Phb2 (prohibitin 2) - Rat Genome Database

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Gene: Phb2 (prohibitin 2) Rattus norvegicus
Analyze
Symbol: Phb2
Name: prohibitin 2
RGD ID: 620203
Description: Predicted to enable amide binding activity; protein dimerization activity; and sphingolipid binding activity. Involved in cellular response to hypoxia; cellular response to retinoic acid; and negative regulation of apoptotic process. Located in axon and mitochondrion. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Orthologous to human PHB2 (prohibitin 2); PARTICIPATES IN estrogen signaling pathway; mitochondria fusion pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell receptor associated protein 37; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; Bap; Bap-37; Bap37; Bcap27; Bcap37; prohibitin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,203,948 - 159,208,561 (+)NCBIGRCr8
mRatBN7.24157,517,662 - 157,522,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,746,152 - 163,750,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,529,057 - 159,533,663 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,170,622 - 158,175,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,230,769 - 157,235,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,248,365 - 224,252,971 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,835,328 - 160,839,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,080,337 - 161,084,834 (+)NCBI
Celera4146,256,324 - 146,260,930 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (EXP)
DDE  (ISO)
Dibutyl phosphate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP)
inositol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
mitoxantrone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
Propiverine  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thiram  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tungsten  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase C activity  (ISO)
antiviral innate immune response  (IEA,ISO)
B cell activation  (IEA,ISO,ISS)
CD40 signaling pathway  (ISO)
cell migration  (IEA,ISO,ISS)
cellular response to hypoxia  (IEP)
cellular response to retinoic acid  (IEP)
estrogen receptor signaling pathway  (IEA,ISO)
mammary gland alveolus development  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
mitochondrion organization  (IBA,ISO)
mitophagy  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of DNA-binding transcription factor activity  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
negative regulation of mammary gland epithelial cell proliferation  (IEA,ISO)
positive regulation of cell cycle G1/S phase transition  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of exit from mitosis  (IEA,ISO)
positive regulation of immunoglobulin production  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
protein import into nucleus  (IEA,ISO)
protein stabilization  (IEA,ISO)
regulation of branching involved in mammary gland duct morphogenesis  (IEA,ISO)
regulation of cardiolipin metabolic process  (IEA,ISO,ISS)
regulation of complement activation  (ISO)
regulation of cytochrome-c oxidase activity  (IEA,ISO,ISS)
RIG-I signaling pathway  (IEA,ISO)
sister chromatid cohesion  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
3. Composition of the synaptic PSD-95 complex. Dosemeci A, etal., Mol Cell Proteomics. 2007 Oct;6(10):1749-60. doi: 10.1074/mcp.M700040-MCP200. Epub 2007 Jul 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer. Girault I, etal., Maturitas. 2006 Jul 20;54(4):342-51. Epub 2006 Jul 5.
6. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
7. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. Kuramori C, etal., Biochem Biophys Res Commun. 2009 Feb 6;379(2):519-25. doi: 10.1016/j.bbrc.2008.12.103. Epub 2008 Dec 29.
8. Dynamic change of Prohibitin2 expression in rat sciatic nerve after crush. Long L, etal., Cell Mol Neurobiol. 2013 Jul;33(5):689-98. doi: 10.1007/s10571-013-9935-6. Epub 2013 Apr 9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Expression of PHB2 in rat brain cortex following traumatic brain injury. Xu T, etal., Int J Mol Sci. 2014 Feb 21;15(2):3299-318. doi: 10.3390/ijms15023299.
16. Effect of all-trans retinoic acid treatment on prohibitin and renin-angiotensin-aldosterone system expression in hypoxia-induced renal tubular epithelial cell injury. Zhou TB, etal., J Renin Angiotensin Aldosterone Syst. 2014 Sep;15(3):243-9. doi: 10.1177/1470320314542727. Epub 2014 Jul 16.
