107,627,377 - 107,627,572UniSTSRnor5.0
RGSC_v3.45104,281,296 - 104,281,452UniSTSRGSC3.4
RGSC_v3.45104,281,257 - 104,281,452UniSTSRGSC3.4
Celera598,308,162 - 98,308,355UniSTS
Celera598,308,201 - 98,308,355UniSTS
Cytogenetic Map5q31UniSTS
G47071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2599,819,473 - 99,819,695 (+)MAPPERmRatBN7.2
Rnor_6.05103,646,221 - 103,646,442NCBIRnor6.0
Rnor_5.05107,645,497 - 107,645,718UniSTSRnor5.0
RGSC_v3.45104,300,068 - 104,300,289UniSTSRGSC3.4
Celera598,326,495 - 98,326,716UniSTS
Cytogenetic Map5q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 159 84 83 52 68 52 6 324 167 10 138 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008999   ⟹   ENSRNOP00000008999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl599,787,847 - 99,827,500 (+)Ensembl
Rnor_6.0 Ensembl5103,479,767 - 103,654,247 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100135   ⟹   ENSRNOP00000081211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5104,729,071 - 104,874,721 (+)Ensembl
mRatBN7.2 Ensembl599,653,189 - 99,825,720 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110787   ⟹   ENSRNOP00000087931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5104,699,345 - 104,874,721 (+)Ensembl
mRatBN7.2 Ensembl599,653,152 - 99,827,500 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111420   ⟹   ENSRNOP00000088763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5104,698,929 - 105,159,896 (+)Ensembl
mRatBN7.2 Ensembl599,653,189 - 100,113,843 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120604   ⟹   ENSRNOP00000098240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5104,698,929 - 104,874,721 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120605   ⟹   ENSRNOP00000098241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5104,833,926 - 104,874,721 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120606   ⟹   ENSRNOP00000098242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5104,783,230 - 104,874,721 (+)Ensembl
RefSeq Acc Id: NM_053935   ⟹   NP_446387
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85104,699,270 - 104,873,575 (+)NCBI
mRatBN7.2599,653,189 - 99,827,500 (+)NCBI
Rnor_6.05103,479,767 - 103,654,247 (+)NCBI
Rnor_5.05107,479,270 - 107,653,523 (+)NCBI
Celera598,159,729 - 98,334,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238359   ⟹   XP_006238421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85104,816,070 - 104,874,724 (+)NCBI
mRatBN7.2599,770,011 - 99,827,154 (+)NCBI
Rnor_6.05103,595,629 - 103,654,507 (+)NCBI
Rnor_5.05107,479,270 - 107,653,523 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287074   ⟹   XP_063143144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85104,791,785 - 104,874,724 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446387 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238421 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143144 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC14883 (Get FASTA)   NCBI Sequence Viewer  
  EDM10450 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087931
  ENSRNOP00000098240
  ENSRNOP00000098241
GenBank Protein O35179 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446387   ⟸   NM_053935
- UniProtKB: O35179 (UniProtKB/Swiss-Prot),   A6J857 (UniProtKB/TrEMBL),   A0A8L2Q412 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238421   ⟸   XM_006238359
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GFM2 (UniProtKB/TrEMBL),   A0A8L2Q412 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008999   ⟸   ENSRNOT00000008999
Ensembl Acc Id: ENSRNOP00000087931   ⟸   ENSRNOT00000110787
Ensembl Acc Id: ENSRNOP00000088763   ⟸   ENSRNOT00000111420
Ensembl Acc Id: ENSRNOP00000081211   ⟸   ENSRNOT00000100135
RefSeq Acc Id: XP_063143144   ⟸   XM_063287074
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q412 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098240   ⟸   ENSRNOT00000120604
Ensembl Acc Id: ENSRNOP00000098241   ⟸   ENSRNOT00000120605
Ensembl Acc Id: ENSRNOP00000098242   ⟸   ENSRNOT00000120606
Protein Domains
BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35179-F1-model_v2 AlphaFold O35179 1-352 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693821
Promoter ID:EPDNEW_R4346
Type:initiation region
Name:Sh3gl2_1
Description:SH3 domain containing GRB2 like 2, endophilin A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05103,479,726 - 103,479,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620276 AgrOrtholog
BIND 130461
  130589
  134434
BioCyc Gene G2FUF-40854 BioCyc
Ensembl Genes ENSRNOG00000006761 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000110787 ENTREZGENE
  ENSRNOT00000120604 ENTREZGENE
  ENSRNOT00000120605 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  Endophilin_A_SH3 UniProtKB/Swiss-Prot
  Endophilin_SH3RF UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:116743 UniProtKB/Swiss-Prot
NCBI Gene 116743 ENTREZGENE
PANTHER ENDOPHILIN-A1 UniProtKB/Swiss-Prot
  SH3 DOMAIN-CONTAINING UniProtKB/Swiss-Prot
Pfam BAR UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Sh3gl2 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
  SPECTRNALPHA UniProtKB/Swiss-Prot
PROSITE BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006761 RatGTEx
SMART BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A8I5ZRH7_RAT UniProtKB/TrEMBL
  A0A8I6ABD8_RAT UniProtKB/TrEMBL
  A0A8I6GFM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q412 ENTREZGENE
  A0ABK0L6X2_RAT UniProtKB/TrEMBL
  A0ABK0L7B2_RAT UniProtKB/TrEMBL
  A6J857 ENTREZGENE, UniProtKB/TrEMBL
  O35179 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-19 Sh3gl2  SH3 domain containing GRB2 like 2, endophilin A1  Sh3gl2  SH3 domain-containing GRB2-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Sh3gl2  SH3 domain-containing GRB2-like 2  Sh3gl2  SH3-domain GRB2-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Sh3gl2  SH3-domain GRB2-like 2    SH3 domain protein 2A  Name updated 1299863 APPROVED
2004-09-10 Sh3gl2  SH3 domain protein 2A  Sh3d2a    Symbol and Name updated 1299863 APPROVED
2002-08-07 Sh3d2a  SH3 domain protein 2A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in brain 633918