Additional References at PubMed
PMID:10359819   PMID:11302691   PMID:12477932   PMID:14651853   PMID:15140878   PMID:15489334   PMID:17008324   PMID:17065319   PMID:17070910   PMID:17785450   PMID:18504258   PMID:18614015  
PMID:18629613   PMID:19906925   PMID:20833797   PMID:20959514   PMID:21328542   PMID:21630459   PMID:22082260   PMID:22417827   PMID:23376485   PMID:23548868   PMID:24625528   PMID:25002582  
PMID:29476059   PMID:29867124   PMID:32357304   PMID:33450132   PMID:37046989   PMID:37958902   PMID:38260951  


Genomics

Comparative Map Data
Phb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,203,948 - 159,208,561 (+)NCBIGRCr8
mRatBN7.24157,517,662 - 157,522,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,746,152 - 163,750,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,529,057 - 159,533,663 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,170,622 - 158,175,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,230,769 - 157,235,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,248,365 - 224,252,971 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,835,328 - 160,839,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,080,337 - 161,084,834 (+)NCBI
Celera4146,256,324 - 146,260,930 (+)NCBICelera
Cytogenetic Map4q42NCBI
PHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,965,327 - 6,970,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,965,327 - 6,970,780 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,074,490 - 7,079,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,944,778 - 6,950,152 (-)NCBINCBI36Build 36hg18NCBI36
Celera128,695,534 - 8,700,935 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,932,980 - 6,938,381 (-)NCBIHuRef
CHM1_1127,073,468 - 7,078,869 (-)NCBICHM1_1
T2T-CHM13v2.0126,978,802 - 6,984,228 (-)NCBIT2T-CHM13v2.0
Phb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,689,252 - 124,693,908 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,689,299 - 124,693,913 (+)EnsemblGRCm39 Ensembl
GRCm386124,712,289 - 124,716,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,712,336 - 124,716,950 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,662,307 - 124,666,963 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,677,955 - 124,682,537 (+)NCBIMGSCv36mm8
Celera6126,394,014 - 126,398,670 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Phb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,558,259 - 4,563,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,557,969 - 4,563,697 (-)NCBIChiLan1.0ChiLan1.0
PHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,531,341 - 12,536,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,528,100 - 12,533,303 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,097,073 - 7,102,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,012,862 - 7,018,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,013,195 - 7,018,053 (-)Ensemblpanpan1.1panPan2
PHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,075,769 - 38,080,440 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,075,652 - 38,080,109 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,536,250 - 8,540,926 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,428,364 - 38,433,040 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,428,395 - 38,433,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,303,246 - 38,307,922 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,344,227 - 38,348,903 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,015,013 - 8,019,689 (-)NCBIUU_Cfam_GSD_1.0
Phb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,186,944 - 102,191,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709854,698 - 858,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709854,493 - 859,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,751,558 - 63,756,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,751,566 - 63,756,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,187,707 - 66,192,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,998,517 - 7,004,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,213,103 - 1,219,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,599,687 - 3,604,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,599,435 - 3,605,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phb2
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:74
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000017472
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
RH128209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,521,941 - 157,522,145 (+)MAPPERmRatBN7.2
Rnor_6.04157,235,049 - 157,235,252NCBIRnor6.0
Rnor_5.04224,252,645 - 224,252,848UniSTSRnor5.0
RGSC_v3.44160,839,607 - 160,839,810UniSTSRGSC3.4
Celera4146,260,604 - 146,260,807UniSTS
Cytogenetic Map4q42UniSTS
RH142323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,522,041 - 157,522,208 (+)MAPPERmRatBN7.2
Rnor_6.04157,235,149 - 157,235,315NCBIRnor6.0
Rnor_6.02196,052,665 - 196,052,847NCBIRnor6.0
Rnor_5.04224,252,745 - 224,252,911UniSTSRnor5.0
Rnor_5.02215,545,992 - 215,546,174UniSTSRnor5.0
RGSC_v3.44160,839,707 - 160,839,873UniSTSRGSC3.4
RGSC_v3.42189,787,523 - 189,787,705UniSTSRGSC3.4
Celera4146,260,704 - 146,260,870UniSTS
Cytogenetic Map4q42UniSTS
MARC_4161-4162:996679469:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,519,411 - 157,520,248 (+)MAPPERmRatBN7.2
Rnor_6.04157,232,519 - 157,233,355NCBIRnor6.0
Rnor_5.04224,250,115 - 224,250,951UniSTSRnor5.0
RGSC_v3.44160,837,078 - 160,837,913UniSTSRGSC3.4
Celera4146,258,074 - 146,258,910UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 141 227 147 69 147 36 45 250 115 145 57 24
Low
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000017472   ⟹   ENSRNOP00000017472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,517,577 - 157,522,269 (+)Ensembl
Rnor_6.0 Ensembl4157,230,895 - 157,235,051 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091464   ⟹   ENSRNOP00000075668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,517,577 - 157,522,272 (+)Ensembl
Rnor_6.0 Ensembl4157,230,769 - 157,235,367 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104665   ⟹   ENSRNOP00000093330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,517,751 - 157,522,235 (+)Ensembl
RefSeq Acc Id: NM_001013035   ⟹   NP_001013053
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,203,948 - 159,208,554 (+)NCBI
mRatBN7.24157,517,662 - 157,522,268 (+)NCBI
Rnor_6.04157,230,769 - 157,235,375 (+)NCBI
Rnor_5.04224,248,365 - 224,252,971 (+)NCBI
RGSC_v3.44160,835,328 - 160,839,933 (+)RGD
Celera4146,256,324 - 146,260,930 (+)RGD
Sequence:
RefSeq Acc Id: XM_063285401   ⟹   XP_063141471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,203,997 - 159,208,561 (+)NCBI
RefSeq Acc Id: NP_001013053   ⟸   NM_001013035
- UniProtKB: P70629 (UniProtKB/Swiss-Prot),   P70630 (UniProtKB/Swiss-Prot),   Q5XIH7 (UniProtKB/Swiss-Prot),   A0A0G2KB63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017472   ⟸   ENSRNOT00000017472
Ensembl Acc Id: ENSRNOP00000075668   ⟸   ENSRNOT00000091464
Ensembl Acc Id: ENSRNOP00000093330   ⟸   ENSRNOT00000104665
RefSeq Acc Id: XP_063141471   ⟸   XM_063285401
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q8H9 (UniProtKB/TrEMBL),   A6ILJ3 (UniProtKB/TrEMBL)
Protein Domains
Band

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIH7-F1-model_v2 AlphaFold Q5XIH7 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693394
Promoter ID:EPDNEW_R3910
Type:initiation region
Name:Phb2_1
Description:prohibitin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,230,785 - 157,230,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620203 AgrOrtholog
BioCyc Gene G2FUF-43089 BioCyc
Ensembl Genes ENSRNOG00000012999 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010230 UniProtKB/Swiss-Prot
  ENSRNOG00060032455 UniProtKB/Swiss-Prot
  ENSRNOG00065028930 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017472.8 UniProtKB/TrEMBL
  ENSRNOT00000091464 UniProtKB/TrEMBL
  ENSRNOT00000091464.2 UniProtKB/Swiss-Prot
  ENSRNOT00000104665.1 UniProtKB/TrEMBL
  ENSRNOT00055017283 UniProtKB/Swiss-Prot
  ENSRNOT00060056212 UniProtKB/Swiss-Prot
  ENSRNOT00065049967 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.479.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2090 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190294 IMAGE-MGC_LOAD
InterPro Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prohibitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114766 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94585 IMAGE-MGC_LOAD
NCBI Gene 114766 ENTREZGENE
PANTHER PROHIBITIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23222 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Phb2 PhenoGen
PRINTS PROHIBITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012999 RatGTEx
  ENSRNOG00055010230 RatGTEx
  ENSRNOG00060032455 RatGTEx
  ENSRNOG00065028930 RatGTEx
SMART PHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KB63 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK88_RAT UniProtKB/TrEMBL
  A0A8L2Q8H9 ENTREZGENE, UniProtKB/TrEMBL
  A6ILJ3 ENTREZGENE, UniProtKB/TrEMBL
  P70629 ENTREZGENE
  P70630 ENTREZGENE
  PHB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70629 UniProtKB/Swiss-Prot
  P70630 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Phb2  prohibitin 2  Bcap37  B-cell receptor-associated protein 37  Symbol and Name updated 1299863 APPROVED
2004-09-10 Bcap37  B-cell receptor-associated protein 37  Bcap27    Symbol updated 1299863 APPROVED
2002-08-07 Bcap27  B-cell receptor-associated protein 37      Symbol and Name status set to provisional 70820 PROVISIONAL